Patent application number | Description | Published |
20090304597 | Use of an Active Biological Substance in Abnormal Cellular and Viral Membrane Physiologies - An active biological substance is disclosed for use in abnormal cellular and viral membrane physiologies in human and mammal organisms. The active substance has diagnostic and/or therapeutic properties and contains or consists of at least one component selected from the group of substances including: histones, covalently modified histones, histone-like polypeptides, biologically active histone sequences and histone-like polypeptides as agents for stopping the supply to solid tumours over their blood vessels, for killing cells infected by virus and for killing tumour cells with disturbed lipid asymmetry. | 12-10-2009 |
20110034370 | BIS-MET HISTONES - The present invention provides a nucleic acid molecule which encodes a polypeptide consisting of two methionine residues as the first and second N-terminal amino acid residues linked via a peptide bond to a mature eukaryotic histone. The present invention furthermore relates to a vector containing said nucleic acid molecule, a host transformed with said vector, polypeptides encoded by the nucleic acid molecule and pharmaceutical and diagnostic compositions. The present invention also relates to the use of the nucleic acid molecule, vectors, hosts and the polypeptide of the invention for the preparation of a composition for the treatment of diseases. Furthermore, the present invention relates to a method of testing for the presence of the nucleic acid molecule or the polypeptide in a sample and to a kit. | 02-10-2011 |
20140315813 | Use of an Active Biological Substance in Abnormal Cellular and Viral Membrane Physiologies - An active biological substance is disclosed for use in abnormal cellular and viral membrane physiologies in human and mammal organisms. The active substance has diagnostic and/or therapeutic properties and contains or consists of at least one component selected from the group of substances including: histones, covalently modified histones, histone-like polypeptides, biologically active histone sequences and histone-like polypeptides as agents for stopping the supply to solid tumours over their blood vessels, for killing cells infected by virus and for killing tumour cells with disturbed lipid asymmetry. | 10-23-2014 |
Patent application number | Description | Published |
20080238182 | Brush head for a toothbrush and method for producing the brush head - The brush head of the toothbrush has filaments that are pointed at one end and led through clearances in the bristle carrier. These filaments have a length of about 10-20 mm. The tips of the pointed filaments produce a height profile other than that of a plane and the ends of the pointed filaments that are remote from the tips are melted. | 10-02-2008 |
20080271276 | Toothbrush Comprising Inclined and Tapered Bristles - Disclosed is a brush head ( | 11-06-2008 |
20080315668 | Method and Device for Producing a Toothbrush by the Two-Component or Multi-Component Injection-Molding Process - The invention relates to a method and a device for producing a toothbrush ( | 12-25-2008 |
20090183331 | Toothbrush With Faceted Handle - The toothbrush according to the invention is equipped with a handle of which the surface is formed, at least in certain sections, in a facet-like manner by way of multiplicity of planar surface-area elements. The surface-area elements are arranged directly adjacent to one another and form a network of element edges. The multiplicity of surface-area elements reproduce, more or less, an essentially rounded handle form, this ensuring comfortable use of the toothbrush in different rotary positions in relation to its longitudinal axis. | 07-23-2009 |
20110167579 | Method and device for producing a toothbrush by the two-component or multi-component injection-molding process - The invention relates to a method and a device for producing a toothbrush or part thereof by the two-component or multi-component injection-molding process. To produce in the brush body segments that are isolated from the rest of the brush body, a mold which comprises three hollow regions is used. Two of these hollow regions that are separate from one another serve for producing the segments and the other regions of the toothbrush from a first component. A third hollow region serves for distributing material to the segments that are isolated from one another and from the other regions, or the corresponding hollow region. The material remaining behind there is removed and sent for disposal. In a further step, connecting elements between the segments and/or the other regions are injection-molded from a second component. | 07-14-2011 |
20120121312 | BRUSH, IN PARTICULAR TOOTHBRUSH, AND ASSOCIATED PRODUCTION METHOD - A brush, in particular a toothbrush, including a head part with a cleaning structure that with bristles, a hand part and a neck part, a cavity with at least one outlet opening for an active substance being located in the head or neck part. In one embodiment, the cavity incorporates an active substance element, which contains the active substance in a carrier material and releases the substance in a controlled manner when it comes into contact with water. The cavity may be adapted to the shape of an active substance element by means of defined external contours. The volume of the cavity is preferably 1-2 times and no more than 4 times greater than the volume of the active substance element, ensuring that the latter is preferably surrounded by water during use. This allows the active substance to be effectively metered and ensures that the brush is easy to use. | 05-17-2012 |
20120284944 | ORAL HYGIENE DEVICE, PARTICULARLY A TOOTHBRUSH, AND METHOD FOR THE PRODUCTION THEREOF - The oral hygiene device, particularly a toothbrush, has in the neck part, a cavity, which is closed off from the surroundings and in which a snap dome is arranged. This snap dome produces an acoustic warning signal when a limiting bending of the neck part is exceeded as a result of a limiting pressing force with which the head part is pressed, for example, against the teeth and gums is exceeded. On the one hand, this has the effect of protecting the snap dome, usually produced from metal, from corrosion and, on the other hand, the cavity serves as a resonance chamber to amplify the warning signal. | 11-15-2012 |
20130086759 | BRUSH HEAD FOR A TOOTHBRUSH AND METHOD FOR PRODUCING THE BRUSH HEAD - The brush head of the toothbrush has filaments that are pointed at one end and led through clearances in the bristle carrier. These filaments have a length of about 10-20 mm. The tips of the pointed filaments produce a height profile other than that of a plane and the ends of the pointed filaments that are remote from the tips are melted. | 04-11-2013 |
20130212823 | BRUSH, IN PARTICULAR TOOTHBRUSH, AND ASSOCIATED PRODUCTION METHOD - A brush, in particular a toothbrush, comprising a head part with a cleaning structure featuring bristles, a hand part and a neck part, and a cavity located in the head or neck part comprising at least one outlet opening for an active substance. In one embodiment, the cavity incorporates an active substance element, which contains the active substance in a carrier material and releases said substance in a controlled manner when it comes into contact with water. In another embodiment, the cavity is adapted to the shape of an active substance element by means of defined external contours. The volume of the cavity is preferably 1-2 times and no more than 4 times greater than the volume of the active substance element, ensuring that the latter is preferably surrounded by water during use. This allows the active substance to be effectively metered and ensures the brush is easy to use. | 08-22-2013 |
20140082866 | BRUSH HEAD FOR A TOOTHBRUSH AND METHOD FOR PRODUCING THE BRUSH HEAD - The brush head of the toothbrush has filaments that are pointed at one end and led through clearances in the bristle carrier. These filaments have a length of about 10-20 mm. The tips of the pointed filaments produce a height profile other than that of a plane and the ends of the pointed filaments that are remote from the tips are melted. | 03-27-2014 |
20140348569 | BRUSH, IN PARTICULAR TOOTHBRUSH, AND ASSOCIATED PRODUCTION METHOD - The invention relates to a brush, specifically a toothbrush, a head part with a cleaning structure that includes bristles, a hand part and a neck part, a cavity of at least one outlet opening for an active substance being located in the head or neck part. In one embodiment, the cavity incorporates an active substance element, which contains the active substance in a carrier material and releases said substance in a controlled manner when it comes into contact with water. In another embodiment, the cavity is adapted to the shape of an active substance element by means of defined external contours. Volume of the cavity is 1-2 times and no more than 4 times greater than the volume of the active substance element, ensuring that the latter is surrounded by water during use. This allows the active substance to be metered and ensures that the brush is easy to use. | 11-27-2014 |