Patent application number | Description | Published |
20110070630 | METHOD FOR DERACEMIZATION OF ENANTIOMER MIXTURES - The invention relates to a process for enzymatic deracemization of enantiomer mixtures of secondary alcohols by a combination of oxidation and reduction reactions by means of stereoselective alcohol dehydrogenases and the cofactors thereof, wherein one enantiomer of an optically active secondary alcohol is in a formal sense selectively oxidized to the corresponding ketone, which is subsequently reduced selectively to the optical antipode, while the reduced form of the cofactor is provided for the reduction reaction by means of an additional enzyme, characterized in that two alcohol dehydrogenases with opposite stereoselectivity and different cofactor selectivity and the two corresponding, different cofactors are used for the oxidation and reduction reactions, and the oxidized and reduced cofactors are interconverted in a parallel enzymatic reaction with the additional enzyme, the direction of the deracemization toward one of the two enantiomers being controllable by the selection of the two alcohol dehydrogenases or using the selectivity difference of the additional enzyme for the two cofactors. | 03-24-2011 |
20110251399 | METHOD FOR PRODUCING ALDEHYDES AND KETONES FROM PRIMARY AND SECONDARY ALCOHOLS - The invention relates to a method for producing aldehydes and ketones from easily accessible primary and secondary alcohols by oxidation with atmospheric oxygen or pure oxygen using a catalyst system which consists of a derivative of a free nitroxyl radical. | 10-13-2011 |
20110269977 | METHOD FOR PRODUCING 2,6-DIOXABICYCLO-(3.3.0)-OCTANE-4,8-DIONE - The invention relates to a method for producing 2,6-dioxabicyclo-(3.3.0)-octane-4,8-dione (I), comprising the oxidation of dianhydrohexitols (II-IV), or of corresponding hydroxy ketones, with an oxygen-containing gas in the presence of a catalyst composition, the reaction proceeding without the addition of halogen sources. | 11-03-2011 |
20120071577 | USE OF ISOCYANATES BASED ON RENEWABLE RAW MATERIALS - The invention relates to the use of 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-D-manitol (I), 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-D-glucitol (II), and/or 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-L-iditol (III). | 03-22-2012 |
20120073472 | REACTIVE DERIVATIVES ON THE BASIS OF DIANHYDROHEXITOL-BASED ISOCYANATES - The invention relates to reactive derivatives on the basis of dianhydrohexitol-based isocyanates. | 03-29-2012 |
20120077932 | COMPOSITIONS BASED ON DIISOCYANATES OBTAINED FROM RENEWABLE RAW MATERIALS - The invention relates to compositions based on 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-D-manitol (I), 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-D-glucitol (II), and/or 2,5-diisocyanato-1,4:3,6-dianhydro-2,5-dideoxy-L-iditol (III), alone or in any mixtures. | 03-29-2012 |
Patent application number | Description | Published |
20130165672 | PROCESS FOR THE DIRECT AMINATION OF SECONDARY ALCOHOLS WITH AMMONIA TO GIVE PRIMARY AMINES - The invention relates to a process for preparing primary amines which comprises the process steps
| 06-27-2013 |
20130245276 | PROCESS FOR HOMOGENEOUSLY CATALYZED, HIGHLY SELECTIVE DIRECT AMINATION OF PRIMARY ALCOHOLS WITH AMMONIA TO PRIMARY AMINES WITH A HIGH VOLUME RATIO OF LIQUID PHASE TO GAS PHASE AND/OR HIGH PRESSURES - The present invention relates to a process for preparing primary amines comprising the process steps
| 09-19-2013 |
20130331580 | PROCESS FOR THE DIRECT AMINATION OF ALCOHOLS USING AMMONIA TO FORM PRIMARY AMINES BY MEANS OF A XANTPHOS CATALYST SYSTEM - The present invention relates to a chemocatalytic liquid-phase process for the direct one-stage amination of alcohols to primary amines by means of ammonia in high yields using a catalyst system containing at least one transition metal compound and a xantphos ligand. | 12-12-2013 |
20140039210 | LIQUID CATION EXCHANGER - The invention relates to a method for removing an organic compound having one or more positive charges from an aqueous solution. Said method consists of the following steps a) the aqueous solution containing the organic compound, and a hydrophobic organic solution which contains a hydrophobic liquid cation exchanger having one or more negative charges and a negative total charge, are provided, b) the aqueous solution and the organic solution are brought into contact with each other and c) the organic solution is separated from the aqueous solution. | 02-06-2014 |
20140039223 | CONTINUOUSLY OPERABLE METHOD FOR PRODUCING CARBONYL COMPOUNDS BY MEANS OF A CATALYST CONTAINING A NITROXYL RADICAL - The invention relates to a method for the oxidation of a primary or secondary alcohol, preferably to form an aldehyde or ketone, comprising the following steps: a) providing a catalyst composition comprising at least one compound containing a nitroxyl radical, at least one NO source, at least one carbon or mineral acid or an anhydride of a carbon or mineral acid; b) producing a reaction mixture by adding at least one primary or secondary alcohol and a gas comprising oxygen and optionally one or more than one solvent to the catalyst composition from step a) or step e); c) incubating the reaction mixture from step b) at a temperature of between 0 and 100° C. or at the boiling point of the solvent; d) simultaneously with or subsequent to step c): crystallizing the reaction product; and e) recovering the catalyst composition by removing the crystallized reaction product from the reaction mixture obtained in step d). | 02-06-2014 |
20140054224 | LIQUID CATION EXCHANGER - The present application relates to a process for removing an organic compound having one or more positive charges from an aqueous solution, comprising the steps a) provision of the aqueous solution comprising the organic compound and of a hydrophobic organic solution which comprises a liquid cation exchanger, where the liquid cation exchanger is hydrophobic, and where the liquid cation exchanger has one or more negative charges and an overall negative charge, b) contacting the aqueous solution and the organic solution, and c) separating off the organic solution from the aqueous solution. | 02-27-2014 |
20140120587 | ENZYMATIC AMINATION - A method comprising the steps (a) contacting a hydrocarbon comprising a hydroxyl group with a biological agent having oxygen-dependent and cofactor-dependent carbohydrate oxidase activity in the presence of oxygen and carbohydrate oxidase cofactor, and (b) contacting the hydrocarbon produced in step a) with a biological agent having transaminase activity and a biological agent having cofactor-dependent amino acid dehydrogenase activity in the presence of amino acid dehydrogenase cofactor and the substrate amino acid of the amino acid dehydrogenase. | 05-01-2014 |
20140242646 | OXIDATION AND AMINATION OF PRIMARY ALCOHOLS - The present invention relates to a method comprising the steps a) providing a primary alcohol of the formula HO—(CH | 08-28-2014 |
20140308717 | OXIDATION AND AMINATION OF SECONDARY ALCOHOLS - The present invention relates to a method comprising the steps a) providing a secondary alcohol, b) oxidizing the secondary alcohol by contacting it with an NAD(P) | 10-16-2014 |
20150010968 | BIOLOGICAL ALKENE OXIDATION - The present invention relates to method for oxidising an alkene comprising contacting said alkene with an AlkB-type oxidoreductase in the presence of oxygen, and a use of an AlkB-type oxidoreductase, preferably AlkB from | 01-08-2015 |
20150044744 | BIOLOGICAL ALKANE OXIDATION - The invention relates to a method for oxidizing an alkane, comprising contacting the alkane with a type alkB oxidoreductase and using a type alkB oxidoreductase to prepare a mixture of oxidation products of an alkane, wherein the ratio of carboxylic acid to alcohol in the oxidation products is preferably greater than 1:1. | 02-12-2015 |
20150099282 | NADP-DEPENDENT ALANINE DEHYDROGENASE - The present invention relates to a polypeptide comprising the amino acid sequence of the | 04-09-2015 |
20150111253 | ENZYMATIC OMEGA-OXIDATION AND OMEGA-AMINATION OF FATTY ACIDS - The invention relates to a method for oxidizing a fatty acid or an ester thereof of formula (I) H3C—(CH2)n-COOR, wherein R is selected from the group that comprises H, methyl, ethyl, propyl, and butyl, wherein n is 0 to 30, preferably 6 to 24, comprising the step of oxidizing the fatty acid or the ester thereof by contacting the fatty acid or the ester thereof with a cytochrome P450 monooxygenase of the CYP153 family in the presence of molecular oxygen and NAD(P)H and a whole-cell catalyst that expresses a recombinant cytochrome P450 monooxygenase of the CYP153 family, a recombinant alcohol dehydrogenase, a recombinant transaminase, and optionally one or more than one recombinant enzyme from the group comprising alanine dehydrogenase, ferredoxin, and ferredoxin reductase, and the use of said whole-cell catalyst to oxidize a fatty acid or an ester thereof. | 04-23-2015 |
20150111254 | METHOD FOR AEROBICALLY PRODUCING ALANINE OR A COMPOUND PRODUCED USING ALANINE - The problem addressed by the invention is solved in a first aspect by a method for producing alanine or a compound produced using alanine, having the steps of (a) providing a cell which expresses a recombinant alanine dehydrogenase or a variant thereof, (b) cultivating the cell under aerobic conditions in the presence of an inorganic nitrogen source in an aqueous phase, and (c) bringing the cell into contact with an organic phase, said cell being a prokaryotic or a lower eukaryotic cell. | 04-23-2015 |
20150203629 | CURABLE COMPOSITIONS BASED ON EPOXY RESINS WITHOUT BENZYL ALCOHOL - The invention relates to curable compositions comprising at least one epoxy resin and at least one hardener wherein the hardener is a compound of formula (I) or (II) | 07-23-2015 |
20150218600 | BIOTECHNOLOGICAL PREPARATION OF 3-HYDROXYISOBUTYRIC ACID - The invention relates to a method comprising the steps a) providing isobutyric acid, b) bringing isobutyric acid into contact with the combination of isobutyrate kinase and phosphotransisobutyrylase and/or isobutyryl-coenzyme A synthetase/ligase and/or isobutyrate-coenzyme A transferase, c) bringing the product from step a) into contact with isobutyryl-coenzyme A dehydrogenase, d) bringing the product from step b) into contact with methacrylyl-coenzyme A hydratase, and e) hydrolyzing the product from step d) to form 3-hydroxyisobutyric acid, where at least one of the enzymes is used in the form of a cell which, compared to its wildtype, comprises a reduced activity of a 3-hydroxyisobutyric acid dehydrogenase or a variant thereof, a cell which has at least one enzyme from the group comprising isobutyryl-coenzyme A synthetase/ligase, isobutyrate-coenzyme A transferase, isobutyrate kinase, phosphotransisobutyrylase, isobutyryl-coenzyme A dehydrogenase, methacrylyl-coenzyme A hydratase and 3-hydroxyisobutyryl-coenzyme A hydrolase and, compared to its wildtype, a reduced activity of a 3-hydroxyisobutyric acid dehydrogenase or a variant thereof, wherein the cell preferably has, in addition, a monooxygenase, more preferably a monooxygenase of the alkBGT type or a variant thereof and the use of such a cell for preparing 3-hydroxyisobutyric acid. | 08-06-2015 |
20150275245 | BIOTECHNOLOGICAL PRODUCTION OF ALCOHOLS AND DERIVATIVES THEREOF - The present invention relates to a microorganism having a reduced fatty acid degradation capacity and expressing a recombinant alkane oxidase, a method for oxidizing an alkyl, comprising a contacting the alkyl with an aqueous solution comprising the inventive cell. | 10-01-2015 |
20150299741 | METHOD FOR CONVERSION OF AN ALKANE OR 1-ALKANOL TO A DIOL - The present invention relates to a method comprising the steps a) providing an alkane or 1-alkanol, b) contacting said alkane or 1-alkanol in an aqueous solution with a cytochrome P450 alkane hydroxylase from the CYP153 family and oxygen for at least 3 hours. | 10-22-2015 |
20150353963 | PROCESS FOR PREPARING AN ALPHA, OMEGA-ALKANEDIOL - The invention relates to a process for preparing an α,ω-alkanediol comprising the steps of a) reacting an alkanoic acid with an alkanol to give an ester, b) oxidizing at least one terminal carbon atom of the ester by contacting with a whole-cell catalyst, which expresses an alkane hydroxylase, in aqueous solution and in the presence of molecular oxygen, to give an oxidized ester, c) hydrogenating the oxidized ester to form the alkanediol and alkanol, and d) removing the alkanol by distillation, forming a reaction mixture depleted with respect to the alkanol, and recycling the alkanol in step b). | 12-10-2015 |
Patent application number | Description | Published |
20090088609 | Method of taking internal physiological measurements - The invention relates to a device for detecting physiological measured variables within the body, comprising a catheter which has a tip supporting a sensor and which can be introduced into a blood vessel, the catheter ( | 04-02-2009 |
20090093764 | CATHETER DEVICE - The catheter device comprises a motor located at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section of the catheter device. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing. | 04-09-2009 |
20090093796 | CATHETER DEVICE - The catheter device comprises a drive shaft connected to a motor, and a rotor mounted on the drive shaft at the distal end section. The rotor has a frame structure which is formed by a screw-like boundary frame and rotor struts extending radially inwards from the boundary frame. The rotor struts are fastened to the drive shaft by their ends opposite the boundary frame. Between the boundary frame and the drive shaft extends an elastic covering. The frame structure is made of an elastic material such that, after forced compression, the rotor unfolds automatically. | 04-09-2009 |
20100063379 | ROD-SHAPED BODY - The invention relates to a rod-shaped body ( | 03-11-2010 |
20100319708 | DEVICE FOR SPLINTING A CAVITY, ORGAN DUCT AND/OR VESSEL - The invention relates to a device for splinting and/or maintaining a cavity, an organ duct and/or a vessel in a human or animal body, said device comprising at least one compressible and self-expanding stent that is composed of at least three phases. | 12-23-2010 |
20120143345 | FIXING APPARATUS FOR FIXING AN APNEA STENT IN THE RESPIRATORY DUCT - This invention relates to a fixing apparatus for fixing an apnea stent in the respiratory duct, the fixing apparatus ( | 06-07-2012 |
20130237744 | CATHETER DEVICE - The catheter device comprises a drive shaft connected to a motor, and a rotor mounted on the drive shaft at the distal end section. The rotor has a frame structure which is formed by a screw-like boundary frame and rotor struts extending radially inwards from the boundary frame. The rotor struts are fastened to the drive shaft by their ends opposite the boundary frame. Between the boundary frame and the drive shaft extends an elastic covering. The frame structure is made of an elastic material such that, after forced compression, the rotor unfolds automatically. | 09-12-2013 |
20130289533 | ROD SHAPED BODY AND MEDICAL DEVICE - The present invention relates to a medical device. In particular, the present invention concerns a medical device which can be detected by means of magnetic resonance imaging (MRI). | 10-31-2013 |
20130345492 | CATHETER DEVICE - The catheter device comprises a motor located at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section of the catheter device. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing. | 12-26-2013 |
20140018839 | STENT FOR SPLINTING A NASAL PASSAGE - The present invention relates to a stent for splinting a nasal passage. The stent ( | 01-16-2014 |
20140284838 | APPARATUS AND METHOD FOR EXTRUDING A MEDICAL INSTRUMENT - According to the invention, an apparatus is provided for extruding a medical instrument which can be inserted into a human or animal body. The apparatus comprises a device for supplying rod-shaped bodies, an extrusion device comprising a housing, said housing having a surrounding side wall which, at the frontward end as seen in the manufacturing direction, is provided with a nozzle wall comprising a discharge nozzle and, at the rearward end as seen in the manufacturing direction, is provided with a spindle sleeve. The space in the housing between the spindle sleeve, the side wall and the discharge nozzle delimits an extrusion space and the housing is provided with a polymer supply device in the area of the extrusion space. Further, a cannula device is provided which extends in the manufacturing direction and is designed to insert at least one rod-shaped body from the device for supplying rod-shaped bodies into the extrusion space in a predetermined spatial arrangement, which comprises at least one tubular cannula having a rearward supply end as seen in the manufacturing direction and a frontward discharge end as seen in the manufacturing direction, the cannula device being arranged approximately in straight alignment with respect to the discharge nozzle and extending through the spindle sleeve such that its discharge end situated in the manufacturing direction terminates at a distance from the discharge nozzle in the extrusion space. | 09-25-2014 |
20150245783 | ROD-SHAPED BODY - The invention relates to a rod-shaped body ( | 09-03-2015 |
20150258262 | CATHETER DEVICE - The catheter device comprises a drive shaft connected to a motor, and a rotor mounted on the drive shaft at the distal end section. The rotor has a frame structure which is formed by a screw-like boundary frame and rotor struts extending radially inwards from the boundary frame. The rotor struts are fastened to the drive shaft by their ends opposite the boundary frame. Between the boundary frame and the drive shaft extends an elastic covering. The frame structure is made of an elastic material such that, after forced compression, the rotor unfolds automatically. | 09-17-2015 |
20160106896 | CATHETER DEVICE - The catheter device comprises a motor located at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section of the catheter device. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing. | 04-21-2016 |
20160106898 | CATHETER DEVICE - The catheter device comprises a motor located at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section of the catheter device. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing. | 04-21-2016 |
20160136341 | CATHETER DEVICE - The catheter device comprises a motor at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing. | 05-19-2016 |
20160136342 | CATHETER DEVICE - The catheter device comprises a motor at the proximal end of the catheter device and a drive shaft, extending from the proximal end section to the distal end section of the catheter device, for driving a rotating element located at the distal end of the catheter device. The catheter device also comprises a hose-like catheter body which encompasses the drive shaft and extends from the proximal end section to the distal end section. At the proximal end of the catheter device, the drive shaft is connected to a motor by a clutch. The clutch is a magnetic clutch with a proximal and a distal magnet unit. The proximal magnet unit is connected to the motor and the distal magnet unit to the drive shaft. The distal magnet unit is mounted fluid-tight in a clutch housing. The proximal end of the catheter body makes a fluid-tight connection with the clutch housing. | 05-19-2016 |
Patent application number | Description | Published |
20080299190 | Direct Compression Formulation and Process - This invention relates to tablets especially tablets formed by direct compression of a dipeptidylpeptidase IV (DPP-IV) inhibitor compound, a process for the preparation thereof; to new pharmaceutical formulations, and new tableting powders comprising DPP-IV inhibitor formulations capable of being directly compressed into tablets. The invention relates further to a process for preparing the tablets by blending the active ingredient and specific excipients into the new formulations and then directly compressing the formulations into the direct compression tablets. The invention also relates to vildagliptin particle size distribution and a new crystal form of vildagliptin particularly adapted for the preparation of improved tablets and other pharmaceutical compositions. | 12-04-2008 |
20090012298 | Process for the Preparation of Rapamycin Derivatives - Processes for the production of a 32-deoxorapamycin from a 32-iodo- or 32-hydroxyrapamycin, wherein the hydroxy group is substituted by the residue of an arylthionocarbonate or an arylthiocarbamate, in the presence of tris(trimethylsilyl)-silan and α,α′-azo-isobutyronitril in organic solvent; and 32-deoxorapamycin in the form of a crystalline solvate. | 01-08-2009 |
20090209639 | PROCESS FOR MODIFYING DRUG CRYSTAL FORMATION - A process for modifying the crystal habit of acicular drug substances, crystals obtained by such a process, and particular crystal forms or modifications of mycophenolic acid or mycophenolate sodium are provided, as well as pharmaceutical compositions comprising the crystals, methods of treatment and uses thereof. | 08-20-2009 |
20110288313 | PROCESS FOR MODIFYING DRUG CRYSTAL FORMATION - A process for modifying the crystal habit of acicular drug substances, crystals obtained by such a process, and particular crystal forms or modifications of mycophenolic acid or mycophenolate sodium are provided, as well as pharmaceutical compositions comprising the crystals, methods of treatment and uses thereof. | 11-24-2011 |
20120015029 | DIRECT COMPRESSION FORMULATION AND PROCESS - This invention relates to tablets especially tablets formed by direct compression of a dipeptidylpeptidase IV (DPP-IV) inhibitor compound, a process for the preparation thereof, to new pharmaceutical formulations, and new tableting powders comprising DPP-IV inhibitor formulations capable of being directly compressed into tablets. The invention relates further to a process for preparing the tablets by blending the active ingredient and specific excipients into the new formulations and then directly compressing the formulations into the direct compression tablets. The invention also relates to vildagliptin particle size distribution and a new crystal form of vildagliptin particularly adapted for the preparation of improved tablets and other pharmaceutical compositions. | 01-19-2012 |