Patterson, NC
Cam Patterson, Chapel Hill, NC US
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20100119476 | SELECTION OF PEPTIDES SPECIFIC FOR HUMAN BLOOD OUTGROWTH ENDOTHELIAL CELLS - Provided herein are compositions and methods for binding outgrowth endothelial cells (OEC). The compositions consist of peptide ligands capable of binding OEC with high affinity and specificity. The compositions of the invention include peptides set forth in SEQ ID NO:1-38 and variants and derivatives thereof. Compositions also include the nucleotide sequences encoding the peptides of the invention. The compositions find use in methods for the isolation of OEC and for the recruitment and retention of OEC to sites of therapeutic interest. Methods for the identification and isolation of other peptides capable of binding OEC are also provided. | 05-13-2010 |
20100190703 | PEPTIDES SPECIFIC FOR HUMAN BLOOD OUTGROWTH ENDOTHELIAL CELLS - Provided herein are compositions and methods for binding outgrowth endothelial cells (OEC). The compositions consist of peptide ligands capable of binding OEC with high affinity and specificity. The compositions of the invention include peptides set forth in SEQ ID NO: 1-38 and variants and derivatives thereof. Compositions also include the nucleotide sequences encoding the peptides of the invention. The compositions find use in methods for the isolation of OEC and for the recruitment and retention of OEC to sites of therapeutic interest. Methods for the identification and isolation of other peptides capable of binding OEC are also provided. | 07-29-2010 |
20100272712 | JNK3 AS A TARGET FOR THE TREATMENT OF ANGIOGENESIS-RELATED DISEASES - Provided herein are methods for treating a subject having or at risk for an angiogenesis-related disorder. The methods include administering to the subject a therapeutically effective amount of an agent that inhibits JNK3 expression, or a therapeutically effective amount of an agent that inhibits JNK3 activity. Disorders that can be treated by these methods include cancer, rheumatoid arthritis, vascular diseases, and other disorders resulting from excessive angiogenesis. The therapeutic agent may be a compound, small molecule, peptide, antibody, antisense nucleic acid, ribozyme, or the like. Methods of identifying a candidate agent that modulates JNK3 expression are also provided. | 10-28-2010 |
20110142820 | Novel Targets for Regulation of Angiogenesis - The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer. | 06-16-2011 |
20140004040 | METHODS AND COMPOSITIONS FOR TARGETING SITES OF NEOVASCULAR GROWTH | 01-02-2014 |
20140294848 | Novel Targets for Regulation of Angiogenesis - The present invention relates to the identification of polynucleotides and polypeptides having increased expression in tumor blood vessels. The invention further relates to the use of the identified polynucleotides and polypeptides, and inhibitors of the polynucleotides and polypeptides, in the regulation of angiogenesis and the diagnosis and treatment of angiogenesis-related diseases such as cancer. | 10-02-2014 |
20150299264 | INHIBITION OF CARDIAC FIBROSIS IN MYOCARDIAL INFARCTION - The described invention provides a method for treating myocardial infarction (MI) in a subject comprising administering to the subject a therapeutic amount of a pharmaceutical composition comprising a polypeptide of amino sequence YARAAARQARAKALARQLGVAA (SEQ ID NO: 1) or a functional equivalent thereof made from a fusion between a first polypeptide that is a cell permeable protein (CPP) selected from the group consisting of a polypeptide of amino acid sequence YARAAARQARA (SEQ ID NO: 2), WLRRIKAWLRRIKA (SEQ ID NO: 21), WLRRIKA (SEQ ID NO: 22), YGRKKRRQRRR (SEQ ID NO: 23), FAKLAARLYR (SEQ ID NO: 25), and KAFAKLAARLYR (SEQ ID NO: 26), and a second polypeptide that is a therapeutic domain (TD), and a pharmaceutically acceptable carrier. The described invention also provides a kit comprising a composition comprising at least one MK2 inhibitor peptide; a means for administering the composition; and a packaging material. | 10-22-2015 |
Charles Beaty Patterson, Wilmington, NC US
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20090022259 | FUEL ROD WITH WEAR-INHIBITING COATING - A fuel rod includes a cladding tube with a wear-inhibiting coating. In one embodiment, the coating is made of a metallic powder material that is applied to the exterior surface of the cladding tube using a thermal spray process. In an alternative embodiment, the coating is a composite made of a metallic powder material, and a ceramic powder material or a metal oxide hard phase powder material that is simultaneously applied with the metallic powder material to coat the cladding tube. The coating can be applied to selected areas of the fuel rods where debris tends to fret the fuel rod. | 01-22-2009 |
Gregory Patterson, High Point, NC US
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20100225395 | Input Buffer With Impedance Cancellation - An exemplary negative impedance converting circuit for functioning as a voltage buffer and/or negating the impedance of a connected load. The negative impedance converting circuit includes inputs, outputs, a first transconductance stage and a second transconductance stage. The transconductance gain value of the first transconductance stage is greater than a transconductance gain value of the second transconductance stage. Exemplary embodiments of a reference voltage buffer using the negative impedance converting circuit are also described. | 09-09-2010 |
Gregory S. Patterson, Morrisville, NC US
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20080226435 | LOADING AND UNLOADING APPARATUS FOR TRAILER BODY - A loading and unloading apparatus adapted for use on a wheel-supported trailer body is provided. The loading and unloading apparatus comprises a plurality of elongate support arms, a plurality of channels under the floor structure of the trailer body allowing the support arms to be mounted thereon and move longitudinally between a stored position and an operating position, at least one deck panel having two opposite end edge portions and means for securing the opposite end edge portions to the support arms. The opposite end edge portions are detachably mounted on the support arms. | 09-18-2008 |
20090199364 | Hinge Mechanism for a Wireless Communication Device - The present application is directed to a hinge for a clamshell-type wireless communication device or other electronic device. In one embodiment, the communication device includes a base portion and a flip portion. A hinge mechanism movably couples the flip portion to the base portion so that the flip portion may pivot between a closed position and an open position. The hinge mechanism comprises first and second hinge parts, an indexing pin, and a spring. The indexing pin is rotatable relative to the first hinge part about a pivot axis. Additionally, the indexing pin is movable axially along the pivot axis. The second hinge part is non-rotatably engaged with the indexing pin and is rotatable about the pivot axis relative to the first hinge part between closed and open positions. The spring applies both an axial force and a rotational force to the indexing pin. The axial force biases the indexing pin into contact with the first hinge part, and the rotational force rotates the indexing pin to move the second hinge part from the closed to the open position. | 08-13-2009 |
Gregory W. Patterson, Jamestown, NC US
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20090273332 | FAST, EFFICIENT REFERENCE NETWORKS FOR PROVIDING LOW-IMPEDANCE REFERENCE SIGNALS TO SIGNAL PROCESSING SYSTEMS - Reference network embodiments are provided for use in pipelined signal converter systems. The network embodiments are fast and power efficient and they generate low-impedance reference signals through the use of a complimentary common-drain output stage, at least one diode-coupled transistor inserted between transistors of the output stage, and a controller. The controller is configured to provide a backgate voltage to the diode-coupled transistor to thereby establish a substantially-constant output current. The controller is further configured to provide gate voltages to the output stage to establish top and bottom reference voltages about the diode-coupled transistor that are spaced from a common-mode voltage. This reference structure maintains a constant output current as the span between the top and bottom reference voltages is selectively altered. In different embodiments, the diode-coupled transistor is replaced with a bipolar junction transistor. | 11-05-2009 |
20090273502 | Fast, efficient reference networks for providing low-impedance reference signals to signal converter systems - Reference network embodiments are provided for use in pipelined signal converter systems. The network embodiments are fast and power efficient and they generate low-impedance reference signals through the use of a complimentary common-drain output stage, an output current valve inserted between transistors of the output stage, and a controller. The controller is configured to provide gate voltages to the output current valve to thereby establish a substantially-constant output current. The controller is further configured to provide gate voltages to the output stage to establish top and bottom reference voltages about the output current valve that are spaced from a common-mode voltage. This reference structure maintains a constant output current as the span between the top and bottom reference voltages is selectively altered. In different embodiments, transistors of the output current valve are arranged in a drain-to-source-coupled configuration and in a source-coupled configuration. | 11-05-2009 |
20100109927 | RESIDUE GENERATORS FOR REDUCTION OF CHARGE INJECTION IN PIPELINED CONVERTER SYSTEMS - Pipelined converter systems include a plurality of converter stages in which some stages generate and pass a residue signal to a succeeding stage for further conversion. The generation of the residue signal can inject spurious charges into a reference source that is used in the generation. The spurious charges reduce the accuracy of the residue signal and the accuracy of the system. Residue generator embodiments are thereby formed to provide reduction charges to the reference source that are arranged to oppose and reduce the spurious charges. This reduction of spurious charges significantly enhances system accuracy and linearity. | 05-06-2010 |
Gregory W. Patterson, High Point, NC US
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20100149015 | FAST, EFFICIENT REFERENCE NETWORKS FOR PROVIDING LOW-IMPEDANCE REFERENCE SIGNALS TO SIGNAL PROCESSING SYSTEMS - Reference network embodiments are provided for use in pipelined signal converter systems. The network embodiments are fast and power efficient and they generate low-impedance reference signals through the use of at least one output transistor, a diode-coupled transistor coupled to the output transistor, and a controller. The controller is configured to provide a backgate voltage to the diode-coupled transistor to thereby establish a substantially-constant output current. The controller is further configured to provide a gate voltage to the output transistor to establish a reference voltage. | 06-17-2010 |
Jason M. Patterson, Kinston, NC US
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20120138101 | DETERGENT DISPENSER FOR IMPROVED DETERGENT REMOVAL - Embodiments of the present invention are related to a detergent dispenser configured to attach to an interior surface of a dishwasher door. The detergent dispenser may comprise a reservoir configured to hold detergent, wherein a portion of the upper wall of the reservoir has been removed to reduce a cross-sectional length thereof such that water flowing down the dishwasher door is encouraged into the reservoir. The detergent dispenser may also comprise a dispenser door comprising a closed configuration and an open configuration, wherein the dispenser door is configured to cover the reservoir in the closed configuration. The detergent dispenser may be configured to encourage water flowing down the interior surface of the dishwasher door to enter the reservoir when the dispenser door is in the open or closed configuration. | 06-07-2012 |
20130025637 | SIPHON BREAK APPARATUS CONFIGURED TO PREVENT A SIPHON EFFECT IN A FLUID CONDUIT OF A DISHWASHER AND AN ASSOCIATED METHOD - According to exemplary embodiments, a dishwasher or other washing appliance includes a siphon break apparatus configured to substantially prevent a siphon effect in a fluid conduit configured to drain fluid from the dishwasher or other washing appliance. The siphon break apparatus may include a body portion that may be divided by a filter into a filter chamber and a flow chamber. The filter chamber may extend perpendicularly from the flow chamber. An aperture may be defined in the filter chamber and sealed shut by a domed closure of a normally-closed umbrella valve. The domed closure may unseal from the aperture and thereby allow air to enter the filter chamber, travel through the filter and into the flow chamber so as to relieve a low pressure region and substantially prevent a siphon effect in the fluid conduit. A related method is also provided. | 01-31-2013 |
Jason M. Patterson, Trenton, NC US
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20100122715 | SCREENING ARRANGEMENT FOR A DISHWASHING APPLIANCE, AND ASSOCIATED APPARATUS - A screening arrangement for screening washing fluid in a dishwashing appliance is provided. Such a screening arrangement comprises intersecting wall members forming a latticework structure, defining opposing inlet and outlet planes, for receiving the washing fluid therethrough. The wall members have inlet and outlet ends disposed toward the respective inlet and outlet planes. The wall member inlet ends, in cross section, have a non-planar apex portion tapering toward the outlet plane. A circumferential member extends about a periphery of the latticework structure, and at least a portion of the circumferential member is sloped toward the latticework structure so as to direct washing fluid received thereby toward the latticework structure. An associated apparatus is also provided. | 05-20-2010 |
Jeremy Christin Patterson, Greensboro, NC US
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20080233784 | Connector assembly with cavity sealing plug - An electrical connector is shown having a housing having terminal receiving passageways, which receives a plurality of electrical terminals therein. The connector housing has a rear wire seal having a plurality of apertures at a rear face thereof for receiving terminals and a terminated conductor therethrough. At least one of the plurality of electrical terminal passageways is empty, and the sealing plug is positioned in the terminal receiving passageway to seal the cavity from the rear side thereof. The sealing plug also includes a latching surface for latching with the latch of the housing, and further provides a forward portion to deflect an installed shunt downwardly to prevent stubbing of a pin contact of a mating connector. | 09-25-2008 |
20080233790 | Electrical connector having lever with protective shroud - An electrical connector assembly is shown having a housing member with a lever assist which rotatably draws complimentary connectors together. The lever assist is attached by way of mounting studs to a shroud on each side of the sidewall of the connector housing where the lever arms are positioned within the shroud to protect the lever arms and the gear teeth on the free ends of the lever arms. | 09-25-2008 |
Joan Diana Patterson, Wilmington, NC US
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20140294355 | LARGE EFFECTIVE AREA FIBER WITH LOW BENDING LOSSES - A fiber having a large effective area at 1550 nm of at least 130 μm | 10-02-2014 |
20140328566 | OPTICAL FIBER WITH LARGE MODE FIELD DIAMETER AND LOW MICROBENDING LOSSES - Optical fibers having a mode field diameter at 1310 nm of at least 8.8 μm, wire mesh covered drum microbending losses at 1550 nm less than 0.03 dB/km, and a 2 m cutoff wavelength less than 1320 nm. The fibers may include a central core region, an inner cladding region, an outer cladding region, a primary coating with an in situ modulus less than 0.20 MPa and glass transition temperature less than −35° C., and a secondary coating with an in situ modulus greater than 1500 MPa. The fibers may further include a depressed index cladding region. The relative refractive index of the central core region may be greater than the relative refractive index of the outer cladding region may be greater than the relative refractive index of the inner cladding region. The fibers may be produced at draw speeds of 30 m/s or greater. | 11-06-2014 |
Josh Patterson, Raleigh, NC US
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20090282469 | AIRCRAFT COMMUNICATIONS SYSTEM USING WHITELISTS TO CONTROL ACCESS AND ASSOCIATED METHODS - A communications system for an aircraft carrying personnel having personal electronic devices (PEDs) includes a wireless access device in the aircraft for the PEDs, and an aircraft server in the aircraft cooperating with the wireless access device for determining airborne validation of a ground server address entered via a corresponding PED. An air-to-ground transceiver in the aircraft cooperates with the aircraft server for communicating over an air-to-ground interface the airborne validated ground server address. A ground server on the ground receives the airborne validated ground server address over the air-to-ground interface, determines ground validation of the airborne validated ground server address, and provides ground access for the corresponding PED for which the entered ground server address has both airborne and ground validation. | 11-12-2009 |
Joshua Patterson, Raleigh, NC US
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20130210387 | AIRCRAFT COMMUNICATIONS SYSTEM USING WHITELISTS TO CONTROL ACCESS AND ASSOCIATED METHODS - A communications system for an aircraft carrying at least one person having a personal electronic device (PED) includes an aircraft server in the aircraft for determining airborne validation of a ground server address entered via a corresponding PED, and a transceiver in the aircraft cooperating with the aircraft server for communicating using the airborne validated ground server address. A ground server on the ground is for determining ground validation of the airborne validated ground server address, and provides ground access for the corresponding PED for which the entered ground server address has both airborne and ground validation. | 08-15-2013 |
Justin Allen Patterson, Morrisville, NC US
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20160072706 | Adaptive Private Network with Dynamic Conduit Process - Systems and techniques, including special messages and state machines, are described that configures an intermediate site to dynamically trigger creation of and removal of a dynamic conduit between two sites based on usage that is tracked at the sites. The intermediate site providing WAN-to-WAN forwarding between the two sites, monitors throughput statistics on each local WAN link (LWL) associated with the two sites. If traffic between the two sites passes a configured first threshold or if LWL usage passes a configured second threshold, the intermediate site sends a message to the two sites to set up a dynamic conduit directly coupling the two sites. Busy lists are used to keep track of eligible site pairs. Once a dynamic conduit is set up between two sites, a grow technique tests the dynamic conduit increasing communication flows between the two sites each configured sampling period before putting the conduit in normal use. | 03-10-2016 |
Kip Errett Patterson, Raleigh, NC US
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20090124920 | BIOFEEDBACK DEVICES, SYSTEMS AND METHOD - Biofeedback devices, systems, and methods for training enhanced performance are provided. A subject's EEG activity can be measured and analyzed, and a feedback signal can provide ongoing, continuous information regarding the subject's success in maintaining the brain's activity within a predetermined, desired state of enhanced performance. There are specific EEG patterns that maintain states of enhanced performance. The differential reduction and enlargement of the amplitudes of the various frequencies at specific sites that produce states of enhanced performance are measured. For example, enhanced performance can be produced when theta activity (4-8 Hz) and low-alpha activity (8-10 Hz) are maintained below a low-activity threshold while maintaining gamma activity (38-42 Hz) above a performance threshold amplitude (e.g., 0.5 microvolts). Additionally, positive feedback can also be withheld unless the subject maintains high-alpha activity (11-13 Hz) above a staging threshold value. The threshold settings used can be varied to target greater degrees of proficiency. | 05-14-2009 |
Richard M. Patterson, Hendersonville, NC US
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20140027487 | Drywall Corner Bead Nailer and Method - The invention is a dual head mechanical nailer and method capable of driving a pair of nails, screws, staples, or other forms of attachments into a drywall corner bead at an offset orientation and at an angle where each of the attachment means is ninety degrees from the other. The nailer can be powered by combustible fuel, by pneumatic power, by electric power supplied by a battery, or by electric power supplied by an electrical service connection. A magazine of nails, screws, staples, or other forms of attachments may be attached to each head of the mechanical nailer for supplying the respective head with the respective attachment. | 01-30-2014 |
Ryan L. Patterson, Mebane, NC US
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20100194013 | CNC MATERIAL PROCESSING SYSTEM WITH WORKPIECE TRAVEL - A CNC system including a travelling drive bar assembly for support of material to be processed. A CNC system including a cutting tool operates on a work piece in at least three axes, with a gantry across the machine that a carriage moves along and a tool that moves vertically on the carriage. A drive bar, oriented perpendicularly to the gantry and to a vertical axis, may travel to support and move the workpiece along its line of orientation. The drive bar may include an elongated structural member, two tracks mounted longitudinally to the elongated member on opposite sides of the elongated member, and a rack, adapted to accept a pinion to urge the drive bar to move, also mounted longitudinally to the elongated member. Guide wheels may receive the tracks to support and align the drive bar. Rollers may further support material that is mounted to the drive bar. | 08-05-2010 |
Steven R. Patterson, Concorde, NC US
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20120212745 | WIDE DYNAMIC RANGE INTERFEROMETRIC TRANSDUCER WITH DIVERGENT BEAM - An apparatus and method for estimating a parameter of interest using values of a beam property from two or more electromagnetic beams that both pass through at least part of an optical displacement device. The apparatus may include a Fabry-Perot interferometer, a collimated light source, and a detection array. At least one mirror of the interferometer may be operably coupled to an element receiving an external stimulus, such as pressure, force, and/or acceleration. The method includes using the apparatus. | 08-23-2012 |