Patent application number | Description | Published |
20080267887 | Pyrrolo-Pyridine, Pyrrolo-Pyrimidine and Related Heterocyclic Compounds - Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: | 10-30-2008 |
20080319677 | Systems and Methods for Designing Molecules with Affinity for Therapeutic Target Proteins - The present invention provides methods for designing molecules with affinity for target proteins. More particularly, the present invention provides systems and methods for docking fragment molecules to target protein binding sites. The systems and methods are useful for designing active molecules in drug discovery. Methods of this invention can be implemented in a computer system and may be embodied as computer code in a computer readable medium. | 12-25-2008 |
20090006040 | Systems and Methods for Representing Protein Binding Sites and Identifying Molecules with Biological Activity - The present invention relates to systems and methods for representing target protein binding sites and for docking fragment molecules and structurally modified fragment molecules to target protein binding sites. The systems and methods are useful for designing active molecules in drug discovery. Methods of this invention can be implemented in a computer system and may be embodied as computer code in a computer readable medium. | 01-01-2009 |
20090018777 | Systems and Methods for Predicitng Ligand-Protein Binding Interactions - The present invention relates to systems and methods for determining a candidate molecule's ability to bind a target protein comprising calculating a score for the candidate molecule, wherein the score is a function of a position of the candidate molecule relative to a field of distribution densities on a three-dimensional target protein structure. The systems and methods are useful for designing active molecules in drug discovery. Methods of this invention can be implemented in a computer system and may be embodied as computer code in a computer readable medium. | 01-15-2009 |
20090176980 | 3-Substituted-6-Aryl Pyridines - 3-substituted-6-aryl pyridines of Formula I are provided: | 07-09-2009 |
20090312567 | SYSTEM AND METHOD FOR SUPPRESSING SUBLIMATION OF MATERIALS DURING CHEMICAL TRANSFORMATION AT HIGH TEMPERATURES - An apparatus for use in reactions of materials with a propensity for sublimation at high temperatures has a central chamber that is immersed in a reaction vessel, attached with an air tight joint. The chamber is surrounded by a cooling jacket filled with a circulating medium, the temperature of which is adjusted below the temperature of the solution of reactants. The central chamber is immersed into the mixture and is partially filled with a liquid. This liquid is cooled by the medium circulating in the cooling jacket. The cooling ensures that the liquid filling the tube has a lower temperature than the mixture, preventing sublimation of the materials. | 12-17-2009 |
20100069371 | THIENOPYRIDINE AND FUROPYRIDINE KINASE INHIBITORS - Compounds having the formula | 03-18-2010 |
20110118273 | PYRROLO-PYRIDINE, PYRROLO-PYRIMIDINE AND RELATED HETEROCYCLIC COMPOUNDS - Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: | 05-19-2011 |
20110281837 | 3-SUBSTITUTED-6-ARYL PYRIDINES - 3-substituted-6-aryl pyridines of Formula I are provided: | 11-17-2011 |