Patent application number | Description | Published |
20090013416 | PDES AS MODIFIERS OF THE IGFR PATHWAYS AND METHODS OF USE - Human PDE genes are identified as modulators of the IGFR pathway and thus are therapeutic targets for disorders associated with defective IGFR function Methods for identifying modulators of IGFR comprising screening for agents that modulate the activity of PDE are provided | 01-08-2009 |
20090025096 | P4HAS AS MODIFIERS OF THE IGFR PATHWAY AND METHODS OF USE - Human P4HA genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of P4HA are provided. | 01-22-2009 |
20090028844 | GALNTS AS MODIFIERS OF THE IGFR PATHWAY AND METHODS OF USE - Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided. | 01-29-2009 |
20090142272 | Pfks as modifiers of the igfr pathway and methods of use - Human PFK genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of PFK are provided. | 06-04-2009 |
20090202563 | C20ORF23 as modifier of the IGFR pathway and methods of use - Human C20ORF23 genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of C20ORF23 are provided. | 08-13-2009 |
20130212716 | PFKs as Modifiers of the IGFR Pathway and Methods of Use - Human PFK genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of PFK are provided. | 08-15-2013 |
Patent application number | Description | Published |
20100132374 | TURBINE FRAME ASSEMBLY AND METHOD FOR A GAS TURBINE ENGINE - A turbine frame assembly for a gas turbine engine includes: (a) a turbine frame including: (i) an outer ring; (ii) a hub; (ii) a plurality of struts extending between the hub and the outer ring; (b) a two-piece strut fairing surrounding each of the struts, including: (i) an inner band; (ii) an outer band; and (iii) an airfoil-shaped vane extending between the inner and outer bands; (d) a plurality of nozzle segments disposed between the outer ring and the hub, each nozzle segment being an integral metallic casting including: (i) an arcuate outer band; (ii) an arcuate inner band; and (ii) an airfoil-shaped vane. | 06-03-2010 |
20100135786 | INTEGRATED SERVICE TUBE AND IMPINGEMENT BAFFLE FOR A GAS TURBINE ENGINE - A service tube apparatus for a gas turbine engine includes a service tube assembly having: (a) an elongated, hollow service tube; and (b) a service tube baffle surrounding the service tube which is pierced with a plurality of impingement cooling holes. | 06-03-2010 |
20100154433 | TURBINE COOLING AIR FROM A CENTRIFUGAL COMPRESSOR - A gas turbine engine turbine cooling system includes an impeller and a diffuser directly downstream of the impeller, a bleed for bleeding clean cooling air from downstream of the diffuser, and one or more channels in fluid communication with the bleed. Each of the channels having a generally radially extending section followed by a generally axially aftwardly extending section terminating at an annular cooling air plenum connected to accelerators. The radially and axially aftwardly extending sections may be connected by a bend section of the cooling air channel and the axially aftwardly extending section may be angled radially inwardly going from the bend section to the cooling air plenum. Each of the cooling channels includes an inner wall formed by a forward end wall extending radially outwardly from an inner combustor casing, an annular cover covering a radially inner portion of the forward end wall, and the inner combustor casing. | 06-24-2010 |
20100158668 | CENTRIFUGAL COMPRESSOR FORWARD THRUST AND TURBINE COOLING APPARATUS - A gas turbine engine centrifugal compressor axial forward thrust apparatus bleeds impeller tip aft bleed flow from between an annular centrifugal compressor impeller of a high pressure rotor and a diffuser directly downstream of the impeller. The apparatus then uses the aft bleed flow to pressurize an annular cavity extending radially between an inner combustor casing and the rotor and extending axially between forward and aft thrust balance seals. Forward and aft thrust balance lands are in sealing engagement with the forward and aft thrust balance seals on the high pressure rotor respectively. An annular stator plenum in fluid communication with the annular cavity is bounded in part by a forward end wall having conical diffusion holes therethrough which may be axially or circumferentially or axially and circumferentially angled. The forward thrust balance seal may be on an aft conical arm of the impeller. | 06-24-2010 |
20100319352 | PRECHORDED TURBINE NOZZLE - A turbine nozzle includes radially inner and outer bands integrally joined to opposite ends of an airfoil. The outer band has forward and aft hooks extending radially outwardly at axially opposite ends. And the hooks have different prechorded circumferential curvatures. | 12-23-2010 |