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| 20090069247 | USE OF TIGHT JUNCTION ANTAGONISTS TO TREAT INFLAMMATORY BOWEL DISEASE - The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents. | 03-12-2009 |
| 20090176244 | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS OF CROHN'S DISEASE - The present invention provides methods and materials, including kits, to evaluate Crohn's disease, including to diagnose, monitor, or determine the efficacy of treatment for Crohn's Disease. The methods involve determining the presence, absence, or level of zonulin in a subject sample. In certain embodiments, the need for more laborious and/or invasive tests to monitor disease state is minimized or obviated. | 07-09-2009 |
| 20090297559 | USE OF TIGHT JUNCTION AGONISTS TO FACILITATE PULMONARY DELIVERY OF THERAPEUTIC AGENTS - The present invention provides materials and methods to facilitate the pulmonary delivery of therapeutic agents. In some embodiments, agonists of tight junctions (e.g., zonulin agonists) are used in compositions to facilitate the uptake of therapeutic agents from the pulmonary mucosa. | 12-03-2009 |
| 20100144646 | METHOD OF DIAGNOSING AND TREATING ASTHMA - The present invention provides materials and methods to diagnose asthma. In some embodiments, the present invention provides a method of diagnosing asthma by measuring the zonulin level of a subject. The present invention also provides methods and compositions for treating asthma that comprise one or more zonulin antagonist. | 06-10-2010 |
| 20100279954 | METHOD FOR TREATING CELIAC DISEASE - Enteric compositions comprising one or more tight junction agonists and/or one or more tight junction antagonists are provided. Compositions of the invention may comprise a delayed-release coating disposed over a tight junction agonist and/or tight junction antagonist layer which may be disposed over an inert core. Delayed-release coatings may be substantially stable in gastric fluid and substantially unstable in intestinal fluid, thus providing for substantial release of the tight junction agonist and/or antagonist from the composition in the duodenum or jejunum of the small intestine. | 11-04-2010 |
| 20110136747 | USE OF TIGHT JUNCTION ANTAGONISTS TO TREAT INFLAMMATORY BOWL DISEASE - The present invention provides materials and methods for the treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis). Materials of the invention may include compositions comprising one or more tight junction antagonists and optionally one or more therapeutic agents. Methods of the invention may comprise treating a subject in need thereof with a composition comprising one or more tight junction antagonists and, optionally one or more therapeutic agents. | 06-09-2011 |
| 20110142881 | TRANSCUTANEOUS DELIVERY OF THERAPEUTIC AGENTS - The present invention provides materials and methods to facilitate the transcutaneous delivery of therapeutic agents. In some embodiments, agonists of tight junctions are used in compositions to facilitate the uptake of therapeutic agents from the skin. In a particular embodiment, the present invention provides immunogenic compositions comprising a tight junction agonist and an antigen. In a particular embodiment, the present invention provides vaccine compositions comprising a tight junction agonist and an antigen. | 06-16-2011 |
| 20110201543 | USE OF TIGHT JUNCTION ANTAGONISTS IN THE TREATMENT OF ACUTE LUNG INJURY AND ACUTE RESPIRATORY DISTRESS - The present application provides compositions and methods for treating acute lung injury and acute respiratory distress syndrome. The methods include administering one or more tight junction antagonists to the lung of a subject in need thereof. | 08-18-2011 |
| 20120076861 | MATERIALS AND METHODS FOR THE TREATMENT OF CELIAC DISEASE - The present invention provides materials and methods for the treatment of celiac disease. In addition, the present invention provides materials and methods of monitoring the treatment of a subject having celiac disease. | 03-29-2012 |
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| 20090126687 | Split-Flow Pre-Filming Fuel Nozzle - Presented is a pre-filming fuel nozzle that is readily manufacturable and consists of a fuel injector, a nozzle insert that fits over the fuel injector outlet, and a housing that generally encloses the fuel injector and nozzle insert. The housing has an atomizing lip, a fuel inlet passage, and an air passage. The nozzle insert has openings near the fuel injector that allows air to flow into the insert. During operation, the fuel injector impinges fuel on an inner surface of the insert and is pulled towards the atomizing lip from air flow through the insert. The air flow through the insert and air flow through the housing join at the atomizing lip, resulting in air flows shearing fuel droplets off of the atomizing lip. The nozzle may have swirler means such as a swirler fin and/or swirler passages on the insert to aid in swirling the air flow. | 05-21-2009 |
| 20090255242 | Low Pressure Drop Mixer for Radial Mixing of Internal Combustion Engine Exhaust Flows, Combustor Incorporating Same, and Methods of Mixing - An exhaust aftertreatment system is provided. The exhaust aftertreatment system includes a mixing arrangement for mixing flows of exhaust along a flow path. The mixing arrangement radially and angularly rearranges segments of two different portions of flow to mix the different portions of flow. The mixing arrangement initially converts a generally radially stratified temperature profile into an angularly stratified temperature profile to increase surface area between cool segments of exhaust gas and hot segments of exhaust gas. The aftertreatment system may also include a combustion chamber, a combustor housing and a combustor liner. The mixing arrangement is downstream from the combustion chamber to direct radially outward hot gas passing through the combustor liner and to direct radially outer cool gas passing between the liner and the combustor housing radially inward in an interleaving fashion. | 10-15-2009 |
| 20100242449 | System and Method for Filtering Diesel Engine Exhaust Particulates - A diesel particulate filtering system that includes a filter configured to capture exhaust particulates from a diesel engine, a regeneration device configured to heat exhaust gases from the diesel engine prior to the exhaust gases reaching the filter, and a controller configured to control operation of the regeneration device, wherein the controller is further configured to turn the regeneration device on when a weighted average of a plurality of normalized parameter values exceeds a threshold value. | 09-30-2010 |
| 20110000193 | SYSTEM AND METHOD FOR DETECTING DIESEL PARTICULATE FILTER CONDITIONS BASED ON THERMAL RESPONSE THEREOF - Systems and methods to determine conditions of a diesel particulate filter (DPF) based on correlation between predicted and actual thermal data of the fluid exiting a DPF are provided. Soot loading, ash loading, and/or DPF damage may be detected, and DPF operational models may be calibrated in accordance with such systems and methods. Further, initiation of regeneration may also be effected in accordance with such systems and methods. | 01-06-2011 |
| 20110062973 | Surface Gap Soot Sensor for Exhaust - A method and apparatus for sensing particulates within an exhaust flow are provided. The methods and apparatus utilize a soot sensor that includes opposed electrodes separated by an insulator. Preferably, a gap is formed between the electrodes and the insulator to prevent electrical current from flowing therebetween. The soot sensor, when positioned in an exhaust flow, will accumulate a layer of particulates on an outer surface thereof. As the layer of particulates increases the particulates will bridge the two electrodes permitting current flow. The sensor is configured with a proper geometry and potential difference between the electrodes to generate currents in the milli-amp range. Further, the sensor is configured to have a regenerative effect that causes the bridge to be broken when particles sees to impinge the soot sensor. | 03-17-2011 |
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| 20090117322 | MULTIFUNCTIONAL ELECTROMAGNETIC SHIELDING - A method of manufacturing a multifunctional shielding mat for an interior of a vehicle is provided. The method includes providing at least one sheet of dampening material, coupling at least one sheet of electromagnetic shielding material to the at least one sheet of dampening material, and configuring the multifunctional shielding mat to cover a predetermined area of the vehicle. | 05-07-2009 |
| 20090127855 | ELECTRICAL SYSTEMS ARCHITECTURE FOR AN AIRCRAFT, AND RELATED OPERATING METHODS - An electrical architecture for an aircraft is provided. The electrical architecture is particularly suitable for relatively small, compact, and lightweight aircraft. In one embodiment, the electrical architecture includes an electrical generator component coupled to the aircraft engine, and an air compression system coupled to the electrical generator component. The electrical generator component is configured to receive mechanical power from the engine and to generate a constant frequency AC electrical power from the engine mechanical power, and the air compression system is configured to receive the constant frequency AC power as an input and, in response thereto, produce a pressurized air output having variable characteristics (for example, a variable flow rate or a variable air pressure). | 05-21-2009 |
| 20100148719 | Power Control For Induction Motors Using Variable Frequency AC Power - An autonomous controller allows an AC induction motor to operate over a broad range of AC power supply frequencies by reducing the amount of current supplied to the motor at lower frequencies. The controller detects the frequency of the power supply and switches the supply current on and off during each AC cycle to limit the RMS current to a value that is related to the detected frequency. Alternatively, the controller switches capacitive reactance into the power supply circuit which reduces the current supplied to the motor at lower AC frequencies. | 06-17-2010 |
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| 20080229240 | Finding Pages Based on Specifications of Locations of Keywords - A palette is displayed that includes widgets. A specification of a first widget selected from among the widgets in the palette is received along with a first widget location, a keyword, and a keyword location. Pages are found that, when rendered, include a term located at a term location and an element located at a respective element location, where the term matches the keyword and the element matches the first widget. In various embodiments, the identifiers of the pages are sorted based on distances between the first widget location and the element location, distances between the keyword location and the term location, differences between widths and heights of the first widget and the element, and/or based on matches between the visual attribute for the first widget and a visual characteristic for the element. | 09-18-2008 |
| 20090083224 | SUMMARIZING DATA REMOVED FROM A QUERY RESULT SET BASED ON A DATA QUALITY STANDARD - A method, article of manufacture and apparatus for graphically summarizing the data in an initial query result set, including when rows are removed from the result set by applying a data quality standard is disclosed. When a user selects to change the data quality standard, a group of target rows are identified and removed from the user's display. A bitmap is generated to graphically represent the location of each row in the initial result set, including removed rows. A bitmap to summarize the data values for one or more columns in the initial result set may also be created. Thus, a user may quickly obtain an intuitive view of what the data looks like, without the need for complex analysis or graphing packages. | 03-26-2009 |
| 20110016410 | Aging and Elimination of Avatars and Associated Objects from Computer Simulated Displayed Virtual Universes - Aging of avatars and objects toward eventual removal or removal from the displayed virtual universe through enabling the setting of defined parameters for the aging of said avatars and objects toward eventual removal of said avatars and objects from said virtual universe space; and predetermining a set of events, the occurrence of any one of which events would modify the aging of selected avatars and objects. | 01-20-2011 |
| 20110066860 | Virtual World Embedded Security Watermarking - A method, apparatus, and program product are provided for using watermarks to embed security features on avatars in a virtual world. A watermark engine receives security information for an avatar in a virtual world. The watermark engine creates a watermark for the avatar using the security information and associates the watermark with the avatar. The watermark may comprise at least one of: security preferences for the avatar, contact information for an owner of the avatar, and graphical information to cause alteration of the avatar when the avatar is recorded. | 03-17-2011 |
| 20110270817 | WEB SERVICE DISCOVERY VIA DATA ABSTRACTION MODEL AUGMENTED BY FIELD RELATIONSHIP IDENTIFICATION - A computer-implemented method includes receiving a selection of a particular logical field via a database query interface. The method includes querying a discovery registry associated with a data abstraction model of a database to discover one or more web services that are resolvable based on the particular logical field. The data abstraction model includes a plurality of logical fields, where each logical field corresponds to a particular data structure of the database. A web service input and a web service output of a particular discovered web service are associated with logical fields of the data abstraction model via the discovery registry. The method further includes initiating execution of a discovered web service that returns a list of values. The list of values obtained by the discovered web service may be augmented with information determined based on field relationship metadata of the data abstraction model, where the field relationship metadata corresponds to the list of values. | 11-03-2011 |
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| 20080241069 | Methods and compositions for treating IgE-mediated diseases - This invention provides recombinant peptides comprising a fragment of an IgE constant region, nucleotide molecules encoding same, recombinant vaccine vectors comprising same, and methods for inducing immune response and treating allergy, asthma and IgE mediated disease comprising same. | 10-02-2008 |
| 20090081248 | Non-hemolytic LLO fusion proteins and methods of utilizing same - The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest. | 03-26-2009 |
| 20090081250 | Compositions and methods for treatment of cervical cancer - The present invention provides methods of treating, protecting against, and inducing immune response against cervical cancer, comprising the step of administering to a sub recombinant | 03-26-2009 |
| 20090186051 | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof - This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant | 07-23-2009 |
| 20090202587 | COMPOSITIONS COMPRISING HMW-MAA AND FRAGMENTS THEREOF, AND METHODS OF USE THEREOF - This invention provides recombinant polypeptides comprising a fragment of a High Molecular Weight Melanoma-Associated Antigen (HMW-MAA), recombinant | 08-13-2009 |
| 20100291140 | ANTIBIOTIC RESISTANCE FREE LISTERIA STRAINS AND METHODS FOR CONSTRUCTING AND USING SAME - The present invention provides | 11-18-2010 |
| 20110223187 | LIVE LISTERIA-BASED VACCINES FOR CENTRAL NERVOUS SYSTEM THERAPY - This invention is directed to methods for treating a central nervous system (CNS) tumor or cancer using live | 09-15-2011 |
| 20110305724 | IMMUNOTHERAPEUTIC, ANTI-TUMORIGENIC COMPOSITIONS AND METHODS OF USE THEREOF - This invention relates to immunotherapeutic vaccine composition comprising an ISG15 tumor antigen and to methods of preventing and treating a tumor growth by using said immunotherapeutic composition. | 12-15-2011 |
