Patent application number | Description | Published |
20110076255 | COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE MYOCARDIAL INJURY DUE TO A VASCULAR INSUFFICIENCY - The described invention provides methods and regimens for treating adverse consequences of a persistent and progressive myocardial injury—due to a vascular insufficiency that occurs early or late in a subject in need thereof, and progressive myocardial injury-preventing compositions that contain a chemotactic hematopoietic stem cell product, and, optionally, an additional active agent. | 03-31-2011 |
20120059357 | COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE MYOCARDIAL INJURY DUE TO A VASCULAR INSUFFICIENCY - The described invention provides methods and regimens for treating adverse consequences of a persistent and progressive myocardial injury-due to a vascular insufficiency that occurs early or late in a subject in need thereof, and progressive myocardial injury-preventing compositions that contain a chemotactic hematopoietic stem cell product, and, optionally, an additional active agent. | 03-08-2012 |
20120064045 | COMPOSITIONS AND METHODS FOR TREATING PROGRESSIVE MYOCARDIAL INJURY DUE TO A VASCULAR INSUFFICIENCY - The described invention provides methods and regimens for treating adverse consequences of a persistent and progressive myocardial injury-due to a vascular insufficiency that occurs early or late in a subject in need thereof, and progressive myocardial injury-preventing compositions that contain a chemotactic hematopoietic stem cell product, and, optionally, an additional active agent. | 03-15-2012 |
20120071855 | COMPOSITIONS AND METHODS OF VASCULAR INJURY REPAIR - The present invention relates to pharmaceutical compositions comprising a chemotactic hematopoietic stem cell product comprising an enriched population of CD34+ cells containing a subpopulation of CD34+/CXCR-4+ cells having CXCR-4-mediated chemotactic activity, methods of preparing these compositions and use of these compositions to treat or repair vascular injury, including infarcted myocardium. | 03-22-2012 |
20120076760 | COMPOSITIONS AND METHODS OF VASCULAR INJURY REPAIR CROSS-REFERENCE TO RELATED APPLICATIONS - The present invention relates to pharmaceutical compositions comprising a chemotactic hematopoietic stem cell product comprising an enriched population of CD34+ cells containing a subpopulation of CD34+/CXCR-4+ cells having CXCR-4-mediated chemotactic activity, methods of preparing these compositions and use of these compositions to treat or repair vascular injury, including infarcted myocardium. | 03-29-2012 |
20130121971 | COMPOSITIONS AND METHODS OF VASCULAR INJURY REPAIR - The present invention relates to pharmaceutical compositions comprising a chemotactic hematopoietic stem cell product comprising an enriched population of CD34+ cells containing a subpopulation of CD34+/CXCR-4+ cells having CXCR-4-mediated chemotactic activity, methods of preparing these compositions and use of these compositions to treat or repair vascular injury, including infarcted myocardium. | 05-16-2013 |
Patent application number | Description | Published |
20130287728 | Compositions and Methods for Treating Progressive Myocardial Injury Due to A Vascular Insufficiency - The described invention provides methods and regimens for treating adverse consequences of a persistent and progressive myocardial injury-due to a vascular insufficiency that occurs early or late in a subject in need thereof, and progressive myocardial injury-preventing compositions that contain a chemotactic hematopoietic stem cell product, and, optionally, an additional active agent. The method treats ongoing vascular insufficiency affecting coronary circulation by (i) stimulating neoangiogenesis in a peri-infarct border zone, thereby improving myocardial perfusion; and, (ii) through a paracrine effect, preventing apoptosis of cardiomyocytes in the peri-infarct border zone. The neoangiogenesis and paracrine-mediated reduction of apoptosis reduces progressive myocardial cell loss, which leads to improvement in cardiac function and a reduction of risk of major adverse cardiovascular events. | 10-31-2013 |
20140056842 | CELLULAR THERAPEUTIC APPROACHES TO TRAUMATIC BRAIN AND SPINAL CORD INJURY - The described invention provides cellular therapeutic approaches for treating a vascular insufficiency following a traumatic injury to head or spine that results in an injury to brain, spinal cord, or both by administering a therapeutic amount of an isolated, nonexpanded population of autologous mononuclear cells comprising a subpopulation of CD34+ cells, which further contains a subpopulation of potent SDF-1 mobile CD34+/CXCR-4 cells that have CXCR-4-mediated chemotactic activity. | 02-27-2014 |
20150100341 | CLINICAL OUTCOME TRACKING AND ANALYSIS - The described invention provides a system and method for clinical outcome tracking and analysis. The clinical outcome tracking and analysis comprises sorting, outcome tracking, quality of life metrics, toxicity to therapy and cost of care. The system and method includes receiving one or more parameters. Exemplary parameters for sorting include sex, age, ethnicity, comorbidities, tobacco use, source of insurance, medical record number, primary care physician, referring physician, hospital, approved service vendors, disease-specific clinical molecular phenotype, therapy intent, stage of therapy, biomarkers, and cost of care. A plurality of patient medical records are sorted, by a clinical outcome tracking and analysis module executed by a processor, to provide a set of patient medical records satisfying the one or more parameters. A nodal address, indicating one or more variables, is applied to the sorted set of patient medical records to determine a clinically relevant set of patient medical records as the sorted set of patient medical records satisfying the one or more variables. The clinically relevant set of patient medical records is analyzed. A communication is transmitted based on the analyzing to a user to effect treatment, to monitor performance, or to reduce at least one of treatment variability, waste or inefficiency while delivering on intended outcome. | 04-09-2015 |
20150127385 | CLINICAL OUTCOME TRACKING AND ANALYSIS - The described invention provides a system and method for clinical outcome tracking and analysis. The clinical outcome tracking and analysis comprises sorting, outcome tracking, quality of life metrics, toxicity to therapy and cost of care. The system and method includes receiving one or more parameters. Exemplary parameters for sorting include sex, age, ethnicity, comorbidities, tobacco use, source of insurance, medical record number, primary care physician, referring physician, hospital, approved service vendors, disease-specific clinical molecular phenotype, therapy intent, stage of therapy, biomarkers, and cost of care. A plurality of patient medical records are sorted, by a clinical outcome tracking and analysis module executed by a processor, to provide a set of patient medical records satisfying the one or more parameters. A nodal address, indicating one or more variables, is applied to the sorted set of patient medical records to determine a clinically relevant set of patient medical records as the sorted set of patient medical records satisfying the one or more variables. The clinically relevant set of patient medical records is analyzed. A communication is transmitted based on the analyzing to a user to effect treatment, to monitor performance, or to reduce at least one of treatment variability, waste or inefficiency while delivering on intended outcome. | 05-07-2015 |
Patent application number | Description | Published |
20090114180 | INTAKE MANIFOLD WITH INTEGRATED CANISTER CIRCUIT FOR A SUPERCHARGED INTERNAL COMBUSTION ENGINE - An intake manifold with integrated canister circuit for a supercharged internal combustion engine; the intake manifold is provided with: a tubular body in which a plenum is defined; a sorting chamber, which is obtained in a wall of the tubular body; a canister solenoid valve, which is arranged in the sorting chamber and is adapted to adjust the introduction of gasoline vapours into the sorting chamber itself; a first pipe, which is obtained in the wall of the tubular body, puts the sorting chamber into communication with the plenum, and defines a first branch of a recovery pipe; a one-way valve, which is arranged in the sorting chamber at the first pipe; and a second pipe, which is obtained in the wall of the tubular body, puts the sorting chamber into communication with the intake pipe upstream of a compressor, and defines an initial portion of a second branch of the recovery pipe. | 05-07-2009 |
20090127484 | COMBINED ACTUATOR WITH RHEOLOGICAL CONTROL BRAKE - A combined actuator provided with: a mobile element; a driver for displacing the mobile element; and a rheological control brake, which is mechanically coupled to the mobile element to adjust the displacement of the mobile element; the rheological control brake has: two contiguous adjustment chambers; a rheological fluid contained in the two adjustment chambers; a sliding piston, which tightly separates the two adjustment chambers and is mechanically connected to the mobile element; at least one external connection pipe, which reciprocally connects the two adjustment chambers; and a driving device which is coupled to the external connection pipe so as to apply a variable electromagnetic field to the rheological fluid contained in the external connection pipe for varying the viscosity of the rheological fluid between a minimum value and a maximum value. | 05-21-2009 |
20100018491 | SUCTION MANIFOLD WITH A PNEUMATIC ACTUATOR MECHANICALLY COUPLED TO A SHAFT OF A CHOKING DEVICE BY MEANS OF A RACK - A suction manifold for an internal combustion engine provided with a head in which a number of cylinders are obtained; the suction manifold displays: a body of the suction manifold in which a suction chamber, which receives fresh air from the external environment, and a number of suction pipes, each of which connects the suction chamber to a corresponding cylinder of the internal combustion engine, are defined and which ends with an outlet mouth; and a choking system for varying the geometry of the suction manifold and comprising, for each suction pipe, a corresponding choking valve provided with a choking element, which is arranged inside the suction pipe and is fitted to a shaft which is rotated about a rotation axis by an actuator device; the shaft of the choking system is provided with a toothed wheel arranged at one end of the shaft itself; and the actuator device displays a movable rod, which is linearly movable and provided with a rack which meshes with the toothed wheel of the shaft of the choking system. | 01-28-2010 |
20100218749 | Intake Manifold With Integrated Canister Circuit For A Supercharged Internal Combustion Engine - An intake manifold with integrated canister circuit for a supercharged internal combustion engine; the intake manifold is provided with: a tubular body in which a plenum is defined; a sorting chamber, which is obtained in a wall of the tubular body; a canister solenoid valve, which is arranged in the sorting chamber and is adapted to adjust the introduction of gasoline vapours into the sorting chamber itself; a first pipe, which is obtained in the wall of the tubular body, puts the sorting chamber into communication with the plenum, and defines a first branch of a recovery pipe; a second pipe, which is obtained in the wall of the tubular body and defines an initial portion of a second branch of the recovery pipe; a first one-way valve which is arranged in the sorting chamber in correspondence of the first pipe and allows, through the first pipe, only a flow towards the plenum; a second one-way valve which is arranged in the sorting chamber in correspondence of the second pipe and allows, through the second pipe, only a flow through the intake pipe. | 09-02-2010 |