Paulo Alexandre
Paulo Alexandre Da Costa Gameiro Guerreiro, Cambridge, MA US
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20130331432 | METABOLIC GENE, ENZYME, AND FLUX TARGETS FOR CANCER THERAPY - A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth. | 12-12-2013 |
Paulo Alexandre Da Costa Lemos, Belas PL
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20100200498 | Process for Maximizing PHA Production in Glycogen Accumulating Organisms - A process is provided for increasing the production of PHA in a mixed culture biomass. In a first stage of the process, organic material associated with a substrate is converted to volatile fatty acids. In the case of a wastewater treatment process, if the wastewater includes sufficient volatile fatty acids (VFAs) to support the process, then it is unnecessary to convert organic material to VFAs. In a second stage of the process, an anaerobic-aerobic selection process is utilized to select glycogen accumulating organisms that cause these organisms to proliferate and dominate the open mixed culture biomass. By providing relatively high organic loading in the form of VFAs in the anaerobic treatment phase of the selection process, glycogen accumulating organisms having a relatively high level of stored glycogen are produced. In a third stage, the PHA accumulation process is practiced where the glycogen rich organisms are fed VFAs under anaerobic or aerobic conditions or combinations thereof. Through the consumption of externally supplied VFAs and internally stored glycogen, relatively high levels of PHA in the biomass are produced. Thereafter PHA is separated from the residual biomass. | 08-12-2010 |
Paulo Alexandre Goncalves Francisco, Vila Nova De Poiares PT
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20150143609 | SUPPORTED GLOVE HAVING GRIP FEATURES - Gloves including a fabric liner; a first polymeric composition adhered to at least a portion of the fabric liner, forming a polymeric coating; and a plurality of raised features comprising a second polymeric composition disposed on a surface of the polymeric coating, wherein the polymeric coating and the plurality of raised features comprise different polymeric compositions adapted to enhance at least one of oil grip properties, dry grip properties, or wet grip properties, and methods of making the gloves, are disclosed. | 05-28-2015 |
20150143610 | POLYMERIC GLOVES HAVING GRIP FEATURES - A glove, including a first polymeric composition disposed as a polymeric coating or polymeric layer; and a plurality of raised features comprising a second polymeric composition disposed on a surface of the polymeric coating, wherein the polymeric coating and the plurality of raised features comprise different polymeric compositions adapted to enhance at least one of oil grip properties, dry grip properties, or wet grip properties, and methods of making the gloves, which may be unsupported gloves, are disclosed. | 05-28-2015 |
Paulo Alexandre Quadros De Oliviera E Santos, Salreu PT
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20090263497 | PRODUCTION METHOD FOR CALCIUM PHOSPHATE NANO-PARTICLES WITH HIGH PURITY AND THEIR USE - The present invention provides a continuous process for producing calcium phosphate nanoparticles in a network mixer or static mixer reactor, fed by a calcium solution, a phosphorous solution and an alkaline solution and, optionally, one solvent or dispersing agent. The proposed process enables the micromixing control, which is essential to form nanometric structures, but it is also a determining factor in the crystals purity, crystallinity and morphology. The reactants distribution scheme at the inlet of the reactor and along the reactor, performed continuously or varying in time, is also a crucial factor to programme the pH of the reactant media along the reactor The calcium phosphate nanoparticles suspension that exits the reactor can be submitted to further aging, ultra-sounds, separation, drying, sintering and milling processes. Some calcium phosphates are considered biomaterials, used as: food additives and nutritional supplements; bone graft for bone replacement, growth and repair; biocements and coating of metallic implant. Some of the most recent applications include their use in cosmetics, toothpaste and in esthetical treatments for diminishing wrinkles by stimulating conjunctive tissue formation. | 10-22-2009 |