Patent application number | Description | Published |
20120021410 | TRIGGERED MOLECULAR GEOMETRY BASED BIOIMAGING PROBES - The present embodiments relate to engineering imaging probes based on “triggered molecular geometry.” Upon detection of a molecular signal, nucleic acid hairpin monomers assemble an imageable molecular shape with prescribed geometry. In some embodiments the prescribed shape can be imaged directly. In some embodiments, the prescribed shape can serve as a spatial organizer or amplification scheme for other imaging entities, such as fluorophore and fluorescent proteins. | 01-26-2012 |
20120022243 | BIOMOLECULAR SELF-ASSEMBLY - The present invention relates generally to programming of biomolecular self-assembly pathways and related methods and constructs for self-assembly of prescribed two and three-dimensional structures. | 01-26-2012 |
20120022244 | SELF-ASSEMBLED POLYNUCLEOTIDE STRUCTURE - The present application provides polynucleotide structures such as nucleic acid ribbons and nucleic acid tubes, methods for making the polynucleotide structures, and methods for making two-dimensional or three-dimensional objects comprising the nucleic acid ribbons and nucleic acid tubes. | 01-26-2012 |
20130261019 | NUCLEIC ACID NANOSTRUCTURE BARCODE PROBES - Provided herein are, inter alia, barcode probes comprised of transiently or stably fhiorescently labeled nucleic acid nanostructures that are fully addressable and able to be read using standard fluorescent microscope and methods of use thereof including methods of use as detectable labels for probes. | 10-03-2013 |
20130274135 | COMPOSITIONS OF TOEHOLD PRIMER DUPLEXES AND METHODS OF USE - Provided herein are primers and primer systems having improved specificity and kinetics over existing primers, and methods of use thereof. | 10-17-2013 |
20140066610 | SPATIAL SEQUESTRATION OF DYNAMIC NUCLEIC ACID CIRCUITS - The invention provides systems and methods for spatial sequestration of elements in nucleic acid circuits. | 03-06-2014 |
20140213778 | COMPOSITIONS AND METHODS RELATING TO NUCLEIC ACID NANO- AND MICRO-TECHNOLOGY - The invention provides nucleic acid structures of controlled size and shape, comprised of a plurality of oligonucleotides, and methods for their synthesis. The structures are formed, at least in part, by the self-assembly of single stranded oligonucleotides. The location of each oligonucleotide in the resultant structure is known. Accordingly, the structures may be modified with specificity. | 07-31-2014 |
20140303320 | COMPOSITIONS AND METHODS FOR SELF-ASSEMBLY OF POLYMERS WITH COMPLEMENTARY MACROSCOPIC AND MICROSCOPIC SCALE UNITS - The invention provides compositions and methods relating to self-assembly of structures of various size and shape completxity. The composition include synthetic single-stranded polymers having a backbone and pre-determined linear arrangement of monomers. | 10-09-2014 |