Pinar
Pinar Akcora, New York, NY US
Patent application number | Description | Published |
---|---|---|
20100303874 | ANISOTROPIC SELF-ASSEMBLY OF NANOPARTICLES IN COMPOSITES - An anisotropic self assembled structure comprises isotropic grafted nanoparticles in a polymeric matrix, the self-assembled structure comprising (a) a one-dimensional string of the grafted nanoparticles within the matrix, the string having a width of one nanoparticle and a length of 1-10 nanoparticles, (b) a substantially two-dimensional sheet of the grafted nanoparticles within the matrix, the sheet having a length and a breadth of at least one micron respectively, wherein the sheet is about 2-5 nanoparticles in thickness, or (c) a plurality of three dimensionally interconnected structures where the width of each of the structures is 1-10 nanoparticles; wherein each grafted nanoparticle comprises a substantially spherical inorganic core nanoparticle and a polymeric brush structure grafted thereto. | 12-02-2010 |
Pinar Akpinar, Santa Monica, CA US
Patent application number | Description | Published |
---|---|---|
20100119489 | Stimulation of Pancreatic Beta Cell Proliferation - This invention provides a polypeptide, TMEM27, and secreted forms thereof, nucleic acids and constructs encoding the same, and cells comprising the same. The TMEM27 protein is expressed in hormone positive cells at early stages of pancreas development and pancreatic β-cells in the mature pancreas, whose expression promotes pancreatic β-cell replication and increased islet mass. Applications of the protein in diagnostics and therapeutics are described. | 05-13-2010 |
Pinar Huri, Ankara TR
Patent application number | Description | Published |
---|---|---|
20150230838 | BONE PLATE - An embodiment of a bone plate comprises a main body which is fixed to a side of the fracture and having a hole in which a connecting element is inserted for purposes of this fixation procedure; a movable part which is associated with the main body, is fixed to the other side of the fracture and having a hole in which a connecting element is inserted for purposes of this fixation procedure and being moveable with respect to the main body; a displacement mechanism enabling movement of the movable part relative to the main body, on the center of which it is positioned; a locking element which stops operation of the displacement mechanism, thereby restricting the movement of the movable part; and a displacement element which is associated with the displacement mechanism for controlling thereof externally. | 08-20-2015 |
Pinar Huri, Baltimore, MD US
Patent application number | Description | Published |
---|---|---|
20160095958 | BONE REGENERATION USING STROMAL VASCULAR FRACTION, PLATELET-DERIVED GROWTH FACTOR-RICH HYDROGEL, THREE-DIMENSIONAL PRINTED POLY-EPSILON-CAPROLACTONE SCAFFOLDS - The presently disclosed subject matter focuses on recapitulating the heterotypic interactions needed to maximize the co-development of vasculature and bone. More particularly, the presently disclosed subject matter explores the potential of cellular aggregation and temporal presentation of factors to induce the cell-cell signaling events required to stimulate ASCs to self-organize into vascularized bone. Further, exogenous PDGF-BB synergizes complex tissue formation in ASC cultures by enhancing vascular stability and osteogenic differentiation. The presently disclosed approach provides a robust protocol to engineer vascularized bone with ASCs in vitro. | 04-07-2016 |
Pinar Karpinar, Goettingen DE
Patent application number | Description | Published |
---|---|---|
20110296539 | Mutant Alpha-Synuclein, and Methods Using Same - The present invention relates to a mutant human alpha-synuclein with increased toxicity compared to wild-type alpha-synuclein, or a homologue thereof, wherein the mutant alpha-synuclein or homologue thereof comprises at least one amino acid substitution selected from the group consisting of a substitution at the alanine at position 56 (A56), at the alanine at position 76 (A76), at the methionine at position 127 (M127) and/or at the valine at position 118 (V118), as defined in the claims. Further, the invention relates to a polynucleotide encoding the mutant alpha-synuclein or homologue thereof, or an expression vector comprising said polynucleotide, a cell comprising the polynucleotide or expression vector, as defined in the claims. Also, a non-human animal comprising the cell of the invention is provided, as defined in the claims. Finally, the invention provides methods for identifying a substance that prevents or reduces toxicity of alpha-synuclein, as defined in the claims. | 12-01-2011 |
20150125951 | Mutant Alpha-Synuclein, and Methods Using Same - The present invention relates to a mutant human alpha-synuclein with increased toxicity compared to wild-type alpha-synuclein, or a homologue thereof, wherein the mutant alpha-synuclein or homologue thereof comprises at least one amino acid substitution selected from the group consisting of a substitution at the alanine at position 56 (A56), at the alanine at position 76 (A76), at the methionine at position 127 (M127) and/or at the valine at position 118 (V118), as defined in the claims. Further, the invention relates to a polynucleotide encoding the mutant alpha-synuclein or homologue thereof, or an expression vector comprising said polynucleotide, a cell comprising the polynucleotide or expression vector, as defined in the claims. Also, a non-human animal comprising the cell of the invention is provided, as defined in the claims. Finally, the invention provides methods for identifying a substance that prevents or reduces toxicity of alpha-synuclein, as defined in the claims. | 05-07-2015 |
20150143556 | Mutant Alpha-Synuclein, and Methods Using Same - The present invention relates to a mutant human alpha-synuclein with increased toxicity compared to wild-type alpha-synuclein, or a homologue thereof, wherein the mutant alpha-synuclein or homologue thereof comprises at least one amino acid substitution selected from the group consisting of a substitution at the alanine at position 56 (A56), at the alanine at position 76 (A76), at the methionine at position 127 (M127) and/or at the valine at position 118 (V118), as defined in the claims. Further, the invention relates to a polynucleotide encoding the mutant alpha-synuclein or homologue thereof, or an expression vector comprising said polynucleotide, a cell comprising the polynucleotide or expression vector, as defined in the claims. Also, a non-human animal comprising the cell of the invention is provided, as defined in the claims. Finally, the invention provides methods for identifying a substance that prevents or reduces toxicity of alpha-synuclein, as defined in the claims. | 05-21-2015 |
Pinar Pir, Cambridge GB
Patent application number | Description | Published |
---|---|---|
20140206057 | NOVEL YEAST STRAINS - There is provided an alkene-producing yeast cell comprising a bacterial fatty acid decarboxylase enzyme, which may comprise the amino acid sequence SEQ ID NO:1 or a functional variant or portion thereof. The alkene may have 15, 17 or 19 carbon atoms. The cell may have a genome comprising a polynucleotide sequence encoding the bacterial fatty acid decarboxylase enzyme. | 07-24-2014 |
Pinar Tabur, Emeryville, CA US
Patent application number | Description | Published |
---|---|---|
20120040396 | METHODS FOR PURIFYING BIO-ORGANIC COMPOUNDS - Methods and systems for purifying bio-organic compounds are described. In certain embodiments, the methods comprise the steps of (a) providing a composition or an emulsion comprising a surfactant, host cells, an aqueous medium and a bio-organic compound produced by the host cells, wherein the solubility of the surfactant in the aqueous medium decreases with increasing temperature and wherein the temperature of the composition or emulsion is at least about 1° C. below a phase inversion temperature of the composition or emulsion; (b) raising the temperature of the composition or emulsion to at least about 1° C. above the phase inversion temperature; and (c) performing a liquid/liquid separation of the composition to provide a crude bio-organic composition or emulsion. | 02-16-2012 |
Pinar Taskiran-Cyr, Doraville, GA US
Patent application number | Description | Published |
---|---|---|
20090158383 | System and Method for Upgrading a Multiprocessor Set-Top Box Device with a Monolithilic Firmware Image - A system and method for downloading a code image at a set-top gateway host that includes an embedded set-top box and an embedded cable modem. The embedded set-top box and the embedded cable modem interact so that each leverages the resources of the other, thereby minimizing the functionality that must be built into each. | 06-18-2009 |
20140007176 | System And Method For Upgrading A Multiprocessor Set-Top Box Device With A Monolithic Firmware Image | 01-02-2014 |
Pinar Wennerberg, Munich DE
Patent application number | Description | Published |
---|---|---|
20090313243 | METHOD AND APPARATUS FOR PROCESSING SEMANTIC DATA RESOURCES - A semantic data resource of a domain is processed by calculating relevance scores for terms which occur in domain corpora and weighting the semantic data resource depending on the relevance scores calculated for these terms. The semantic data resource may include domain-specific terms and relations, such as a domain ontology, a domain terminology and a domain classification. The domain ontology may include a domain-specific-hierarchy of terms assigned to nodes which are connected by edges and may be encoded in a web ontology language. The relevance scores may be chi-square scores which are calculated depending on a frequency of a term in the domain corpora and an expected frequency of the term. | 12-17-2009 |
20110016130 | Method and an apparatus for providing at least one configuration data ontology module - A method and an apparatus provide at least one configuration data ontology module. Modules are extracted from an ontology under consideration of the semantics of the ontology. Therefore, individual concepts are selected from the ontology which are in a subsequent step connected by relations. The method and apparatus are used in ontology modularization, and especially in biomedical application domains. | 01-20-2011 |
Pinar Yanardag Delul, West Lafayette, IN US
Patent application number | Description | Published |
---|---|---|
20150379167 | CROWD-SOURCED OPERATIONAL METRIC ANALYSIS OF VIRTUAL APPLIANCES - A system and method for performing an operational metric analysis for a virtual appliance uses application operational data from multiple instances of the virtual appliance. The application operational data is then used to generate an operational metric prediction for the virtual appliance. | 12-31-2015 |
Pinar Zorlutuna, Ankara TR
Patent application number | Description | Published |
---|---|---|
20100167401 | STACKED, PATTERNED BIOMATERIALS AND/OR TISSUE ENGINEERING SCAFFOLDS - Stacked, lamellar constructs comprised of, synthetic or natural, polymeric membrane structures which are brought together to form 3D scaffolds for biomaterial and guided tissue engineering applications have been developed. Each layer can have 2D or 3D nano and micro topographical features similar to or different than each other which can be arranged during the construction of each lamellae and their orientation can be adjusted during construction phase of the 3D structure. Such a construct was utilized in the development of an artificial cornea with human primary cells, in which patterned surface of the components of the lamellar structure mimics the oriented collagen structure inherent in natural cornea. Similar exploitation of the 3D patterned structure can be made for tissues where aligned ECM architecture is crucial, such as ligaments, bone, tendon, skin. | 07-01-2010 |
20120315699 | STACKED, PATTERNED BIOMATERIALS AND/OR TISSUE ENGINEERING SCAFFOLDS - Stacked, lamellar constructs comprised of, synthetic or natural, polymeric membrane structures which are brought together to form 3D scaffolds for biomaterial and guided tissue engineering applications have been developed. Each layer can have 2D or 3D nano and micro topographical features similar to or different than each other which can be arranged during the construction of each lamellae and their orientation can be adjusted during construction phase of the 3D structure. Such a construct was utilized in the development of an artificial cornea with human primary cells, in which patterned surface of the components of the lamellar structure mimics the oriented collagen structure inherent in natural cornea. Similar exploitation of the 3D patterned structure can be made for tissues where aligned ECM architecture is crucial, such as ligaments, bone, tendon, skin. | 12-13-2012 |