Patent application number | Description | Published |
20100041773 | DISRUPTORS OF EARLY/RECYCLING ENDOSOMES - A delivery system for introducing a cargo molecule into cytosol of a living cell can include: a first membrane binding element linked to an endosomal compartment disrupting element through a first linker having one or more anionic moieties; and a second membrane binding element linked to an exogenous cargo molecule through a second linker having one or more anionic moieties, the second linker having a region that is selectively cleavable, wherein the first and second membrane binding elements both induce endocytosis into an early/recycling endosome and the endosomal compartment disrupting element destabilizes the early/recycling endosome such that the exogenous cargo molecule is released from the second membrane binding element and into the cytosol of the living cell. | 02-18-2010 |
20100160657 | SYNTHETIC MIMICS OF MAMMALIAN CELL SURFACE RECEPTORS: METHOD AND COMPOSITIONS - The present invention relates to new synthetic receptors. More particularly, the present invention relates to methods for synthesizing preferred membrane-binding elements, preferably cholesterylamine derivatives, including 3β-amino-5-cholestene (3β-cholesterylamine) and related 3β-halides through i-steroid and retro-i-steroid rearrangements. The invention further relates to use of the synthetic receptors for delivering a protein, peptide, drug, prodrug, lipid, nucleic acid, carbohydrate or small molecule into a target cell via receptor-mediated endocytosis. According to the invention, novel synthetic mimics of cell surface receptors have been designed and methods for use of the same are disclosed. | 06-24-2010 |
20120208771 | SYNTHETIC CHOLESTERYLAMINE-LINKER DERIVATIVES FOR AGENT DELIVERY INTO CELLS - Synthetic cholesterylamine-linkers can include derivatives of cholesterol, cholesteryl, or sitosteryl coupled through the linker to an agent for delivery into cells. The cholesterylamines are thought to mimic cholesterol in the capacity and mechanism for enhanced entry into cells. The configuration of the cholesterylamine-linker that is thought to provide for enhanced entry into cells includes a cholesterylamine that is coupled to a linker from the amine, and which linker includes a negative charge at a spatial distance from the amine of the cholesterylamine. | 08-16-2012 |
Patent application number | Description | Published |
20100057483 | Software tool for developing patent submissions - A computer readable medium configured to store instructions for executing the following steps (A) accepting a first number of user parameters to be organized as a patent idea, (B) accepting a second number of user parameters to add to the patent idea, and (C) automatically converting the patent idea into a patent disclosure. The patent disclosure may comply with a number of criteria specific to a particular organization. | 03-04-2010 |
20100127978 | POINTING DEVICE HOUSED IN A WRITING DEVICE - A method for controlling a pointing icon in a computer, including the steps of (A) establishing a wireless connection between a pointing device and the computer, (B) generating directional information through one or more three dimensional movements of the pointing device, (C) transmitting the directional information from the pointing device to the computer and (D) translating the directional information into movements of the pointing icon on a screen of the computer using a device driver program stored on the computer. | 05-27-2010 |
20100131450 | AUTOMATIC CLASSIFICATION OF DEFECTS - A method of automatically classifying defects. The method generally includes the steps of (A) receiving information for a current defect, (B) extracting field values from the current defect, (C) counting a number of occurrences of one or more keywords in the current defect, (D) determining one or more new keywords occurring in the current defect and storing the one or more new keywords in a database and (E) creating one or more linkages in the database between a first record corresponding to the current defect and one or more second records corresponding to previous defects based upon one or more similarities between the first and the second records. | 05-27-2010 |
20100131497 | METHOD FOR DETERMINING WHICH OF A NUMBER OF TEST CASES SHOULD BE RUN DURING TESTING - A method that includes an example embodiment for evaluating one or more tests comprising the steps of (A) generating one or more queries relating to an aspect of the one or more tests, (B) comparing results received from the one or more queries to scoring data stored in one or more databases, (C) generating a score in response to the comparison, and (D) determining if a first of the tests should be run based on whether the score is above a predetermined value. | 05-27-2010 |
20100251118 | HELP UTILITY WITH EXPANDED CONTENT DISPLAY - A method of using a help utility user interface to facilitate data entry into a software application. The method includes receiving via the help utility user interface a first user input relating to a data field of the application software, storing the first user input in a data cell associated with the data field of the application software corresponding with a current item and receiving via the help utility user interface a second user input related to moving to another item. The help utility user interface presents an active data field for receiving the first user input for the current item, a first inactive field representing a previous item and a second inactive field representing a subsequent item. | 09-30-2010 |
Patent application number | Description | Published |
20080223449 | VALVE FOR AN INFLATABLE PRODUCT | 09-18-2008 |
20080245096 | FOLD-UP INSULATED CONTAINER - A cooler having two compartments connected together along a common edge. The cooler is configurable between an open configuration and a closed configuration by rotating the compartments about the edge. The cooler may include a handle connected to each compartment near the edge, and the two compartments may be secured to one another by a zipper or other fastener. A cooler is also provided having a bag with a zipper with sets of teeth extending along portions of the top edge of the bag. The cooler may be closed by closing the zipper and folding the bag in a manner so as to create flaps that can be folded downwards and secured to the bag. | 10-09-2008 |
20090249700 | AIR FRAMES FOR OUTDOOR GOODS - A backpack ( | 10-08-2009 |
20100059095 | REVERSIBLE TENT RAINFLY - A rainfly ( | 03-11-2010 |
20100192298 | SLEEPING BAG WITH MESH PANEL - A sleeping bag ( | 08-05-2010 |
20110155199 | TENT WITH AUTOMATICALLY STORING WINDOW AND DOOR COVERINGS - A tent having an automatically stored window covering. As a window for the tent is moved from a closed position, where a fabric cover covers the window opening, to an open position, where the fabric cover is partially or fully removed from the opening, the fabric cover automatically stores itself. The only use effort to both open and store the fabric cover is in opening the fabric cover. | 06-30-2011 |