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Paul L.
Paul L. Anderson, Alexandria, MN US
| Patent application number | Description | Published |
|---|---|---|
| 20080223615 | Methods and Apparatus for Forming Hole in Ground - An apparatus for forming a hole in ground ( | 09-18-2008 |
Paul L. Bartruff, Leesburg, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20110197280 | Network Managed Antivirus Appliance - Data can be scanned using a network managed appliance. The network managed appliance may integrate commercial hardware elements connected through a basic or simplified operating system environment expressly developed for the appliance, thus being more malware resistant and less vulnerable to attacks from the scanned data or other sources. The network managed appliance may be a self-contained apparatus with an integrated chassis, designed and configured as “single-purpose” device. Such appliances may be connected to an appliance management network including central management servers in communication with appliances in remote locations. The central management servers may ensure that scanning software and the definitions lists for each of the appliances are current and match an enterprise-approved configuration. | 08-11-2011 |
Paul L. Benenati, Wadsworth, OH US
| Patent application number | Description | Published |
|---|---|---|
| 20080261011 | MICROPOROUS MATERIAL CONTAINING A SECURITY FEATURE - Provided is a microporous material, e.g., a microporous sheet material, having a matrix of polyolefin, finely-divided, substantially water insoluble particulate filler, a network of interconnecting pores communicating throughout the microporous material, and at least one retrospectively identifiable taggant material embedded within the matrix, wherein the polyolefin is present in the microporous material in an amount of 20 to 60 weight percent, based on the weight of the microporous material. The taggant material provides a marker, signature or code that is capable of retrospective identification by machine, instrument or by the naked eye. Articles including the microporous material and processes for preparing the microporous material also are provided. | 10-23-2008 |
| 20080286593 | MULTI-LAYER ARTICLES PREPARED FROM MICROPOROUS MATERIALS - Provided is a multi-layer article including (1) a sheet of microporous material having opposing surfaces, and (2) an adhesive composition applied over at least a portion of at least one of the surfaces of the sheet. The microporous material contains (A) a polymeric matrix component of 5 to 100 weight percent of low melt flow index polypropylene; 0 to 90 weight percent of ultrahigh molecular weight polyethylene; and 0 to 90 weight percent of high density polyethylene; (B) a finely divided, particulate filler component dispersed throughout the polymeric matrix (A) including siliceous and non-siliceous materials; and (C) a network of interconnecting pores communicating substantially throughout the microporous material, the pores constituting 10 to 80 percent by volume of the microporous material, wherein the weight ratio of filler component (B) to polymeric matrix component (A) ranges from 0.1 to 10.0. | 11-20-2008 |
| 20090155548 | MICROPOROUS MATERIALS SUITABLE AS SUBSTRATES FOR PRINTED ELECTRONICS - Provided is a microporous material including (a) a polyolefin matrix which is 30 to 80 weight percent high density polyolefin, (b) finely divided particulate filler distributed throughout the matrix including 10 to 30 weight percent or less of calcium carbonate, and (c) at least 35 percent by volume of a network of interconnecting pores communicating throughout the microporous material. The microporous material has a density ranging from 0.5 to 0.8 g/cc, a Sheffield smoothness of less than or equal to 40, a air flow rate of 1000 or more Gurley seconds, and MD stress at 1% strain of greater than or equal to 200 psi. Printed electronic devices prepared from the microporous material also are provided. | 06-18-2009 |
| 20090246487 | MICROPOROUS MATERIALS SUITABLE AS SUBSTRATES FOR PRINTED ELECTRONICS - Provided is a microporous material including (a) a polyolefin matrix which contains ultrahigh molecular weight polyolefin having a molecular weight greater than 7 million grams per mole and 30 to 80 weight percent high density polyolefin, (b) finely divided particulate filler having a density ranging from 2.21 to 3.21 grams per cubic centimeter distributed throughout the matrix, and (c) at least 35 percent by volume of a network of interconnecting pores communicating throughout the microporous material. The microporous material has a density ranging from 0.6 to 0.9 g/cc, a Sheffield smoothness of less than or equal to 40, and an air flow rate of 1000 or more Gurley seconds. Printed electronic devices prepared from and methods of making the microporous material also are provided. | 10-01-2009 |
| 20090311504 | MICROPOROUS MATERIALS AND MULTI-LAYER ARTICLES PREPARED THEREFROM - A microporous material is provided in the form of a singly extruded microporous sheet having opposing first and second surfaces, comprising: | 12-17-2009 |
| 20110127763 | MICROPOROUS MATERIAL CONTAINING A SECURITY FEATURE - Provided is a microporous material, e.g., a microporous sheet material, having a matrix of polyolefin, finely-divided, substantially water insoluble particulate filler, a network of interconnecting pores communicating throughout the microporous material, and at least one retrospectively identifiable taggant material embedded within the matrix, optionally the at least one taggant being unique to an end user for the microporous material, wherein the polyolefin is present in the microporous material in an amount of 20 to 35 weight percent, based on the weight of the microporous material. The taggant material provides a marker, signature or code that is capable of retrospective identification by machine, instrument or by the naked eye. Articles including the microporous material and processes for preparing the microporous material also are provided. | 06-02-2011 |
| 20110198837 | LASER MARKABLE MICROPOROUS MATERIAL - Provided is a microporous material including a polyolefin matrix material; finely divided, substantially water-insoluble filler distributed throughout the matrix material, where the filler includes a positive amount of titanium dioxide; a network of interconnecting pores communicating throughout the microporous material; and optionally, a contrasting enhancing amount of a contrast enhancing material. The sum of the weight percent of the titanium dioxide and the weight percent of the optional contrast enhancing material is at least 3 weight percent based on total weight of the microporous material. Multilayer articles having a layer of the microporous material also are provided. | 08-18-2011 |
Paul L. Borrill, Palo Alto, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090037451 | Attack and Disaster Resilient Cellular Storage Systems and Methods - Systems, methods, and apparatus for providing data storage services storage using self-organizing replica management. In one embodiment, a cellular system operates storage objects, for example, data files, for clients. The system stores the storage objects as generally more than one substitutable replica, with each replica being stored on a separate cell. In some aspects, the system maintains multiple layers of overlapping trees and uses them for managing storage object replicas. In other aspects, a single self specializing substitutable cell performs dynamic specialization of itself in the system, while persistence is provided by the system as a whole. In other aspects, the system gives replicas special status while their storage object is being updated and returns them to a state of being fully substitutable after all changes have been successfully propagated to the replicas. | 02-05-2009 |
Paul L. Brazdzionis, Glastonbury, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20110060670 | SYSTEM AND METHOD FOR MANAGING DATA RELATING TO INVESTMENTS FROM A VARIETY OF SOURCES - A computer system for furnishing data relating to investments has a processor and one or more memory storage devices in communication with the processor. Data relating to investments is stored in the one or more memory storage devices. A catalog includes at least data stored in at least one of the one or more memory storage devices, the data including at least logical locations for the data relating to investments. The processor is adapted to execute services for calling to the catalog for locations of the data, and, employing at least logical locations of the selected data obtained from the catalog, access the selected data from at least one of the memory storage devices, perform one or more operations on the selected data, and provide the selected data for display to a user. | 03-10-2011 |
Paul L. Brohlin, Parker, TX US
| Patent application number | Description | Published |
|---|---|---|
| 20100002472 | System and method for switch mode power supply delay compensation - A delay applied to a turn-on time for a high side switch in a switch mode power converter prevents oscillation between continuous and discontinuous conduction modes under light load conditions. The delay equalizes turn-on time for a high side switch with respect to continuous and discontinuous modes, so that turn-on time is not treated differently between the different modes. The delay value can be set for be equivalent to a propagation delay through a driver for a low side switch, in addition to a turn-off time for the low side switch. The addition of the delay element tends to maintain the switch mode power converter in a discontinuous mode under light load conditions and avoids oscillation between discontinuous and continuous conduction modes. | 01-07-2010 |
| 20100052762 | Sensor Node Voltage Clamping Circuit and Method - A voltage clamping circuit includes a current source having a fixed current source and a variable current source and a variable resistor receiving current from the current source. The variable resistor varies its resistance in response to an environmental operating condition. The voltage clamping circuit also includes an amplifier configured to compare a sensor node voltage with a reference voltage, the sensor node voltage being in communication with the voltage drop across the variable resistor. The amplifier is configured and connected to provide a control output to control the variable current source to modify current output from the variable current source to at least in part prevent the sensor node voltage from exceeding a reference voltage when certain operating conditions are present. | 03-04-2010 |
| 20100066345 | Battery Charger Short Circuit Monitor - Various apparatuses and methods for supplying an electrical current are disclosed herein. For example, some embodiments provide an apparatus including a current regulation switch connected in a current path between a power input and a current output. A current regulator is connected to the current regulation switch. The current regulator includes a current set terminal, and the current through the current regulation switch is proportional to the current through current set terminal. An impedance monitor is connected to the current set terminal. | 03-18-2010 |
| 20120025901 | SENSOR NODE VOLTAGE CLAMPING CIRCUIT AND METHOD - A voltage clamping circuit includes a current source having a fixed current source and a variable current source and a variable resistor receiving current from the current source. The variable resistor varies its resistance in response to an environmental operating condition. The voltage clamping circuit also includes an amplifier configured to compare a sensor node voltage with a reference voltage, the sensor node voltage being in communication with the voltage drop across the variable resistor. The amplifier is configured and connected to provide a control output to control the variable current source to modify current output from the variable current source to at least in part prevent the sensor node voltage from exceeding a reference voltage when certain operating conditions are present. | 02-02-2012 |
Paul L. Bugyik, Reseda, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20100259323 | VARIABLE GAIN INSTRUMENTATION AMPLIFIER - Techniques for providing an instrumentation amplifier having a plurality of selectable gain settings. In an exemplary embodiment, a gain adjustment block for accepting a differential input voltage is coupled to a differential-to-single-ended conversion block for generating a single-ended output voltage. The gain adjustment block may have a plurality of gain settings selectable by one or more switches. The instrumentation amplifier advantageously offers precise gain control without the need for external calibration, while being robust and simple to design. | 10-14-2010 |
Paul L. Chen, Shanghai CN
| Patent application number | Description | Published |
|---|---|---|
| 20120096975 | SAFETY TRIGGER MECHANISM AND FUNCTIONAL FRAME FOR MOTION FURNITURE - The present invention discloses a safety trigger mechanism and functional frame for motion furniture for driving a drive mechanism of motion furniture. The safety trigger mechanism includes a mounting board, and a pull wire, a fork and a first restoring spring connected in turn. The fork is mounted turnably about a first rivet on the mounting board by the first rivet, and a bent hook is disposed on one end of the fork and interlocked with a driving arm of the drive mechanism. The safety trigger mechanism further includes a safety hook with a notch, which is mounted turnably about a second rivet on the mounting board by the second rivet. One side edge of the safety hook abuts against the bent hook of the fork, and the driving aim has an arresting pin disposed thereon. The initial position of the arresting pin is in the notch of the safety hook, and the arresting pin is detached from the notch of the safety hook when the safety hook turns clockwise. Since the arresting pin of the driving arm is hooked by the safety hook to ensure that the drive mechanism cannot be unfolded, the present invention has more safety. Even if a large external force acts on the driving arm, the drive mechanism won't unfold itself. | 04-26-2012 |
Paul L. Corredoura, Redwood City, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20090237274 | SYSTEM FOR DETERMINING POINTER POSITION, MOVEMENT, AND ANGLE - An a data input system includes an encoded pad having position encoding and a data input device adapted to image a portion of the encoded pad to determine position and orientation of the data input device relative to the encoded pad. The encoding pad includes a plurality of correlation windows. Each correlation window includes a primary encoding marker in form of vertical line segment and a set of secondary encoding markers in form of diagonal line segments, at least one diagonal line segment intersecting the vertical line segment at an intersection angle. Spacing of the diagonal line segments encodes the X-axis position of the input device relative to the encoding pad. Intersection angle encodes the Y-axis position of the input device relative to the encoding pad. Angle of the primary encoding marker vertical line segment within the frame of the captured image encodes the angular orientation of the input device relative to the axes of the encoded pad. | 09-24-2009 |
Paul L. Cutsinger, Redmond, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20110035702 | TARGET ELEMENT ZOOM - Various embodiments provide a target element zoom component that is configured to perform a focal point zoom operation on a target element using an appropriate zoom factor. In at least some embodiments, the target element zoom component receives a request to perform a zoom operation at a focal point of a target element in a page displayed in a display area. In at least some embodiments, the request is received via two-finger tap input on a screen of a touch enabled device. The target element zoom component then determines an appropriate zoom factor for the zoom operation. Responsive to determining the appropriate zoom factor, the target element zoom component performs the zoom operation on the page using the appropriate zoom factor so that the target element remains within the display area with the focal point retained. | 02-10-2011 |
| 20120066666 | ADD-ON PERFORMANCE ADVISOR - Various embodiments provide an add-on advisor that is designed to assist users in managing add-ons for a browser and/or other application programs. In at least some embodiments, the add-on advisor can be implemented to detect newly installed add-ons and provide notifications to a user of the detected add-ons. The notifications regarding new add-ons can be configured with options to permit the user to enable or disable the add-ons. Add-ons that are not explicitly enabled by a user can be prevented from operating by the add-on advisor. Further, in at least some embodiments, the add-on advisor can be implemented to monitor performance impact of add-ons and provide notifications to a user when add-ons adversely affect performance. The user can then interact with the add-on advisor to improve performance by selectively enabling and disabling add-ons. | 03-15-2012 |
Paul L. Cutsinger, Jr., Redmons, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20100235733 | DIRECT MANIPULATION OF CONTENT - Various embodiments provide techniques for direct manipulation of content. The direct manipulation of content can provide an intuitive way for a user to access and interact with content. In at least some embodiments, content manipulation is “direct” in that content displayed in a user interface (e.g., one or more Web pages in a Web browser interface) can be moved in and/or out of the user interface in a direction that corresponds to user-initiated physical movements, such as the user dragging or flicking the content with the user's finger or some other type of input device. | 09-16-2010 |
Paul L. Feintuch, San Dimas, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080211715 | GLOBAL POSITIONING SYSTEM USING BROADBAND NOISE REDUCTION - The present invention is directed to a global positioning system (GPS) having improved signal-to-noise ratio for reducing the required signal level for which GPS may be implemented in electronic devices or cell phones. The acquisition function of the GPS receiver is improved by inserting new signal processing for broadband noise reduction that allows subsequent improved estimation of critical time shift and frequency shift parameters needed for GPS acquisition at lower received signal levels. The decoding of the navigation bits from the satellite transmissions is improved to provide ephemeris data needed for computing navigation solutions at lower received signal levels, by examining the output of the same new signal processing for broadband noise reduction for spikes in the power of the output time series that correspond to navigation bit flips. | 09-04-2008 |
Paul L. Garvison, Frederick, MD US
| Patent application number | Description | Published |
|---|---|---|
| 20080245405 | Integrated Solar Cell Roofing System and Method of Manufacture - An integrated solar cell roofing system comprised of strips of solar cell groups. Each strip is comprised of a length of a substrate of a flexible, waterproof material. A first layer of bonding material is laid on the substrate onto which a group of pre-wired photovoltaic (PV) cells are positioned. A second layer of bonding material is applied and an individual rigid sheet of glass is laid on the second layer over each group of PV cells. Heat and vacuum is then applied to melt the bonding materials thereby bonding the group of PV cells and the glass sheet onto the substrate to form spaced solar cell groups thereon. The strip can then be folded into a fan-fold configuration for handling. | 10-09-2008 |
| 20090044854 | Framed Solar Module and Method of Installing - A framed solar module and a method for installing. The frame comprises contoured sides that can conform with the tiers of tiles on an inclined roof. The framed solar module can be installed with brackets which do not require roof-penetrating fasteners. Each front bracket has a clip portion and a face portion. The front brackets are manipulated between two adjacent overlapping tiers of tiles until the clip portion of each bracket engages the rear of a tile. A first module is then attached to the front bracket, e.g. the module is positioned so that the faces of the front brackets will lie inside the front edge of the frame. A fastener, such as a bolt or other threaded faster, is passed through an opening in the front of the frame and is threaded into an opening in the face of the front bracket to secure the module to the bracket. Additional modules to form an array are installed in the same manner by using additional, properly spaced sets of front brackets. A back bracket(s) is attached to the back of the uppermost module to aid in securing the array to the roof. | 02-19-2009 |
Paul L. Heirtzler, Northville, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20080258505 | VEHICLE DOOR GLASS BLOCKER AND BREAKER - A vehicle door glass blocker assembly including a blocking bracket securable to a vehicle door frame panel, and a blocking edge integrally formed with the blocking bracket, being substantially normal to a vertical edge of a vehicle window, and being capable of at least partially shattering the vehicle window when the window impacts the blocking edge during a vehicle crash event. A blocking protrusion may be coupled to the blocking bracket, be longitudinally disposable between the vehicle window and a vehicle door latch mechanism, and be capable of at least partially preventing transverse displacement of the vehicle window. A support bracket may be secured to the blocking bracket, and a glass run extrusion may be secured to the support bracket, be adapted to accept a vertical edge of the vehicle window, and be capable of reducing vibrations in the vehicle window. | 10-23-2008 |
| 20100242373 | RELIEF LIP FOR FLOCKED TAPE BELT SEAL - A belt seal structure for engaging a glass window of an automobile. Included is an inner belt seal and an outer belt seal, both the inner and outer belt seals engageably attached to at least one flange of an automobile door frame. Also included is a plurality of sealing lips connected to and extending away from the inner and outer belt seals, where a surface portion of the sealing lips contact the glass window. The contacting surface portion is covered with the low friction material. Further included is a relief lip of at least one of the sealing lips. The relief lip is located proximate a substantially curved contacting surface portion of the sealing lip, where the low friction material extends to cover a surface of the relief lip. | 09-30-2010 |
| 20120055094 | Frameless Multi-Layer Window Panel with Adhesive Bonded Edges - A multi-layer, laminated panel for a frameless window assembly has an adhesive bead extending along a frameless edge of the panel to contacting and structurally bond the two outer layers of the pane, thereby increasing the stiffness of the panel. The panel is used in a movable window assembly for an automotive vehicle in which a regulator is mounted to the vehicle adjacent a window opening, a seal is installed in the window opening, and the panel is moved by the regulator to a closed position wherein the frameless edge of the panel engages the seal. | 03-08-2012 |
Paul L. Hermonat, Little Rock, AR US
| Patent application number | Description | Published |
|---|---|---|
| 20080199434 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CARDIOVASCULAR CONDITIONS - The present invention provides methods and compositions for treating a cardiovascular condition. In particular, provided is a method comprising administering to a subject an agent that increases the level and/or activity of angiotensin II type 2 receptors. Also provided is a method for evaluating the risk of having or developing a cardiovascular condition | 08-21-2008 |
| 20080269159 | COMPOSITIONS AND METHODS FOR REGULATION OF SMOOTH MUSCLE CELLS AND BLOOD PRESSURE - The invention encompasses a composition for regulating smooth muscle cells. In particular, the invention encompasses a vector comprising a smooth muscle promoter operably-linked to a nucleic acid encoding a calcium-activated potassium channel. | 10-30-2008 |
| 20110213018 | COMPOSITIONS AND METHODS FOR REGULATION OF SMOOTH MUSCLE CELLS AND BLOOD PRESSURE - The invention encompasses a composition for regulating smooth muscle cells. In particular, the invention encompasses a vector comprising a smooth muscle promoter operably-linked to a nucleic acid encoding a calcium-activated potassium channel. | 09-01-2011 |
Paul L. Kebabian, Acton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100057390 | SYSTEM AND METHOD FOR PRECISION PHASE SHIFT MEASUREMENT - In one embodiment, a frequency generator produces an excitation signal, a local oscillator signal, and a reference signal at a difference frequency of the excitation signal and local oscillator signal. The excitation signal is applied to a physical system to produce a response signal, which is mixed with the local oscillator signal. A filter selects a difference frequency component. The frequencies of the excitation signal and/or local oscillator signal are varied, such that the magnitude of the difference frequency is constant, but a sign of the difference frequency changes from positive to negative. The phase shift of the difference frequency component, with respect to the reference signal, at each of the two signs of the difference frequency, is measured. The measured phase shift at the negative sign is subtracted from the measured phase shift at the positive sign, and the difference is divided in half, to produce a result. | 03-04-2010 |
Paul L. Kornblith, Pittsburgh, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20090042221 | PRECISE EFFICACY ASSAY METHODS FOR ACTIVE AGENTS INCLUDING CHEMOTHERAPEUTIC AGENTS - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best treatment or agent for the particular patient. Specific method innovations such as tissue sample preparation techniques render this method practically as well as theoretically useful. One particularly important tissue sample preparation technique is the initial preparation of cohesive multicellular particulates of the tissue sample, rather than enzymatically dissociated cell suspensions or preparations, for initial tissue culture monolayer preparation. With respect to the culturing of malignant cells, for example, it is believed (without any intention of being bound by the theory) that by maintaining the malignant cells within a multicellular particulate of the originating tissue, growth of the malignant cells themselves is facilitated versus the overgrowth of fibroblasts or other cells which tends to occur when suspended tumor cells are grown in culture. Practical monolayers of cells may thus be formed to enable meaningful screening of a plurality of treatments and/or agents. Growth of cells is monitored to ascertain the time to initiate the assay and to determine the growth rate of the cultured cells; sequence and timing of drug addition is also monitored and optimized. By subjecting uniform samples of cells to a wide variety of active agents (and concentrations thereof), the most promising agent and concentration for treatment of a particular patient can be determined. For assays concerning cancer treatment, a two-stage evaluation is contemplated in which both acute cytotoxic and longer term inhibitory effect of a given anti-cancer agent are investigated. | 02-12-2009 |
| 20090042225 | Method for selecting therapeutic agents for cancer treatment - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly important tissue sample preparation technique is the initial preparation of cohesive multicellular particulates of the tissue sample. For assays concerning cancer treatment, a two-stage evaluation is contemplated in which both acute cytotoxic and longer term inhibitory effect of a given anti-cancer agent are investigated. The tissue sample technique of the present invention is also useful in assaying expression and/or secretion of various markers, factors or antigens present on or produced by the cultured cells for diagnostic purposes and for using such expression to monitor the applicability of certain candidate therapeutic or chemotherapeutic agents and the progress of treatment with those agents. | 02-12-2009 |
| 20090286255 | METHODS FOR ASSESSING EFFICACY OF CHEMOTHERAPEUTIC AGENTS - Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide insight into the in vivo effectiveness of a therapeutic, and lead to more effective chemotherapeutic treatment. | 11-19-2009 |
| 20100120070 | PRECISE EFFICACY ASSAY METHODS FOR ACTIVE AGENTS INCLUDING CHEMOTHERAPEUTIC AGENTS - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying. One particularly important tissue sample preparation technique is the initial preparation of cohesive multicellular particulates of the tissue sample. For assays concerning cancer treatment, a two-stage evaluation is contemplated in which both acute cytotoxic and longer term inhibitory effect of a given anti-cancer agent are investigated. The tissue sample technique of the present invention is also useful in assaying expression and/or secretion of various markers, factors or antigens present on or produced by the cultured cells for diagnostic purposes and for using such expression to monitor the applicability of certain candidate therapeutic or chemotherapeutic agents and the progress of treatment with those agents. | 05-13-2010 |
| 20100330613 | METHODS FOR DETERMINING EFFICACY OF CHEMOTHERAPEUTIC AGENTS - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best treatment or agent for the particular patient. Specific method innovations such as tissue sample preparation techniques render this method practically as well as theoretically useful. By subjecting uniform samples of cells to a wide variety of active agents (and concentrations thereof), the most promising agent and concentration for treatment of a particular patient can be determined. | 12-30-2010 |
| 20110020826 | METHODS FOR ASSESSING EFFICACY OF CHEMOTHERAPEUTIC AGENTS - Methods are provided for accurately predicting efficacy of chemotherapeutic agents. Methods of the invention increase the positive predictive value of chemosensitivity assays by assessing both the ability of a chemotherapeutic to destroy cells and the genetic propensity of those cells for resistance. Results obtained using methods of the invention provide insight into the in vivo effectiveness of a therapeutic, and lead to more effective chemotherapeutic treatment. | 01-27-2011 |
| 20120088264 | METHODS FOR DETERMINING EFFICACY OF CHEMOTHERAPEUTIC AGENTS - An improved system for screening a multiple of candidate therapeutic or chemotherapeutic agents for efficacy as to a specific patient, in which a tissue sample from the patient is harvested, cultured and separately exposed to a plurality of treatments and/or therapeutic agents for the purpose of objectively identifying the best treatment or agent for the particular patient. Specific method innovations such as tissue sample preparation techniques render this method practically as well as theoretically useful. By subjecting uniform samples of cells to a wide variety of active agents (and concentrations thereof), the most promising agent and concentration for treatment of a particular patient can be determined. | 04-12-2012 |
Paul L. Modrich, Chapel Hill, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20110195849 | METHODS AND COMPOSITIONS FOR IDENTIFYING INHIBITORS OF MUTS-alpha OR MUTS-beta INTERACTION WITH MUTL-alpha - Disclosed are methods and kits for screening potential inhibitors of MutSβ by screening agents for the ability to selectively inhibit interaction between MutSβ and MutLα. Also disclosed are kits for performing the methods of the invention. | 08-11-2011 |
Paul L. Olson, Charlotte, NC US
| Patent application number | Description | Published |
|---|---|---|
| 20090177694 | CREDENTIAL MANAGEMENT - A method, system and program product for managing, distributing and authenticating custom credentials such as diplomas, licenses and certifications awarded to target individuals and organizations by academic institutions, governmental authorities and professional and trade organizations. The custom credentials are authentic but prejudicial information not needed by a recipient has been removed by the target party to whom the credential applies without destroying the integrity of the credential. The custom credential is efficiently provided to an interested party along with other application forms and data without the need for the interested party to request credentials from the issuing credential source authority. Accordingly the issuing credential source authority need not respond to random requests for credentials and an interested party need not negotiate the different formats provided by the various issuing credential source authorities. | 07-09-2009 |
Paul L. Pickard, Wilsonville CA
| Patent application number | Description | Published |
|---|---|---|
| 20100005793 | EXHAUST COMPONENT ASSEMBLIES WITH DIVIDER PLATES - A exhaust component assembly includes an exhaust component and a divider plate. The exhaust component includes an inner wall defining a gas passageway. The divider plate is inserted in the gas passageway and secured to the exhaust component by mechanical locking means, generally in an interference-fit relationship. | 01-14-2010 |
Paul L. Purdef, Concord Twp., OH US
| Patent application number | Description | Published |
|---|---|---|
| 20120088051 | Reconfigurable Multilayer Laminates and Methods - A multilayer laminate including a liner, a film, and an adhesive layer between the liner and film layers is described. The laminate includes a first release layer between the film layer and the adhesive layer, and a second release layer between the liner and the adhesive layer. The release characteristics of the two release layers are controlled to thereby enable the film layer, after receiving printed designs and/or text, to be removed from the remaining portion of the laminate, re-oriented, and then re-applied to the remaining portion of the laminate. Related methods associated with reconfiguring the laminate and application to articles or other receiving surfaces are also described. | 04-12-2012 |
Paul L. Raden, Pheonixville, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20100217691 | Transfer Instrument - A method performed by a transfer instrument issuer involves issuing, to a recipient, a certificate which is linked to a national card account obtained by the transfer instrument issuer from an account issuer different from the transfer instrument issuer, without both issuing and providing a physical card for the national card account to the recipient of the certificate, the certificate having been purchased by a purchaser, who is not also the recipient, and containing all information necessary for the purchase of goods or services from any merchant who is capable of processing economic transactions involving one of the plurality national card accounts for which a physical card has issued, but without presentment of the physical card. | 08-26-2010 |
Paul L. Raden, Phoenixville, PA US
| Patent application number | Description | Published |
|---|---|---|
| 20110206197 | Method and System of Enabling Electronic Communication Without Knowledge of Receiving Party's Electronic Contact Information - By providing identification information for a second party, a first party may access address profiles to send an electronic communication to the second party without knowing the electronic contact information for the second party. The address profiles are created by collecting electronic contact information from a plurality of public and private sources. A code may then be assigned to the information from each source for each party identified. Codes from respective sources may then be analyzed for similarities in order to identify codes that may correspond to the same party above a similarity threshold. When codes correspond above the similarity threshold for the same party, an address profile may be associated with the codes and may be associated with the same party. An internal identifier may then be assigned to the address profile to, for example, identify the address profile and/or the matched codes associated with the address profile so that the address profile may be accessed without knowledge of whose address profile is be accessed. | 08-25-2011 |
| 20120059761 | Transfer Instrument - A method performed by a transfer instrument issuer involves issuing, to a recipient, a certificate which is linked to a national card account obtained by the transfer instrument issuer from an account issuer different from the transfer instrument issuer, without both issuing and providing a physical card for the national card account to the recipient of the certificate, the certificate having been purchased by a purchaser, who is not also the recipient, and containing all information necessary for the purchase of goods or services from any merchant who is capable of processing economic transactions involving one of the plurality national card accounts for which a physical card has issued, but without presentment of the physical card. | 03-08-2012 |
Paul L. Rogers, Fort Collins, CO US
| Patent application number | Description | Published |
|---|---|---|
| 20100250842 | HYBRID REGION CAM FOR REGION PREFETCHER AND METHODS THEREOF - A first address is received and is used to determine a first address range. The first address range includes a second address range and a third address range. If the first address is in the second address range, a fourth address range is determined. The fourth address range is different from the first address range. Information is retrieved from a memory in response to determining that a second address is in the first address range or the fourth address range. If the first address is in the third address range, a fifth address range is determined. The fifth address range is different from the first address range. Other information is retrieved from the memory in response to determining the second address is in the first address range or the fifth address range. | 09-30-2010 |
| 20100262750 | REGION PREFETCHER AND METHODS THEREOF - A prefetch device and method are disclosed that determines from which addresses to speculatively fetch data based on information collected regarding previous cache-miss addresses. A historical record showing a propensity to experience cache-misses at a particular address-offset from a prior cache-miss address within a region of memory provides an indication that data needed by future instructions has an increased likelihood to be located at a similar offset from a current cache-miss address. The prefetch device disclosed herein maintains a record of the relationship between a cache-miss address and subsequent cache-miss addresses for the most recent sixty-four unique data manipulation instructions that resulted in a cache-miss. The record includes a weighted confidence value indicative of how many cache-misses previously occurred at each of a selection of offsets from a particular cache-miss address. | 10-14-2010 |
Paul L. Runnels, Floyd, IA US
| Patent application number | Description | Published |
|---|---|---|
| 20110256178 | BORRELLIA BURGDORFERI BACTERIN - A bacterin including effective immunizing amounts of two non-crossprotective isolates of inactivated | 10-20-2011 |
Paul L. Salvas, Norton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20100016869 | Surgical Devices - The present disclosure relates to a surgical device including a shaft having an outer member and an inner member slidably received within the outer member, a handle coupled to the shaft, and a means for providing movement to the inner member coupled to the inner member. A method of tissue repair is also disclosed. | 01-21-2010 |
Paul L. St. Cyr, Shelton, CT US
| Patent application number | Description | Published |
|---|---|---|
| 20110122396 | PHOTONIC MEASUREMENT INSTRUMENT USING FIBER OPTICS - A photonic measurement system, such as an atomic absorption spectrometer, includes source, sample and detection modules that are interconnected by fiber optic cables. A first set of fiber optic cables guides light from one or more light sources in the source module to each of at least two analysis chambers in the sample module. A second set of fiber optic cables guides light from the analysis chambers to a detector in the detection module. The detector provides to a processing sub-system signals that correspond to intensities of the guided light. One analysis chamber is selected to perform a sample analysis at a given time, and the processing sub-system processes the signals associated with the selected analysis chamber as measurement signals. The processing sub-system may further process the signals associated with a given non-selected analysis chamber as reference signals. | 05-26-2011 |
Paul L. Thee, Haymarket, VA US
| Patent application number | Description | Published |
|---|---|---|
| 20100208267 | System and method for detecting a target substance - A system and a method for detecting the existence of a target substance, the system includes a laser with a broad spectral output and a detector for detecting an absorption spectrum of a laser beam from the laser. The method includes emitting a laser beam into the atmosphere using a laser light with a broad spectral output; measuring the absorption spectrum of said laser beam; comparing the absorption spectrum to known absorption spectrums for target substances using a detector; and detecting the existence of a target substance. | 08-19-2010 |
Paul L. Valint, Pittsford, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20090098176 | MEDICAL DEVICES WITH TRIGGERABLE BIOADHESIVE MATERIAL - Described herein are implantable medical devices comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. The triggerable bioadhesive property of the polymer can be triggered or activated by exposure to a stimulus. Also, the present invention pertains to methods of making an implantable medical device comprising a biocompatible polymer comprising a triggerable bioadhesive property that allows the device to adhere to body tissue. | 04-16-2009 |
Paul L. Valint, Jr., Pittsford, NY US
| Patent application number | Description | Published |
|---|---|---|
| 20100162661 | Packaging Solutions - Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. A packaging system includes an ophthalmic device stored in an aqueous packaging solution comprising a brush copolymer comprising (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer. | 07-01-2010 |
| 20100162663 | Packaging Solutions - Packaging systems for storing ophthalmic devices such as contact lenses and to methods for packaging such ophthalmic devices with solutions to improve the comfort of the lenses during wear are disclosed. | 07-01-2010 |
| 20100168356 | Biomedical Devices - Biomedical devices are provided herein which are formed from a polymerization product of a monomeric mixture comprising (a) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (b) a biomedical device-forming comonomer. | 07-01-2010 |
| 20100168850 | Brush CoPolymers - Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated-containing monomer containing one or more boronic acid moieties; and (b) monomeric units derived from an ethylenically unsaturated-containing macromonomer having hydrophilic units and boronic acid units are disclosed. | 07-01-2010 |
| 20100168851 | Surface Modified Biomedical Devices - Disclosed are surface modified biomedical devices having a coating on a surface thereof, the coating comprising an inner layer comprising a polymer comprising monomeric units derived from an ethylenically unsaturated monomer containing a boronic acid moiety, and an outer layer comprising a hydrophilic hydrolyzed reactive polymer comprising monomeric units derived from an ethylenically unsaturated containing monomer having hydrolyzable reactive functionalities. | 07-01-2010 |
| 20100168852 | Brush Copolymers - Brush copolymers containing (a) monomeric units derived from an ethylenically unsaturated monomer containing one or more boronic acid moieties and; and (b) monomeric units derived from an ethylenically unsaturated-containing hydrophilic macromonomer are disclosed. | 07-01-2010 |
| 20100168855 | Method of Applying Renewable Polymeric Lens Coating - Disclosed are biomedical devices having a hydrophilic coating on a portion of a surface thereof, the biomedical device comprising: (a) a biomedical device obtained from a polymerization product of a monomeric mixture comprising (i) a polymerizable monomer containing a boronic acid moiety and an electron withdrawing moiety; and (ii) a biomedical device-forming comonomer; and (b) a hydrophilic reactive polymer having complementary reactive functionalities along the polymer chain, wherein the complementary reactive functionalities along the polymer chain of the hydrophilic reactive polymer of (b) bind with the boronic acid moieties of the biomedical device of (a), thereby producing a biocompatible coating which can be removed and re-applied to restore the surface properties of the biomedical device to substantially as-new condition. Methods for treating the biomedical device are also disclosed. | 07-01-2010 |
Paul L. Washicko, Carlsbad, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110166742 | Method and system for connecting a telematics device to a vehicle using wireless transceivers configured to transmit and receive diagnostic data - An embodiment provides a system for connecting a telematics device to a host vehicle. The system may comprise a short-range wireless transmitter and a short-range wireless receiver. The short-range wireless transmitter may be connected to an in-vehicle diagnostic system. The short-range wireless receiver may be connected to the telematics device installed in the host vehicle. The short-range wireless transmitter may be configured to wirelessly transmit diagnostic data to the short-range wireless receiver. | 07-07-2011 |
Paul L. Weiden Md, Seattle, WA US
| Patent application number | Description | Published |
|---|---|---|
| 20120122825 | USE OF PICOPLATIN TO TREAT PROSTATE CANCER - The invention provides a method of treatment of metastatic hormone-refractory prostate cancer involving substantially as concurrent administration of picoplatin and docetaxel. Prednisone may also be administered. Dosages and dosing regimens are provided. | 05-17-2012 |
Paul L. Wetters, Rockford, MI US
| Patent application number | Description | Published |
|---|---|---|
| 20110114444 | CONVEYOR SYSTEM AND METHOD OF LATERALLY DISPLACING ARTICLES - A conveyor system and method of laterally displacing articles includes a conveyor defining a conveying surface and conveying articles in a longitudinal direction with the conveying surface. A diverting assembly is positioned diagonally at least partially across the conveying surface. The diverting assembly travels generally vertically between a non-actuated position below the conveying surface and an actuated position extending above the conveying surface. The diverting assembly has a diverting surface that is adapted to laterally displace articles on the conveying surface when in the actuated position. | 05-19-2011 |