Parunak
Gene Parunak, Ann Arbor, MI US
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20100197008 | PROCESSING PARTICLE-CONTAINING SAMPLES - A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof. | 08-05-2010 |
Gene Parunak, Saline, MI US
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20100173393 | MICROFLUIDIC VALVE AND METHOD OF MAKING SAME - The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve. | 07-08-2010 |
20110303343 | MICROFLUIDIC BONDING TECHNOLOGY - The invention is directed to forming a bond between dissimilar polymer surfaces. By providing one substrate that comprises a vinyl acetate polymer, and then by modifying the surface energy of that substrate, that substrate may be advantageously bonded with a second polymer substrate having a surface whose surface energy has been modified. In one example, the first substrate is a rigid substrate, while the second substrate is a flexible membrane that is comprised of a thermoplastic elastomer and a vinyl acetate. | 12-15-2011 |
20130071851 | MOVING MICRODROPLETS IN A MICROFLUIDIC DEVICE - The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which fluid flows, and a plurality of gas actuators integral with the substrate. One such gas actuator is coupled to the network at a first location for providing gas pressure to move a microfluidic sample within the network. Another gas actuator is coupled to the network at a second location for providing gas pressure to further move at least a portion of the microfluidic sample within the network. A valve is coupled to the microfluidic network so that, when the valve is closed, it substantially isolates the second gas actuator from the first gas actuator. | 03-21-2013 |
20140212882 | PROCESSING PARTICLE-CONTAINING SAMPLES - A microfluidic device includes an input port for inputting a particle-containing liquidic samples into the device, a retention member, and a pressure actuator. The retention member is in communication with the input port and is configured to spatially separate particles of the particle-containing liquidic sample from a first portion of the liquid of the particle containing fluidic sample. The pressure actuator recombines at least some of the separated particles with a subset of the first portion of the liquid separated from the particles. The device can also include a lysing chamber that receives the particles and liquid from the retention member. The lysing chamber thermally lyses the particles to release contents thereof. | 07-31-2014 |
20150038925 | NOZZLE - A nozzle is provided herein for ophthalmic dispensers which is configured to accommodate microdosing. The nozzle includes a converging pathway. Preferably, the pathway converges so as to impart momentum to liquid passing therethrough through an increase of velocity. A tapered portion may be provided flared openly from the inlet to best accept liquid flow thereinto and provide a funneling effect into the flowpath. Preferably, the flowpath terminates at an outlet which is internally un-radiused and circumscribed by a chamfered surface. | 02-05-2015 |
20150064702 | MICROFLUIDIC VALVE AND METHOD OF MAKING SAME - The present technology provides for a microfluidic substrate configured to carry out PCR on a number of polynucleotide-containing samples in parallel. The substrate can be a single-layer substrate in a microfluidic cartridge. Also provided are a method of making a microfluidic cartridge comprising such a substrate. Still further disclosed are a microfluidic valve suitable for use in isolating a PCR chamber in a microfluidic substrate, and a method of making such a valve. | 03-05-2015 |
Gene Parunak US
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20090202369 | Methods and Systems for Fluid Control - A magnetically coupled fluid actuator for microfluidic applications which affords the actuated fluid some degree of separation from the drive mechanism, increasing biocompatibility and making part of the device potentially disposable. | 08-13-2009 |
Gene P. Parunak, Saline, MI US
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20130274740 | SURGICAL INSTRUMENT FOR TISSUE REMOVAL - An electrosurgical instrument for removal of tissue from a patient. The electrosurgical instrument includes a handle portion having a pair of end effectors configured to remove tissue, connected to and supported by the handle portion for relative movement generally toward one another. One of the end effectors includes a conductive cutting portion that is configured to receive electrical energy from an electrical energy source. The other of the end effectors includes an opposing portion. The opposing portion is brought into a position generally opposing the conductive cutting portion during relative movement of the end effectors toward one another. When electrical energy is conducted through the conductive cutting portion, removal and cauterization of the tissue from the patient is facilitated. | 10-17-2013 |
20140121662 | SURGICAL METHOD FOR TISSUE REMOVAL - A method for removal of tissue from a patient utilizing an electrosurgical instrument. The electrosurgical instrument includes a handle portion having a pair of end effectors configured to remove tissue, connected to and supported by the handle portion for relative movement generally toward one another. One of the end effectors includes a conductive cutting portion that is configured to receive electrical energy from an electrical energy source. The other of the end effectors includes an opposing portion. The opposing portion is brought into a position generally opposing the conductive cutting portion during relative movement of the end effectors toward one another. When electrical energy is conducted through the conductive cutting portion, removal and cauterization of the tissue from the patient is facilitated. | 05-01-2014 |
20150038964 | SURGICAL INSTRUMENT - An electrosurgical instrument for removal of tissue from a patient and a method for doing the same. The electrosurgical instrument includes a pair of lever members each of which having an associated end effector associated. One of the end effectors includes a cutting element forming a loop on the end of the end effector. The cutting element is also configured to receive electrical energy from an electrical energy source. The other of the end effectors includes a pad that can be brought into a position generally opposing the cutting element during relative movement of the end effectors toward one another. When electrical energy is discharged from the cutting element and the end effectors moved toward one another, dissection and cauterization of tissue from a patient is facilitated. | 02-05-2015 |
Henry Van Dyke Parunak, Ann Arbor, MI US
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20120284269 | HIERARCHICAL ANT CLUSTERING AND FORAGING - A clustering method yields a searchable hierarchy to speed retrieval, and can function dynamically with a changing document population. Nodes of the hierarchy climb up and down the emerging hierarchy based on locally sensed information. Like previous ant clustering algorithms, the inventive process is dynamic, decentralized, and anytime. Unlike them, it yields a hierarchical structure. For simplicity, and reflecting our initial application in the domain of textual information, the items being clustered are documents, but the principles may be applied to any collection of data items. | 11-08-2012 |
H. Van Dyke Parunak, Ann Arbor, MI US
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20110178978 | CHARACTERIZING AND PREDICTING AGENTS VIA MULTI-AGENT EVOLUTION - A method of predicting the behavior of software agents in a simulated environment involving modeling a plurality of software agents representing entities to be analyzed, which may be human beings. Using a set of parameters that governs the behavior of the agents, the internal state of at least one of the agents is estimated by its behavior in the simulation, including its movement within the environment. This facilitates a prediction of the likely future behavior of the agent based solely upon its internal state; that is, without recourse to any intentional agent communications. In one embodiment, the simulated environment is based upon a digital pheromone infrastructure. The simulation integrates knowledge of threat regions, a cognitive analysis of the agent's beliefs, desires, and intentions, a model of the agent's emotional disposition and state, and the dynamics of interactions with the environment. | 07-21-2011 |