Patent application number | Description | Published |
20100310463 | Anti-EpCAM Antibodies - Disclosed are antibodies that bind to Epithelial Cell Adhesion Molecule (EpCAM) and display certain advantages over known antibodies which bind to EpCAM, for example, the antibodies of the invention show good affinity, good cross-reactivity profiles and excellent ADCC and CDCC activity. Antibodies comprising specific heavy and light chain CDRs are disclosed. The invention thus relates to these antibodies and all uses thereof, in particular in the treatment of cancer. The present invention thus provides new antibody-based compositions, methods and combined protocols for treating cancer. Advantageous immunoconjugate compositions and methods using the new anti-EpCAM antibodies are also provided. | 12-09-2010 |
20100310464 | Antibodies - The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields. | 12-09-2010 |
20130196379 | Antibodies - The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields. | 08-01-2013 |
20130236535 | Antibodies - The present invention provides antibodies which bind to an epitope in the extracellular domain of human CC chemokine receptor 4 (CCR4) and which are capable of inhibiting the binding of macrophage-derived chemokine (MDC) and/or thymus and activation regulated chemokine (TARC) to CCR4. Also provided are inter alia immunoconjugates and compositions comprising such antibodies and methods and uses involving such antibodies, particularly in the medical and diagnostic fields. | 09-12-2013 |
Patent application number | Description | Published |
20130216359 | COMPRESSOR - An axial compressor is provided. The compressor has an annular flow channel, in which adjustable blades of a blade ring that extend through the flow channel are rotatably mounted. Each blade has a lug on the rotor-side of the vane for mounting an inner ring. In order to provide a wear-free, self-centering inner ring, the ring is designed as a split ring with two opposing ends and a spring element for spreading the split ring. | 08-22-2013 |
20140234111 | BLADE ARRANGEMENT - A blade arrangement is provided having a blade carrier and a retaining groove arranged therein, which retaining groove has projections extending along side walls thereof forming undercuts and into which a number of blades are inserted forming a blade ring of a turbomachine. Each blade has a blade root which engages into the undercuts, and each blade is pressed against the projections by an element arranged between a blade root underside and a groove base of the retaining groove. It is further provided that each element is of plate-like form and has, in the projection of the blade airfoil in the direction of the groove base, at least one bead, arranged beneath the blade airfoil, for imparting a pressing action, and in the longitudinal direction of the retaining groove, only part of the blade root which the element presses against is covered. | 08-21-2014 |