Patent application number | Description | Published |
20080269206 | CFTR INHIBITOR COMPOUNDS AND USES THEREOF - The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-6 or encompassed by formulas I-VI) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease. | 10-30-2008 |
20090264433 | Compounds, Compositions and Methods Comprising Triazine Derivatives - The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease. | 10-22-2009 |
20090270398 | Compounds, Compositions and Methods Comprising Pyridazine Derivatives - The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Table 1 or encompassed by formula I) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease. | 10-29-2009 |
20090318429 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives - The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease. | 12-24-2009 |
20100144733 | Compounds, compositions and methods comprising heteroaromatic derivatives - The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease. | 06-10-2010 |
Patent application number | Description | Published |
20130217664 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES - Novel imidazolopyridines according to Formula I, able to inhibit JAK are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. | 08-22-2013 |
20130217722 | NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES - A novel imidazolopyridine according to Formula I, able to inhibit JAK as disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 or interferons. | 08-22-2013 |
Patent application number | Description | Published |
20080304597 | SYSTEM AND METHOD FOR DECODING AUTOMATIC IDENTIFICATION SYSTEM SIGNALS - Various embodiments are described herein for a system and method of detecting Automatic Identification System (AIS) signals in space and decoding these signals. In one aspect, a system for performing this function is described which includes a receiver configured to receive the plurality of AIS signals and pre-process the plurality of AIS signals to produce digital input data, and a processing unit configured to process the digital input data to identify one or more candidate AIS message signals based on Doppler offsets associated with the digital input data, determine corresponding Doppler offset estimates and time estimates of the one or more candidate AIS message signals, decode the one or more candidate AIS message signals to obtain corresponding message segments and validate the decoded message segments for proper AIS formatting. | 12-11-2008 |
20110075602 | SYSTEMS AND METHODS FOR DECODING AUTOMATIC IDENTIFICATION SYSTEM SIGNALS - A method of extracting automatic identification system (AIS) message segments from AIS signals received by a satellite. The method includes: (a) receiving AIS signals from satellite antennas; (b) generating multiple versions of the AIS signals; (c) extracting message segments contained within each of the AIS signals using one or more AIS receivers; (d) sorting the message segments by time; and (e) deleting any duplicate message segments. Multiple versions of the AIS signals may be generated by one or more of the following methods: (i) processing the AIS signals multiple times, each time with different AIS receiver parameter settings; (ii) splitting each signal into multiple signals and filtering each of the multiple signals separately; (iii) receiving multiple AIS signals and combining them with different phases and amplitudes to produce a plurality of combined AIS signals; and (iv) removing extracted message segments from the received AIS signals and reprocessing the modified AIS signals. | 03-31-2011 |
20110268229 | SYSTEM AND METHOD FOR DECODING AUTOMATIC IDENTIFICATION SYSTEM SIGNALS - Various embodiments are described herein for a system and method of detecting Automatic Identification System (AIS) signals in space and decoding these signals. In one aspect, a system for performing this function is described which includes a receiver configured to receive the plurality of AIS signals and pre-process the plurality of AIS signals to produce digital input data, and a processing unit configured to process the digital input data to identify one or more candidate AIS message signals based on Doppler offsets associated with the digital input data, determine corresponding Doppler offset estimates and time estimates of the one or more candidate AIS message signals, decode the one or more candidate AIS message signals to obtain corresponding message segments and validate the decoded message segments for proper AIS formatting. | 11-03-2011 |
20130275842 | METHODS AND SYSTEMS FOR CONSISTENCY CHECKING AND ANOMALY DETECTION IN AUTOMATIC IDENTIFICATION SYSTEM SIGNAL DATA - Methods and systems for validating positions reported in AIS message signals by fitting suitably chosen functions to signal characteristic data, such as timing and Doppler shift data, derived from a plurality of AIS message signals. Ships whose reported positions deviate from the fitted function may be flagged as suspect. | 10-17-2013 |