Patent application number | Description | Published |
20080214525 | Alkyl 4- [4- (5-Oxo-2,3,5, 11A-Tetrahydo-5H-Pyrrolo [2, 1-C] [1,4] Benzodiazepine-8-Yloxy) -Butyrylamino]-1H-Pyrrole-2-Carboxylate Derivatives and Related Compounds For the Treatment of a Proliferative Disease - A compound of formula (I); or a salt or solvate thereof, wherein: the dotted line indicates the optional presence of a double bond between C2 and C3; R | 09-04-2008 |
20100113425 | PYRROLOBENZODIAZEPINES - Compounds of the formula I: | 05-06-2010 |
20110162227 | PYRROLOBENZODIAZEPINES - Methods of preparing ZC-423 (I) which result in varying enantiomeric ratios. | 07-07-2011 |
20110196148 | UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES - Claimed are unsymmetrical Pyrrolobenzodiazepine-dimers (PBD-dimers) of formula (I), that are unsymmetrical due at least to the values that the variables R | 08-11-2011 |
20110201803 | PYRROLOBENZODIAZEPINES - The invention relates to certain pyrrolobenzodiazepines (PBDs), and in particular pyrrolobenzodiazepine dimers bearing C2 substitutions, including compounds of formula (T): wherein: R | 08-18-2011 |
20110256157 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF - Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer. | 10-20-2011 |
20130028917 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF - Conjugates and compounds for making conjugates which are PBD molecules linked via the N10 position are disclosed, along with the use of the conjugates for treating proliferative diseases, including cancer. | 01-31-2013 |
20130028919 | TARGETED PYRROLOBENZODIAZAPINE CONJUGATES - Provided are Conjugate comprising PBDs conjugated to a targeting agent and methods of using such PBDs. | 01-31-2013 |
20130035484 | INTERMEDIATES USEFUL FOR THE SYNTHESIS OF PYRROLOBENZODIAZEPINES - A compound of formula (I): which is substantially free of any of the corresponding compound of formula (IB): methods of making such compounds, and the further transformation of such compounds. | 02-07-2013 |
20130059800 | PYRROLOBENZODIAZEPINES USED TO TREAT PROLIFERATIVE DISEASES - Pyrrolobenzodiazepine dimers I having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds. | 03-07-2013 |
20130266595 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF - A conjugate of formula (A): | 10-10-2013 |
20140030279 | ANTI-CD22 ANTIBODIES AND IMMUNOCONJUGATES - The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same. | 01-30-2014 |
20140066435 | PYRROLOBENZODIAZEPINES USED TO TREAT PROLIFERATIVE DISEASES - Pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a conjugated double or triple bond at the C2 position or an alkyl group at the C2 position on the other monomer unit, and conjugates of these compounds. | 03-06-2014 |
20140120118 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF - A compound which is selected from A: | 05-01-2014 |
20140127239 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF - A compound which is either A: | 05-08-2014 |
20140142090 | UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES - The present invention is directed to novel pyrrolobenzodiazepine dimers and methods of using the dimers in the treatment of proliferative diseases. | 05-22-2014 |
20140234346 | PYRROLOBENZODIAZEPINES - A compound with the formula I: wherein: R | 08-21-2014 |
20140274907 | PYRROLOBENZODIAZEPINES - A compound with the formula (I), wherein: R | 09-18-2014 |
20140275522 | SYNTHESIS METHOD AND INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLOBENZODIAZEPINES - A compound of formula I wherein: R | 09-18-2014 |
20140286970 | PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES - A compound, or a pharmaceutically acceptable salt or solvate thereof, or conjugates thereof, selected from the group consisting of formula wherein: (a) R | 09-25-2014 |
20140294868 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF - Conjugate compounds of formula (A): | 10-02-2014 |
20140302066 | PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES - This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates. | 10-09-2014 |