Parang
Keykavous Parang, Wakefield, RI US
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20080207551 | MODIFIED OLIGONUCLEOTIDES CONTAINING DIPHOSPHODIESTER INTERNUCLEOTIDE LINKAGES - The synthesis and biochemical utility of modified oligonucleotides containing diphosphodiester internucleotide linkages. The synthesis of these compounds was carried out using diphosphitylating reagents. Oligonucleotides containing diphosphate diester bridges wherein said oligonucleotides are synthesized via a solid-phase synthesis strategy to form modified oligonucleotides. Diphosphitylating, triphosphitylating, tetraphosphitylating, β-triphosphitylating, bifunctional diphosphitylating, bifunctional triphosphitylating, and bifunctional tetraphosphitylating reagents wherein, the phosphorus atoms are linked together through oxygen, sulfur, amino, or methylene groups and/or are substituted with chlorine, diisopropylamine and cyanoethoxy groups. | 08-28-2008 |
20110039798 | SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES - The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS. | 02-17-2011 |
Keykavous Parang, Saunderstown, RI US
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20110034670 | BISUBSTRATE INHIBITORS OF PROTEIN KINASES AS THERAPEUTIC AGENTS - A bisubstrate inhibitor of Src kinases, having a nucleotide or N-heteroaromatic moiety; and a peptide/phosphopeptide, peptidomimetic, or phosphopeptide mimic moiety. The moieties are linked by a rigid or a flexible linker. The nucleotide or N-heteroaromatic moiety is ATP, ATP-mimics, N-heteroaromatics including purine-based derivatives, pyrimidine-based derivatives such as 2,4-diamino-5-substituted pyrimidine derivatives, pyrazole[3,4-d]pyrimidine derivatives, pyrrolo[2,3-d]pyrimidine derivatives, pyrido[2,3-d]pyrimidine derivatives, amino-substituted dihydropyrimido[4,5-d]pyrimidinone derivatives, thieno- and furo-substituted derivatives, quinazoline derivatives, and quinoline derivatives, and several natural products such as aminogenistein. The phosphopeptide mimics comprise phosphonate-based phosphotyrosine mimetics such as phosphonomethylphenylalanine (Pmp) and its analogues, carboxylic acid-based phosphotyrosine mimetics such as malonyltyrosine or phenylalanine analogues and their derivatives such as carboxymethyl phenylalanine, uncharged pTyr mimetics, and conformationally constrained peptides. The phosphopeptide or phosphopeptide mimics inhibits the Src kinases SH2 domain. | 02-10-2011 |
20140336259 | PHENOLIC COMPOUNDS WITH ANTIOXIDANT AND ANTI-CANCER PROPERTIES, ANALOGS AND SYNTHESIS THEREOF - The present document describes a phytochemical isolated from maple syrup and composition comprising the same. More specifically, the document describes an antioxidant phytochemical compound, derivates thereof, and composition comprising the same. The document also describes a process of synthesizing the antioxidant phytochemical compound. | 11-13-2014 |
Keykavous Parang, Irvine, CA US
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20150038671 | Efficient Synthesis of CN2097 and RC7 and Their Analogs - Synthesized macrocyclic ligand, CN2097 and analogs, optimized with systemic structure modifications to develop the compounds with lower molecular weights and less peptidic characters. | 02-05-2015 |
Reza Parang, San Francisco, CA US
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20140180788 | METHOD AND SYSTEM FOR IMPLEMENTING A CLOUD-BASED SOCIAL MEDIA MARKETING METHOD AND SYSTEM - Disclosed is an approach for implementing a system, method, and computer program product for performing social marketing using a cloud-based system. The approach is capable of accessing data across multiple types of internet-based sources of social data and commentary and to perform analysis upon that data. A social marketing campaign can then be generated and implemented in an integrated manner using the system. This permits realtime reaction to trends, with rapid ability to react to opportunities in the marketplace. | 06-26-2014 |
Touraj Parang, Los Altos, CA US
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20110292930 | Method And System For Communicating Across Telephone And Data Networks - A method and system for communicating across telephone and data networks are disclosed. According to one embodiment, a computer-implemented method, comprises receiving a first call from a first user phone that converts the first call from a format of a first local phone network to a first digital call. The first digital call is transmitted over a large area data network. The first digital call is converted to a format of a second local phone network to generate a second call. The second call is transmitted to a second user phone over the second local phone network. A real-time bi-directional voice communication session is established between the first user phone and the second user phone. | 12-01-2011 |
20140036907 | METHOD AND SYSTEM FOR COMMUNICATING ACROSS TELEPHONE AND DATA NETWORKS - A method and system for communicating across telephone and data networks are disclosed. According to one embodiment, a computer-implemented method, comprises receiving a first call from a first user phone that converts the first call from a format of a first local phone network to a first digital call. The first digital call is transmitted over a large area data network. The first digital call is converted to a format of a second local phone network to generate a second call. The second call is transmitted to a second user phone over the second local phone network. A real-time bi-directional voice communication session is established between the first user phone and the second user phone. | 02-06-2014 |