Pfrengle
Andreas Pfrengle, Bischberg DE
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20090301881 | METHOD FOR PRODUCING CERAMIC COMPONENTS - A method for producing ceramic components, includes providing a dispersing agent comprising at least one first and one second powder fraction of an oxide ceramic, and a third powder fraction of an inter-metallic compound mixed in a liquid. The first powder fraction comprises a nanoscale particle fraction with particle sizes ranging from about 2 nm to 200 nm and functions as a binder. The second powder fraction comprises a sintering additive. The share of the third powder fraction, relative to the sum of all powder fractions, has a volume share of between about 50% and about 95%. The method further includes forming a green body with aid of precipitation by electrophoresis from the mixture, the precipitation by electrophoresis of the powder fractions occurring simultaneously. The green body is then sintered in an oxidizing atmosphere to form a ceramic component. | 12-10-2009 |
Fabian Pfrengle, Berlin DE
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20160060324 | Methods and Compositions for Treating Bleeding Disorders - The present invention provides immune conjugates for inducing antigen specific immune tolerance to coagulation Factor VIII. The immune conjugates contain a FVIII protein or antigenic fragment that is conjugated to a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods of using the FVIII immune conjugates to induce immune tolerance to FVIII in a subject. Additionally provided in the invention are methods for treating bleeding disorders such as hemophilia A via the use of the FVIII immune conjugates and an unconjugated FVIII with coagulating activity. | 03-03-2016 |
Udo Pfrengle, Voerstetten DE
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20140079303 | SYSTEMS AND METHODS FOR AUTOMATIC DETECTION AND TESTING OF IMAGES FOR CLINICAL RELEVANCE - Disclosed herein are systems and methods for automatic detection of clinical relevance of images of an anatomical situation. The method includes comparing a first image and a second image and determining whether a difference between the first and second images is at least one of a local type difference and a global type difference. The local type difference is a local difference of the first image and the second image and the global type difference is a global difference between the first image and the second image. The second image is determined as having a clinical relevance if it is determined that the difference between the first image and the second image comprises a local type difference. | 03-20-2014 |
Waldemar Pfrengle, Biberach An De Riss DE
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20130184204 | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions - The present invention relates to substituted quinazolines of formula (I): | 07-18-2013 |
Waldemar Pfrengle, Biberach DE
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20090192314 | PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1YL)-XANTHINES - The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines. | 07-30-2009 |
20100210842 | PROCESS FOR PREPARING - The present invention relates to a method of preparing compounds of general formula I | 08-19-2010 |
20110046395 | PROCESS FOR THE MANUFACTURE OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE - The present invention relates to a process for the manufacture of the compound 4-[(Z)-[[4-[(dimethylamino)methyl]phenyl]amino](6-fluoro-1,2-dihydro-2-oxo-3H-in-dol-3-ylidene)methyl]-benzenepropanoic acid and to a new intermediate for the synthesis. | 02-24-2011 |
20110130437 | SALT FORMS OF A 6-FLUORO-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE DERIVATIVE, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME - The present invention relates to salt forms of the compound 4-[(Z)-[[4-[(dimethylaminoJmethyllphenyllaminolCe-fluoro-1,2-dihydro2-oxo-3H-indol-3-ylidene)methyl]-benzenepropanoic acid which are suitable for pharmaceutical development and to a process for their manufacture. | 06-02-2011 |
20110301350 | PROCESS FOR PREPARING CYCLOALKYL-SUBSTITUTED PIPERAZINE COMPOUNDS - The present invention relates to a process for preparing compounds of general formula I | 12-08-2011 |
20120116080 | PROCESS FOR THE STEREOSELECTIVE PREPARATION OF BICYCLIC HETEROCYCLES - The present invention relates to a process for the stereoselective preparation of compounds of general formula (I) | 05-10-2012 |
20120142712 | 8-(3-AMINO-PIPERIDIN-1-YL)-XANTHINES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICALS - The invention relates to 8-[3-amino-piperidin-1-yl]-xanthines and the physiologically acceptable salts thereof, particularly the hydrochlorides thereof. | 06-07-2012 |
Waldemar Pfrengle, Ingelheim Am Rhein DE
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20100174067 | Method for Producing Scopine Esters - The invention relates to a novel method for producing scopine esters of the general formula (1), wherein X—, R, R1, R2, R3, R4, R3′, R4′, R6 and R6′ can have the meanings indicated in the claims and in the description. | 07-08-2010 |
Waldemar Pfrengle, Biberach An Der Riss DE
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20120129874 | SALT FORMS OF ORGANIC COMPOUND - The present invention relates to novel salt forms of 1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)-amino-piperidin-1-yl)-xanthine, a DPP-4 inhibitor and their use in pharmaceutical compositions useful in the treatment of type 2, diabetes, as well as their production. | 05-24-2012 |
20130178485 | PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1-YL)-XANTHINES - The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines. | 07-11-2013 |
20130289049 | ACID ADDITION SALTS OF THE 2-[2-[[(4-METHOXY-2,6-DIMETHYLPHENYL)SULFONYL]-(METHYL)AMINO]ETHOXY]-N-ME- THYL-N-[3-(4-METHYLPIPERAZIN-1-YL)CYCLOHEXYL] ACETAMIDE AND THE USE THEREOF AS BRADYKININ B1 RECEPTORANTAGONISTS - The present invention relates to the new acid addition salts AB of the following free base of formula A | 10-31-2013 |
20140303194 | SALT FORMS OF ORGANIC COMPOUND - The present invention relates to novel salt forms of a certain DPP-4 inhibitor and their use in pharmaceutical compositions useful in the treatment of type 2 diabetes, as well as their production. | 10-09-2014 |
20140371226 | 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY-QUINAZOLINE-6-YLOXY]-1,4-DI- AZA-SPIRO[5.5]UNDECANE-5-ONE DIMALEATE, USE THEREOF AS A MEDICAMENT AND METHOD FOR THE PRODUCTION THEREOF - The present invention relates to a compound of formula (I), | 12-18-2014 |
20150025089 | PROCESS FOR THE PREPARATION OF CHIRAL 8-(3-AMINOPIPERIDIN-1-YL)-XANTHINES - The invention relates to an improved process for preparing enantiomerically pure 8-(3-aminopiperidin-1-yl)-xanthines. | 01-22-2015 |
20150112062 | SUBSTITUTED QUINAZOLINES, THE PREPARATION THEREOF AND THE USE THEREOF IN PHARMACEUTICAL COMPOSITIONS - The present invention relates to substituted quinazolines of formula (I) wherein X and Y are defined as in claim | 04-23-2015 |
Waldermar Pfrengle, Biberach An Der Riss DE
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20130030003 | 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY-QUINAZOLINE-6-YLOXY]-1,4-DI- AZA-SPIRO[5.5]UNDECANE-5-ONE DIMALEATE, USE THEREOF AS A MEDICAMENT AND METHOD FOR THE PRODUCTION THEREOF - The present invention relates to a compound of formula (I), | 01-31-2013 |