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Pincus, US
Allan Pincus, Green Brook, NJ US
| Patent application number | Description | Published |
|---|---|---|
| 20120098742 | Hand-Held Orthopedic Electronic Interface Device and Method of Manufacture - An orthopedic cursor control device that supports a user's hand, or other controlling anatomy, in a functionally neutral posture. The device has a motion sensor housed in a base, a mound attached to the top of the base and an optional carpal support attached to the base. The surfaces of the base, mound and optional carpal support together support a user's hand, or other controlling anatomy, in the functionally neutral, or other appropriate, posture. The mound conforms to an interior portion of the user's hand when in a grasping configuration. An inner surface of the carpal support conforms to, and supports, the user's wrist in the functionally neutral posture. The carpal support extends beyond a distal end of the user's ulna bone when the user grasps the cursor control device. The functionally neutral posture has, at the distal end, the user's radial bone substantially vertically above their ulna bone. | 04-26-2012 |
Jonathan Seth Pincus, Marietta, GA US
| Patent application number | Description | Published |
|---|---|---|
| 20080252005 | Object holding mechanism - An object connector for building a structure. The object connector is made of a light weight material with slots to hold various objects such as blocks and playing cards around the circumference of the connector as well as on the top and bottom of the connector. The top and bottom of the connector has a swiveling feature so the objects can be connected at a precise location. | 10-16-2008 |
Mark Pincus US
| Patent application number | Description | Published |
|---|---|---|
| 20110040844 | Communication Systems and Methods with Social Network Filtering - A method for a computer system include determining a first social distance for a first user with respect to a second user, determining a second social distance for a third user with respect to the second user, determining a first trust-metric for the first user in response to the first social distance, determining a second trust-metric for the third user in response to the second social distance, and prioritizing a first communication from the first user over a second communication from the third user, in response to the first trust-metric and the second trust-metric. | 02-17-2011 |
Mark Pincus, San Franciso, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110219073 | METHODS AND APPARATUS FOR INTEGRATING SOCIAL NETWORK METRICS AND REPUTATION DATA - A method for a computer system includes determining a first social distance for a first user with respect to a second user, determining a second social distance for a third user with respect to the second user, determining a first qualitative rating associated with the first user, determining a second qualitative rating associated with the second user, determining a first trust-metric for the first user in response to the first social distance and the first qualitative rating, determining a second trust-metric for the third user in response to the second social distance and the second qualitative rating, and prioritizing a first listing from the first user over a second listing from the third user for the second user, in response to the first trust-metric and the second trust-metric. | 09-08-2011 |
Mark Jonathan Pincus, San Francisco, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100227675 | Virtual Playing Chips in a Multiuser Online Game Network - In various embodiments, virtual currency is used within a multiplayer online game in a restricted manner. | 09-09-2010 |
| 20120015715 | VIRTUAL PLAYING CHIPS IN A MULTIUSER ONLINE GAME NETWORK - Methods, systems, and computer programs are presented for executing game transactions in an online game to acquire virtual currency. One method includes an operation for detecting a request from a player to purchase virtual currency for use in the online game. Cash or credit is received, in an online transaction, to make the purchase of the virtual currency. The virtual currency of the online game is not redeemable for cash or credit so the virtual currency cannot be considered gambling proceeds. The method further includes an operation for crediting the player with an amount of virtual currency based on the amount of the received cash or credit. | 01-19-2012 |
| 20120015724 | EMBEDDING OF GAMES INTO THIRD PARTY WEBSITES - Systems and methods for embedding and tracking revenue from fully operational games into third party websites are disclosed. | 01-19-2012 |
| 20120015725 | EMBEDDING OF GAMES INTO THIRD PARTY WEBSITES - Systems and methods for embedding and tracking revenue from fully operational games into third party websites are disclosed. | 01-19-2012 |
| 20120015747 | EMBEDDING OF GAMES INTO THIRD PARTY WEBSITES - Systems and methods for embedding and tracking revenue from fully operational games into third party websites are disclosed. | 01-19-2012 |
Matthew Pincus, Brooklyn, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090286861 | PHENOTYPIC REVERSION OF PANCREATIC CARCINOMA CELLS - The present invention provides peptides (including analogs and derivatives thereof) corresponding to residues 96-110 and 35-47 of ras-p21, which peptides have attached thereto a membrane-penetrating leader sequence. The subject peptides, analogs and derivatives thereof are useful in treatment of cancers and have been shown to induce phenotypic reversion of pancreatic cancer cells to non-cancerous cells. Pharmaceutical compositions comprising one or more subject peptides are also provided by the present invention. The present invention further provides replication incompetent Adenovirus (AdV) vectors comprising a promoter sequence and a nucleotide sequence encoding a subject peptide. Methods of treating cancer by administering one or more subject peptides, pharmaceutical compositions, and/or AdV vectors are also provided. | 11-19-2009 |
Matthew R. Pincus, Brooklyn, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100144636 | PEPTIDES DERIVED FROM RAS-P21 AND USES THEREFOR - A method of treating ras-transformed and ras-related cancer, including: administering to a plurality cells, including ras-transformed cancer cells and normal cells, a peptide material having a membrane resident peptide and a ras-p21 component, the membrane resident peptide attached to the carboxyl or amino terminal end of the ras-p21 component. | 06-10-2010 |
| 20110183915 | Small Molecule Cancer Treatments that cause Necrosis in Cancer Cells but do not Affect Normal Cells - A method of treating cancer in a subject, including: providing a subject having a plurality of cancer cells; and administering to the subject, a therapeutically effective amount of a composition including: an HDM-2 binding component; and a membrane resident component, the membrane resident component bound to the HDM-2 binding component. Also provided are a method of selectively necrosing cancer cells, a method of causing membranolysis in cancer cells, and a cancer treatment composition. | 07-28-2011 |
Seth Pincus, New Orleans, LA US
| Patent application number | Description | Published |
|---|---|---|
| 20090054919 | Channel Current Cheminformatics And Bioengineering Methods For Immunological Screening, Single-Molecule Analysis, And Single-Molecular-Interaction Analysis - Analytical tools and methods employing processing of channel current blockade measurements to detect or assess changes in environmental conditions generally, and more specifically, to detect and assess interactions between a blockade-producing auxiliary molecule in the channel and either the surrounding conductive medium generally or molecules in that conductive medium. The auxiliary molecule is disposed within the channel in order to generate a highly structured channel current blockade signal. The blockade signal resulting from inducing ionic current flow through the channel with auxiliary molecule present, is based on an auxiliary molecule chosen to be highly susceptible to modulation when the auxiliary molecule interacts with other molecules in the surrounding conductive medium, or when it otherwise is modified or affected at the molecular level by changes in the physical or chemical conditions of that surrounding medium. The tools and methods enable, amongst other things, candidate antibody screening, molecular affinity and bond strength analysis and detection of a variety of changes in test media, even at the molecular level. | 02-26-2009 |
Stephanie Pincus, Buffalo, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100184970 | Porphyrin-based compounds for tumor imaging and photodynamic therapy - This invention describes a first report on the synthesis of certain | 07-22-2010 |
| 20110223102 | MULTIMODALITY AGENTS FOR TUMOR IMAGING AND THERAPY - A compound that is a conjugate of an antagonist to an integrin expressed by a tumor cell and at least one of a tumor avid tetrapyrollic photosensitizer, a fluorescent dye, and a radioisotope labeled moiety wherein the radioisotope is | 09-15-2011 |
| 20110264027 | B RING REDUCED-D RING OXIDIZED TETRAPYROLLIC PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY AND TUMOR IMAGING - Tetrapyrollic photosensitizers and imaging agent compounds having A, B, C, and D rings and having a reduced B ring and an oxidized D ring. The compounds preferably have a purity of at least 95 percent and preferably have a fused system connected at an unsaturated carbon atom of the C ring nearest the D ring and at the unsaturated carbon atom between the C and D rings. The invention also includes a method of making the compounds at over 95 percent yield by starting with a B and D ring oxidized tetrapyrollic compound and dissolving it in a halogenated hydrocarbon solvent and treating it with sufficient nitroalkane solution of FeCl | 10-27-2011 |
| 20110288234 | SILICA NANOPARTICLES POSTLOADED WITH PHOTOSENSITIZERS FOR DRUG DELIVERY IN PHOTODYNAMIC THERAPY - A nanoparticle including a polysiloxane base having an exterior surface and having a photosensitizer at least partly exposed at its exterior surface, said photosensitizer being secured to the exterior surface by loading the photosensitizer onto the surface after formation of the polysiloxane base of the nanoparticle. The nanoparticle may have tumor targeting moieties and may be post loaded with cyanine dye. The nanoparticle preferably includes post loaded moieties providing at least two of tumor specificity, photodynamic properties and imaging capabilities and the photosensitizer is tagged with a radioisotope. A method for preparation of the nanoparticle is also provided. | 11-24-2011 |
Stephanie H. Pincus, Buffalo, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100292762 | METHOD FOR CONTROLLING PHOTODYNAMIC THERAPY IRRADIATION AND RELATED INSTRUMENTATION - In a first embodiment, there is no monitoring, and instead light is delivered according to a predetermined ‘recipe.’ In a second embodiment, the instrumentation provides a means for making the reflectance measurements during therapy without requiring the brief interruption. This device may therefore allow more accurate measurement of treatment-induced changes to the reflectance measurement. In a third embodiment, an adjustable aperture is used to constrict the area of a treatment beam. | 11-18-2010 |
Zachary Pincus, New Haven, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20110169937 | MODE OF ACTION SCREENING METHOD - Certain aspects of this disclosure relate to a screening method. In general terms, the screening assay comprises contacting test cells with a test compound to provide contacted test cells, obtaining values for a plurality of cytological attributes of the contacted test cells, and scoring the cells using the values to provide a likelihood score for at least one of a plurality of classifiers, where the plurality of classifiers are defined using values for cytological attributes obtained from cells that have been contacted with compounds of known mode of action. | 07-14-2011 |