Inventors list

Assignees list

Classification tree browser

Top 100 Inventors

Top 100 Assignees


Paul C.

Paul C. Appler, Windsor CA

Patent application numberDescriptionPublished
20090183516INSPECTION PORT - A manifold gauge set has at least one sight glass window for viewing contents of a refrigeration system or an air conditioning system being serviced. The window may be non-planar to achieve an appearance that varies with the presence or absence of liquid. Such a non-planar window may be in the form of a dome, prism or a fresnel lens. The gauge set may have a second light transmissive window to allow light to illuminate system contents being viewed. A light source may be provided to illuminate system contents being viewed. The light source may provide light through the same window that is used for viewing contents. A diffuser may be provided with a second window to achieve an illuminated background for viewing system contents. Similar configurations may be used in standalone sight glasses, vacuum pumps, and recovery machines.07-23-2009

Paul C. Badavas, Southboro, MA US

Patent application numberDescriptionPublished
20100011127METHODS AND APPARATUS FOR CONTROL USING CONTROL DEVICES THAT PROVIDE A VIRTUAL MACHINE ENVIRONMENT AND THAT COMMUNICATE VIA AN IP NETWORK - The invention provides improved methods and apparatus for control using field and control devices that provide a virtual machine environment and that communicate via an IP network. By way of non-limiting example, such field device can be an “intelligent” transmitter or actuator that includes a low power processor, along with a random access memory, a read-only memory, FlashRAM, and a sensor interface. The processor can execute a real-time operating system, as well as a Java virtual machine (JVM). Java byte code executes in the JVM to configure the field device to perform typical process control functions, e.g., for proportional integral derivative (PID) control and signal conditioning. Control networks can include a plurality of such field and control devices interconnected by an IP network, such as an Ethernet.01-14-2010
20100076604METHOD AND APPARATUS FOR CONTROL USING CONTROL DEVICES THAT PROVIDE A VIRTUAL MACHINE ENVIRONMENT AND THAT COMMUNICATE VIA AN IP NETWORK - The invention provides improved methods and apparatus for control using field and control devices that provide a virtual machine environment and that communicate via an IP network. By way of non-limiting example, such field device can be an “intelligent” transmitter or actuator that includes a low power processor, along with a random access memory, a read-only memory, FlashRAM, and a sensor interface. The processor can execute a real-time operating system, as well as a Java virtual machine (JVM). Java byte code executes in the JVM to configure the field device to perform typical process control functions, e.g., for proportional integral derivative (PID) control and signal conditioning. Control networks can include a plurality of such field and control devices interconnected by an IP network, such as an Ethernet.03-25-2010

Patent applications by Paul C. Badavas, Southboro, MA US

Paul C. Begovac, Flagstaff, AZ US

Patent application numberDescriptionPublished
20080281393Bioabsorbable Self-Expanding Endolumenal Devices - The present invention is directed to bioabsorbable self-expanding medical devices for use inside or outside body conduits that self-expand at, or below, normal human body temperature without requisite for a polymeric thermal transition.11-13-2008

Paul C. Belvedere, Edina, MN US

Patent application numberDescriptionPublished
20090308403ORAL APPLIANCES WITH MAJOR CONNECTORS AND METHODS FOR MANUFACTURE - Oral appliances adapted to for spacing the occlusal surfaces of the teeth of a user are disclosed. The oral appliances have a major connector interconnecting a first bite pad and a second bite pad. The first bite pad can include a first spacer and the second bite pad can include a second spacer that are configured to maintain the spacing of the occlusal surfaces of opposing teeth of a user during clenching or upon an impact to the jaw. Methods for the manufacture of composite oral appliances are also disclosed. The methods include forming a composite oral appliance over a model of a user's mouth.12-17-2009
20100252053METHODS AND APPARATUS FOR REDUCTION OF LACTATE - Oral apparatus and methods to inhibit the increase of lactate levels during physical and/or mental exertion are disclosed. The oral apparatus include at least a first bite pad and a second bite pad. The first bite pad and the second bite pad are each configured to be positioned between at least two of the molars of a user. The bite pads are generally configured to direct the posterior of the lower mandible downward and/or forward in response to a clenching force exerted by a user. When worn during physical and/or mental exertion, the oral apparatus can reduce the accumulation of lactate normally generated by the physical and/or mental exertion without the oral apparatus.10-07-2010
20100269836COMPOSITE ORAL APPLIANCES AND METHODS FOR MANUFACTURE - Oral appliances adapted to for spacing the occlusal surfaces of the teeth of a user are disclosed. The oral appliances have an integral retention band interconnecting a first bite pad and a second bite pad. The first bite pad can include a first spacer and the second bite pad can include a second spacer that are configured to maintain the spacing of the occlusal surfaces of opposing teeth of a user during clenching or upon an impact to the jaw. Methods for the manufacture of composite oral appliances are also disclosed. The methods include forming a composite oral appliance over a model of a user's mouth.10-28-2010

Paul C. Boulware, Columbus, OH US

Patent application numberDescriptionPublished
20110006047METHOD AND SYSTEM FOR MONITORING AND CHARACTERIZING THE CREATION OF A MANUAL WELD - A method and system for monitoring and characterizing the creation of a manual weld is disclosed. The system generally includes a welding gun having a target, an imaging system, a processor, and a display. During the creation of a manual weld, the imaging system captures a plurality of images of the target. The processor analyzes the plurality of images of the target to calculate a plurality of position and orientation characteristics associated with the manipulation of the welding gun during the welding process. The display illustrates at least one of the plurality of position and orientation characteristics to provide feedback regarding the creation of the weld. In one embodiment, the disclosed method and system may be utilized as a tool for training welders.01-13-2011
20110117527WELDING TRAINING SYSTEM - A system for training welders that includes a data generating component, a data capturing component and a data processing and visualization component. The data generating component operates in real time and derives data from an actual manually-executed weld and further includes a weld process-specific jig, a calibration block positioned on the jig, wherein the geometric configuration of the calibration block is specific to a particular type of weld joint, a weld coupon positioned on the welding process-specific jig adjacent to the calibration block, a welding gun for use by a trainee, wherein the welding gun is operative to form the weld; and at least one target mounted on the welding gun that is recognized by the data processing and visualization component for providing multidimensional position and orientation feedback to the trainee.05-19-2011

Paul C. Brown, Buffalo, NY US

Patent application numberDescriptionPublished
20120121402CENTRIFUGAL COMPRESSOR DIFFUSER - A system, in certain embodiments, includes a centrifugal compressor diffuser vane including a leading edge, a trailing edge, and a constant thickness section extending between the leading edge and the trailing edge. A radius of curvature of the leading edge and a radius of curvature of the trailing edge vary along a span of the vane. A ratio of a length of the constant thickness section to a chord length of the vane is at least approximately 50%, and the ratio is substantially constant along the span of the vane.05-17-2012

Paul C. Castella, San Francisco, CA US

Patent application numberDescriptionPublished
20080268466Method and Device for Trichomonas Detection - A method and kit for detecting 10-30-2008

Paul C. Ciccolella, Redwood City, CA US

Patent application numberDescriptionPublished
20100297448MINIATURIZED MICROPARTICLES - A system and method for encoded microparticles is described. One embodiment includes an encoded microparticle comprising a plurality of segments, wherein the plurality of segments form a spatial code; contrast coating on at least one segment of the plurality of segments, wherein the contrast coating further encodes the microparticle; an outer surface, wherein the outer surface encloses the spatial code and contrast coating, and wherein the spatial code and contrast coating are detectable through the outer surface.11-25-2010

Paul C. Currit, Issaquah, WA US

Patent application numberDescriptionPublished
20100229152PRESCRIPTIVE ARCHITECTURE FOR APPLICATION DEVELOPMENT - A prescriptive architecture for application development is provided. In some embodiments, the architecture comprises a service, a receiver, a sender, and a transport. The service functions to perform the actual business logic, is decorated with service deployment metadata; and is operable to communicate via types. The receiver is coupled to the service and is generated entirely from the service deployment metadata. The receiver is operable to receive messages, convert the received messages into types, and communicate with the service using the types. The sender is coupled to the receiver and is generated entirely from the service deployment metadata. The sender functions as a proxy for the service to a service consumer, and is operable to communicate using types with the service consumer. The sender is operable to convert the types to messages, and communicate with the receiver via messages. The transport functions as a message exchange technology that allows the sender and receiver to communicate, and is designated by the service deployment metadata and implemented as an underlying technology of the sender and the receiver.09-09-2010
20100229154DECLARATIVE ASPECTS AND ASPECT CONTAINERS FOR APPLICATION DEVELOPMENT - An aspect container being operable to generate an instance of itself at run time is provided. The aspect container comprises logic operable to create an instance of the aspect container by reading configuration information specifying a sequence of one or more aspects from an aspect container configuration file corresponding to the aspect container. The logic is also operable to generate instances of the aspects in the sequence, configure each aspect instance with its configuration information from an aspect configuration file corresponding to the aspect, and chain the aspect instances according to the specified sequence, such that the chain of aspect instances preamble and postamble activities of a class or method.09-09-2010

Paul C. Demshur, Okemos, MI US

Patent application numberDescriptionPublished
20120031963MOBILE POWER SHARING - An apparatus may include a vehicle cover having a plurality of photovoltaic cells, an inverter, a vehicle battery connector, a plug, and a switch assembly configured to operatively couple the inverter selectively to one of the vehicle battery connector and the plug based, at least in part, on a charge level of the battery. Another apparatus may include a receptacle configured to receive a plug having an identification tag; an identification tag reader to obtain, from the identification tag, identification data associated with a customer of a power company providing a power distribution system; and a controller to receive the identification data and provide the identification data to an account server associated with the power company. A method may include receiving a plug including an identification tag, reading identification data, contacting an account server, and providing the identification data to the account server.02-09-2012

Paul C. Dulany, San Diego, CA US

Patent application numberDescriptionPublished
20090192855Computer-Implemented Data Storage Systems And Methods For Use With Predictive Model Systems - Systems and methods for performing fraud detection. As an example, a system and method can be configured to contain a raw data repository for storing raw data related to financial transactions. A data store contains rules to indicate how many generations or to indicate a time period within which data items are to be stored in the raw data repository. Data items stored in the raw data repository are then accessed by a predictive model in order to perform fraud detection.07-30-2009
20090192957Computer-Implemented Data Storage Systems And Methods For Use With Predictive Model Systems - Systems and methods for performing fraud detection. As an example, a system and method can be configured to contain a raw data repository for storing raw data related to financial transactions. A data store contains rules to indicate how many generations or to indicate a time period within which data items are to be stored in the raw data repository. Data items stored in the raw data repository are then accessed by a predictive model in order to perform fraud detection.07-30-2009
20090234683Detecting and Measuring Risk with Predictive Models Using Content Mining - Computer implemented methods and systems of processing transactions to determine the risk of transaction convert high categorical information, such as text data, to low categorical information, such as category or cluster IDs. The text data may be merchant names or other textual content of the transactions, or data related to a consumer, or any other type of entity which engages in the transaction. Content mining techniques are used to provide the conversion from high to low categorical information. In operation, the resulting low categorical information is input, along with other data, into a statistical model. The statistical model provides an output of the level of risk in the transaction. Methods of converting the high categorical information to low categorical clusters, of using such information, and other aspects of the use of such clusters are disclosed.09-17-2009

Paul C. Dziadik, San Francisco, CA US

Patent application numberDescriptionPublished
20100180887Solar Energy Collection System and Components - A solar energy collection system and components includes a vacuum and an air compressor. The system includes a plurality of flexible units each having a backing portion and a solar cell portion upwardly adjacent and coupled to the backing portion. Each backing portion includes adhesive and at least one channel in the adhesive. Each channel is configured for communication with the vacuum to withdraw air from the channel when the adhesive is initially coupled to a structure and for communication with an air compressor to provide air to the channel to separate the adhesive from the structure. Each solar cell portion has an electricity generating element. The structure for coupling units transfers electricity between units. Each unit has an electricity outlet for passing electricity generated by at least one generating element for storage or use.07-22-2010

Paul C. Edwards, Ii, Marysville, OH US

Patent application numberDescriptionPublished
20110240606SPIKE RESISTANCE SPOT WELDING SYSTEM AND METHOD - A system and method for performing one-sided resistance spot welding on parts to be welded. The system uses a resistance spot welding device that transfers electric welding current through a consumable welding spike to a localized spot on the parts to be welded. The welding spike is pressed against one side of the parts to be welded by a weld electrode during the spot welding process. The consumable welding spike is preferably melted and absorbed into the melt pool produced by the electric welding current.10-06-2011

Paul C. Goodley, Cupertino, CA US

Patent application numberDescriptionPublished
20100230589Method and Apparatus for Surface Desorption Ionization by Charged Particles - An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.09-16-2010

Patent applications by Paul C. Goodley, Cupertino, CA US

Paul C. Gottshall, Washington, IL US

Patent application numberDescriptionPublished
20090115438REMANUFACTURE OF ELECTRONIC ASSEMBLIES - A method for remanufacturing an electronic assembly allows the assembly to be disassembled, tested and reassembled despite certain components being permanently affixed to a housing of the assembly. The electronic assembly includes a circuit assembly within the housing. During remanufacture, a first portion of the housing is removed to expose a first side of the circuit assembly and a second portion of the housing is removed to expose a second side of the circuit assembly. When removing the second portion of the housing, one of the components of the circuit assembly may also be removed. During remanufacture a connector assembly including a replacement component substantially similar to the removed component, and including one or more pins connected to the replacement component and situated to mate with one or more empty sockets of the circuit assembly is used to facilitate testing of the assembly.05-07-2009

Paul C. Gottshall, Peoria, IL US

Patent application numberDescriptionPublished
20090127321ELECTRONIC ASSEMBLY REMANUFACTURING SYSTEM AND METHOD - A method for remanufacturing an electronic assembly includes removing a first portion of an assembly housing to expose an underside of an enclosed circuit assembly. One or more solder joints on the underside of the circuit assembly are associated with at least one component that is also affixed to a portion of the housing. The opened electronic assembly is lowered onto a desoldering fixture having a plurality of solder pots configured to encompass, and thus desolder, the solder joints associated with the component that is affixed to a portion of the housing. Once the affected solder joints are melted, the remaining portion of the housing and the component affixed thereto may be lifted away, exposing the top surface of the circuit assembly for analysis, repair, and or adjustment.05-21-2009

Paul C. Ho, Honolulu, HI US

Patent application numberDescriptionPublished
20090030503METHOD AND APPARATUS FOR PERCUTANEOUS AORTIC VALVE REPLACEMENT - A method for percutaneous aortic valve (PAV) replacement and a temporary aortic valve used to facilitate the same. The temporary valve is comprised of a reversibly expandable occluding means, such as balloons, surrounding a central catheter mechanism. The temporary valve is positioned within the ascending aorta, just above and downstream from the coronary ostia. The occluding means is configured such that, when fully expanded against the aortic wall, gaps are left that promote continuous coronary perfusion during the cardiac cycle. The native aortic valve is next dilated, and then ablated through deployment of an ablation stent. The ablation stent displaces the native valve tissues and remains within the aortic annulus to receive and retain the PAV. The PAV can then be positioned and deployed within the ablation stent with precision and ease. Ablation of the native aortic valve removes the structural obstacles to precise PAV placement. The temporary aortic valve mediates the hemodynamic forces encountered by the surgeon following native valve ablation. The temporary valve also promotes patient stability through continuous coronary perfusion and a moderated transvavlular pressure gradient. Mathematical considerations for determining the optimum cross-sectional area for the temporary valve blood perfusion gaps are also described.01-29-2009
20090030510METHODS AND APPARATUS FOR PERCUTANEOUS AORTIC VALVE REPLACEMENT - A delivery system and method for percutaneous aortic valve (PAV) replacement and apparatus used therein. A temporary aortic valve comprised of a reversibly expandable occluding means, such as balloons, surrounds a central catheter mechanism. The temporary valve is positioned within the ascending aorta, just above and downstream from the coronary ostia. The occluding means is configured such that, when fully expanded against the aortic wall, gaps are left that promote continuous coronary perfusion during the cardiac cycle. The temporary valve with occluding means substitutes for the function of the native aortic valve during its replacement. The native aortic valve is next dilated, and then ablated through deployment of low profile, elongated, sequentially delivered stents. The ablation stent(s) displace the native valve tissues and remain within the aortic annulus to receive and provide a structure for retaining the PAV. The PAV is delivered, positioned and deployed within the ablation stent(s) at the aortic annulus with precision and relative ease. Ablation of the native aortic valve removes the structural obstacles to precise PAV placement. The temporary aortic valve mediates the hemodynamic forces upon the devices as encountered by the surgeon following native valve ablation. The temporary valve also promotes patient stability through continuous coronary perfusion and a moderated transvalvular pressure gradient and regurgitation. Sequential delivery of low profile PAV components minimize the risk of trauma and injury to vascular tissues. Mathematical considerations for determining the optimum cross-sectional area for the temporary valve blood perfusion gaps are also described.01-29-2009
20120116439METHOD AND SYSTEM FOR BALLOON COUNTERPULSATION DURING AORTIC VALVE REPLACEMENT - Methods and systems for regulating aortic regurgitation during aortic valve replacement or repair procedures utilize a temporary aortic valve (TAV) catheter and a controller. The temporary aortic valve catheter has an expandable occlusion device which can partially occlude the aortic lumen during ventricular diastole with a lesser occlusion during ventricular systole. Exemplary balloon structures include multiple, independently inflatable balloons which are inflated in synchrony with the cardiac cycle by the controller. By controlling aortic regurgitation, the repair or replacement protocols can be conducted with less interference from blood flow.05-10-2012

Paul C. Hogrebe, Salt Lake City, UT US

Patent application numberDescriptionPublished
20090324683CONTROLLED RELEASE TISSUE GRAFT COMBINATION BIOMATERIALS - In one aspect, the invention relates to tissue graft combination biomaterials capable of controlled release of bioactive agents or pharmaceutically active agents through a rate-controlling polymer coating encapsulating the graft material, methods for preparing same, methods of controlled release using same, and methods for treating tissue defects. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.12-31-2009

Paul C. Hsieh, Dali City TW

Patent application numberDescriptionPublished
20100307088CLADDING TILE - A cladding tile includes a base having an adhesive layer connected to a surface thereof and facing stones are securely connected to the adhesive layer. The facing stones are so securely connected to the base so that when the cladding tile can be conveniently used on vertical surfaces without worry peel-off of the facing stones.12-09-2010

Paul C. Huffman, Sharon CA

Patent application numberDescriptionPublished
20080256053EXECUTION OF DATABASE QUERIES INCLUDING FILTERING - A query processing system has a query processor and a data manager. The query processor calls the data manager to carry out data access for a query including a filtering operation. The data manager accesses the data in a set of data and before returning the data, initiates a callback to the query processor to determine if the located data meets the filtering criteria. Where the data does not satisfy the filtering criteria, the data manager seeks additional data in the set of data, without having to return the first located data to the query processor.10-16-2008

Paul C. Kermis, Henrietta, NY US

Patent application numberDescriptionPublished
20090203273No Drill Multiport Drive Shower - A cooling apparatus for a marine propulsion system outdrive unit that can be attached to an outdrive unit without the need to drill holes in any portion of the outdrive unit. The cooling apparatus has a distribution tube assembly with at least one pickup port and a water delivery feature such as dump ports, the pickup port being open to receive cooling water into the distribution tube assembly when mounted on a marine propulsion system outdrive unit and the water delivery feature positioned to face the drive unit for delivering cooling water from the distribution tube assembly to the outdrive unit. A no drill bracket attached to the distribution tube assembly attaches to the lift ram assembly shaft of the outdrive unit, and an upper mounting bracket that is attached to the distribution tube assembly attaches to the outdrive unit.08-13-2009

Paul C. Kierce, Cohasset, MA US

Patent application numberDescriptionPublished
20110226645BLADE EXCHANGE DEVICE, SYSTEM AND METHOD - A blade exchange device may be used to remove or install a blade on a medical or surgical instrument such as a dermatome. The blade exchange device generally includes a base portion and a blade engaging portion that engages the blade being removed or installed. The blade exchange device may be used in a system that also includes a magnetic tool for coupling and moving the blades that are removed or installed. The blade exchange device, system and method may be used, for example, with commercially available dermatome instruments such as the type known as the Goulian-Weck knife.09-22-2011

Paul C. Kuhl, Vista, CA US

Patent application numberDescriptionPublished
20110050516RADOMES, AIRCRAFT AND SPACECRAFT INCLUDING SUCH RADOMES, AND METHODS OF FORMING RADOMES - Radomes include an outer wall having a first average thickness and an inner wall having a second average thickness that is different from the first average thickness. At least a major portion of the inner wall is separated from at least a major portion of the outer wall by a space therebetween. The outer wall may comprise a layer of ceramic matrix composite (CMC) material. Aircraft and spacecraft include such radomes. Methods of forming radomes include forming an outer wall having a first average thickness, forming an inner wall having a different second average thickness, and coupling together the inner wall and the outer wall in such a manner as to provide a space between at least a major portion of the outer wall and at least a major portion of the inner wall.03-03-2011

Paul C. Lavesque, Yardley, PA US

Patent application numberDescriptionPublished
20080274505Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof - The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.11-06-2008

Paul C. Leavis, Epping, NH US

Patent application numberDescriptionPublished
20080293149ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate.11-27-2008
20080299677NEW ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate.12-04-2008
20080305468ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate.12-11-2008
20080305552ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate.12-11-2008
20090011427ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate.01-08-2009
20090029919Leptin peptide antagonists - Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence.01-29-2009
20100197040ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate.08-05-2010
20110190473LEPTIN PEPTIDE ANTAGONISTS - Disclosed herein are peptides comprising a leptin sequence and methods for their use in preventing ObR signaling in a leptin-responsive cell. A leptin peptide of the present invention binds to but does not activate ObR signaling in a leptin-responsive cell, thereby inhibiting the up-regulatory effects of leptin on ObR signaling in the leptin-responsive cell. Administration of the peptide effectively prevents embryo implantation in a mammal to which the peptide has been administered. Also disclosed herein is a method for identifying a peptide antagonist of ObR, wherein the peptide comprises a leptin sequence.08-04-2011
20120009605NEW ASSAYS FOR PREIMPLANTATION FACTOR AND PREIMPLANTATION FACTOR PEPTIDES - The present invention relates to assay methods used for detecting the presence of PIF, and to PIF peptides identified using this assay. In particular, the present invention relates to flow cytometry assays for detecting PIF. It is based, at least in part, on the observation that flow cytometry using fluorescently labeled anti-lymphocyte and anti-platelet antibodies demonstrated an increase in rosette formation in the presence of PIF. It is further based on the observation that flow cytometry demonstrated that monoclonal antibody binding to CD2 decreased in the presence of PIF. The present invention further relates to PIF peptides which, when added to Jurkat cell cultures, have been observed to either (i) decrease binding of anti-CD2 antibody to Jurkat cells; (ii) increase expression of CD2 in Jurkat cells; or (iii) decrease Jurkat cell viability. In additional embodiments, the present invention provides for ELISA assays which detect PIF by determining the effect of a test sample on the binding of anti-CD2 antibody to a CD2 substrate.01-12-2012

Patent applications by Paul C. Leavis, Epping, NH US

Paul C. Mcclay, South Berwick, ME US

Patent application numberDescriptionPublished
20110220622APPARATUS AND METHOD FOR PREFERENTIAL FORMATION OF WELD JOINT - A weld set-up and weld process are provided that alleviate micro-cracking as between a pair of welded pieces. The weld set-up is provided in which the weld pieces are configured to cause micro-cracking to occur in a portion of the welded pieces that is then removed by post-processing machining techniques. This weld set-up includes a primary weld piece and a secondary weld piece with a flange portion that extends over the primary weld piece. When used in conjunction with electron beam welding, application of the weld beam onto the secondary weld piece causes the formation of a preferential nailhead that is formed exclusively in the first weld piece.09-15-2011

Paul C. Mioduski, Tucson, AZ US

Patent application numberDescriptionPublished
20090118802Hyperthermia Treatment Systems and Methods - Systems and methods are disclosed to control the temperature of an RF hyperthermia system with minimum overshoot and to improve safety by, among other things, detecting a defective temperature sensor. Temperature overshoot may be minimized by compensating for the short-term temperature difference between the area being treated and the applicator delivering the RF energy. The RF energy may heat the tissue and then the tissue may transfer heat to the applicator sensor. The system may also adapt to various applicator sizes and shapes by modifying control loop coefficients based on initial probe response.05-07-2009

Paul C. Nasvik, Hudson, WI US

Patent application numberDescriptionPublished
20100088989Concrete veneer panel with air entrained concrete core - A multi-layered veneer panel that includes a foamed core, a concrete surface layer, and a mounting device. The concrete surface layer forms a front surface and an edge perimeter region of the veneer panel. The front surface approximates a desired topography of a simulated wall. The foamed core forms a back surface of the veneer panel and is disposed adjacent the concrete surface layer. The mounting device is cast into at least one of the concrete surface layer and the foamed core and extends from the edge perimeter region. A method of making a multi-layered veneer panel is also disclosed.04-15-2010

Patent applications by Paul C. Nasvik, Hudson, WI US

Paul C. Parries, Hopewell Junction, NY US

Patent application numberDescriptionPublished
20110193193STRUCTURE AND METHOD FOR FORMING ISOLATION AND BURIED PLATE FOR TRENCH CAPACITOR - A structure and method for forming isolation and a buried plate for a trench capacitor is disclosed. Embodiments of the structure comprise an epitaxial layer serving as the buried plate, and a bounded deep trench isolation area serving to isolate one or more deep trench structures. Embodiments of the method comprise angular implanting of the deep trench isolation area to form a P region at the base of the deep trench isolation area that serves as an anti-punch through implant.08-11-2011
20120012971Method of Fabricating Isolated Capacitors and Structure Thereof - A structure and method is provided for fabricating isolated capacitors. The method includes simultaneously forming a plurality of deep trenches and one or more isolation trenches surrounding a group or array of the plurality of deep trenches through a SOI and doped poly layer, to an underlying insulator layer. The method further includes lining the plurality of deep trenches and one or more isolation trenches with an insulator material. The method further includes filling the plurality of deep trenches and one or more isolation trenches with a conductive material on the insulator material. The deep trenches form deep trench capacitors and the one or more isolation trenches form one or more isolation plates that isolate at least one group or array of the deep trench capacitors from another group or array of the deep trench capacitors.01-19-2012

Paul C. Parries, Wappingers Falls, NY US

Patent application numberDescriptionPublished
20090173980PROVIDING ISOLATION FOR WORDLINE PASSING OVER DEEP TRENCH CAPACITOR - A memory cell has an access transistor and a capacitor with an electrode disposed within a deep trench. STI oxide covers at least a portion of the electrode, and a liner covers a remaining portion of the electrode. The liner may be a layer of nitride over a layer of oxide. Some of the STI may cover a portion of the liner. In a memory array a pass wordline may be isolated from the electrode by the STI oxide and the liner.07-09-2009
20090174031DRAM HAVING DEEP TRENCH CAPACITORS WITH LIGHTLY DOPED BURIED PLATES - By controlling buried plate doping level and bias condition, different capacitances can be obtained from capacitors on the same chip with the same layout and deep trench process. The capacitors may be storage capacitors of DRAM/eDRAM cells. The doping concentration may be less than 3E19cm−3, a voltage difference between the biases of the buried electrodes may be at least 0.5V, and a capacitance of one capacitor may be at least 1.2 times, such as 2.0 times the capacitance of another capacitor.07-09-2009
20090184356DEEP TRENCH CAPACITOR IN A SOI SUBSTRATE HAVING A LATERALLY PROTRUDING BURIED STRAP - A deep trench is formed to a depth midway into a buried insulator layer of a semiconductor-on-insulator (SOI) substrate. A top semiconductor layer is laterally recessed by an isotropic etch that is selective to the buried insulator layer. The deep trench is then etched below a bottom surface of the buried insulator layer. Ion implantation is performed at an angle into the deep trench to dope the sidewalls of the deep trench beneath the buried insulator layer, while the laterally recessed sidewalls of the top semiconductor layer are not implanted with dopant ions. A node dielectric and trench fill materials are deposited into the deep trench. A buried strap has an upper buried strap sidewall that is offset from a lower buried strap sidewall and a deep trench sidewall.07-23-2009
20090240875CONTENT ADDRESSABLE MEMORY WITH HIDDEN TABLE UPDATE, DESIGN STRUCTURE AND METHOD - Disclosed are embodiments of memory circuit having two discrete memory devices with two discrete memory arrays that store essentially identical data banks. The first device is a conventional memory adapted to perform all maintenance operations that require read functions (i.e., all update and refresh operations). The second device is a DRAM-based CAM device adapted to perform parallel search and overwrite operations only. Performance of overwrite operations by the second device occurs in conjunction with performance of maintenance operations by the first device so that corresponding memory cells in the two devices store essentially identical data values. Since the data banks in the memory devices are essentially identical and since maintenance and parallel search operations are not performed by the same device, the parallel search operations can be performed without interruption. Also disclosed are embodiments of an associated design structure and method.09-24-2009
20090289291SOI DEEP TRENCH CAPACITOR EMPLOYING A NON-CONFORMAL INNER SPACER - A bottle shaped trench for an SOI capacitor is formed by a simple processing sequence. A non-conformal dielectric layer with an optional conformal dielectric diffusion barrier layer underneath is formed on sidewalls of a deep trench. Employing an isotropic etch, the non-conformal dielectric layer is removed from a bottom portion of the deep trench, leaving a dielectric spacer covering sidewalls of the buried insulator layer and the top semiconductor layer. The bottom portion of the deep trench is expanded to form a bottle shaped trench, and a buried plated is formed underneath the buried insulator layer. The dielectric spacer may be recessed during formation of a buried strap to form a graded thickness dielectric collar around the upper portion of an inner electrode. Alternately, the dielectric spacer may be removed prior to formation of a buried strap.11-26-2009
20100237417Through-Gate Implant for Body Dopant - The present invention, provides a semiconductor device including a substrate including a semiconductor layer overlying an insulating layer, wherein a back gate structure is present underlying the insulating layer and a front gate structure on the semiconductor layer; a channel dopant region underlying the front gate structure of the substrate, wherein the channel dopant region has a first concentration present at an interface of the semiconductor layer and the insulating layer and at least a second concentration present at the interface of the front gate structure and the semiconductor layer, wherein the first concentration is greater than the second concentration; and a source region and drain region present in the semiconductor layer of the substrate.09-23-2010
20110092043DEEP TRENCH CAPACITOR IN A SOI SUBSTRATE HAVING A LATERALLY PROTRUDING BURIED STRAP - A deep trench is formed to a depth midway into a buried insulator layer of a semiconductor-on-insulator (SOI) substrate. A top semiconductor layer is laterally recessed by an isotropic etch that is selective to the buried insulator layer. The deep trench is then etched below a bottom surface of the buried insulator layer. Ion implantation is performed at an angle into the deep trench to dope the sidewalls of the deep trench beneath the buried insulator layer, while the laterally recessed sidewalls of the top semiconductor layer are not implanted with dopant ions. A node dielectric and trench fill materials are deposited into the deep trench. A buried strap has an upper buried strap sidewall that is offset from a lower buried strap sidewall and a deep trench sidewall.04-21-2011
20110291169REDUCED CORNER LEAKAGE IN SOI STRUCTURE AND METHOD - A structural alternative to retro doping to reduce transistor leakage is provided by providing a liner in a trench, undercutting a conduction channel region in an active semiconductor layer, etching a side, corner and/or bottom of the conduction channel where the undercut exposes semiconductor material in the active layer and replacing the removed portion of the conduction channel with insulator. This shaping of the conduction channel increases the distance to adjacent circuit elements which, if charged, could otherwise induce a voltage and cause a change in back-channel threshold in regions of the conduction channel and narrows and reduces cross-sectional area of the channel where the conduction in the channel is not well-controlled; both of which effects significantly reduce leakage of the transistor.12-01-2011
20110316061STRUCTURE AND METHOD TO CONTROL BOTTOM CORNER THRESHOLD IN AN SOI DEVICE - Semiconductor structures and methods to control bottom corner threshold in a silicon-on-insulator (SOI) device. A method includes doping a corner region of a semiconductor-on-insulator (SOI) island. The doping includes tailoring a localized doping of the corner region to reduce capacitive coupling of the SOI island with an adjacent structure.12-29-2011
20120086077FET STRUCTURES WITH TRENCH IMPLANTATION TO IMPROVE BACK CHANNEL LEAKAGE AND BODY RESISTANCE - An FET structure on a semiconductor substrate which includes forming recesses for a source and a drain of the gate structure on a semiconductor substrate, halo implanting regions through the bottom of the source and drain recesses, the halo implanted regions being underneath the gate stack, implanting junction butting at the bottom of the source and drain recesses, and filling the source and drain recesses with a doped epitaxial material. In exemplary embodiments, the semiconductor substrate is a semiconductor on insulator substrate including a semiconductor layer on a buried oxide layer. In exemplary embodiments, the junction butting and halo implanted regions are in contact with the buried oxide layer. In other exemplary embodiments, there is no junction butting. In exemplary embodiments, halo implants implanted to a lower part of the FET body underneath the gate structure provide higher doping level in lower part of the FET body to reduce body resistance, without interfering with FET threshold voltage.04-12-2012
20120122303SEMICONDUCTOR STRUCTURE HAVING WIDE AND NARROW DEEP TRENCHES WITH DIFFERENT MATERIALS - Disclosed is a method of forming a semiconductor device structure in a semiconductor layer. The method includes forming a first trench of a first width and a second trench of a second width in the semiconductor layer; depositing a layer of first material which conforms to a wall of the first trench but does not fill it and which fills the second trench; removing the first material from the first trench, the first material remaining in the second trench; depositing a second material into and filling the first trench and over a top of the first material in the second trench; and uniformly removing the second material from the top of the first material in the second trench, wherein the first trench is filled with the second material and the second trench is filled with the first material and wherein the first material is different from the second material.05-17-2012

Patent applications by Paul C. Parries, Wappingers Falls, NY US

Paul C. Sheil, Akron, OH US

Patent application numberDescriptionPublished
20090020926INSULATING REFRACTORY LINING - An insulating refractory lining for insulating the inner surface of a vessel defined by a metal shell. The refractory lining is comprised of a first refractory layer overlaying an inner surface of a metal shell. The first refractory layer is comprised of a cast refractory material and has a first side facing the metal shell and a second side facing away from the metal shell. A plurality of discrete, spaced-apart cavities are formed in the first side of the first refractory layer. The cavities define air pockets between the metal shell and the first refractory layer.01-22-2009
20090020927INSULATING REFRACTORY LINING - An insulating refractory lining for insulating the inner surface of a vessel defined by a metal shell. The refractory lining is comprised of a first refractory layer overlaying an inner surface of a metal shell. The first refractory layer is comprised of a cast refractory material and has a first side facing the metal shell and a second side facing away from the metal shell. A plurality of discrete, spaced-apart cavities are formed in the first side of the first refractory layer. The cavities define air pockets between the metal shell and the first refractory layer.01-22-2009

Paul C. Thulen, Granby, CT US

Patent application numberDescriptionPublished
20090242679WEAR PLATE ASSEMBLY FOR VERTICAL ROTOR OF A PULVERIZER - A wear plate assembly includes a body portion and an abutment flange extending from a radially outer circumferential edge of the body portion and substantially normal thereto. The abutment flange is cooperatively configured with respect to another abutment flange of a respective adjacent wear plate that interengages with the wear plate such that a convoluted edge of the another abutment flange of the respective adjacent wear plate intermeshes with a respective convoluted edge of the abutment flange of the wear plate. At least one polygonal recess and a corresponding abutment ramp are substantially aligned therewith at a same latitude on the body portion, the recess further includes a through hole extending through the wear plate. A first clip configured is partially received in the polygonal recess, the clip having a plurality of exposed impact surface faces.10-01-2009
20100300336REDUCTION OF MERCURY FROM A COAL FIRED BOILER - A method and system are disclosed for achieving reduced mercury emissions from a power plant at a minimum cost. The parameters of the combustion chamber and a sorbent injector are manipulated to control the residual carbon in ash and the injected sorbent. These two elements combine to reduce mercury in the exhaust gas to an acceptable level.12-02-2010

Patent applications by Paul C. Thulen, Granby, CT US

Paul C. Van Der Wilt, New York, NY US

Patent application numberDescriptionPublished
20090309104SYSTEMS AND METHODS FOR CREATING CRYSTALLOGRAPHIC-ORIENTATION CONTROLLED poly-SILICON FILMS - In accordance with one aspect, the present invention provides a method for providing polycrystalline films having a controlled microstructure as well as a crystallographic texture. The methods provide elongated grains or single-crystal islands of a specified crystallographic orientation. In particular, a method of processing a film on a substrate includes generating a textured film having crystal grains oriented predominantly in one preferred crystallographic orientation; and then generating a microstructure using sequential lateral solidification crystallization that provides a location-controlled growth of the grains orientated in the preferred crystallographic orientation.12-17-2009
20110108108FLASH LIGHT ANNEALING FOR THIN FILMS - A method of making a crystalline film includes providing a film comprising seed grains of a selected crystallographic surface orientation on a substrate; irradiating the film using a pulsed light source to provide pulsed melting of the film under conditions that provide a mixed liquid/solid phase and allowing the mixed solid/liquid phase to solidify under conditions that provide a textured polycrystalline layer having the selected surface orientation. One or more irradiation treatments may be used. The film is suitable for use in solar cells.05-12-2011
20110121306Systems and Methods for Non-Periodic Pulse Sequential Lateral Solidification - The disclosed systems and method for non-periodic pulse sequential lateral solidification relate to processing a thin film. The method for processing a thin film, while advancing a thin film in a selected direction, includes irradiating a first region of the thin film with a first laser pulse and a second laser pulse and irradiating a second region of the thin film with a third laser pulse and a fourth laser pulse, wherein the time interval between the first laser pulse and the second laser pulse is less than half the time interval between the first laser pulse and the third laser pulse. In some embodiments, each pulse provides a shaped beam and has a fluence that is sufficient to melt the thin film throughout its thickness to form molten zones that laterally crystallize upon cooling. In some embodiments, the first and second regions are adjacent to each other. In some embodiments, the first and second regions are spaced a distance apart.05-26-2011

Patent applications by Paul C. Van Der Wilt, New York, NY US

Paul C. Waelder, Syracuse, NY US

Patent application numberDescriptionPublished
20100089900Ignition Element and Method for Kindling Solid Fuel - An igniter element for igniting solid fuel particles in a retort furnace is disclosed. The igniter element is a substantially planar shaped element that is in direct contact with the fuel to be ignited. A configuration of various sections is formed into the planar igniter element in order to facilitate the conversion of electrical energy into thermal energy. The igniter element uses a control system to reliably facilitate the ignition of all solid fuels including difficult to start fuels, such as anthracite coal. The service life of the heat igniter is extended by its planar shape in contact with the surface of the retort and its ability to dissipate the thermal energy produced within the retort region.04-15-2010

Paul C. Ward-Dolkas, Palo Alto, CA US

Patent application numberDescriptionPublished
20080233667MICRODISPLAY PACKAGING SYSTEM - Some embodiments provide a microdisplay integrated circuit (IC), a substantially transparent protective cover coupled to the microdisplay IC, and a base coupled to the microdisplay IC. Thermal expansion characteristics of the base may be substantially similar to thermal expansion characteristics of the protective cover. According to some embodiments, at least one set of imaging elements is fabricated on an upper surface of a semiconductor substrate, and a base is affixed to a lower surface of the semiconductor substrate to generate substantially negligible mechanical stress between the semiconductor substrate and the base.09-25-2008
20120032205MICRODISPLAY PACKAGING SYSTEM - Some embodiments provide a microdisplay integrated circuit (IC), a substantially transparent protective cover coupled to the microdisplay IC, and a base coupled to the microdisplay IC. Thermal expansion characteristics of the base may be substantially similar to thermal expansion characteristics of the protective cover. According to some embodiments, at least one set of imaging elements is fabricated on an upper surface of a semiconductor substrate, and a base is affixed to a lower surface of the semiconductor substrate to generate substantially negligible mechanical stress between the semiconductor substrate and the base.02-09-2012

Patent applications by Paul C. Ward-Dolkas, Palo Alto, CA US

Paul C. Werntz, Long Beach, CA US

Patent application numberDescriptionPublished
20080204341BEAM WAVEGUIDE INCLUDING MIZUGUCHI CONDITION REFLECTOR SETS - A beam waveguide may include a first set of dual offset reflectors and a second set of dual offset reflectors. The first set of dual offset reflectors and the second set of dual offset reflectors may each include reflector geometries to produce a radiation pattern that is symmetric about a first axis between the first and second set of dual offset reflectors and to produce an axi-symmetric beam from the second set of dual offset reflectors that is unaffected by any rotation of the first and second set of dual offset reflectors relative to one another about the first axis.08-28-2008

Patent applications by Paul C. Werntz, Long Beach, CA US

Paul C. Yatkowski, Scottsdale, AZ US

Patent application numberDescriptionPublished
20110272083Glove Finger Cap and Method of Installing Same - A glove patch system for a finger of a glove includes a tubular cap and an adhesive. A method of installing the tubular cap onto the glove finger includes partially turning the tubular cap inside out to form a pocket on a closed end of the tubular cap. The adhesive is applied to at least a portion of the glove finger. The pocket of the cap is positioned over the adhesive applied to a fingertip of the glove finger, and pressure is applied to adhere an inner surface of the tubular cap within the pocket of the cap to the glove finger. The tubular cap is unrolled down a length of the glove finger to adhere a remainder of the inner surface of the tubular cap to the glove finger using the adhesive.11-10-2011

Paul C. Zamecnik, Boston, MA US

Patent application numberDescriptionPublished
20080287379Oligonucleotide Complex Compositions and Methods of Use as Gene Alteration Tools - Compositions and methods of treatments of cells are provided for altering the phenotype of a cell by administering an oligonucleotide complex to the cell, the complex having two strands and chemical modifications.11-20-2008
20100204310NEW MODALITIES FOR TREATMENT OF DRUG-RESISTANT TUBERCULOSIS AND OTHER DISEASES - The invention provides antibacterial compounds comprising an oligonucleotide having a sequence complementary to a translation initiation region of an mRNA encoding a mycolyl transferase of 08-12-2010

Patent applications by Paul C. Zamecnik, Boston, MA US