| Patent application number | Description | Published |
|---|
| 20110033850 | COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION - Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule. | 02-10-2011 |
| 20110098215 | PEPTIDES AND METHODS OF USE AS THERAPEUTICS AND SCREENING AGENTS - Host RNA/viral protein interaction as a target of intervention in the replication of viruses, e.g., the human immunodeficiency virus (HIV) are described. The target being upstream of the final replication product, and being crucial to the viral replication, is less likely to be genetically altered to drug resistance. Peptides that intervene in this RNA/viral protein interaction are also described, as well as compositions containing the same and methods of use thereof. | 04-28-2011 |
| 20110190154 | METHODS AND COMPOSITIONS FOR DETERMINING THE PURITY OF CHEMICALLY SYNTHESIZED NUCLEIC ACIDS - This application describes an antibody that specifically binds to a synthetic oligomer (e.g., an oligonucleotide or oligopeptide) having a organic protecting group covalently bound thereto, which antibody does not bind to that synthetic oligomer when the organic protecting group is not covalently bound thereto. Methods of making and using such antibodies are also disclosed, along with cells for making such antibodies and articles carrying immobilized oligomers that can be used in assay procedures with such antibodies. | 08-04-2011 |
| Patent application number | Description | Published |
|---|
| 20110160650 | RETENTION SYSTEMS AND METHODS - A system for retaining a fluid delivery device, the fluid delivery device may include a reservoir and a plunger arm operatively connected to a plunger head arranged for movement within the reservoir, the plunger arm having an arm portion operatively engageable with a drive member configured to move the plunger arm and the plunger head when the plunger arm and the plunger head are connected to the drive member. The system may include a rigid member arranged for movement and a bias member configured to urge the rigid member toward the plunger arm to force the plunger arm against the drive member to operatively engage the plunger arm to the drive member. | 06-30-2011 |
| 20110160654 | ALIGNMENT SYSTEMS AND METHODS - A delivery system for delivering fluidic media may include a second housing configured to be selectively operatively engaged with and disengaged from a first housing portion adapted to be carried by a user. One of the housing portions may support a reservoir for containing fluidic media and a plunger head moveable within the reservoir. A drive device may be supported by the other of the housing portions for coupling with the reservoir upon the housing portions being operatively engaged. A first interactive element may be supported on the first housing portion for interacting with a second interactive element supported on the second housing portion. Circuitry may be configured to detect an interaction between the interactive elements and configured to provide a signal or a change in state in response to the housing portions being operatively engaged and an interaction between the interactive elements being detected. | 06-30-2011 |
| 20110160655 | CONNECTION AND ALIGNMENT SYSTEMS AND METHODS - A delivery system for delivering fluidic media to a user having a second housing portion configured to be selectively operatively engaged with and disengaged from a first housing portion, the first housing portion and the second housing portion configured to be slidable relative to each other to operatively engage each other; and a fluid connector supported by one the housing portions in a position to engage a reservoir supported by an other of the housing portions in a case where the first housing portion and the second housing portion are slid relative to each other to operatively engage each other. | 06-30-2011 |
| 20110160666 | ENGAGEMENT AND SENSING SYSTEMS AND METHODS - A delivery device for delivering fluidic media may include a second housing portion configured to be selectively engaged with and disengaged from a first housing portion adapted to be carried by a user, a drive device configured to be operatively engageable with a plunger arm connected to a plunger head arranged for movement in an axial direction of a reservoir supported by one of the first and second housing portion to drive fluidic media from the reservoir, a drive linkage for operatively engaging the drive device with the plunger arm for allowing the drive device to move the plunger arm, the drive device including a first gear engageable with the plunger arm and a second gear configured for lateral movement to allow the second gear to engage the plunger arm. | 06-30-2011 |
| 20110213306 | CONNECTION AND ALIGNMENT SYSTEMS AND METHODS - A delivery system for delivering fluidic media to a user having a second housing portion configured to be selectively operatively engaged with and disengaged from a first housing portion, the first housing portion and the second housing portion configured to be slidable relative to each other to operatively engage each other; and a fluid connector supported by one the housing portions in a position to engage a reservoir supported by an other of the housing portions in a case where the first housing portion and the second housing portion are slid relative to each other to operatively engage each other. | 09-01-2011 |
| 20110233393 | MOTOR ASSEMBLY SENSOR CAPTURE SYSTEMS AND METHODS - A motor may be configured to drive a drive shaft and an engagement member supported on the drive shaft. A detectable feature comprising a rotary member may be supported on the drive shaft such that movement of the drive shaft by the motor changes a state of the detectable feature. At least one sensor may be arranged to detect the state of the detectable feature. Circuitry may be configured to provide a signal in response to a change in the state of the detectable feature detected by the at least one sensor. | 09-29-2011 |
| 20110237916 | AMBIENT TEMPERATURE SENSOR SYSTEMS AND METHODS - A first sensor may be configured to measure a sensed amount of a physiological parameter and to generate a first signal based on the sensed amount of the physiological parameter measured by the first sensor. A second sensor may be configured to measure a temperature and to generate a second signal based on the temperate measured by the second sensor. A housing may have heat-generating electronics including a processor that may be configured to determine an overall amount of the physiological parameter based on the first signal generated from the first sensor and the second signal generated from the second sensor. The second sensor may be thermally insulated from the heat-generating electronics. | 09-29-2011 |
| 20120004602 | CONNECTION AND ALIGNMENT DETECTION SYSTEMS AND METHODS - A medical device includes a first housing portion (FHP) and a second housing portion (SHP) configured to be to be movable relative to each other from a first position to operatively engage at a second position to couple at least one of a drive device and a needle-inserting device supported by one of the FHP and the SHP to a reservoir supported by the other of the FHP and the SHP. Electronic circuitry configured to detect at least one of a first magnetic interaction between a magnet and at least one of a first magnetically attractive material and a first magnet-responsive device and a second magnetic interaction between the magnet and at least one of a second magnetically attractive material and a second magnet-responsive device, and to provide a signal or a change in state in response to detecting at least one of the interactions. | 01-05-2012 |
| Patent application number | Description | Published |
|---|
| 20090036870 | INFUSION MEDIUM DELIVERY DEVICE AND METHOD WITH DRIVE DEVICE FOR DRIVING PLUNGER IN RESERVOIR - A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions. | 02-05-2009 |
| 20090171291 | SYSTEMS AND METHODS ALLOWING FOR RESERVOIR FILLING AND INFUSION MEDIUM DELIVERY - A system includes a durable portion with a durable housing and a separable disposable portion with a disposable housing that selectively engage with and disengage from each other. The disposable housing secures to a patient and may be disposed of after it has been in use for a prescribed period. Components that normally come into contact with a patient or with an infusion medium may be part of the disposable portion to allow for disposal after a prescribed use. A reservoir for holding the infusion medium may be part of the disposable portion, and may be supported by the disposable housing. The durable portion may include other components such as electronics for controlling delivery of the infusion medium from the reservoir, and a drive device including a motor and drive linkage. | 07-02-2009 |
| 20090270811 | INFUSION MEDIUM DELIVERY DEVICE AND METHOD WITH DRIVE DEVICE FOR DRIVING PLUNGER IN RESERVOIR - A delivery device includes first and second housing portions that selectively engage and disengage. A reservoir on one housing portion operatively engages a drive device and/or a needle inserting device on the other housing portion. Upon proper engagement of the housing portions, the reservoir operatively couples to the drive device and/or the needle inserting device. A first magnet on the first housing portion and a second magnet (or a magnetically-attractive material) on the second housing portion are positioned to magnetically interact with each other, upon operative engagement of the housing portions. A third magnet on the second housing portion may be opposed to the first magnet to help align the housing portions for connection. A magnet-responsive device may be on one or both housing portions to detect alignment and/or connection of the housing portions. | 10-29-2009 |
| 20100331824 | INFUSION MEDIUM DELIVERY SYSTEM, DEVICE AND METHOD WITH NEEDLE INSERTER AND NEEDLE INSERTER DEVICE AND METHOD - An infusion medium delivery system, device and method for delivering an infusion medium to a patient-user, includes a needle inserter device and method for inserting a needle and/or cannula into a patient-user to convey the infusion medium to the patient-user. The needle inserter device and method operate to insert a needle and cannula into a patient-user's skin and automatically withdraw the needle from the patient-user, leaving the cannula in place and in fluid flow communication with a reservoir. The delivery device may include a base portion and a durable portion connectable to the base portion, and wherein the base portion can be separated from the durable portion and disposed of after one or more specified number of uses. The base portion supports the reservoir and the needle inserter device, while the durable portion supports a drive device for selectively driving the infusion medium out of the reservoir and into the needle and/or cannula. | 12-30-2010 |
| Patent application number | Description | Published |
|---|
| 20090051443 | Oscillator Stabilized for Temperature and Power Supply Variations - A circuit may comprise an amplifier powered by a first supply voltage, with a first input of the amplifier coupled to a stable reference voltage, and the output voltage of the amplifier provided as a designated supply voltage to an oscillator configured to produce a periodic signal having a specified frequency. The circuit may further include a control circuit coupled to a second input of the amplifier, to the output of the amplifier, and to ground, and configured to control the rate of change of the output voltage of the amplifier with respect to temperature. This rate of change may be specified according to a characterization of the oscillator over supply voltage and temperature, and may result in stabilizing the specified frequency across temperature. The periodic signal may therefore be unaffected by variations in the first supply voltage, and the amplitude of the periodic signal may be proportional to the stable reference voltage. | 02-26-2009 |
| 20090212842 | Level Shifter with Memory Interfacing Two Supply Domains - A level-shifter circuit configured to transfer data between two voltage supply domains may eliminate crowbar current while simultaneously providing a valid output signal. The level-shifter circuit may transfer a data signal between the two voltage domains using a latch that is capable of maintaining its output level—based on the destination supply rail—to correspond to the same state to which the level of the input signal—based on the originating supply rail—corresponds, even when the originating supply is decreased to a zero-volt state, or to a voltage equivalent to a low state. During normal operation, when both power supplies are available, the signal at the output of the latch, and hence at the output of the level-shifter circuit may toggle to always track the input signal. Thus, the level of the signal at the output of the level-shifter may always represent the same state (e.g. binary value) as the level of the input signal, during normal operation and also when the originating power supply is powered down. | 08-27-2009 |
| 20100176875 | Method for Improving Power-Supply Rejection - An electronic circuit may comprise an input stage powered by a supply voltage and configured to receive a reference signal. The circuit may further comprise an output stage powered by the supply voltage and coupled to the input stage, and configured to generate an error signal based on: the reference signal, and a feedback signal based on an output signal. The circuit may also include a pass transistor powered by the supply voltage and configured to generate the output signal based on the error signal. A capacitor coupled between the supply voltage and the output stage may increase the current flowing in the output stage, resulting in the output stage conducting current even during a rising edge of the supply voltage, preventing the output signal from reaching the level of the supply voltage during the rising edge of the supply voltage. | 07-15-2010 |
| 20100201406 | Temperature and Supply Independent CMOS Current Source - An improved current source may provide an improvement over a typical ΔV | 08-12-2010 |
| 20100201410 | Power-up Control for Very Low-Power Systems - A power-on-reset (POR) circuit may comprise a first circuit powered by a first supply voltage and configured to generate a second supply voltage based on the first supply voltage, the second supply voltage having a nominal value lower than a nominal value of the first supply voltage. The POR circuit may also include a second circuit powered by the second supply voltage and configured to generate a POR signal. The second circuit may be configured to assert the POR signal when the second supply voltage reaches a value that is sufficiently high for the second circuit to become operational, keep the POR signal asserted until the first supply voltage reaches a second value that is higher than the nominal value of the second supply voltage by a specified difference voltage value, and deassert the POR signal once the first supply voltage reaches the second value. | 08-12-2010 |
| 20110291707 | Driver with Accurately Controlled Slew Rate and Limited Current - A driver circuit, that provides slew rate control of its output voltage, including a current generator, an output transistor, and optionally, a capacitor. The current generator has an input port, an output port and reference port. The output port couples to the gate of the output transistor. The capacitor couples between the gate and drain of the output transistor. The current generator controls a current I | 12-01-2011 |
| Patent application number | Description | Published |
|---|
| 20110160717 | ENERGY DELIVERY SYSTEMS AND USES THEREOF - The present invention relates to comprehensive systems, devices and methods for delivering energy to tissue for a wide variety of applications, including medical procedures (e.g., tissue ablation, resection, cautery, vascular thrombosis, treatment of cardiac arrhythmias and dysrhythmias, electrosurgery, tissue harvest, etc.). In certain embodiments, systems, devices, and methods are provided for treating a tissue region (e.g., a tumor) through application of energy. | 06-30-2011 |
| 20110238060 | MICROWAVE SURGICAL DEVICE - A medical instrument or device used to decrease blood loss during surgery and/or other medical procedures. The device includes a microwave antenna housed in a handset (or laparoscopic probe) that is placed in close proximity to the tissue of interest. The device runs in the microwave spectrum and receives power from a from a microwave generator. When turned on (triggered), the device delivers microwave energy to tissue, providing a cutting or cautery effect. | 09-29-2011 |
| 20110238061 | MICROWAVE DEVICE FOR VASCULAR ABLATION - A method and system delivers microwave energy to a vessel, such as a vein for the treatment of varicose veins, in a controllable heating pattern and to provide relatively fast heating and ablation of the vessel. The method and system comprises a microwave delivery device for heating the vessel, and a microwave power source for supplying microwave power to the delivery device. The method and system may also include a cooling system, a temperature monitoring, feedback and control system, an ultrasound or other imaging device, and/or a device for assuring generally uniform energy delivery in the vessel. | 09-29-2011 |
| Patent application number | Description | Published |
|---|
| 20100121738 | METHOD FOR PROVIDING PROTEIN MICROARRAYS - The present application relates to methods for providing a protein microarray product and related products and services to a customer, methods, kits, and systems for labeling a probe for a protein microarray, and methods for determining protein concentrations using a protein microarray. The methods for providing a protein microarray can include, in certain aspects, a computer function for performing some of the steps of the methods. Methods and kits for labeling a probe can include a control array that includes a molecule that binds to a label of a probe. | 05-13-2010 |
| 20110034350 | Protein Arrays and Methods of Use Thereof - The present invention provides human protein arrays that include at least 1000 human proteins. In another embodiment, the present invention provides a method for identifying a substrate of an enzyme, comprising contacting the enzyme with a positionally addressable array comprising at least 100 proteins immobilized on functionalized glass surface, and identifying a protein on the positionally addressable array that is bound and/or modified by the enzyme, wherein a binding or modifying of the protein by the enzyme indicates that the protein is a substrate for the enzyme. In additional embodiments, provided herein are methods for making an array of at least 1000 human proteins under non-denaturing conditions, including human proteins that are difficult to express and/or difficult to isolate in a non-denatured state. | 02-10-2011 |
| Patent application number | Description | Published |
|---|
| 20090176417 | Method and apparatus for providing power to a marine vessel - A system and a method for providing power to a marine vessel and, more particularly to a tugboat is disclosed. The system includes diesel engines and generators and batteries which can be charged using power supplied by the generators, shore power or regenerated power. The tugboat is operated utilizing battery power only and the generators are used to provide additional power if needed or to recharge the batteries. | 07-09-2009 |
| 20120071043 | METHOD FOR OPERATING A VESSEL - A method for operating a vessel is provided. The method can include determining the most efficient power source from a plurality of power sources for operating the vessel. The power sources can include a battery bank and an AC power source. The method can also include drawing power from the most efficient power source to operate the vessel; harvesting energy from electrical rotating sources; monitoring the battery bank; and charging the battery bank when a state of charge of the battery bank drops below a predetermined state of charge, wherein the charging is performed using the harvested energy, the AC power source, an external power source, or a combination thereof. | 03-22-2012 |
| 20120071044 | SYSTEM FOR OPERATING A VESSEL - One or more embodiments of a system for operating a vessel is provided herein. An illustrative system can include a plurality of power sources for operating the vessel. The power sources can include a battery bank and an AC power source. The system can also include an auxiliary device disposed on the vessel, wherein the auxiliary device comprises an electrical rotating source. Energy can be harvested from the electrical rotating source and transferred to the DC power source, a load of the vessel, or both. The illustrative system can also include a power management system that can include a processor; a data storage in communication with the processor; and a plurality of computer instructions stored on the data storage. | 03-22-2012 |
| Patent application number | Description | Published |
|---|
| 20090255109 | BATTERIES AND COMPONENTS THEREOF AND METHODS OF MAKING AND ASSEMBLING THE SAME - Exemplary embodiment include method of sealing battery cooling plates, and methods of assembling battery using battery cooling plate racks and a single component including multiple cooling plates an connection portions therebetween. | 10-15-2009 |
| 20090258288 | BATTERIES AND COMPONENTS THEREOF AND METHODS OF MAKING AND ASSEMBLING THE SAME - An exemplary embodiment includes a method of sealing battery cooling plates. | 10-15-2009 |
| 20090258289 | BATTERY COOLING PLATE DESIGN WITH DISCRETE CHANNELS - One exemplary embodiment including a battery cooling plate has discrete channels. In one exemplary embodiment each of the channels has a width ranging from about 1 mm to about 5 mm. In another exemplary embodiment the battery cooling plate includes a first cooling channel having a flow path generally in a U shape, and a plurality of other channels each having a generally U-shaped flow path, and wherein the other flow channels are in a nested position with respect to the first flow channel. In another exemplary embodiment the battery cooling plate a battery cooling plate includes a serpentine shaped cooling flow path formed therein, the cooling flow path including a first cooling segment and an adjacent upstream second cooling segment, wherein the second cooling segment includes at least a first cooling channel and a second cooling channel and at least a first land interposed between the first cooling channel and second cooling channel, and wherein the second cooling segment has at least one more land and one more channel than the first cooling segment. | 10-15-2009 |
| 20090280359 | SIDE SPRING COMPRESSION RETENTION SYSTEM - A compression retention system for a fuel cell system is provided. The compression retention system includes a first end unit and a second end unit configured to hold a fuel cell stack therebetween. A spring configured to apply a compressive force to the fuel cell stack is disposed between a first spring plate and a second spring plate. The first spring plate has an aperture formed therein. The compression retention system further includes a pair of sheets coupled to the first spring plate and the first end unit, and a spring strut disposed through the aperture of the first spring plate and coupled to the second spring plate and to the second end unit. A fuel cell system and method for assembling the fuel cell system with the compression retention system are also provided. | 11-12-2009 |
| 20110101074 | QUICK CHANGE OVER TOOLING FOR A WELDER - A weld stack includes a horn having a weld end, a polar mount adapted to receive a portion of the horn therein, a first adjustment ring coupled to the polar mount at a pre-determined distance from the weld end of the horn, and a second adjustment ring coupled to the polar mount adjacent the first adjustment ring, wherein the second adjustment ring includes a fine adjustment device for adjusting a relative position of the first adjustment ring and the second adjustment ring. | 05-05-2011 |
| 20110108181 | METHOD AND SYSTEM FOR ONLINE QUALITY MONITORING AND CONTROL OF A VIBRATION WELDING PROCESS - A method for monitoring and controlling a vibration welding system includes collecting sensory data during formation of a welded joint using sensors positioned with respect to welding interfaces of a work piece. A host machine extracts a feature set from a welding signature collectively defined by the sensory data, compares and correlates the feature set with validated information in a library, and executes a control action(s) when the present feature set insufficiently matches the information. A welding system includes a sonotrode, sensors, and the host machine. The host machine is configured to execute the method noted above. | 05-12-2011 |
| 20110168331 | QUICK CHANGE OVER TOOLING FOR A WELDER - A weld stack includes a horn having a weld end, a polar mount adapted to receive a portion of the horn therein, a first adjustment ring coupled to the polar mount at a pre-determined distance from the weld end of the horn, and a second adjustment ring coupled to the polar mount adjacent the first adjustment ring, wherein the second adjustment ring includes a fine adjustment device for adjusting a relative position of the first adjustment ring and the second adjustment ring. | 07-14-2011 |
| 20110186204 | HEATING APPARATUS AND METHOD OF USE OF THE SAME IN A VIBRATION WELDING PROCESS - A method for heating a work piece or a welding interface using a vibration welding system includes positioning the work piece adjacent to a welding tool to define the welding interface and then heating the work piece or the welding interface to within a calibrated threshold temperature using a thermal device, e.g., a heat rod, laser device, or blower. A high-frequency vibration may be applied to form a weld. The work piece may include an adjacent interconnecting member and battery tab. The thermal device may be embedded within the welding tool and controlled via a temperature controller. A vibration welding system includes a welding tool, a thermal device, and a controller. The controller controls the thermal device to thereby control the welding temperature at or along the welding interface. The thermal device may be embedded within the welding tool, which may be configured as an anvil body in one embodiment. | 08-04-2011 |
| 20110186616 | THERMALLY-INSULATED VIBRATION WELDING TOOL - A welding assembly for forming a weld along a welding interface of a work piece(s) using vibrations includes a welding tool and a thermal barrier. The thermal barrier is at least a chemical and/or mechanical insulating layer positioned adjacent to the welding tool, which minimizes the rate of dissipation of heat generated by the vibrations at or along the welding interface. The welding assembly may also include a wear-resistant layer adjacent to the thermal barrier, which protects the thermal barrier from damage or wear. The welding tool is a portion an anvil assembly and/or a sonotrode assembly. A method of insulating a welding tool includes applying or connecting a thermal barrier to a surface of the welding tool, and minimizing the rate of dissipation of heat generated by the vibrations at or along the welding interface using the thermal barrier, which includes an insulating layer. | 08-04-2011 |
| 20110248069 | ULTRASONIC WELD PAD FOR WELDING BATTERY CELL TABS - A weld pad for an ultrasonic welding horn for welding a battery cell tab is described. The weld pad includes a plurality of inner knurls having at least one sharp edge; and a plurality of outer knurls surrounding the plurality of inner knurls, the outer knurls being shorter than the inner knurls and having a rounded outer edge. A method of welding battery cell tabs using the weld pad is also described. | 10-13-2011 |
| 20120006810 | INDUCTION HEATING-ASSISTED VIBRATION WELDING METHOD AND APPARATUS - A method for heating a work piece or a welding interface using a vibration welding system includes positioning the work piece adjacent to a welding tool such that the welding interface is also adjacent to the welding tool, and then using an induction heating device to generate an eddy current in one of the welding tool and the work piece to thereby heat the welding interface to a calibrated threshold temperature or temperature range. A high-frequency vibration thereafter may be applied using a sonotrode of the vibration welding system to form a weld. The method may include adjusting the position and orientation of the induction heating device relative to the work piece to change the location of the eddy current. A vibration welding system includes a welding tool, the induction heating device, and a control module which controls the induction heating device to thereby control the welding temperature. | 01-12-2012 |
