Patent application number | Description | Published |
20090287139 | IRRITATION-REDUCING OCULAR IONTOPHORESIS DEVICE - The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1. | 11-19-2009 |
20100010452 | APPARATUS FOR INTRA-OCULAR INJECTION - The present technology relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and a guide operable to guide a needle into the interior of an eye, characterized in that it comprises means for displacing a superficial layer ( | 01-14-2010 |
20100030150 | APPARATUS FOR INTRA-OCULAR INJECTION - The application relates to an apparatus for intraocular injection comprising a plate adapted for being brought into contact with an eye and guiding means for guiding a needle into the interior of an eye, characterized in that the plate comprises a cut-out having an edge adapted to be positioned along the limbus delimiting the cornea and the sclera of the eye, so as to adjust the position of the guiding means with respect to the limbus. | 02-04-2010 |
20100125539 | Hybrid audio-visual categorization system and method - Meta-data (tags) for an audiovisual file can be generated by prompting a user to input certain tags (meta-data) descriptive of the audiovisual file, to serve as an initial estimate of the tags, and then revising the initial estimate (notably to expand it and/or render it more precise) based on the assumption that the relationships which hold between the different tags for a set of manually-tagged training examples will also hold for the tags of the input file now being tagged. | 05-20-2010 |
20100174695 | ONE-CLICK SELECTION OF MUSIC OR OTHER CONTENT - A set of temporal phases are defined, occurring successively during the playback of music (or other content) to a user. Each temporal phase is associated with a set of selection criteria. If the user operates a selection device (which can be a computer mouse button) while a piece of music or other content is being played back, the selection phase applicable at the time of user-action is determined and further content is selected based on the selection criteria associated with the applicable phase. This enables the user, with minimal action, to influence the content being rendered. The selection criteria can be related to the meta-data of the content being played back at the time of user action. The meaning attributed to the applicable temporal phase can be varied depending on the pressure of the mouse button click. | 07-08-2010 |
20110010321 | MARKOVIAN-SEQUENCE GENERATOR AND NEW METHODS OF GENERATING MARKOVIAN SEQUENCES - A new type of Markovian sequence generator and generation method generates a Markovian sequence having controllable properties, notably properties that satisfy at least one control criterion which is a computable requirement holding on items in the sequence. The Markovian sequence is generated chunkwise, each chunk containing a plurality of items in the sequence. During generation of each chunk a search is performed in the space of Markovian sequences to find a chunk-sized series of items which enables the control criterion to be satisfied. The search can be performed using a generate and test approach in which chunk-sized Markovian sequences are generated then tested for compliance with the requirement(s) of the control criteria. Alternatively, the search can be performed by formulating the sequence-generation task as a constraint satisfaction problem, with one or more constraints ensuring that the generated sequence is Markovian and one or more constraints enforcing the requirement(s) of the control criteria. The sequence generator can be used in an interactive system where a user specifies the control criterion via an inputting device ( | 01-13-2011 |
20110082574 | ANIMAL-MACHINE AUDIO INTERACTION SYSTEM - An animal-machine audio interaction system includes a sound monitor for monitoring the sounds made by one or more animals, a sound segmenter for identifying coherent sound segments within the sounds made by the animal(s), a sound analyzer for analyzing and assigning a category to each sound segment, an output sound selector for selecting an output sound appropriate to the category assigned by the sound analyzer, and a sound output unit for outputting the selected output sound to the animal(s). A different control protocol may be used to define the categories assigned to the animal sounds and to determine the respective audio responses that are appropriate to the different sound categories. During operation of the system, a closed-loop audio interaction is set up between the animal(s) and the system. This interaction may be used for various purposes, such as investigating animal behaviour, entertaining the animal(s) and controlling animal behaviour. | 04-07-2011 |
20110098632 | DEVICE DELIVERING MEDICINES BY TRANSPALPEBRAL ELECTROPHORESIS - The invention concerns a device for ocular application of an active principle ( | 04-28-2011 |
20110166500 | IRRITATION-REDUCING OCULAR IONTOPHORESIS DEVICE - The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1. | 07-07-2011 |
20110278323 | Self-Cleaning Tip - The invention relates to a device for packaging and dispensing a generally liquid or viscous product, including a container for containing the product to be packaged and dispensed in the form of clean or sterile calibrated doses or drops using a dispensing accessory including a tip, wherein the assembly of the container and the accessory includes an additional flexible and deformable chamber actuated simultaneously with the accessory and capable of either sucking the residual drop at the end of said accessory after dispensing a calibrated dose or drop, or of blowing said calibrated dose or drop without permitting the formation of a residual drop. The invention can be used for packaging and dispensing clean or sterile products, in particular doses or drops in the field of ophthalmology. | 11-17-2011 |
20110301526 | SYSTEM AND METHOD FOR OCULAR IONTOPHORESIS WITH BUFFERING - Compositions, devices, methods of manufacture, and methods of delivery of a therapeutic substance across a surface of an eyeball via iontophoresis including a therapeutic media reservoir and a buffer system within an iontophoretic chamber. When energized, an electrode provides an electromotive force that transfers a dosage of the therapeutic substance from the iontophoretic chamber across the surface of the eyeball. The buffering system includes a buffer media and at least one buffer element, or agent that regulates pH during iontophoretic transfer of the therapeutic substance. The buffer media includes at least one of a foam, a gel (solid or liquid), a membrane, and a plurality of multiparticulates. The buffer media can be included within the iontophoretic chamber, together with the therapeutic media reservoir, in various arrangements including one or more layers and one or more concentric cylinders. | 12-08-2011 |
20110306923 | IRRITATION-REDUCING OCULAR IONTOPHORESIS DEVICE - The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a pH lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1. | 12-15-2011 |
20110319789 | EYE SAMPLING DEVICE - The eye sampling device ( | 12-29-2011 |
20120089077 | OCULAR IONTOPHORESIS DEVICE - The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis. | 04-12-2012 |
20120246209 | METHOD FOR CREATING A MARKOV PROCESS THAT GENERATES SEQUENCES - The present invention relates to a method for creating a Markov process that generates sequences. Each sequence has a finite length L, comprises items from a set of a specific number n of items, and satisfies one or more control constraints specifying one or more requirements on the sequence. The method comprises the steps of receiving data defining an initial Markov process of a specific order d and having an initial probability distribution and of receiving data defining one or more control constraints. The method further comprises the step of generating data defining intermediary matrices, each matrix being of dimension nd by n, by zeroing out transitions in the initial Markov process data that are forbidden by the one or more control constraints. | 09-27-2012 |
20130178821 | DEVICE AND METHOD FOR CORNEAL DELIVERY OF RIBOFLAVIN BY IONTOPHORESIS FOR THE TREATMENT OF KERATOCONUS - Ocular iontophoresis device and method for delivering any ionized drug solution to the cornea includes: a reservoir containing a solution suitable to be positioned on the eye; an active electrode disposed in or on the reservoir; and a passive electrode suitable to be placed on the skin of the subject, elsewhere on the body; elements for irradiating the cornea surface with suitable light for obtaining corneal cross-linking after the drug delivery; wherein the reservoir and the active electrode are transparent to UV light and/or visible light and/or IR light. The method includes: positioning the iontophoretic device on the eye to be treated; driving the solution by a cathodic current applied for 0.5 to 5 min, at an intensity not higher than 2 mA; and thereafter irradiating, with UV light for 5 to 30 min at a power of 3 to 30 mW/cm | 07-11-2013 |
20130211335 | APPARATUS FOR INJECTION INTO AN EYE - The invention relates to an apparatus for injection into an eye comprising of a means for displacing a conjunctival layer of the eye over an underlying scleral layer of the eye so as to form a fold in the conjunctival layer, and means for guiding a needle through the conjunctival layer once the fold has been formed. | 08-15-2013 |
20130310732 | CORNEAL DELIVERY OF CROSS-LINKING AGENTS BY IONTOPHORESIS FOR THE TREATMENT OF KERATOCONUS AND RELATED OPHTHALMIC COMPOSITIONS - Iontophoresis for delivering ophthalmic compositions (in particular. collyriums) preferably containing riboflavin, or other cross-linking agents, designed to imbibe the corneal stroma in the practice of the corneal collagen cross-linking (CXL) for the keratoconus treatment, and the corresponding ophthalmic compositions adapted to be administrated by iontophoresis in the treatment of keratoconus by corneal collagen cross-linking. Additionally, an ophthalmic composition for the treatment of keratoconus by corneal iontophoresis characterized by the fact that it includes cross-linking agents having buffering properties and whose initial pH value is included between 5 and 6, and/or bio-enhancers, and/or photo-enhancers. | 11-21-2013 |
20140107559 | OCULAR IONTOPHORESIS DEVICE - The invention relates to a device of ocular iontophoresis for delivering active substances, comprising a reservoir having an outer wall and a hollow body at least partly delimited by the outer wall, wherein the hollow body is capable of receiving an electrical conductive medium and active substances contained in the medium and has an outlet defining a surface, so-called “application surface”, intended to received a determine part of an eyeball surface, the application surface being at least partly limited by an outer line concave towards the optical axis of the eyeball, wherein the outer wall extends from the outer line with a global outwardly with respect to the said optical axis. | 04-17-2014 |
20140303173 | CROSS-LINKING COMPOSITION DELIVERED BY IONTOPHORESIS, USEFUL FOR THE TREATMENT OF KERATOCONUS - An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus. | 10-09-2014 |
20140309554 | DEVICE FOR SAMPLING TEAR FLUID - Device for sampling tear fluid that comprises: an extraction element ( | 10-16-2014 |
20140323947 | DEVICE FOR DELIVERING MEDICINES BY TRANSPALPEBRAL ELECTROPHORESIS - The invention concerns a device for ocular application of an active principle ( | 10-30-2014 |