Pandey, MA
Ashwini K. Pandey, Marlborough, MA US
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20090082722 | REMOTE NAVIGATION ADVANCER DEVICES AND METHODS OF USE - Various systems for advancing medical devices within a subject's body are provided that configured to engage the outer surface of the medical device at a number of points about the circumference of the medical device, to thereby grip the medical device for enabling advancement of the device. The advancing systems include engaging portions configured to engage the outer surface of a medical device at a number of points about the circumference of the medical device. The engaging portions preferably engage opposing sides of the medical device's outer surface over a predetermined longitudinal length, to clamp against a longitudinal portion of the medical device that provides improved surface contact with the medical device over conventional roller guides. Various methods for performing medical procedures utilizing various medical devices and advancer systems are also provided. | 03-26-2009 |
20090131927 | METHOD AND APPARATUS FOR REMOTE DETECTION OF RF ABLATION - Devices for the generation and detection of an ablative plasma discharge in a subject are presented. Methods of use, including navigation and operation of the devices to facilitate minimally invasive therapeutic procedures are disclosed. | 05-21-2009 |
20090138009 | MAGNETICALLY GUIDED ENERGY DELIVERY APPARATUS - This invention describes an energy delivery apparatus for delivering electrical energy at a target location, said energy delivery apparatus being usable in combination with a magnetic field and comprising an electrical conductor having a substantially elongated configuration; an electrode for delivering electrical energy at the target location, with the electrode being electrically coupled to the electrical conductor and having an exposed surface with at least a portion of the exposed surface having one of its principal radii of curvature smaller than 0.35 mm; an insulating dielectric coating along a substantial portion of the length of the electrical conductor, with the dielectric coating having a dielectric constant smaller than about 3; at least one guiding element mounted to the electrical conductor, with at least one of the guiding elements including a magnetically responsive material. The magnetic field is used to move the guiding element in order to position the electrode substantially adjacent to the target location. | 05-28-2009 |
Ashwini K. Pandey, Marlborogh, MA US
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20080287909 | METHOD AND APPARATUS FOR INTRA-CHAMBER NEEDLE INJECTION TREATMENT - A method is disclosed that enables intra-chamber needle injection treatment using a navigable interventional device. The method includes navigation steps to systematically inject cells, drugs, or other agents in diagnostically identified target tissues, such as ischemic heart wall tissues. Magnetic navigation of a specifically designed needle catheter permits safe access to remote structures of the heart and depth-adaptable needle injections. | 11-20-2008 |
Rajendra K. Pandey, Framingham, MA US
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20110250138 | SINGLE-STRANDED AND DOUBLE-STRANDED OLIGONUCLEOTIDES COMPRISING A METAL-CHELATING LIGAND - The invention provides modified oligonucleotides of formula (I), comprising at least one metal chelator which provides a powerful tool for study of the pharmacokinetics of siRNA and its correlation with in vivo activity. The chelated metals provide luminescent properties enable detection of the oligonucleotides through the use of time-resolved fluorescent quenching based on energy transfer from the metal ion to a nonfluorescent quencher which can be used as non-isotopic labels of oligonucleotides for diagnostics and evaluation of cellular uptake. | 10-13-2011 |
Rajendra K. Pandey, South Grafton, MA US
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20090005549 | Processes and Reagents for Desilylation of Oligonucleotides - The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating phosphoramidites in oligonucleotide synthesis. Another aspect of the present invention relates to a method of preparing oligonucleotides via the phosphoramidite method using an activator of the invention. Another aspect of the present invention relates to sulfur-transfer agents. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to a method of preparing a phosphorothioate by treating a phosphite with a sulfur-transfer reagent of the invention. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to compounds that scavenge acrylonitrile produced during the deprotection of phosphate groups bearing ethylnitrile protecting groups. In a preferred embodiment, the acrylonitrile scavenger is a polymer-bound thiol. Another aspect of the present invention relates to agents used to oxidize a phosphite to a phosphate. In a preferred embodiment, the oxidizing agent is sodium chlorite, chloroamine, or pyridine-N-oxide. Another aspect of the present invention relates to methods of purifying an oligonucleotide by annealing a first single-stranded oligonucleotide and second single-stranded oligonucleotide to form a double-stranded oligonucleotide; and subjecting the double-stranded oligonucleotide to chromatographic purification. In a preferred embodiment, the chromatographic purification is high-performance liquid chromatography. | 01-01-2009 |
20090187027 | PROCESSES AND REAGENTS FOR SULFURIZATION OF OLIGONUCLEOTIDES - The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating phosphoramidites in oligonucleotide synthesis. Another aspect of the present invention relates to a method of preparing oligonucleotides via the phosphoramidite method using an activator of the invention. Another aspect of the present invention relates to sulfur-transfer agents. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to a method of preparing a phosphorothioate by treating a phosphite with a sulfur-transfer reagent of the invention. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to compounds that scavenge acrylonitrile produced during the deprotection of phosphate groups bearing ethylnitrile protecting groups. In a preferred embodiment, the acrylonitrile scavenger is a polymer-bound thiol. Another aspect of the present invention relates to agents used to oxidize a phosphite to a phosphate. In a preferred embodiment, the oxidizing agent is sodium chlorite, chloramine, or pyridine-N-oxide. Another aspect of the present invention relates to methods of purifying an oligonucleotide by annealing a first single-stranded oligonucleotide and second single-stranded oligonucleotide to form a double-stranded oligonucleotide; and subjecting the double-stranded oligonucleotide to chromatographic purification. In a preferred embodiment, the chromatographic purification is high-performance liquid chromatography. | 07-23-2009 |
Rajendra K. Pandey, Cambridge, MA US
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20110196145 | PROCESS FOR DESILYLATION OF OLIGONUCLEOTIDES - The present invention relates to processes and reagents for oligonucleotide synthesis and purification. One aspect of the present invention relates to compounds useful for activating phosphoramidites in oligonucleotide synthesis. Another aspect of the present invention relates to a method of preparing oligonucleotides via the phosphoramidite method using an activator of the invention. Another aspect of the present invention relates to sulfur-transfer agents. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to a method of preparing a phosphorothioate by treating a phosphite with a sulfur-transfer reagent of the invention. In a preferred embodiment, the sulfur-transfer agent is a 3-amino-1,2,4-dithiazolidine-5-one. Another aspect of the present invention relates to compounds that scavenge acrylonitrile produced during the deprotection of phosphate groups bearing ethylnitrile protecting groups. In a preferred embodiment, the acrylonitrile scavenger is a polymer-bound thiol. Another aspect of the present invention relates to agents used to oxidize a phosphite to a phosphate. In a preferred embodiment, the oxidizing agent is sodium chlorite, chloroamine, or pyridine-N-oxide. Another aspect of the present invention relates to methods of purifying an oligonucleotide by annealing a first single-stranded oligonucleotide and second single-stranded oligonucleotide to form a double-stranded oligonucleotide; and subjecting the double-stranded oligonucleotide to chromatographic purification. In a preferred embodiment, the chromatographic purification is high-performance liquid chromatography. | 08-11-2011 |
20120035115 | CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION - The invention features compounds of formula I or II: | 02-09-2012 |
Richa Pandey, Boston, MA US
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20140001455 | Spectrally Tunable Broadband Organic Photodetectors | 01-02-2014 |
Shree Prakash Pandey, Boston, MA US
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20100222410 | Nuclease compositions and methods - The present invention generally relates to various nucleases and uses thereof, and in some cases, to the UPF0054 protein superfamily. Members of the UPF0054 protein superfamily, such as the | 09-02-2010 |
Suresh Pandey, Chelmsford, MA US
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20100184970 | Porphyrin-based compounds for tumor imaging and photodynamic therapy - This invention describes a first report on the synthesis of certain | 07-22-2010 |
Suresh K. Pandey, North Chelmsford, MA US
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20150196672 | COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS - The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs. | 07-16-2015 |