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Park, MA

Alex Park, Watertown, MA US

Patent application numberDescriptionPublished
20090132252Unsupervised Topic Segmentation of Acoustic Speech Signal - Disclosed methods and apparatus segment a signal, such as an acoustic speech signal, into coherent segments, such as coherent topics. In the case of an acoustic speech signal, the segmentation relies on only raw acoustic information and may be performed without requiring access to, or generation of, a transcript of the acoustic speech signal. Recurring acoustic patterns are found by matching pairs of sounds, based on acoustic similarity. Information about distributional similarity from multiple local comparisons is aggregated and is further processed to fill gaps in the data by growing regions that represent recurring acoustic patterns. Selection criteria are used to identify coherent topics represented by the grown regions and topic boundaries therebetween. Another signal, such as a video signal, may be partitioned according to topic boundaries identified in an acoustic speech signal that is related to the video signal. Other (non-acoustic) one-dimensional signals, such as electrocardiogram (EKG) signals, may be automatically segmented into parts, such as parts that relate to normal and to abnormal heart beats.05-21-2009

Boris Hyle Park, Somerville, MA US

Patent application numberDescriptionPublished
20120127476PROCESS, SYSTEM AND SOFTWARE ARRANGEMENT FOR DETERMINING AT LEAST ONE LOCATION IN A SAMPLE USING AN OPTICAL COHERENCE TOMOGRAPHY - A system, process and software arrangement are provided to determine at least one position of at least one portion of a sample. In particular, information associated with the portion of the sample is obtained. Such portion may be associated with an interference signal that includes a first electro-magnetic radiation received from the sample and a second electro-magnetic radiation received from a reference. In addition, depth information and/or lateral information of the portion of the sample, may be obtained. At least one weight function can be applied to the depth information and/or the lateral information so as to generate resulting information. Further, a surface position, a lateral position and/or a depth position of the portion of the sample may be ascertained based on the resulting information.05-24-2012

Chan Young Park, Cambridge, MA US

Patent application numberDescriptionPublished
20110091922Bio-Matrix Stretcher - Embodiments provide techniques for measuring and characterizing the dynamics of cell traction forces. Tunable elastic gel substrates can be disposed in multi-well plates. The gels can be of a uniform predetermined thickness. A multi-well plate can be loaded with gels of different shear moduli. An array of punch indenters can be attached to a loading platen such that the each indenter is aligned to a gel substrate. The indenters can apply tensile or compressive strains to the gel substrates. The magnitude, duration, and frequency of the strain can be controlled by a motor assembly coupled to a control system. The apparatus can be disposed in an incubator for long term cell culture experiments. The cell culture can be observed while a strain is applied. A ring-shaped indenter can be mounted on a microscope, coaxial to the objective lens, and lowered by a calibrated amount onto the underlying gel.04-21-2011

Edward Park, Waltham, MA US

Patent application numberDescriptionPublished
20090192821Medical image annotation - Incorporating new technology into an existing medical practice is often difficult. Documents associated with a patient, for example, a patient's medical charts, are typically provided physically, i.e., as “hard copies,” when a patient is being serviced by multiple health care providers Disclosed are means for electronically annotating an image associated with a patient workflow. In one implementation, there is a method that includes receiving an image via a communications network, presenting the image to a user, and capturing an annotation made to the image by the user. The annotations and the image to a medical practice management server via the communications network and the annotated image is stored as part of a patient medical record.07-30-2009

Edward H. Park, Sharon, MA US

Patent application numberDescriptionPublished
20090013484Gum Massaging Oral Brush - A toothbrush including a head having an elastomeric support member is described herein. The elastomeric support member supports a plurality of upstanding projections. At least a portion of the upstanding projections include non-elastomeric projections and elastomeric projections.01-15-2009

Patent applications by Edward H. Park, Sharon, MA US

Eun Sun Park, Arlington, MA US

Patent application numberDescriptionPublished
20110319277PRPK-TPRKB MODULATORS AND USES THEREOF - The present invention provides methods of identifying an agent that modulates PRPK, TPRKB, OSGEP, LAGE3 and its homologs, PRPK/TPRKB complex, and/or KEOPS complex. The present invention also provides compositions of such agents and methods of treating a disease, disorder, or condition associated with PRPK, TPRKB, OSGEP, LAGE3 and its homologs family (CT antigens), PRPK/TPRKB complex, and/or KEOPS complex using such an agent or composition.12-29-2011

Ga Young Park, Cambridge, MA US

Patent application numberDescriptionPublished
20130029959COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER - The present invention relates to compositions, kits, and methods for treatment of cancers. In some cases, the composition comprises a platinum compound comprising a phenanthridine ligand.01-31-2013

Hee-Young Park, Weston, MA US

Patent application numberDescriptionPublished
20090053707Methods for lightening skin and hair - Methods are described wherein the skin of a vertebrate, or the skin or hair of a mammal can be lightened by administration of an agent, e.g., protein, peptide, active fusion protein, active fragment, or molecular mimic, that binds to BMP-4 transmembrane receptors on melanocytes and decreases the level of melanin synthesis. Also described are methods to identify molecules that mimic the function of BMP-4 in causing a decrease in melanin in melanocytes.02-26-2009

Hongkun Park, Cambridge, MA US

Patent application numberDescriptionPublished
20100022012NANOSENSORS - Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized. Nanodetector devices are described.01-28-2010
20120094382MOLECULAR DELIVERY WITH NANOWIRES - A molecular delivery system including a plurality of nanowires (e.g., Si NWs), each of the nanowires having a surface layer formed of a silicon-containing material and a covalently bound linker (e.g., silane linker) attached to the surface layer and optionally including a substrate to which the nanowires are adhered or a molecule to be delivered attached to the linker. Also disclosed is a method of delivering into a cell an exogenous molecule.04-19-2012

Hongkun Park, Lexington, MA US

Patent application numberDescriptionPublished
20080211040NANOSENSORS - Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized. Nanodetector devices are described.09-04-2008
20090057650Nanoscale wires and related devices - The present invention relates generally to sub-microelectronic circuitry, and more particularly to nanometer-scale articles, including nanoscale wires which can be selectively doped at various locations and at various levels. In some cases, the articles may be single crystals. The nanoscale wires can be doped, for example, differentially along their length, or radially, and either in terms of identity of dopant, concentration of dopant, or both. This may be used to provide both n-type and p-type conductivity in a single item, or in different items in close proximity to each other, such as in a crossbar array. The fabrication and growth of such articles is described, and the arrangement of such articles to fabricate electronic, optoelectronic, or spintronic devices and components. For example, semiconductor materials can be doped to form n-type and p-type semiconductor regions for making a variety of devices such as field effect transistors, bipolar transistors, complementary inverters, tunnel diodes, light emitting diodes, sensors, and the like.03-05-2009
20100155698Nanoscale wires and related devices - The present invention relates generally to sub-microelectronic circuitry, and more particularly to nanometer-scale articles, including nanoscale wires which can be selectively doped at various locations and at various levels. In some cases, the articles may be single crystals. The nanoscale wires can be doped, for example, differentially along their length, or radially, and either in terms of identity of dopant, concentration of dopant, or both. This may be used to provide both n-type and p-type conductivity in a single item, or in different items in close proximity to each other, such as in a crossbar array. The fabrication and growth of such articles is described, and the arrangement of such articles to fabricate electronic, optoelectronic, or spintronic devices and components. For example, semiconductor materials can be doped to form n-type and p-type semiconductor regions for making a variety of devices such as field effect transistors, bipolar transistors, complementary inverters, tunnel diodes, light emitting diodes, sensors, and the like.06-24-2010
20100243990NANOSENSORS - Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized. Nanodetector devices are described.09-30-2010
20100258784Method Of Efficient Coupling Of Light From Single-Photon Emitter To Guided Radiation Localized To Sub-Wavelength Dimensions On Conducting Nanowires - A cavity free, broadband approach for engineering photon emitter interactions via sub-wavelength confinement of optical fields near metallic nanostructures. When a single CdSe quantum dot (QD) is optically excited in close proximity to a silver nanowire (NW), emission from the QD couples directly to guided surface plasmons in the NW, causing the wire's ends to light up. Nonclassical photon correlations between the emission from the QD and the ends of the NW demonstrate that the latter stems from the generation of single, quantized plasmons. Results from a large number of devices show that the efficient coupling is accompanied by more than 2.5-fold enhancement of the QD spontaneous emission, in a good agreement with theoretical predictions.10-14-2010
20110315962NANOSENSORS - Electrical devices comprised of nanowires are described, along with methods of their manufacture and use. The nanowires can be nanotubes and nanowires. The surface of the nanowires may be selectively functionalized Nanodetector devices are described.12-29-2011

Patent applications by Hongkun Park, Lexington, MA US

Hong-Kun Park, Lexington, MA US

Patent application numberDescriptionPublished
20110165587Method for live-cell activity assay - Provided are technologies capable of direct measurement of activity of a bioactive substance in cell using nanowires, more particularly, a method for measuring intracellular activity of a bioactive substance using a nanowire support to which cells are immobilized and a nanowire support to which target substances for the subject bioactive substance are immobilized, and a chip for measuring intracellular activity of a bioactive substance including nanowires to which cells are immobilized and nanowires to which a target substance for the subject bioactive substance is immobilized.07-07-2011

In-Hyun Park, Boston, MA US

Patent application numberDescriptionPublished
20110151447METHOD TO PRODUCE INDUCED PLURIPOTENT STEM (IPS) CELLS FROM NON-EMBRYONIC HUMAN CELLS - The invention provides methods for generating induced pluripotent stem (iPS) cells from normal and mutant adult cells, as well as the iPS cells so generated from such methods. In some aspects, iPS cells are generated by ectopically expressing SOX2 and OCT4 nucleic acids in such adult cells. Other nucleic acids such as but not limited to MYC may also be ectopically expressed in such adult cells in the methods described herein.06-23-2011

Ji-Soo Park, Andover, MA US

Patent application numberDescriptionPublished
20090321882EPITAZIAL GROWTH OF CRYSTALLINE MATERIAL - A device includes an epitaxially grown crystalline material within an area confined by an insulator. A surface of the crystalline material has a reduced roughness. One example includes obtaining a surface with reduced roughness by creating process parameters which result in the dominant growth component of the crystal to be supplied laterally from side walls of the insulator. In a preferred embodiment, the area confined by the insulator is an opening in the insulator having an aspect ratio sufficient to trap defects using an ART technique.12-31-2009
20100072515FABRICATION AND STRUCTURES OF CRYSTALLINE MATERIAL - A surface of the first semiconductor crystalline material has a reduced roughness. A semiconductor device includes a low defect, strained second semiconductor crystalline material over the surface of the first crystalline material. A surface of the strained second semiconductor crystalline material has a reduced roughness. One example includes obtaining a surface with reduced roughness by creating process parameters that reduce impurities at an interfacial boundary between the first and second semiconductor crystalline materials. In one embodiment, the first semiconductor crystalline material can be confined by an opening in an insulator having an aspect ratio sufficient to trap defects using Aspect Ratio Trapping techniques.03-25-2010
20110121310SOLID STATE LIGHTING DEVICES WITH SELECTED THERMAL EXPANSION AND/OR SURFACE CHARACTERISTICS, AND ASSOCIATED METHODS - Solid state lighting devices with selected thermal expansion and/or surface characteristics, and associated methods are disclosed. A method in accordance with a particular embodiment includes forming an SSL (solid state lighting) formation structure having a formation structure coefficient of thermal expansion (CTE), selecting a first material of an interlayer structure to have a first material CTE greater than the substrate CTE, and selecting a second material of the interlayer structure based at least in part on the second material having a second material CTE less than the first material CTE. The method can further include forming the interlayer structure over the SSL formation structure by disposing (at least) a first layer of the first material over the SSL formation structure, a portion of the second material over the first material, and a second layer of the first material over the second material. The SSL formation structure supports an SSL emitter material, and the method further includes counteracting a force placed on the formation structure by the first material, by virtue of the difference between the second material CTE and the first material CTE. In other embodiments, the SSL formation structure can have an off-cut angle with a non-zero value of up to about 4.5 degrees.05-26-2011
20120098034Epitaxial Growth of Crystalline Material - A device includes an epitaxially grown crystalline material within an area confined by an insulator. A surface of the crystalline material has a reduced roughness. One example includes obtaining a surface with reduced roughness by creating process parameters which result in the dominant growth component of the crystal to be supplied laterally from side walls of the insulator. In a preferred embodiment, the area confined by the insulator is an opening in the insulator having an aspect ratio sufficient to trap defects using an ART technique.04-26-2012

Patent applications by Ji-Soo Park, Andover, MA US

Ji-Soo Park, Methuen, MA US

Patent application numberDescriptionPublished
20100216277Formation of Devices by Epitaxial Layer Overgrowth - Methods and structures are provided for formation of devices, e.g., solar cells, on substrates including, e.g., lattice-mismatched materials, by the use of aspect ratio trapping (ART) and epitaxial layer overgrowth (ELO). In general, in a first aspect, embodiments of the invention may include a method of forming a structure. The method includes forming a first opening in a masking layer disposed over a substrate that includes a first semiconductor material. A first layer, which includes a second semi-conductor material lattice-mismatched to the first semiconductor material, is formed within the first opening. The first layer has a thickness sufficient to extend above a top surface of the masking layer. A second layer, which includes the second semiconductor material, is formed on the first layer and over at least a portion of the masking layer. A vertical growth rate of the first layer is greater than a lateral growth rate of the first layer and a lateral growth rate of the second layer is greater than a vertical growth rate of the second layer.08-26-2010
20120068226Formation of Devices by Epitaxial Layer Overgrowth - Methods and structures are provided for formation of devices on substrates including, e.g., lattice-mismatched materials, by the use of aspect ratio trapping and epitaxial layer overgrowth. A method includes forming an opening in a masking layer disposed over a substrate that includes a first semiconductor material. A first layer, which includes a second semiconductor material lattice-mismatched to the first semiconductor material, is formed within the opening. The first layer has a thickness sufficient to extend above a top surface of the masking layer. A second layer, which includes the second semiconductor material, is formed on the first layer and over at least a portion of the masking layer. A vertical growth rate of the first layer is greater than a lateral growth rate of the first layer and a lateral growth rate of the second layer is greater than a vertical growth rate of the second layer.03-22-2012
20120199876Defect Reduction Using Aspect Ratio Trapping - Lattice-mismatched epitaxial films formed proximate non-crystalline sidewalls. Embodiments of the invention include formation of facets that direct dislocations in the films to the sidewalls.08-09-2012

Patent applications by Ji-Soo Park, Methuen, MA US

John S. Park, Fall River, MA US

Patent application numberDescriptionPublished
20100224404DUAL ACCESS LUMINAIRE JUNCTION BOX - A recessed fixture having a junction box positioned adjacent at least one ceiling support structure comprises a recessed luminaire fixture, the junction box mounted to the recessed luminaire frame, the junction box being horizontally oriented, the junction box having a first facing junction box door and a second junction box door, the first junction box door and the second junction box door being oppositely positioned and pivotally connected to a junction box housing, the first and second junction doors being in a substantially horizontal orientation in a closed position, one of the first junction box door and the second junction box door facing substantially upwardly and the other of the first junction box door and the second junction box door facing substantially downwardly, wherein the horizontal orientation allows the junction box doors to be positioned adjacent a ceiling structure without limiting opening of the junction box doors.09-09-2010
20110103062RECESSED LIGHTING FIXTURE WITH SOCKET ADJUSTMENT MECHANISM - A recessed luminaire with adjustable socket assembly comprises a housing having a sidewall, a top wall and a lower opening allowing light output, a socket adjustment assembly disposed in the housing, the socket adjustment assembly having: a lamp socket connected to a socket carriage, a track having a socket carriage movably positioned on the track, wherein the carriage moves along the track and the lamp socket is movable in at least one of a vertical or a horizontal direction.05-05-2011
20110103068RECESSED LIGHTING REMODELER FIXTURE WITH SLIDING HOUSING - A recessed luminaire with adjustable socket assembly comprises a housing having a sidewall, a top wall and a lower opening allowing light output, a socket adjustment assembly disposed in the housing, the socket adjustment assembly having: a lamp socket connected to a socket carriage, a track having a socket carriage movably positioned on the track wherein the carriage moves along the track and the lamp socket is movable in at least one of a vertical or a horizontal direction.05-05-2011

Jong Keun Park, Hudson, MA US

Patent application numberDescriptionPublished
20120171617POLYMERS, PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are polymers that include a unit comprising a particular acetal moiety and a unit comprising a lactone moiety. Also provided are photoresist compositions containing such a polymer, substrates coated with the photoresist compositions and methods of forming photolithographic patterns. The polymers, compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices.07-05-2012
20120219901PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are photoresist compositions useful in forming photolithographic patterns. Also provided are substrates coated with the photoresist compositions and methods of forming photolithographic patterns. The compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices.08-30-2012
20120219902PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are photoresist compositions useful in forming photolithographic patterns. Also provided are substrates coated with the photoresist compositions and methods of forming photolithographic patterns. The compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices.08-30-2012
20120288794POLYMERS, PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are polymers containing a unit having a particular acetal moiety and photoresist compositions containing such a polymer. Also provided are substrates coated with the photoresist compositions and methods of forming photolithographic patterns. The polymers, photoresist compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices.11-15-2012
20130011783MONOMERS, POLYMERS, PHOTORESIST COMPOSITIONS AND METHODS OF FORMING PHOTOLITHOGRAPHIC PATTERNS - Provided are (meth)acrylate monomers containing acetal moieties, polymers containing a unit formed from such a monomer and photoresist compositions containing such a polymer. The monomers, polymers and photoresist compositions are useful in forming photolithographic patterns. Also provided are substrates coated with the photoresist compositions, methods of forming photolithographic patterns and electronic devices. The compositions, methods and coated substrates find particular applicability in the manufacture of semiconductor devices.01-10-2013

Joshua C. Park, Billerica, MA US

Patent application numberDescriptionPublished
20120038807IMAGING SIGNAL PROCESSING METHODS AND APPARATUS - Methods and apparatus are provided for performing multiple correlated double sampling (CDS) operations on an imaging pixel, and in some cases on an array of imaging pixels, during a single integration cycle of the pixel(s). The multiple CDS operations may produce multiple CDS values, which may be processed in combination to produce a resulting value substantially free of various types of noise. The CDS operations may be performed using a CDS circuit including a single-ended charge amplifier having an input capacitor. The charge amplifier may also include a variable capacitance providing a variable gain. The variable capacitance may be provided by a feedback capacitor.02-16-2012
20120217376IMAGING SIGNAL PROCESSING METHODS AND APPARATUS - Methods and apparatus are provided for performing multiple correlated double sampling (CDS) operations on an imaging pixel, and in some cases on an array of imaging pixels, during a single integration cycle of the pixel(s). The multiple CDS operations may produce multiple CDS values, which may be processed in combination to produce a resulting value substantially free of various types of noise. The CDS operations may be performed using a CDS circuit including a single-ended charge amplifier having an input capacitor. The charge amplifier may also include a variable capacitance providing a variable gain. The variable capacitance may be provided by a feedback capacitor.08-30-2012

Juhyun Park, Cambridge, MA US

Patent application numberDescriptionPublished
20110114244Self-assembly of macromolecules on multilayered polymer surfaces - The invention is directed toward systems and methods for the formation of two dimensional monolayer structures of ordered biomacromolecules, such as viruses, atop cohesive polyelectrolyte multilayers to create functional thin films. Methods for the formation of such thin films are disclosed that involve an interdiffusion-induced assembly process of the biomacromolecules. The inventive systems provide a general platform for the systematic incorporation and assembly of organic, biological and inorganic materials and will enable many potential technological applications such as, for example, chemical and biological sensors, power devices and catalytic membranes.05-19-2011

Jun-Geun Park, Cambridge, MA US

Patent application numberDescriptionPublished
20110306354Method and Apparatus for Constructing a User-Generated Geological System - A method and apparatus are provided to permit location discovery, including location discovery in indoor settings. The method may identify a wireless fingerprint present at a geographical location and determine whether the wireless fingerprint corresponds to a previously observed wireless fingerprint associated with the predefined geographical location. A new wireless fingerprint and a geographical location, or bind, may be received by the system and the system may evaluate whether or not the new bind is erroneous or not, or if the new bind is an improvement over existing binds in determining whether or not to accept the new bind.12-15-2011
20120208500METHODS, APPARATUSES AND COMPUTER PROGRAM PRODUCTS FOR PROVIDING A PRIVATE AND EFFICIENT GEOLOCATION SYSTEM - An apparatus for preserving privacy of a determined location(s) of a device may include a processor and memory storing executable computer code causing the apparatus to at least perform operations including receiving a request for determining a location of a device based on received fingerprint data corresponding to a summary of radio information identifying a physical place, location, area, or region. The summary based on information received from radio frequency (RF) devices. The computer program code may further cause the apparatus to determine whether fingerprint data associated with a geographical location of the RF devices is stored locally for determining whether to request a network device to determine the location of the device based on providing the network device with fingerprint data and false fingerprint data relating to a location(s) that does not correspond to a current location of the device. Corresponding methods and computer program products are also provided.08-16-2012

Jung Hwan Park, Salem, MA US

Patent application numberDescriptionPublished
20100294590Method, Apparatus, and Arrangement for a Lifeline System - A shuttle member for a horizontal lifeline system having at least one elongate line attached between at least two anchorage points. The shuttle member includes: a body having: (i) an upper portion configured for attachment to the line by at least partially surrounding the line; (i) an intermediate portion that, together with the upper portion, defines at least one passage slit that is sized such that the elongate line cannot pass therethrough; and (iii) an attachment portion configured for attachment of at least a portion of a lanyard. A shuttle member arrangement and a passing method are also disclosed.11-25-2010

Jungrae Park, Andover, MA US

Patent application numberDescriptionPublished
20120297888Wireless Passive Radio-Frequency Strain And Displacement Sensors - Wireless strain and displacement sensors wirelessly monitor structural health and integrity, and are made by printing inductor-interdigital capacitor sensing circuits on a variety of substrates, including ceramic substrates, with thermally processable conductive inks. Sensors of the invention can be employed to detect strain and displacement of civil structures, such as bridges and buildings. The sensors include sensing elements that are mounted or printed on stiff, inflexible substrates, which prevent the sensing elements from bending, stretching, or otherwise warping when the sensor is strained. An interlayer between the sensing elements allows the sensing elements to move with respect to each other during application of strain. Thus, strain causes the sensing elements to move but not to deform, causing changes in sensor resonance that can be detected through wireless radio-frequency interrogation. Because the sensing elements do not change shape when under strain, the sensor can undergo millions of measurement cycles before breaking.11-29-2012

Jun Y. Park, Brookline, MA US

Patent application numberDescriptionPublished
20090081698High throughput cell-based assays, methods of use and kits - In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform the washing step(s) the plate is placed into a carrier pate having open wells in register with the wells of the filter plate or one may use a wicking device or an underdrain attached to the bottom of the filter plate. Sufficient wash liquid is added to allow for filtration by the effect of gravity to occur. Cells are retained within the wells at a rate of 4 times that of other rapid methods.03-26-2009
20110189703High Throughput Cell-Based Assays, Methods of Use and Kits - In the present invention cells are placed in a multiwell plate and grown. When the assay is to be performed, one uses gravity to wash away any unbound ligands rather than vacuum or centrifugation. The cells are then examined to detect the bound ligand. To perform the washing step(s) the plate is placed into a carrier plate having open wells in register with the wells of the filter plate or one may use a wicking device or an underdrain attached to the bottom of the filter plate. Sufficient wash liquid is added to allow for filtration by the effect of gravity to occur. Cells are retained within the wells at a rate of 4 times that of other rapid methods.08-04-2011

Kevin Park, Boston, MA US

Patent application numberDescriptionPublished
20090305333Promoting Axon Regeneration in the Adult CNS through Control of Protein Translation - Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous activator of protein translation; and (b) detecting the resultant promotion of the survival of, or axon regeneration in the neuron.12-10-2009

Kyoo-Chul Park, Cambridge, MA US

Patent application numberDescriptionPublished
20120268524INK JET PRINT HEAD FRONT FACE HAVING A TEXTURED SUPEROLEOPHOBIC SURFACE AND METHODS FOR MAKING THE SAME - An ink jet print head front face or nozzle plate having a textured superoleophobic surface that prevents undesirable drooling, wetting and/or adhesion of the ink on the print head. The textured surface includes a rim formed around the nozzle. Also described are methods for forming the textured superoleophobic ink jet print head front face or nozzle plate from silicon having the textured, oleophobic surface.10-25-2012
20120270344INK JET PRINT HEAD FRONT FACE HAVING A TEXTURED SUPEROLEOPHOBIC SURFACE AND METHODS FOR MAKING THE SAME - An ink jet print head front face or nozzle plate having a textured superoleophobic surface that prevents undesirable drooling, wetting and/or adhesion of the ink on the print head. The textured surface includes a rim formed around the nozzle. Also described are methods for forming the textured superoleophobic ink jet print head front face or nozzle plate from silicon having the textured, oleophobic surface.10-25-2012
20130025322PROCESS FOR MAKING NANOCONE STRUCTURES AND USING THE STRUCTURES TO MANUFACTURE NANOSTRUCTURED GLASS - Fabrication method. At least first and second hardmasks are deposited on a substrate, the thickness and materials of the first and second hardmask selected to provided etch selectivity with respect to the substrate. A nanoscale pattern of photoresist is created on the first hardmask and the hardmask is etched through to create the nanoscale pattern on a second hardmask. The second hardmask is etched through to create the desired taper nanocone structures in the substrate. Reactive ion etching is preferred. A glass manufacturing process using a roller imprint module is also disclosed.01-31-2013

Larry C. Park, Waltham, MA US

Patent application numberDescriptionPublished
20090118278COMPOSITIONS USEFUL AS INHIBITORS OF GSK-3 - The present invention provides a compound of formula I:05-07-2009

Melvin A. Park, Billerica, MA US

Patent application numberDescriptionPublished
20090032700THREE-DIMENSIONAL RF ION TRAPS WITH HIGH ION CAPTURE EFFICIENCY - In a three-dimensional Paul RF ion trap at least one of the ring electrode and end cap electrodes is structured to produce a high capture efficiency for analyte ions introduced into the trap. The electrode structuring may be produced by an electrode surface profile having edges or protrusions, resulting in a scattering reflection of the introduced ions. Alternatively, at least one electrode may be formed by physically separate electrode components. In one embodiment, the trap can be switched between operating as a linear ion trap with good capture efficiency and operating as a three-dimensional ion trap with good ion reaction conditions.02-05-2009
20110121170APPARATUS AND METHOD FOR PARALLEL FLOW ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY - Analyte ions entrained in a carrier gas are analyzed by parallel flow ion mobility spectrometry prior to analysis by a mass analyzer. An extended ion funnel is located in the vacuum system of the mass analyzer and has an ion focusing section and an ion mobility analyzing section. The carrier gas together with entrained ions is introduced into the ion focusing section where the ions are focused to the axis of the funnel by applied RF voltages. In the ion mobility section, the action of an RF quadrupolar field, the movement of the carrier gas and axial DC field, separates the ions on the basis of their mobilities. The mobility separated ions are released into the mass analyzer where the ions may be further separated on the basis of mass.05-26-2011
20110139976Method for operating three-dimensional RF ion traps with high ion capture efficiency - In a three-dimensional Paul RF ion trap the ring electrode and end cap electrodes are formed from pairs of pole rods. This multipole rod system is then operated as a linear ion trap with a constant field distribution along the multipole rod system. While the system is operating as a linear ion trap, analyte ions are introduced and stored within the linear ion trap. After the ions have been stored, a single-phase RF voltage is supplied to all rods of a middle segment thus forming a three-dimensional ion trap, thereby collecting the ions in a spherical cloud within this middle segment. The collected analyte ions can then be reacted in the three-dimensional ion trap and the product ions resulting from the reactions can be ejected for mass analysis.06-16-2011

Patent applications by Melvin A. Park, Billerica, MA US

Melvin Andrew Park, Billerica, MA US

Patent application numberDescriptionPublished
20090127455Ion guide for mass spectrometers - The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to ion guides for use therein. The invention described herein comprises an improved method and apparatus for transporting ions from a first pressure region in a mass spectrometer to a second pressure region therein. More specifically, the present invention provides a segmented ion funnel for more efficient use in mass spectrometry (particularly with ionization sources) to transport ions from the first pressure region to the second pressure region.05-21-2009
20120273670Spectrum Acquisition Modes For Ion Mobility Spectrometers Using Trapped Ions - In an ion mobility spectrometer in which a gas flows through a gas-tight tube with a radially quadrupolar RF field therein and blows ions against a DC electric field barrier, a mobility scan with a mobility scale that is linear in time is obtained by holding the height of the DC electric field barrier constant while changing the pressure and temperature conditions of the flowing gas. Alternatively, the mobility scan is performed by holding the pressure and temperature conditions of the flowing gas constant and reducing the height of the DC electric field barrier non-linearly with respect to time.11-01-2012
20120273673Selective Ion Mobility Spectrometer - Ions with a predetermined range of ion mobilities are produced by filtering input ions with at least two consecutive ion mobility high pass and/or low pass filters. Each ion mobility filter is formed by entraining ions in a moving gas and applying a DC electric field to the ions which causes the ions to move in a direction opposite to the gas flow. An ion mobility high pass filter is formed when the DC electric field drives the ions against the flow of gas, whereas an ion mobility low pass filter is formed when a the gas flow drives entrained ions against an DC electric field barrier.11-01-2012
20120273674Resolution Enhancement For Ion Mobility Spectrometers - In an ion mobility spectrometer in which a gas pushes ions along a spectrometer axis against and over an electrical field barrier, the electric field barrier is generated with a plateau of slightly increasing height along the axis of the spectrometer. Alternately, the electric filed barrier may have a plateau with constant height, but the gas flow decreases in velocity along the axis of the spectrometer in the vicinity of the plateau.11-01-2012
20120286156SELECTIVE ION MOBILITY SPECTROMETER - Ions with a predetermined ion mobility range are produced by filtering ions entrained in a stream of moving gas with two ion mobility low pass filters located consecutively in the gas stream. Each filter is formed by applying a DC electric field to the gas stream which causes the ions to move in a direction opposite to the gas flow. Ions are collected between the two filters and transferred to a detector or analyzing device. In one embodiment, the maximum field strength of the electric field barrier in the first ion mobility low pass filter is continued as a plateau of essentially constant field strength up to the electric field barrier in the second ion mobility low pass filter, which has a maximum field strength higher that the maximum field strength of the electric field barrier in the first ion mobility low pass filter.11-15-2012
20120298860MEANS AND METHOD FOR FIELD ASYMMETRIC ION MOBILITY SPECTROMETRY COMBINED WITH MASS SPECTROMETRY - Analyte ions are analyzed first by field asymmetric ion mobility spectrometry (FAIMS) before being analyzed by a mass analyzer. Analyte ions are produced at near atmospheric pressure and transferred via a dielectric capillary into the vacuum system of the mass analyzer. While passing through the capillary, the ions are analyzed by FAIMS via electrodes on the interior wall of the capillary. Improved ion transmission is achieved by providing smooth geometric transitions between the channel in FAIMS analyzer and the channel in the remainder of the capillary.11-29-2012
20120305758ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT AND SELECTION OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections.12-06-2012
20120305759ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT, SELECTION AND TRAPPING OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can act as linear ion traps or Paul ion traps.12-06-2012
20130009050ABRIDGED MULTIPOLE STRUCTURE FOR THE TRANSPORT, SELECTION, TRAPPING AND ANALYSIS OF IONS IN A VACUUM SYSTEM - An abridged multipole structure for the transport and selection of ions along a central axis in a vacuum system is constructed from a plurality of rectilinear electrode structures, each having a substantially planar face with a first dimension and a second dimension perpendicular to the first dimension. When a voltage is applied across the second dimension, an electrical potential is produced at the planar face whose amplitude is a linear function of position along the second dimension. Two electrode structures can be arranged parallel to each other with the first dimension extending along the central axis or more electrodes structures can be arranged to form multipole structures with various polygonal cross sections. Additional embodiments can be used to excite ions into secular motion, inductively detect the ions, and thereby generate a mass spectrum.01-10-2013
20130009051ABRIDGED ION TRAP - TIME OF FLIGHT MASS SPECTROMETER - An improved trap-TOF mass spectrometer has a set of electrodes arranged to produce both a quadrupolar RF confining field and a substantially homogeneous dipole field. In operation, ions are first confined by the RF field and then, at a selected time, the RF confining field is discontinued and the dipole field is used to accelerate the ions so as to initiate a TOF MS analysis. The apparatus of the present invention may be used alone or in conjunction with other analyzers to produce mass spectra from analyte ions.01-10-2013

Patent applications by Melvin Andrew Park, Billerica, MA US

Mi-Ae Park, Newton, MA US

Patent application numberDescriptionPublished
20080302950System and Method for Performing Single Photon Emission Computed Tomography (Spect) with a Focal-Length Cone-Beam Collimation - A system and method are provided for obtaining data that may be used to generate images of a brain or other bodily organ. The system can include a pair of detecting arrangements and a collimating arrangement associated with each detecting arrangement. A first collimating arrangement can include a cone-beam collimating arrangement having a focal point located within the brain or other organ being imaged. A second collimating arrangement can include a fan-beam collimating arrangement having a focal length selected such that the organ being imaged lies within its field of view to ensure data sufficiency. Cone-beam collimating arrangements having improved hole geometries can also be utilized to provide further increases in imaging sensitivity.12-11-2008

Peter Park, Somerville, MA US

Patent application numberDescriptionPublished
20110256153CD37-Binding Molecules and Immunoconjugates Thereof - Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to CD37 are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.10-20-2011

Peter U. Park, Somerville, MA US

Patent application numberDescriptionPublished
20090304710NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of killing CD3812-10-2009
20110195021CD20 ANTIBODIES AND USES THEREOF - CD20 is a transmembrane protein of the tetra-spanin family expressed on the surface of B-cells and has been found on B-cells from peripheral blood as well as lymphoid tissues. CD20 expression persists from the early pre-B cell stage until the plasma cell differentiation stage. Conversely, it is not found on hematopoietic stem cells, pro-B cells, differentiated plasma cells or non-lymphoid tissues. In addition to expression in normal B-cells, CD20 is expressed in B-cell derived malignancies such as non-Hodgkin's lymphoma (NHL) and B-cell chronic lymphocytic leukemia (CLL). CD20 expressing cells are known to play a role in other diseases and disorders, including inflammation. The present invention includes anti-CD20 antibodies, forms and fragments, having superior physical and functional properties; immunoconjugates, compositions, diagnostic reagents, methods for inhibiting growth, therapeutic methods, improved antibodies and cell lines; and polynucleotides, vectors and genetic constructs encoding same.08-11-2011
20110195022CD20 ANTIBODIES AND USES THEREOF - CD20 is a transmembrane protein of the tetra-spanin family expressed on the surface of B-cells and has been found on B-cells from peripheral blood as well as lymphoid tissues. CD20 expression persists from the early pre-B cell stage until the plasma cell differentiation stage. Conversely, it is not found on hematopoietic stem cells, pro-B cells, differentiated plasma cells or non-lymphoid tissues. In addition to expression in normal B-cells, CD20 is expressed in B-cell derived malignancies such as non-Hodgkin's lymphoma (NHL) and B-cell chronic lymphocytic leukemia (CLL). CD20 expressing cells are known to play a role in other diseases and disorders, including inflammation. The present invention includes anti-CD20 antibodies, forms and fragments, having superior physical and functional properties; immunoconjugates, compositions, diagnostic reagents, methods for inhibiting growth, therapeutic methods, improved antibodies and cell lines; and polynucleotides, vectors and genetic constructs encoding same.08-11-2011
20110262454NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of killing CD3810-27-2011
20120156217Novel EGFR-Binding Molecules and Immunoconjugates Thereof - Novel anti-cancer agents, including, but not limited to, antibodies and immunoconjugates, that bind to EGFR are provided. Methods of using the agents, antibodies, or immunoconjugates, such as methods of inhibiting tumor growth are further provided.06-21-2012
20120156218NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER - Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of killing CD3806-21-2012
20120276119CD37-Binding Molecules and Immunoconjugates Thereof - Methods of using CD37 agents, including, but not limited to, antibodies and immunoconjugates, that bind to CD37 to deplete B-cells (e.g., non-cancerous B-cells) and methods of treating autoimmune and inflammatory diseases are further provided.11-01-2012

Patent applications by Peter U. Park, Somerville, MA US

Sang Ki Park, Brookline, MA US

Patent application numberDescriptionPublished
20090111733PAR-4 RELATED METHODS AND COMPOSITIONS - Provided herein are methods and compositions for treating or preventing mood disorders and certain other mental disorders. Methods may comprise increasing PAR-4 levels or activity and/or the interaction between PAR-4 and the dopamine (D2) receptor04-30-2009

Seung Bum Park, Arlington, MA US

Patent application numberDescriptionPublished
20120021933SMALL MOLECULE PRINTING - The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm01-26-2012

Sooho Park, Cambridge, MA US

Patent application numberDescriptionPublished
20090187515QUERY SUGGESTION GENERATION - Described herein is a system that facilitates assigning indications of usefulness to query suggestions. The system includes a query suggestion generator component that receives a query and generates a query suggestion based at least in part upon the received query. A model component outputs an indication of usefulness with respect to the query suggestion, wherein the model component is a machine-learned model of user behavior with respect to query suggestions.07-23-2009

Soojin Park, Amherst, MA US

Patent application numberDescriptionPublished
20080230514METHOD OF PRODUCING NANOPATTERNED TEMPLATES - Nanopatterned substrates can be prepared by a method that includes forming a block copolymer film on a substrate, annealing the block copolymer film, surface reconstructing the annealed block copolymer film, coating an etch-resistant layer on the surface reconstructed block copolymer film, etching the resist-coated block copolymer film to create an etched article comprising a nanopatterned substrate, and separating the etch-resistant layer and the block copolymer film from the nanopatterned substrate. The method is applicable to a wide variety of substrate materials, avoids any requirement for complicated procedures to produce long-range order in the block copolymer film, and avoids any requirement for metal functionalization of the block copolymer.09-25-2008
20100075116SELF-ASSEMBLY OF BLOCK COPOLYMERS ON TOPOGRAPHICALLY PATTERNED POLYMERIC SUBSTRATES - Highly-ordered block copolymer films are prepared by a method that includes forming a polymeric replica of a topographically patterned crystalline surface, forming a block copolymer film on the topographically patterned surface of the polymeric replica, and annealing the block copolymer film. The resulting structures can be used in a variety of different applications, including the fabrication of high density data storage media. The ability to use flexible polymers to form the polymeric replica facilitates industrial-scale processes utilizing the highly-ordered block copolymer films.03-25-2010
20100086801METHOD OF PRODUCING NANOPATTERNED ARTICLES, AND ARTICLES PRODUCED THEREBY - Nanopatterned surfaces are prepared by a method that includes forming a block copolymer film on a substrate, annealing and surface reconstructing the block copolymer film to create an array of cylindrical voids, depositing a metal on the surface-reconstructed block copolymer film, and heating the metal-coated block copolymer film to redistribute at least some of the metal into the cylindrical voids. When very thin metal layers and low heating temperatures are used, metal nanodots can be formed. When thicker metal layers and higher heating temperatures are used, the resulting metal structure includes nanoring-shaped voids. The nanopatterned surfaces can be transferred to the underlying substrates via etching, or used to prepare nanodot- or nanoring-decorated substrate surfaces.04-08-2010
20100112308METHOD OF PRODUCING NANOPATTERNED ARTICLES, AND ARTICLES PRODUCED THEREBY - A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film. The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media.05-06-2010
20120211871METHOD OF PRODUCING NANOPATTERNED ARTICLES, AND ARTICLES PRODUCED THEREBY - A nanopatterned surface is prepared by forming a block copolymer film on a miscut crystalline substrate, annealing the block copolymer film, then reconstructing the surface of the annealed block copolymer film The method creates a well-ordered array of voids in the block copolymer film that is maintained over a large area. The nanopatterned block copolymer films can be used in a variety of different applications, including the fabrication of high density data storage media.08-23-2012

Patent applications by Soojin Park, Amherst, MA US

Sung Park, Chestnut Hill, MA US

Patent application numberDescriptionPublished
20110209726SYSTEMS AND METHODS FOR ROBOTIC GUTTER CLEANING ALONG AN AXIS OF ROTATION - In embodiments of the present invention, a gutter-cleaning device comprises a housing containing an impeller drive facility, the housing configured to fit into a gutter, an impeller, disposed at an end of the housing and driven by the impeller drive facility, and a transport facility for transporting the housing along the gutter09-01-2011
20120059345SYSTEMS AND METHODS FOR WASTE DISPOSAL USING A WEARABLE DISPOSAL BAG - In embodiments of the present invention improved capabilities are described for waste disposal. A disposal bag may be configured to receive waste, wherein the bag is wearable. The disposal bag may include a frame associated with the bag at an opening, the frame being configured to enable a user to close the bag in a single-handed operation when opposing sides of the frame are brought into contact with one another and a sealing facility disposed on the frame for providing a resealable closure of the bag when opposing sides of the frame are brought into contact with one another.03-08-2012

William Park, Somerville, MA US

Patent application numberDescriptionPublished
20080310595THIN WALLED TUBE RADIATOR FOR BREMSSTRAHLUNG AT HIGH ELECTRON BEAM INTENSITIES - Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.12-18-2008
20110255669THIN WALLED TUBE RADIATOR FOR BREMSSTRAHLUNG AT HIGH ELECTRON BEAM INTENSITIES - Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.10-20-2011

William H. Park, Somerville, MA US

Patent application numberDescriptionPublished
20110073781ION IMPLANTATION APPARATUS - An ion implanter has an implant wheel with a plurality of wafer carriers distributed about a periphery of the wheel. Each wafer carrier has a heat sink for removing heat from a wafer on the carrier during the implant process by thermal contact between the wafer and the heat sink. The wafer carriers have wafer retaining fences formed as cylindrical rollers with axes in the respective wafer support planes of the wafer carriers. The cylindrical surfaces of the rollers provide wafer abutment surfaces which can move transversely to the wafer support surfaces so that no transverse loading is applied by the fences to wafer edges as the wafer is pushed against the heat sink by centrifugal force. The wafer support surfaces comprise layers of elastomeric material and the movable abutment surfaces of the fences allow even thermal coupling with the heat sink over the whole area of the wafer.03-31-2011
20120104273Ion Source and a Method of Generating an Ion Beam Using an Ion Source - Multiple control electrodes are provided asymmetrically within the plasma chamber of an ion source at respective positions along the length of the plasma chamber. Biasing the control electrodes selectively can selectively enhance the ion extraction current at adjacent positions along the length of the extraction slit. A method of generating an ion beam is disclosed in which the strengths of the transverse electric fields at different locations along the length of the plasma chamber are controlled to modify the ion beam linear current density profile along the length of the slit. The method is used for controlling the uniformity of a ribbon beam.05-03-2012
20120146554A D.C. Charged Particle Accelerator, A Method of Accelerating Charged Particles Using D.C. Voltages and a High Voltage Power Supply Apparatus for use Therewith - A d. c. charged particle accelerator comprises accelerator electrodes separated by insulating spacers defining acceleration gaps between adjacent pairs of electrodes. Individually regulated gap voltages are applied across each adjacent pair of accelerator electrodes. In embodiments, the individually regulated gap voltages are generated by electrically isolated alternators mounted on a common rotor shaft driven by an electric motor. Alternating power outputs from the alternators provide inputs to individual regulated d. c. power supplies to generate the gap voltages. The power supplies are electrically isolated and have outputs connected in series across successive pairs of accelerator electrodes. The described embodiment enables an ion beam to be accelerated to high energies and high beam currents, with good accelerator stability.06-14-2012