Patent application number | Description | Published |
20080305115 | Reduced-mass, long-acting dosage forms - Methods and compositions are disclosed whereby free antibody or nucleic acid co-administered with a long-acting formulation, such as a microparticle or implant, containing the antibody or nucleic acid to achieve a long duration of antibody or nucleic acid release. One result is that less of the long-acting formulation excipient or polymer is needed allowing for small-volume administrations as required, for example, for ocular, intra-dermal, orthopedic, brain and spinal delivery. In one aspect, the free antibody or nucleic acid alone has efficacy for an extended period, during which time, very little or no long-acting formulation antibody or nucleic acid is released. In one aspect, after the free antibody or nucleic acid has diminished activity, is gone, or no longer has activity, the long-acting formulation antibody or nucleic acid begins to release for a desired preprogrammed duration to provide long-acting durations. Less formulation mass is needed because the entire antibody or nucleic acid is not encapsulated or implanted with encapsulation or implant excipient or polymer. In addition, more antibody or nucleic acid can be administered to afford longer-acting formulations. | 12-11-2008 |
20090124535 | VISCOUS TERPOLYMERS AS DRUG DELIVERY PLATFORM - Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed. | 05-14-2009 |
20100003300 | INJECTABLE DELIVERY OF MICROPARTICLES AND COMPOSITIONS THEREFORE - Compositions and methods of making and using of microparticle compositions that provide faster flow or improved injectability through smaller or small-diameter needles have been developed. Notably, the microparticle compositions can be successfully delivered or administered through smaller-diameter needles than other microparticle compositions prepared from biocompatible or biodegradable polymers including, for example, poly(lactide), poly(lactide-co-glycolide), polycaprolactone, or poly-3-hydroxybutyrate. The microparticle compositions can exhibit a higher solids loading for a given needle size and/or faster flow through needles than other microparticle compositions. Further, blending or mixing the polymer of the microparticle composition with other polymer formulations can enhance the injectability of the resulting formulation. | 01-07-2010 |
20100158978 | BIOACTIVE SPRAY COATING COMPOSITIONS AND METHODS OF MAKING AND USES THEREOF - Described herein are spray coating compositions, implant devices comprising the compositions, and methods of making and using same, including point of use methods. | 06-24-2010 |
20100168807 | BIOACTIVE TERPOLYMER COMPOSITIONS AND METHODS OF MAKING AND USING SAME - Described herein are terpolymer compositions, kits comprising the compositions, implant devices comprising the compositions, and methods of making and using same, including point of use methods. | 07-01-2010 |
20100189800 | CONTINOUS DOUBLE EMULSION PROCESS FOR MAKING MICROPARTICLES - Described herein are improved methods for microparticle encapsulation. In one aspect, the disclosed methods comprise a substantially continuous double emulsion process. In a further aspects, microparticles comprising a bioactive agent therein are made by the disclosed methods. | 07-29-2010 |
20110129422 | Viscous Terpolymers as Drug Delivery Platform - Disclosed are terpolymer compositions of lactide, glycolide, and caprolactone and methods of making such polymers with an initiator. Methods of using the terpolymers as a drug delivery platform are also disclosed. | 06-02-2011 |
20110142906 | Implant Devices that Differ by Release Profile and Methods of Making and Using Same - Described herein are implant devices, kits comprising the implant devices, and methods of making and using the devices and kits. In one aspect, a plurality implant devices comprises at least two implants that exhibit a different release profile of a bioactive agent. In another aspect, an implant device comprises one or more adjoined polymer bodies, wherein at least two of the polymer bodies provide a different release profile of a bioactive agent. In another aspect, a kit comprises one or more disclosed implant devices. In another aspect, methods of delivering a bioactive agent to a subject comprise administering to the subject one or more disclosed implant devices. | 06-16-2011 |
20110204533 | Emulsion-Based Process for Preparing Microparticles and Workhead Assembly for Use with Same - The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles. | 08-25-2011 |
20110236496 | Emulsions for Microencapsulation Comprising Biodegradable Surface-Active Block Copolymers as Stabilizers - Disclosed herein are surface-active biodegradable block copolymers comprising one or more hydrophobic blocks and one or more hydrophilic blocks. The surface-active polymers are used as stabilizers in emulsions which are used in microencapsulation processes. Also disclosed are microparticles prepared from the emulsions. | 09-29-2011 |
20120004323 | IMPLANT PROCESSING METHODS FOR THERMALLY LABILE AND OTHER BIOACTIVE AGENTS AND IMPLANTS PREPARED FROM SAME - Disclosed herein are processes for preparing implants that are particularly useful for thermally labile bioactive agents but can also generally be used with any bioactive agent. The disclosed processes avoid the use of heat during processing and therefore avoid heat induced degradation of the bioactive agent. Also disclosed are implants prepared by the disclosed methods. | 01-05-2012 |
20120004324 | Process for Preparing Cyclic Esters Comprising Unsaturated Functional Groups and Polyesters Prepared From Same - Disclosed herein are process for preparing cyclic esters comprising unsaturated functional groups. Also disclosed are copolymers prepared from the cyclic esters. The copolymers can be used to form microparticles, polymer micelles, etc., which are useful in drug delivery applications. | 01-05-2012 |