Pan, US
Anlian Pan, Tempe, AZ US
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20110272744 | Laterally Varying II-VI Alloys and Uses Thereof - Described herein are semiconductor structures comprising laterally varying II-VI alloy layer formed over a surface of a substrate. Further, methods are provided for preparing laterally varying II-VI alloy layers over at least a portion of a surface of a substrate comprising contacting at least a portion of a surface of a substrate within a reaction zone with a chemical vapor under suitable reaction conditions to form a laterally varying II-VI alloy layer over the portion of the surface of the substrate, wherein the chemical vapor is generated by heating at least two II-VI binary compounds; and the reaction zone has a temperature gradient of at least 50-100° C. along an extent of the reaction zone. Also described here are devices such as lasers, light emitting diodes, detectors, or solar cells that can use such semiconductor structures. In the case of lasers, spatially varying wavelength can be realized while in the case of solar cells and detectors multiple solar cells can be achieved laterally where each cell absorbs solar energy of a given wavelength range such that entire solar spectrum can be covered by the said solar cell structure. For LED applications, spatial variation of alloy composition can be used to engineer colors of light emission. | 11-10-2011 |
Bei Pan, Los Angeles, CA US
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20140114556 | TRAFFIC PREDICTION USING REAL-WORLD TRANSPORTATION DATA - Real-time high-fidelity spatiotemporal data on transportation networks can be used to learn about traffic behavior at different times and locations, potentially resulting in major savings in time and fuel. Real-world data collected from transportation networks can be used to incorporate the data's intrinsic behavior into a time-series mining technique to enhance its accuracy for traffic prediction. For example, the spatiotemporal behaviors of rush hours and events can be used to perform a more accurate prediction of both short-term and long-term average speed on road-segments, even in the presence of infrequent events (e.g., accidents). Taking historical rush-hour behavior into account can improve the accuracy of traditional predictors by up to 67% and 78% in short-term and long-term predictions, respectively. Moreover, the impact of an accident can be incorporated to improve the prediction accuracy by up to 91%. | 04-24-2014 |
Caofeng Pan, Atlanta, GA US
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20120137783 | Hybrid Nanogenerator for Harvesting Chemical and Mechanical Energy - A generator includes a bio-compatible substrate onto which one mechanical generating unit is disposed. A plurality of elongated piezoelectric fibers each have a first end that is in electrical communication with a first electrode and an opposite second end that is in electrical communication with a second electrode. An insulative layer covers the first electrode, the second electrode and the elongated piezoelectric fibers. A third electrode and a fourth electrode are each disposed on the bio-compatible substrate opposite from the mechanical generating unit. A proton conducting member is in contact with both the third electrode and the fourth electrode. A glucose catalyzing enzyme is electrically coupled to the third electrode. An oxidase enzyme is electrically coupled to the fourth electrode. The third electrode is in electrical communication with each first electrode and the fourth electrode is in electrical communication with each second electrode. | 06-07-2012 |
20130049531 | Triboelectric Generator - A generator includes a thin first contact charging layer and a thin second contact charging layer. The thin first contact charging layer includes a first material that has a first rating on a triboelectric series. The thin first contact charging layer has a first side with a first conductive electrode applied thereto and an opposite second side. The thin second contact charging layer includes a second material that has a second rating on a triboelectric series that is more negative than the first rating. The thin first contact charging layer has a first side with a first conductive electrode applied thereto and an opposite second side. The thin second contact charging layer is disposed adjacent to the first contact charging layer so that the second side of the second contact charging layer is in contact with the second side of the first contact charging layer. | 02-28-2013 |
Chinglin Pan, Mauldin, SC US
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20120146262 | TREAD DE-MOLDING SYSTEM - A method and apparatus for tread de-molding is provided and, more particularly, a method and apparatus for removing a tread element such as e.g., a tread belt from a mold is provided. The apparatus may be inserted between upper and lower mold elements to allow for removal of a tread element from a mold. The apparatus may be adjustable for height. | 06-14-2012 |
20140060730 | METHODS AND APPARATUS FOR JOINING TREADS - The subject invention includes methods and apparatus for joining treads. Such methods include the step of providing a first tread portion and a second tread portion for forming a joined tread, each tread portion comprising a section of tire tread extending lengthwise from a terminal end. Additional steps include providing a first fixture configured to retain the first tread portion and a second fixture configured to retain the second tread portion and securing the first tread portion into the first fixture and securing the second tread portion into the second fixture, each of the first and second fixtures being arranged within the first and second fixtures such that the terminal end of each tread portion is in communication with a joining side of each fixture. The methods further include directing the terminal ends towards each other and into forceful engagement with an elastomeric joining material arranged between the terminal ends. | 03-06-2014 |
20140130961 | METHODS AND APPARATUS FOR INSTALLING A TREAD RING UPON A TIRE CARCASS - Exemplary embodiments of the subject invention comprise methods and apparatus for mounting a tread ring onto a tire carcass. Such methods may include the step of providing a tire tread ring having opposing side edges; arranging the tread ring in an initial ring arrangement in communication with a pressure source, the pressure source being in communication with an outer side of the tread ring; expanding the tread ring radially outward from the initial ring arrangement to an expanded arrangement, the tread ring being expanded by applying vacuum pressure along the outer side of the tread ring supplied by the pressure source; inserting a tire carcass within a central opening of the tread ring while in the expanded arrangement; contracting the tread ring into an installed arrangement about an outer surface of the tire carcass; and, releasing the vacuum along the outer side of the tread ring. | 05-15-2014 |
Chongxian Pan, Davis, CA US
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20140161719 | PORPHYRIN MODIFIED TELODENDRIMERS - The present invention provides amphiphilic telodendrimers that aggregate to form nanocarriers characterized by a hydrophobic core and a hydrophilic exterior. The nanocarrier core may include amphiphilic functionality such as cholic acid or cholic acid derivatives, and the exterior may include branched or linear poly(ethylene glycol) segments. Nanocarrier cargo such as hydrophobic drugs and other materials may be sequester in the core via non-covalent means or may be covalently bound to the telodendrimer building blocks. Telodendrimer structure may be tailored to alter loading properties, interactions with materials such as biological membranes, and other characteristics. | 06-12-2014 |
Dipanjan Pan, St. Louis, MO US
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20100297007 | LIGAND DIRECTED TOROIDAL NANOPARTICLES FOR THERAPY AND DIAGNOSTIC IMAGING - The present invention provides nanoparticles, methods of making the nanoparticles, and methods of using the nanoparticles to deliver therapeutic agents and/or imaging agents. | 11-25-2010 |
20100297019 | PARTICLES FOR IMAGING - The invention encompasses particles comprising metal atoms, methods of making the particles, and methods for using the particles. In particular, the particles may be used to image biological tissues or to deliver a bioactive agent. | 11-25-2010 |
20130122100 | PRODRUG COMPOSITIONS, PRODRUG NANOPARTICLES, AND METHODS OF USE THEREOF - Nanoparticles comprising a prodrug and prodrugs linked to phospholipids, wherein the linkages facilitate release of the prodrugs from the nanoparticles to sites within a target cell or cell membrane by fusion of the particle and the cell membrane are disclosed. Also disclosed are methods for producing and using the nanoparticles and their constituents. | 05-16-2013 |
20130230452 | CELL PERMEABLE NANOCONJUGATES OF SHELL-CROSSLINKED KNEDEL (SCK) AND PEPTIDE NUCLEIC ACIDS ("PNAs") WITH UNIQUELY EXPRESSED OR OVER-EXPRESSED mRNA TARGETING SEQUENCES FOR EARLY DIAGNOSIS AND THERAPY OF CANCER - A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50. | 09-05-2013 |
Dongfeng Pan, Charlottesville, VA US
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20130144035 | COMPOSITIONS AND METHODS FOR LEUKOCYTE-TARGETING MULTI-VALENT IMAGING PROBES - The present application discloses a new multivalent peptide ligand specifically targeting polymorphonuclear leukocytes (PMNs) with favorable pharmacological parameters to monitor sites of inflammation for imaging. The detailed synthesis, characterization, and pharmacological evaluation of the ligands are reported here. Two separate peptide binding ligands for formyl peptide and tuftsin receptors were chosen to link together based on the high expression levels of the two receptors on activated PMNs The heterobivalency and pegylated links were incorporated in the structural design to improve the sensitivity of the detection and to improve the bioavailability along with blood clearance profile, respectively. Two chemical constructs: cFLFLF-(PEG) | 06-06-2013 |
20140248213 | COMPOSITIONS AND METHODS FOR TUMOR IMAGING AND TARGETING BY A CLASS OF ORGANIC HEPTAMETHINE CYANINE DYES THAT POSSESS DUAL NUCLEAR AND NEAR-INFRARED PROPERTIES - The present invention provides for heptamethine cyanine dyes that possess both nuclear and near-infrared imaging capabilities. These dyes can be used for imaging, targeting and detecting tumors in patients. | 09-04-2014 |
20150050213 | COMPOSITIONS AND METHODS FOR IMAGING INFLAMMATION OF TRAUMATIC BRAIN INJURY - The present application provides compositions and methods for imaging traumatic brain injury using PET. The present application discloses using PET ligands targeting infiltrating neutrophils, such as a ligand of FPR, is useful for imaging inflammation. In one aspect, the ligand and imaging agent cFLFLF-PEG- | 02-19-2015 |
Enhui Pan, Durham, NC US
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20110236371 | Compositions And Methods For The Treatment Of Neurologic And Psychiatric Conditions - The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain. | 09-29-2011 |
20130177576 | Compositions And Methods For The Treatment Of Neurologic And Psychiatric Conditions - The invention provides pharmaceutical compositions and methods of use thereof for preventing or ameliorating disorders of the nervous system. More specifically, the invention provides pharmaceutical compositions, including phosphopeptides, that when administered disrupt TrkB-mediated activation of PLCγ1 phosphorylation. The invention further provides method of treatment comprising administering inhibitors of TrkB-mediated activation of PLCγ1 phosphorylation alone or in combination with other pharmaceutical compositions to prevent or ameliorate nervous system disorders such as epilepsy, stroke, anxiety, migraine, and pain. | 07-11-2013 |
Fong-Ioon Pan, Fort Wayne, IN US
Patent application number | Description | Published |
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20110015830 | SYSTEM AND METHOD FOR CONTROLLING AIR GAP BETWEEN A TRACTOR AND A TRAILER - A highway tractor ( | 01-20-2011 |
20110018699 | DIGITAL CAMERA REAR-VIEW SYSTEM - A rear-view system for a vehicle has a camera disposed on the vehicle. An electronic control unit receives and processes the image information from the camera. A display displays the processed image information from the electronic control unit. An alarm is operated by the electronic control unit. The electronic control unit is used to detect an object from the processed image information. If the distance between the vehicle and the object is less than a predetermined distance, the electronic control unit will activate the alarm. | 01-27-2011 |
Fong-Loon Pan, Fort Wayne, IN US
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20080217957 | AERODYNAMIC FOREBODY SHAPE FOR VAN TRAILER - An aerodynamic forebody device is provided for use with a tractor-trailer combination vehicle to be installed on the front of the semi-trailer. By optimizing the inclination angle of the top surface of the aerodynamic forebody device, aerodynamic drag is minimized. It is emphasized that this abstract is provided to comply with the rules requiring an abstract that will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 09-11-2008 |
Guirong Pan, Sumter, SC US
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20110293466 | ZIRCONIUM ALLOYS WITH IMPROVED CORROSION/CREEP RESISTANCE DUE TO FINAL HEAT TREATMENTS - Articles, such as tubing or strips, which have excellent corrosion resistance to water or steam at elevated temperatures, are produced from alloys having 0.2 to 1.5 weight percent niobium, 0.01 to 0.6 weight percent iron, and optionally additional alloy elements selected from the group consisting of tin, chromium, copper, vanadium, and nickel with the balance at least 97 weight percent zirconium, including impurities, where a necessary final heat treatment includes one of i) a SRA or PRXA (15-20% RXA) final heat treatment, or ii) a PRXA (80-95% RXA) or RXA final heat treatment. | 12-01-2011 |
Helen Kankan Pan, Portland, OR US
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20080238794 | Configurable antenna for mixed wireless networks - Methods and apparatus to reconfigure an antenna for use with mixed wireless networks are described. In one embodiment, a switch is coupled between a first portion and a second portion of an antenna to cause the antenna to tune to a plurality of radio frequency bands. Other embodiments are also described. | 10-02-2008 |
20150029064 | OPTICALLY TRANSPARENT ANTENNA FOR WIRELESS COMMUNICATION AND ENERGY TRANSFER - Embodiments of an optically transparent antenna are generally described herein. In some embodiments, the optically transparent antenna may comprise a plurality of electrically-isolated conductive patches arranged on a non-conductive surface. A combination of a size of the conductive patches and a spacing between the conductive patches is less than a human visual acuity for a predetermined viewing distance so that the patches are not be visible or perceptible to a human. In some embodiments, optically transparent antenna may serve as one or more antennas on a mobile platform. | 01-29-2015 |
Hongguang Pan, Rockville, MD US
Hongmu Pan, Newark, DE US
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20090270512 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal - Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor. | 10-29-2009 |
20100331418 | Pan-Antagonists For The Androgen Receptor And Androgen Receptor Mutants Associated With Anti-Androgen Withdrawal - Disclosed herein are novel antagonists of the androgen receptor and androgen receptor mutations associated with clinical failure of currently prescribed anti-androgens and use of said antagonists in the treatment of conditions associated with inappropriate activation of the androgen receptor. | 12-30-2010 |
Hua Pan, St. Louis, MO US
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20110123438 | UNIVERSAL ANCHOR PEPTIDE FOR NANOPARTICLES - The present invention provides a substantially non-lytic, non-cytotoxic anchor peptide that is capable of stably inserting into lipid membranes. In particular, the invention provides nanoparticles comprising stably inserted anchor peptides, which may be conjugated to a variety of different cargo complexes. | 05-26-2011 |
Huaizhong Pan, Salt Lake City, UT US
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20110085979 | CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS - Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. | 04-14-2011 |
20130156722 | POLYMERIC DRUG DELIVERY CONJUGATES AND METHODS OF MAKING AND USING THEREOF - Described herein are biodegradable drug delivery conjugates for effectively delivering bioactive agents to a subject. The drug delivery conjugates comprise a water-soluble high molecular weight linear biodegradable polymer backbone comprising a plurality of linear water-soluble polymeric segments connected to one another by a first (main-chain) cleavable linker, wherein a bioactive agent is covalently bonded to at least one water-soluble polymeric segment, at least one cleavable linker, or a combination thereof. The conjugates possess numerous advantages over prior art delivery conjugates. Also described herein are methods for making and using the conjugates. | 06-20-2013 |
20140212357 | CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS - Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed. | 07-31-2014 |
Huapu Pan, Charlottesville, VA US
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20100327382 | High Bandwidth, Monolithic Traveling Wave Photodiode Array - The monolithic application of a high speed TWPDA with impedance matching. Use of the high speed monolithic TWPDA will allow for more efficient transfer of optical signals within analog circuits and over distances. | 12-30-2010 |
20130113063 | HIGH BANDWIDTH, MONOLITHIC TRAVELING WAVE PHOTODIODE ARRAY - The monolithic application of a high speed TWPDA with impedance matching. Use of the high speed monolithic TWPDA will allow for more efficient transfer of optical signals within analog circuits and over distances. | 05-09-2013 |
Hui Pan, Coto De Caza, CA US
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20140167851 | CURRENT-MODE LINE DRIVER - Disclosed are various embodiments of a current-mode line driver that may facilitate transmitting signals to a load. The current-mode line driver may comprise a common-mode current sense element that provides a signal corresponding to the common-mode output current of the line driver. A transconductance element receives the signal from the common-mode current sense element and provides a compensating current that is based at least in part on the signal. The compensating current may reduce the common-mode output current of the line driver. | 06-19-2014 |
20150071136 | Full-Duplex Driver with Hybrid Adaptation - A system includes a full-duplex driver to drive signals on a load. A hybrid element connected with the full-duplex driver controls a flow of transmission and receipt of the signals. A gain control element connected with the full-duplex driver tunes a transconductance of the full-duplex driver to match an impedance of the load. The controlled gain is based on a leakage voltage value of the full-duplex driver. | 03-12-2015 |
James Nanhsi Pan, West Jordan, UT US
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20100000805 | SELF-PROPELLED LUGGAGE BAG WITH DETATCHABLE FOLDABLE WHEELS - The main body of the luggage bag has a special tilted shape that puts more weight at the top instead of at the bottom of the luggage bag. There are two sets of wheels. The first set of wheels is at the bottom of the luggage bag. The second set of wheels has a spring, screws or fixed positions attached to adjust the height. This second set of wheels can be foldable (into a box), or detachable from the luggage, and be attached to any existing traditional luggage bag. There is an “L” shape lever as part of the handle to release the stress of the human arm while dragging the luggage bag. The wheels can be connected and powered by electrical sources or batteries. | 01-07-2010 |
20100123065 | Foldable Detachable Curtain Rods - The set of foldable rods (or pipes) can be used for shower or window curtains. Most of the existing curtains are attached to one long fixed rod through many contacting devices, causing lots of friction and potential damages to the system and also to the human body. The new foldable system is composed of many shorter rods or pipes. Each rod or pipe is slightly smaller in diameter to fit into the previous section (rod or pipe). One hook (for window curtain) or two hooks (for shower curtain) are attached to each section (rod or pipe). There is only one wheel connecting the original long rod (fixed to the wall). So the friction between the foldable rods and the original long rod is minimized (but more wheels can be attached to the multiple pipes). One end of the rods is attached to the long fixed original rod through a clinching device. The other end of the rods is attached to the single wheel. | 05-20-2010 |
Jason Pan, Los Angeles, CA US
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20140243054 | MOBILE DEVICE CASE WITH CUSHION DEVICES - A case for a mobile device including a base wall and a plurality of side walls extending from the base wall to cover side surfaces of the mobile device. A plurality of cushion devices may pass through the side walls to cushion the mobile device from a force exerted upon the case. | 08-28-2014 |
Jia Pan, Jupiter, FL US
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20120190820 | FACILE AMIDE FORMATION VIA S-NITROSO THIOACID INTERMEDIATES - Provided are methods for forming a reactive S-nitroso thioacid (NTA), comprising nitrosation of a thioacid with a nitrosation reagent. Also provided are methods for: acylating a nucleophile including selective acylation with a high degree of selectivity toward amines over hydroxyls; amide or peptide bond formation; forming a dipeptide or polypeptide; and peptide coupling/ligation, comprising use of thioacid and amine starting materials, wherein the reactions are mediated by very reactive S-nitroso thioacid (NTA) intermediates enabling extremely fast reactions under mild conditions, providing for broad applications. | 07-26-2012 |
Jiahui Pan, Atlanta, GA US
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20090051931 | Systems and methods for measuring sample surface flatness of continuously moving samples - Measurement of sample surface flatness of a continuously moving sample. A conveyor continuously conveys a sample beneath a grating disposed at a non-zero angle with respect to the plane of conveyance. The relative distance between the sample and the angled grating changes with the horizontal translation of the sample. A camera disposed above the sample and the grating captures, at constant time intervals, a sequence of images, each image comprising a shadow moiré fringe pattern that is indicative of the sample's surface flatness. The continuous change in relative distance between the sample and the grating introduces a known or unknown phase step between the shadow moiré fringe patterns of each successive image. A computer associated with the camera processes the images to determine phase values of pixels at, and the relative height of the sample surface at, selected pixel locations of the sample. | 02-26-2009 |
Jian Pan, Salem, NH US
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20130265160 | Diagnostics of Hot-Standby/Redundant Owner System in an Ethernet/IP Adapter Device - Method, apparatuses, and software are described, in which an adapter in an EtherNet/IP network may determine whether a first redundant owner connection between the adapter and a first scanner is open. If it is determined that the first redundant owner connection is not open, then a network status light or other indicator of the adapter may be caused to emit a solid green color or otherwise indicate a first status if a second redundant owner connection between the adapter and a second scanner is open, and to emit a flashing red color or a flashing green color (or otherwise indicate a second or third status) if no redundant owner connection to the adapter is open. | 10-10-2013 |
Jin Pan, Hillsboro, OR US
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20140152383 | INTEGRATED CIRCUITS AND SYSTEMS AND METHODS FOR PRODUCING THE SAME - Three dimensional integrated circuits including semiconductive organic materials are described. In some embodiments, the three dimensional integrated circuits include one or more electronic components that include a semiconductive region formed of one or more semiconductive organic materials. The electronic components of the three dimensional integrated circuits may also include insulating regions formed from organic insulating materials, and conductive regions form from conductive materials. The three dimensional integrated circuits may be formed by an additive manufacturing process such as three dimensional printing. Apparatus and methods for producing and testing three dimensional integrated circuits are also described. | 06-05-2014 |
Jin Pan, Portland, OR US
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20140002994 | THERMAL INTERFACE FOR MULTI-CHIP PACKAGES | 01-02-2014 |
20140266285 | INTEGRATED CIRCUIT TESTING ARCHITECTURE - In accordance with one aspect of the present description, an interface between an integrated circuit device and a test controller for testing the integrated circuit device includes a plurality of boards coupled together. In one embodiment, the test interface includes a plurality of interchangeable auxiliary boards, each having test circuitry, which may be coupled to a primary board and reused as appropriate to test various integrated circuits. Other aspects are described. | 09-18-2014 |
Jing Jong Pan US
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20100027096 | Tunable Optical Filter and Method of Manufacture Thereof - A tunable optical filter is formed in the structure of an etalon. A thin electro-optic ceramic substrate is fixed between two end substrates. Each end substrate has an inner parallel surface toward said electro-optic ceramic substrate covered by an electrode layer and a reflecting layer. An adhesive which attaches the electro-optic ceramic substrate to each first and second end substrates has a consistency so as to avoid stress on the electro-optic ceramic substrate. A voltage imposed on the electro-optic ceramic substrate by the electrode layers on the inner parallel surfaces of the first and second end substrates effectively controls an optical distance between the reflective coating layers on the inner parallel surfaces of the first and second end substrates of the etalon structure. The electro-optic ceramic substrate is preferably PMN-PT ((1-x)Pb(Mg⅓Nb⅔)O | 02-04-2010 |
Jingning Pan, Tucson, AZ US
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20100021084 | RESOLUTION ENHANCEMENT OF VIDEO SEQUENCES WITH ARBITRARY ENHANCEMENT FACTOR - Restoration based super-resolution combines a video sequence of low-resolution noisy blurred images using maximum likelihood estimation without regularization to produce a higher resolution image or video sequence up to a maximum enhancement factor r for the given video sequence. The maximum r value for a given sequence of low-resolution images that guarantees each high-resolution bin (pixel) will have at least one assigned pixel value from a low-resolution image is calculated. With the knowledge of max r, the system can select an r less than or equal to max r and thus operate without regularization. System robustness is further enhanced by providing a modified MLE estimator that can perform super resolution for arbitrary real-valued r so that enhancement is not limited to integer values. | 01-28-2010 |
Jiuping Pan, Raleigh, NC US
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20120092904 | COORDINATED CONTROL OF MULTI-TERMINAL HVDC SYSTEMS - Multi-terminal HVDC systems and control methods therefore are disclosed. Methods for controlling multi-terminal HVDC systems having a plurality of converter stations may include receiving a plurality of measurements from a plurality of measurement units disposed on the HVDC system, identifying from the measurements a disruption within the HVDC system, monitoring the measurements to identify a steady-state disrupted condition for the HVDC system, calculating a new set point for at least one of the plurality of converter stations, which new set point may be based on the steady-state disrupted condition and the measurements, and transmitting the new set point to the at least one of the plurality of converter stations. In some examples, the HVDC systems may include an HVDC grid interconnecting the plurality of converter stations and a controller communicatively linked to the plurality of measurement units and the plurality of converter stations. | 04-19-2012 |
20120248874 | METHOD AND APPARATUS FOR IMPROVING THE OPERATION OF AN AUXILIARY POWER SYSTEM OF A THERMAL POWER PLANT - Apparatus and method for controlling power in an auxiliary power system of a thermal power plant having a generator and one or more auxiliary buses. The apparatus includes adjustable speed drives and capacitance sources for connection to the one or more auxiliary buses and sensors for measuring voltage and reactive power on the one or more auxiliary buses. A controller is operable to control the adjustable speed drives and the capacitance sources to control the power factor of the auxiliary power system, while providing steady state voltage regulation and dynamic voltage support. | 10-04-2012 |
20130197704 | DC CONNECTION SCHEME FOR WINDFARM WITH INTERNAL MVDC COLLECTION GRID - Connection schemes for offshore power generation with an internal collection grid include a power generation system which includes a plurality of generator-rectifier subsystems. The scheme further includes a medium voltage DC (MVDC) collection network with positive pole cables and negative pole cables connected to the DC outputs of the generator-rectifier subsystems. At least one offshore substation includes a positive bus bar and a negative bus bar correspondingly connected to the positive pole cables and negative pole cables of the MVDC collection network and a plurality of main DC-DC converters. Each main DC-DC converter includes multiple modules connected to the MVDC bus bars and each module has a positive and a negative output such that the modules' outputs are serially connected to one another. The schemes may also include a high voltage DC (HVDC) transmission system connected to the modules' outputs and at least one DC/AC converter at an onshore substation. | 08-01-2013 |
20130200714 | MEDIUM VOLTAGE DC COLLECTION SYSTEM - A power generation system includes at least one generator having at least two sets of stator windings, an active rectifier comprising power cell based modular converters associated with each set of generator windings. Each set of windings is connected to an AC voltage side of the associated active rectifier, with each active rectifier having a positive DC voltage output and a negative DC voltage output. The DC voltage outputs of active rectifiers are connected to each other in series. A medium voltage DC (MVDC) collection network comprises positive pole cables and negative pole cables, wherein each positive pole cable is connected to the positive DC voltage output of a first active rectifier and each negative pole cable is connected to the negative DC voltage output of a last active rectifier. A substation receives the negative and positive pole cables of the MVDC collection network for further transformation and transmission. | 08-08-2013 |
20140197639 | Turbine-Based Energy Generation System With DC Output - An energy generation system includes a turbine, an electric generator, a step-up transformer, and a converter. The turbine is operable to extract energy from a fluid flow and convert the extracted energy into mechanical energy. The electric generator is operable to convert the mechanical energy from the turbine into AC electrical energy. The step-up transformer is operable to transfer the AC electrical energy at a lower voltage from the electric generator to a higher voltage. The converter is operable to convert the AC electrical energy at the higher voltage to DC electrical energy. The converter includes a converter leg for a phase of the AC electrical energy. The converter leg has an upper arm with a first plurality of sub-modules and a lower arm with a second plurality of sub-modules. Each sub-module is operable to function as a controlled voltage source. | 07-17-2014 |
20140240880 | COORDINATED CONTROL METHOD FOR POWER DISTRIBUTION SYSTEM WITH DC BUS ELECTRIFICATION SCHEME AND APPARATUS THEREOF - The present invention discloses a coordinated control method for power distribution system with DC bus electrification scheme and apparatus thereof. The method comprises: detecting what kind of disturbances occurs, and at least one of following steps: restoring the voltages of the failed DC buses if power loss is detected on the DC buses due to temporary or permanent failures of upstream power supplies; controlling the voltage of the abnormal DC buses if overvoltage or under-voltage is detected on the DC buses due to internal or external disturbances; and supporting the voltages of the abnormal AC buses if overvoltage or under-voltage is detected on the AC buses due to internal or external disturbances. The methods and apparatus can further improve the fault-ride-through capability for power plant under external or internal disturbances, and facilitate smooth automatic switching process between two DC buses etc. | 08-28-2014 |
20140254053 | TRAVELLING-WAVE BASED FAULT PROTECTION OF HIGH-VOLTAGE TRANSMISSION LINES - An improved method of fault detection in a high-voltage direct current (HVDC) power transmission line is provided. The fault detection is based on fault-induced travelling waves. The method comprises estimating an amplitude of fault-induced travelling waves at the fault location, and calculating a fault resistance (R | 09-11-2014 |
20140336833 | Wind Park With Real Time Wind Speed Measurements - A system for producing electrical power based on wind energy is capable of predicting its power output. The system includes a set of wind turbine units, a first plurality of sensors each adapted to sense at least one wind characteristic at some of the wind turbine units, and a second plurality of sensors remotely located. At least one wind characteristic is estimated at the wind turbines not having one of the first plurality of sensors based on sensing by the first plurality of sensors and an estimate of changes in wind characteristic at wind turbine units caused by presence of other wind turbine units. The magnitude of electrical power production by the set of wind turbine units at at least one predefined point in time in the future is predicted based on the estimated wind characteristics and sensed wind characteristics. | 11-13-2014 |
Juiping Pan, Raleigh, NC US
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20120181862 | Internal Electrification Scheme For Power Generation Plants - An apparatus for use in an electrical power generation plant. The apparatus includes: at least two adjustable speed drives, each connected, on an alternating current side, to an associated auxiliary motor; at least one reactive power consuming auxiliary device connected to an alternating current bus; a controller; a converter for converting alternating current to direct current or vice versa between the alternating current bus and a direct current bus; and at least one electrical power source arranged to provide power to the direct current bus. Each of the at least two adjustable speed drive is connected, on a direct current side, to the direct current bus. | 07-19-2012 |
20130077204 | BREAKER FAILURE PROTECTION OF HVDC CIRCUIT BREAKERS - A breaker failure protection system for a high voltage direct current, HVDC, circuit breaker is provided. The circuit breaker is arranged for interrupting a DC circuit upon reception of a trip signal. The protection system includes a current sensor, at least one inductor, and a breaker failure detection unit. The current sensor is arranged for measuring a current I(t) through the DC circuit. The at least one inductor is connected in series with the DC circuit. The breaker failure detection unit is arranged for assessing, whether the circuit breaker has failed, and sending, if the circuit breaker has failed, a trip signal to an adjacent circuit breaker. The assessment is based on the measured current. The stability of HVDC grids may be improved by sending, in case of a breaker failure, a trip signal to adjacent circuit breakers. Further, a method of breaker failure protection for an HVDC circuit breaker is provided. | 03-28-2013 |
20130088802 | FAULT PROTECTION OF HVDC TRANSMISSION LINES - A protection system for high voltage direct current, HVDC, transmission lines is provided. The protection system includes a direct current, DC, bus, a device configured to connect an HVDC transmission line to the bus, at least one DC circuit breaker arranged for disconnecting the transmission line from the bus upon reception of a trip signal, current and voltage sensors, an inductor arranged such that the current through the transmission line passes the inductor, and a fault detection unit. The fault detection unit is arranged for assessing, on the basis of current and/or voltage measurements, whether a fault exists on the transmission line, and sending, if a fault is detected on the transmission line, a trip signal to the circuit breaker. The additional inductance limits the rise in fault current and facilitates a selective fault detection. Further, a method of fault protection for an HVDC transmission line is provided. | 04-11-2013 |
Lee Pan, Tampa, FL US
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20110144570 | SYSTEMS AND METHODS FOR PERFORMING PERITONEAL DIALYSIS - Systems and methods for providing multiple pass continuous flow dialysis therapy are provided. The present invention includes a fluid circuit connected to a patient via a catheter thereby defining a fluid loop along which a therapy fluid including a dialysate can be continuously circulated into, through and out of a peritoneal cavity of a patient to remove a therapeutically effective amount of excess water and solutes including uremic toxins. The feed rate and discharge rate of therapy fluid into the fluid loop can be controllably regulated in proportion to the circulation rate of fluid in the fluid loop such that the therapy fluid can pass a multiple number of times along the fluid loop prior to discharge. | 06-16-2011 |
Lu Pan, Milpitas, CA US
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20140063637 | Systems and Methods for NPML Calibration - The present invention is related to systems and methods for adaptive parameter modification in a data processing system. | 03-06-2014 |
Min-Chun Pan US
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20120085908 | BIDIRECTIONAL OPTICAL SCANNER ASSISTING IN MAMMOGRAPHY - A bidirectional optical scanner assisting in mammography is revealed. The optical scanner that calculates functional images obtained by diffuse optical tomography, used in combination with a mammography machine can reduce the number of mammograms taken and the dose exposure. The bidirectional optical scanner includes a compression module, a first optical detection module, and a second optical detection module. The same test position of the tested breast can be detected twice in different directions by the first and the second optical detection modules. No matter where the tumor is located, the tumor can be detected. Besides structural images provided by the mammography machine, functional tomographic images of the breast are obtained by the bidirectional optical scanner. Thus diagnostic accuracy in the detection of breast cancer is improved. | 04-12-2012 |
Minghu A. Pan, Knoxville, TN US
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20130264747 | SELF-ASSEMBLY PATTERNING OF ORGANIC MOLECULES ON A SURFACE - The embodiments disclosed herein include all-electron control over a chemical attachment and the subsequent self-assembly of an organic molecule into a well-ordered three-dimensional monolayer on a metal surface. The ordering or assembly of the organic molecule may be through electron excitation. Hot-electron and hot-hole excitation enables tethering of the organic molecule to a metal substrate, such as an alkyne group to a gold surface. All-electron reactions may allow a direct control over the size and shape of the self-assembly, defect structures and the reverse process of molecular disassembly from single molecular level to mesoscopic scale. | 10-10-2013 |
Pai-Hung Pan, Boise, ID US
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20080203542 | ION-ASSISTED OXIDATION METHODS AND THE RESULTING STRUCTURES - Oxidation methods and resulting structures including providing an oxide layer on a substrate and then re-oxidizing the oxide layer by vertical ion bombardment of the oxide layer in an atmosphere containing at least one oxidant. The oxide layer may be provided over diffusion regions, such as source and drain regions, in a substrate. The oxide layer may overlie the substrate and is proximate a gate structure on the substrate. The at least one oxidant may be oxygen, water, ozone, or hydrogen peroxide, or a mixture thereof. These oxidation methods provide a low-temperature oxidation process, less oxidation of the sidewalls of conductive layers in the gate structure, and less current leakage to the substrate from the gate structure. | 08-28-2008 |
20110129985 | METHODS FOR FORMING ISOLATION STRUCTURES FOR SEMICONDUCTOR DEVICES - A shallow isolation trench structure and methods of forming the same wherein the method of formation comprises a layered structure of a buffer film layer over a dielectric layer that is atop a semiconductor substrate. The buffer film layer comprises a material that is oxidation resistant and can be etched selectively to oxide films. The layered structure is patterned with a resist material and etched to form a shallow trench. A thin oxide layer is formed in the trench and the buffer film layer is selectively etched to move the buffer film layer back from the corners of the trench. An isolation material is then used to fill the shallow trench and the buffer film layer is stripped to form an isolation structure. When the structure is etched by subsequent processing step(s), a capped shallow trench isolation structure that covers the shallow trench corners is created. | 06-02-2011 |
20130001737 | SEMICONDUCTOR DEVICES STRUCTURES INCLUDING AN ISOLATION STRUCTURE - A shallow isolation trench structure and methods of forming the same wherein the method of formation comprises a layered structure of a buffer film layer over a dielectric layer that is atop a semiconductor substrate. The buffer film layer comprises a material that is oxidation resistant and can be etched selectively to oxide films. The layered structure is patterned with a resist material and etched to form a shallow trench. A thin oxide layer is formed in the trench and the buffer film layer is selectively etched to move the buffer film layer back from the corners of the trench. An isolation material is then used to fill the shallow trench and the buffer film layer is stripped to form an isolation structure. When the structure is etched by subsequent processing step(s), a capped shallow trench isolation structure that covers the shallow trench corners is created. | 01-03-2013 |
20130309855 | METHODS FOR REOXIDIZING AN OXIDE AND FOR FABRICATING SEMICONDUCTOR DEVICES - Oxidation methods and resulting structures including providing an oxide layer on a substrate and then reoxidizing the oxide layer by vertical ion bombardment of the oxide layer in an atmosphere containing at least one oxidant. The oxide layer may be provided over diffusion regions, such as source and drain regions, in a substrate. The oxide layer may overlie the substrate and is proximate a gate structure on the substrate. The at least one oxidant may be oxygen, water, ozone, or hydrogen peroxide, or a mixture thereof. These oxidation methods provide a low-temperature oxidation process, less oxidation of the sidewalls of conductive layers in the gate structure, and less current leakage to the substrate from the gate structure. | 11-21-2013 |
Peiliang Pan, Falls Church, VA US
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20130325982 | CHAT ROOM VIEWING - A system and method allows a user to view communications exchanged between other participants within an online chat room without the user becoming a participant within the online chat room. The online chat room enables ongoing exchanges of electronic communications between two or more participants whose participation within the chat room are mutually revealed to each other. A user is enabled to perceive the existence of the online chat room without the user becoming a participant within the online chat room. Selection of the online chat room by the user is received. Responsive to user selection of the online chat room and without the user becoming a participant within the online chat room, at least some of the communications exchanged between the participants within the online chat room are made perceivable to the user as the communications are exchanged. | 12-05-2013 |
Pingping Pan, Cupertino, CA US
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20140153038 | PRINTER RANKINGS IN CLOUD PRINTING - An approach is provided for ranking cloud printing devices. A printing device ranking service is configured to retrieve printing device information data that specifies one or more attributes of a plurality of printing devices and print job data that specifies one or more attributes of a plurality of print jobs that have been processed by the plurality of printing devices. The printing device ranking service determines, based at least upon the printing device information data and the print job data, rankings data for the plurality of printing devices, wherein the rankings data indicate a ranking of the printing devices from the plurality of printing devices. | 06-05-2014 |
Ray Pan, Oak Creek, WI US
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20130190966 | SYSTEM AND METHOD FOR MONITORING MINING MACHINE EFFICIENCY - A mining machine comprising a power monitor sensing power consumption of the mining machine during a select time period to generate power consumption data; a sensor sensing payload of the mining machine during the select time period to generate payload data; and a monitoring module. The monitoring module including computer readable media for comparing the power consumption data and the payload data to generate shovel efficiency data, and outputting the shovel efficiency data. | 07-25-2013 |
Shaoher X. Pan US
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20080273233 | MICRO-DEVICE ENCAPSULATION HAVING LIGHT AND MOISTURE CONTROL - An encapsulated micro device includes a micro device on a substrate within a chamber, a transparent encapsulation cover in part defining the chamber, an opaque layered structure on the encapsulation cover and inside the chamber. The layered structure includes an opening over the micro device and is configured to absorb light and moisture In the chamber. A spacer wall between the substrate and the encapsulation cover in part defines the chamber. | 11-06-2008 |
20080308835 | SILICON BASED SOLID STATE LIGHTING - A semiconductor device includes a substrate comprising a first surface having a first orientation and a second surface having a second orientation and a plurality of III-V nitride layers on the substrate, wherein the plurality of III-V nitride layers are configured to emit light when an electric current is produced in one or more of the plurality of III-V nitride layers. | 12-18-2008 |
20110175055 | SOLID STATE LIGHTING DEVICE ON A CONDUCTIVE SUBSTRATE - A light emitting device includes a conductive substrate having a first substrate surface and comprising a conductive material, a protrusion formed on the conductive substrate, wherein the protrusion is defined in part by a first protrusion surface that is not parallel to the first substrate surface, and light emission layers disposed over the first protrusion surface. The light emission layers can emit light when an electric field is applied across the light emission layers. | 07-21-2011 |
20110177636 | MANUFACTURING PROCESS FOR SOLID STATE LIGHTING DEVICE ON A CONDUCTIVE SUBSTRATE - A method for fabricating a light emitting device includes forming a trench in a first surface on a first side of a substrate. The trench comprises a first sloped surface not parallel to the first surface, wherein the substrate has a second side opposite to the first side of the substrate. The method also includes forming light emission layers over the first trench surface and the first surface, wherein the light emission layer is configured to emit light and removing at least a portion of the substrate from the second side of the substrate to form a protrusion on the second side of the substrate to allow the light emission layer to emit light out of the protrusion on the second side of the substrate. | 07-21-2011 |
Shimei Pan US
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20110060983 | PRODUCING A VISUAL SUMMARIZATION OF TEXT DOCUMENTS - A method and system of producing a visual text summarization. According to the method, a plurality of topics may be extracted from a collection of text documents, where each of the topics comprises a distribution of topic keywords. An importance ranking for each of the topics may be determined, and an importance ranking for each of the topic keywords of a topic may also be determined. A graph may be displayed having a plurality of stacked layers representing a group of topics selected from the plurality of topics based on the importance ranking of the topics. A keyword cloud within each layer of the graph may also be displayed, where the one keyword cloud is a group of topic keywords selected from the extracted topic keywords based on the importance ranking of the extracted topic keywords. | 03-10-2011 |
Shuchong Pan, Rochester, MN US
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20100204094 | DIURETIC AND NATRIURETIC POLYPEPTIDES - This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have diuretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing diuretic and/or natriuretic activities within a mammal. | 08-12-2010 |
20130143816 | ISOFORMS OF BRAIN NATRIURETIC PEPTIDE - Methods and materials for diagnosing and treating heart conditions (e.g., heart failure) and kidney conditions (e.g., kidney failure) are described. | 06-06-2013 |
20130143820 | DIURETIC AND NATRIURETIC POLYPEPTIDES - This document provides diuretic and natriuretic polypeptides. For example, this document provides polypeptides having diuretic and/or natriuretic activities. In some cases, a polypeptide provided herein can have diuretic and natriuretic activities, while lacking the ability to lower blood pressure. This document also provides methods and materials for inducing diuretic and/or natriuretic activities within a mammal. | 06-06-2013 |
Shuyang Pan, Southgate, MI US
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20110178224 | MULTIFUNCTIONAL GRAPHENE-SILICONE ELASTOMER NANOCOMPOSITE, METHOD OF MAKING THE SAME, AND USES THEREOF - A nanocomposite composition having a silicone elastomer matrix having therein a filler loading of greater than 0.05 wt %, based on total nanocomposite weight, wherein the filler is functional graphene sheets (FGS) having a surface area of from 300 m | 07-21-2011 |
Tai-Jee Pan, Beaverton, OR US
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20140192679 | Convergent Network Node with the Automatic Reconfiguration Capability - An embodiment is a portable in-home display/controller device including a power line communication interface providing two-way communication over a power line communication medium, a wireless communication interface providing two-way communication over a wireless network, and a docking station configured to receive the portable in-home display/controller for connection to the power line communication medium. The wireless communication interface provides access point functionality when the in-home display/controller device is docked to the docking station and connects to a communication network via the power line communication interface. The in-home display/controller device is configured to automatically, without operator intervention, function as a wireless client when it is removed from the docking station. | 07-10-2014 |
Tsung-Yu Pan, Ypsilanti, MI US
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20120315399 | METHOD OF MAKING NANOPARTICLE REINFORCED METAL MATRIX COMPONENTS - A method of making a nanoparticle reinforced metal matrix component is provided. The method involves solid state processing nanoparticles into a metal matrix material at solid state processing conditions to form a master alloy. At least a portion of the master alloy is added to a mass of metal melt to produce the nanoparticle reinforced metal matrix component. | 12-13-2012 |
Wei-Ping Pan, Bowling Green, KY US
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20120214106 | CHEMICAL LOOPING COMBUSTION - A chemical looping combustion process for producing heat or steam or both from a hydrocarbon fuel. A metal oxide oxygen carrier is reduced from an initial oxidation state in a first reduction reaction with a hydrocarbon fuel to provide CO | 08-23-2012 |
Wie-Hin Pan, Canton, MI US
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20100043135 | ADJUSTABLE SHOWERHEAD ASSEMBLY - An example adjustable showerhead assembly includes a shroud and a showerhead movable between a first position attached to the shroud and a second position detached from the shroud. A flexible conduit communicates fluid to the showerhead. The shroud contains the flexible conduit when the showerhead is in the first position. | 02-25-2010 |
Xiao Pan, Fargo, ND US
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20130036939 | NOVEL ACETOACETOXY AND ENAMINE COMPOUNDS AND COATINGS THEREFROM - The invention relates to enamine resins which are the reaction products of a) an acetoacetylated resin, and a C | 02-14-2013 |
20140336301 | HIGHLY FUNCTIONAL EPOXIDIZED RESINS AND COATINGS - The invention provides highly functional epoxy resins that may be used themselves in coating formulations and applications but which may be further functionalized via ring-opening reactions of the epoxy groups yielding derivative resins with other useful functionalities. The highly functional epoxy resins are synthesized from the epoxidation of vegetable or seed oil esters of polyols having 4 or more hydroxyl groups/molecule. In one embodiment, the polyol is sucrose and the vegetable or seed oil is selected from corn oil, castor oil, soybean oil, safflower oil, sunflower oil, linseed oil, tall oil fatty acid, tung oil, vernonia oil, and mixtures thereof. Methods of making of the epoxy resin and each of its derivative resins are disclosed as are coating compositions and coated objects using each of the resins. | 11-13-2014 |
Xiong Pan, Raleigh, NC US
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20130319753 | ELECTRICAL EQUIPMENT ENCLOSURES HAVING RECONFIGURABLE CABLE DUCT SYSTEMS AND RELATED METHODS THEREOF - An electrical enclosure that may house electrical equipment having a reconfigurable cable duct system with one or more movable flaps to form alternative pathways in the enclosure for routing electrical cables from connections inside the enclosure to designated areas outside the enclosure. Methods of routing electrical cables through an enclosure and of assembling a cable duct system within an enclosure are also provided, as are other aspects. | 12-05-2013 |
20130320831 | SEALED DOORS, ENCLOSURES, AND METHODS ADAPED FOR USE WITH ELECTRICAL ARC-PRONE COMPONENTS - A sealed enclosure is disclosed. Sealed enclosure has a case configured to receive an arc-prone electrical component, a face frame defining an opening, a door configured to cover the opening, a sealing surface on the face frame or on the door, and one or more flaps having an sealing portion, the sealing portion being angled relative to the sealing surface, the one or more flaps being operational to flex from a disengaged position when not under pressure, to an engaged position in contact with the sealing surface when exposed to pressure inside the case during an arcing event. Sealed enclosure doors and methods of sealing an enclosure during an arcing event are also provided, as are other aspects. | 12-05-2013 |
Yan Pan, Tallahassee, FL US
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20090085574 | Method for locating phase to ground faults in DC distribution systems - A method for locating phase to ground faults in DC distribution systems. The method includes utilizing wavelet analysis using Multi-Resolution Analysis (MRA) as a signal processing tool for recognition of characteristic features in the voltage signal. The voltage signal contains characteristic information in the high frequency range above the switching frequencies of the PE converters which allows for localization of the fault. | 04-02-2009 |
Yinghui Pan, Cheyenne, WY US
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20110123902 | Permselective Membrane-Free Direct Fuel Cell and Components Thereof - There is disclosed a direct fuel cell comprising an anode and a cathode immersed in an electrolyte in the presence of a reductant and oxidant. Specifically, the fuel cell lacks a permselective membrane or other chemical barrier between the anode and cathode. Instead, the fuel cell has a mechanical/electrical porous separator that permits the free diffusion of liquid between all elements of the fuel cell. The fuel cell further contains an anode electrode of conductive substrate with catalyst and a cathode comprising a hydrophobic coated material that prevents cathode flooding. As a result, oxidation of the anode fuel and reduction of the cathode fuel occur to a substantial extent only at the anode and cathode, respectively, and is capable for ambient pressure/temperature and passive operation. | 05-26-2011 |
Yong Pan, Covington, KY US
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20120139540 | METHOD OF EVALUATING PERFORMANCE CHARACTERISTICS - A non-destructive method of visualizing penetration of a soil and/or fabric conditioning component in a fabric using imaging techniques. The method may be used to determine qualitatively and/or quantitatively the penetration of soil and/or fabric conditioning component into the fabric. By comparing images before and after fabric treatment processes, the efficacy of a fabric treatment processes can be assessed. | 06-07-2012 |
Yongchun Pan, Newarl, DE US
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20130289036 | SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-B][1,2,- 4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME - The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof. | 10-31-2013 |
Yuan-Cheng Pan, Portland, OR US
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20130105951 | BLOCK POWER SWITCH WITH EMBEDDED ELECTROSTATIC DISCHARGE (ESD) PROTECTION AND ADAPTIVE BODY BIASING | 05-02-2013 |
Yuancheng Christopher Pan, Portland, OR US
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20120257618 | Method for Expanding a Single Chassis Network or Computing Platform Using Soft Interconnects - A system and method for expanding a chassis network using soft interconnects, including a hybrid chassis comprising a first fabric card comprising a first switching fabric, a second fabric card comprising a second switching fabric, a first set of line cards coupled to the first switching fabric via a first set of hard connections, and coupled to an interface associated with the second switching fabric via a soft connection, and a second set of line cards coupled to the second fabric card. | 10-11-2012 |
Yuanlong Pan, Chesterfield, MO US
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20090054386 | Compositions and Methods for Inducing Bone Growth and Inhibiting Bone Loss - Compositions useful for inducing bone growth or inhibiting bone loss in an animal comprising one or more isoflavones or isoflavone metabolites and methods for inducing bone growth or inhibiting bone loss in an animal utilizing such compositions. The compositions and methods are particularly useful for post-menopause, post-andropause, gonadectomized, spayed, or neutered animals. | 02-26-2009 |
20100233304 | COMPOSITIONS COMPRISING UNSATURATED FATTY ACIDS AND NITRIC OXIDE RELEASING COMPOUNDS AND USE THEREOF FOR ENHANCING COGNITIVE AND RELATED FUNCTIONS - Compositions comprising one or more unsaturated fatty acids and one or more nitric oxide releasing compounds, and methods for using such compositions for enhancing cognitive function, reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal. Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals. | 09-16-2010 |
20100292330 | COMPOSITIONS AND METHODS FOR ENHANCING COGNITIVE FUNCTION - The invention provides compositions comprising one or more long chain polyunsaturated fatty acids, nitric oxide releasing compounds, and medium chain triglycerides and methods for using such compositions for enhancing cognitive function, reducing or preventing a decline of social interaction, reducing or preventing age-related behavioral changes, increasing trainability, maintaining optimal brain function, facilitating learning and memory, reducing memory loss, retarding brain aging, preventing or treating strokes, and preventing or treating dementia in an animal. Preferably, the compositions are food compositions useful for enhancing cognitive function in humans and companion animals. | 11-18-2010 |
20110162981 | METHODS AND COMPOSITIONS FOR PREVENTING, REDUCTING OR TREATING DAMAGE CAUSED BY ISCHEMIA AND SCHEMIA-LIKE CONDITIONS - Methods for using wolfberry for one or more of preventing, reducing, or treating damage caused by ischemia and ischemia-like conditions; preventing, reducing, or treating strokes and damage caused by strokes; preventing, reducing, or treating alterations in brain function; preventing, reducing, or treating cognitive dysfunction syndrome; preventing, reducing, or treating mild cognitive impairment; preventing, reducing, or treating dementia; preventing, reducing, or treating a decline in social interaction; preventing, reducing, or treating age-related behavioral changes; facilitating, maintaining, and enhancing cognitive function; facilitating, maintaining, and enhancing learning and memory; facilitating, maintaining, and enhancing optimal brain function; reducing memory loss; increasing trainability; improving the quality of life; and promoting the health and wellness in an animal. | 07-07-2011 |
20110165125 | METHODS FOR ENHANCING ENERGY METABOLISM - The invention provides methods for one or more of enhancing energy metabolism, promoting healthy energy metabolism, maintaining healthy energy metabolism, preventing conditions that result in a decline or deficiency in energy metabolism, treating conditions that result in a decline or deficiency in energy metabolism, and preventing the accumulation of excess body fat in animals without reducing energy intake by the animals. The methods comprise administering isoflavones to the animals, preferably in amounts of from about 0.001 to about 10 g/kg/day. | 07-07-2011 |
20110165198 | METHOD FOR REDUCING LIPID ABSORPTION BY AN ANIMAL - The invention provides methods for using fatty acid alkanolamides for reducing lipid absorption from the intestine of an animal. Reducing lipid absorption results in fewer lipids available for an animal to convert to body fat. Converting fewer lipids to body fat means that the animal reduces body fat, body weight, and/or body weight gain when consuming an equivalent amount of lipids without the fatty acid alkanolamides. | 07-07-2011 |
20110183870 | GENE EXPRESSION PROFILES ASSOCIATED WITH LEAN PHENOTYPE AND USES THEREOF - Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed | 07-28-2011 |
20120040855 | TISSUE-SPECIFIC AGING BIOMARKERS - The invention provides methods of developing tissue-specific biomarkers of aging, sets of robust biomarkers identified by those methods, and uses of the biomarkers to identify nutrients and other functional ingredients or agents having anti-aging properties. | 02-16-2012 |
20120149777 | COMPOSITIONS AND METHODS FOR IMPROVING CELLULAR SURVIVAL AND REDUCING APOPTOSIS AFTER ISCHEMIC EPISODE IN THE BRAIN - Compositions and methods for enhancing vascular integrity in animals are disclosed. The compositions and methods, which utilize long chain polyunsaturated fatty acids and nitric oxide releasing compounds are also effective for reducing ischemia-induced brain injury in an animal. | 06-14-2012 |
20120202759 | ISOFLAVONE COMPOSITIONS FOR REDUCING ACCUMULATION OF BODY FAT IN MALE MAMMALS, AND METHODS FOR THEIR USE - Edible compositions useful for weight management in male animals are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites and are particularly useful for reducing or preventing the accumulation of body fat. Also disclosed are methods useful for weight management in an animal utilizing compositions comprising one or more isoflavones. The compositions and methods are particularly useful for the reduction or prevention of body fat accumulation during periods of excess caloric intake, and preferably have a sparing effect on lean body mass. | 08-09-2012 |
20120238515 | METHODS FOR PREVENTING OR TREATING SARCOPENIA AND MUSCLE ATROPHY IN ANIMALS - The invention provides methods for one or more of preventing or treating sarcopenia and muscle atrophy in animals. The methods comprise administering isoflavones to the animals, preferably in amounts of from about 0.001 to about 10 g/kg/day. | 09-20-2012 |
20120270814 | COMPOSITIONS AND METHODS FOR REDUCING OR PREVENTING OBESITY - Compositions useful for weight management in an animal are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites, and in some embodiments include conjugated linoleic acid, and/or L-carnitine. Also disclosed are methods useful for weight management in an animal utilizing compositions comprising one or more isoflavones, conjugated linoleic acid, and/or L-carnitine. Preferably, the compositions and methods employ a combination of one or more isoflavones, or a combination of one or more isoflavones in conjunction with conjugated linoleic acid, and L-carnitine. | 10-25-2012 |
20120270954 | METHODS FOR MAINTAINING EYE HEALTH AND AMELIORATING OPTHALMIC MALADIES IN CANINES - The invention provides novel methods for maintaining eye health and ameliorating ophthalmic maladies in canines by administering to the canines an ophthalmic malady ameliorating amount of one or more carotenes. Generally, the carotenes are administered to the canines in amounts of from about 0.1 to about 5000 mg or in amounts of from about 0.1 to about 500 mg per day to ameliorate maladies such as impaired vision, cataracts, cloudy eye, retinal degeneration, eye injury caused by radiation, reducing or preventing a decline of social interaction, promoting overall health and wellness, improving the quality of life, and extending the prime for canines. | 10-25-2012 |
20120277300 | COMPOSITIONS AND METHODS FOR INDUCING BONE GROWTH AND INHIBITING BONE LOSS - Compositions useful for inducing bone growth or inhibiting bone loss in an animal comprising one or more isoflavones or isoflavone metabolites and methods for inducing bone growth or inhibiting bone loss in an animal utilizing such compositions. The compositions and methods are particularly useful for post-menopause, post-andropause, gonadectomized, spayed, or neutered animals. | 11-01-2012 |
20130122147 | METHODS FOR ENHANCING THE PALATABILITY OF COMESTIBLE COMPOSITIONS - The invention provides methods for enhancing the palatability of comestible compositions by combining the comestible compositions with a palatability enhancing amount of one or more fatty acid alkanolamides and the compositions produced by such methods. | 05-16-2013 |
20130209583 | METHODS AND COMPOSITIONS SUITABLE FOR PROMOTING HEALTHY SKIN - The invention provides methods, compositions, and dietary formulations useful for preventing or treating dermatitis, promoting healthy skin, and retarding skin aging. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents. | 08-15-2013 |
20130309329 | METHODS AND COMPOSITIONS FOR TREATING, REDUCING OR PREVENTING DETERIORATION OF THE VISUAL SYSTEM OF ANIMALS - Methods and compositions for treating, reducing, or preventing deterioration of at least one component of the visual system of an animal are disclosed. The methods comprise administering to the animal a composition comprising UFA and NORC in an amount effective to treat, reduce, or prevent deterioration of at least one component of the visual system. Methods extending the prime years of an animal's life, improving the quality of life, and promoting health and wellness of an animal using compositions comprising UFA and NORC are also disclosed. | 11-21-2013 |
20130316029 | METHODS AND COMPOSITIONS SUITABLE FOR MANAGING BLOOD GLUCOSE IN ANIMALS - The invention provides methods, compositions, and dietary formulations useful for managing blood glucose, preventing or treating insulin resistance, and improving insulin sensitivity. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents. | 11-28-2013 |
20130324608 | METHODS AND COMPOSITIONS FOR TREATING, REDUCING OR PREVENTING DAMAGE TO THE NERVOUS SYSTEM OF ANIMALS - Methods and compositions for treating, reducing, or preventing damage to at least one component of the nervous system of an animal are disclosed. The methods comprise administering to the animal a composition comprising UFA and NORC in an amount effective to treat, reduce, or prevent damage to at least one component of the nervous system. Methods extending the prime years of an animal's life, improving the quality of life, and promoting health and wellness of an animal using compositions comprising UFA and NORC, and optionally, antioxidant(s) and/or B vitamins are also disclosed. | 12-05-2013 |
20140037583 | METHODS AND COMPOSITIONS SUITABLE FOR PREVENTING AND TREATING HYPERLEPTINEMIA - The invention provides methods and compositions suitable for preventing and treating hyperleptinemia, preventing and treating insulin resistance, preventing and treating cardiovascular disease, preventing and treating obesity, preventing and treating hyperlipidemia, and preventing and treating hypertension in an animal. The methods comprise administering one or more isoflavones to the animal, preferably in amounts of from about 0.001 to about 10 g/kg/day. | 02-06-2014 |
20140039047 | METHODS FOR REGULATING SIRTUIN GENE EXPRESSION - The invention provides methods useful for regulating sirtuin gene expression, mimicking caloric restriction, preventing and treating Alzheimer's disease, increasing longevity and retarding aging in an animal. The methods comprise administering one or more isoflavones to the animals, preferably in amounts of from about 0.001 to about 10 g/kg/day. | 02-06-2014 |
20140056851 | METHODS FOR MANAGING WEIGHT LOSS AND BODY MASS - The invention provides methods for promoting weight loss by an animal, promoting weight loss by an animal while preventing or minimizing loss of lean body mass by the animal preventing a reduction in energy metabolism by an animal reducing the risk of regaining weight by an animal after weight loss, and ameliorating undesirable animal behaviors associated with reduced caloric intake by intermittently feeding an animal a first diet containing calories that meet the animal's maintenance energy requirements and a second diet containing calories that do not meet the animal's maintenance energy requirements. In preferred embodiments, the described feeding pattern and diets are ted in conjunction with one or more weight loss agents. | 02-27-2014 |
20140134135 | METHODS AND COMPOSITIONS FOR PRESERVING LEAN BODY MASS DURING WEIGHT LOSS - The invention provides compositions and methods for preserving lean body mass during weight loss in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day. | 05-15-2014 |
20140134747 | METHODS FOR DETERMINING IF AN ANIMAL'S METABOLISM IS KETOGENIC - The invention provides methods for determining if an animal's metabolism has been shifted to ketogenic status by collecting a first urine sample from the animal when the animal's metabolism is not in a ketogenic status; collecting a second urine sample from the animal when the animal's metabolism is possibly in a ketogenic status; analyzing the first urine sample and the second urine sample for beta-hydroxy butyrate; and determining that the animal's metabolism has been shifted to ketogenic status if the concentration of beta-hydroxy butyrate in the second urine sample exceeds the concentration of beta-hydroxy butyrate in the first urine sample by ten percent (10%) or more. | 05-15-2014 |
20140193370 | METHODS AND COMPOSITIONS FOR PROMOTING LEAN BODY MASS GROWTH - The invention provides methods for promoting lean body mass growth in an animal. The methods comprise administering OEA to the animals, preferably in amounts of from about 0.01 to about 1000 mg/kg/day. | 07-10-2014 |
20140199267 | METHODS FOR AMELIORATING SYMPTOMS OR CONDITIONS CAUSED BY STRESS - The invention provides methods for using fatty acid alkanolamides for ameliorating one or more symptoms or conditions caused by stress, e.g., loss of appetite, or for maintaining and enhancing nutrient and caloric intake by an animal under stress or that has experienced stress. Generally, the fatty acid alkanolamides in amounts of from about 0.1 to about 1500 mg/kg/day before, during or after stress, preferably on a regular or daily basis as a component of a food composition or as a dietary supplement. | 07-17-2014 |
20140309137 | GENE EXPRESSION PROFILES ASSOCIATED WITH LEAN PHENOTYPE AND USES THEREOF - Gene expression profiles associated with improved or maintained lean body mass or reduced body fat are disclosed. The gene expression profiles were determined in adipose, liver, and muscle tissue of animals subjected to lean-promoting regimens such as consumption of a high protein diet, ingestion of conjugated linolenic acid, and/or increased exercise. Methods of using such profiles for the identification of pharmaceutical substances, nutraceutical substances, dietary substances, or treatment regimens that modulate or contribute to desired phenotypes in animals are also disclosed | 10-16-2014 |
Zaiqi Pan, Hockessin, DE US
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20110077929 | METHOD AND SYSTEM FOR MODELING DURABILITY OF INSECTICIDAL CROP TRAITS - Systems, methods and other means for evaluating durability of genetic traits for the control of damage by pests are provided. Inputs parameters associated with the genetic traits, pests, and one or more fields may be received by a computer and/or other type of machine, which may apply a computer-implemented model to determine, e.g., durability of the genetic traits. Some embodiments may also or instead include an output associated with, e.g., the durability. The computer-implemented model may provide, in some embodiments, for modeling dynamic movement of the pests within a Bt field and one or more of the fields being Bt fields. The computer-implemented model may also or instead provide, in some embodiments, for modeling blended refuge seed products. | 03-31-2011 |
Zexin Pan, Madison, AL US
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20100149958 | METHOD AND SYSTEM FOR MODULATION CODING AND SYNCHRONIZATION - The present techniques provide systems and methods for modulation coding of data on optical disks, such as holographic data disks, and techniques for reading that data back from the disks. The techniques involve parsing a bit stream into a sequence of individual bit-patterns, and then using the individual bit patterns to select a symbol, or matrix, from a lookup table of previously selected matrices. The symbols are selected according to predetermined criteria that may help make the disk more resistant to interferences and errors, such as surface scratches, and the like. For example, criteria that may be used to select the symbols are the number of reflective and non-reflective regions within each matrix, and the number of sequential reflective regions, among others. The symbols may be written to the disk in a two-dimensional fashion, e.g., across adjacent tracks, or in a three-dimensional fashion, e.g., across adjacent data layers. | 06-17-2010 |
20100165816 | SYSTEM AND METHOD FOR TRACKING IN SINGLE-BIT HOLOGRAPHIC DATA STORAGE - A system and method for controlling tracking in a holographic data storage system, including: impinging a beam on a holographic data disc, wherein the beam is reflected from a micro-hologram disposed within the holographic data disc; detecting the reflected beam from the holographic data disc by a multi-element detector; and analyzing a pattern detected by multi-element detector to generate a tracking error signal. | 07-01-2010 |
Zhengmin Benjamin Pan, California, CA US
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20140153738 | WIRELESS INDUCTION SYSTEM FOR PRODUCING AUDIO - A wireless induction system includes a first device and a second device wirelessly connected the first device, the first device and the second device separated from each other. The first device is configured for generating electromagnetic signals and includes a signal source and a transmitting unit electrically connected with the signal source. The second device is configured for receiving electromagnetic signals and converting it into audio signals, and includes a receiving unit, a processor and a loudspeaker. | 06-05-2014 |
Zhengwei Pan, Bogart, GA US
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20120193578 | NEAR INFRARED DOPED PHOSPHORS HAVING A ZINC, GERMANIUM, GALLATE MATRIX - Phosphors based on transition metal-activated gallates, particularly Cr | 08-02-2012 |
20120261617 | NEAR INFRARED DOPED PHOSPHORS HAVING AN ALKALINE GALLATE MATRIX - Phosphors based on doping of an activator (an emitter) into a host matrix are disclosed herein. Such phosphors include alkaline gallate phosphors doped with Cr | 10-18-2012 |
20120319049 | EU2+-ACTIVATED ALUMINATES NANOBELTS, WHISKERS, AND POWDERS, METHODS OF MAKING THE SAME, AND USES THEREOF - Embodiments of the present disclosure relate to visible luminescent phosphors, visible luminescent nanobelt phosphors, methods of making visible luminescent phosphors, methods of making visible luminescent nanobelt phosphors, mixtures of visible luminescent phosphors, methods of using visible luminescent phosphors, waveguides including visible luminescent phosphors, white light emitting phosphors, and the like. | 12-20-2012 |
20130099163 | NEAR INFRARED DOPED PHOSPHORS HAVING AN ALKALINE GALLATE MATRIX - Phosphors based on doping of an activator (an emitter) into a host matrix are disclosed herein. Such phosphors include alkaline gallate phosphors doped with Cr | 04-25-2013 |
Zhengzheng Pan, Indianapolis, IN US
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20100330598 | METHOD, SYSTEM, AND COMPUTER PROGRAM PRODUCT FOR PROVIDING BOTH AN ESTIMATED TRUE MEAN BLOOD GLUCOSE VALUE AND ESTIMATED GLYCATED HEMOGLOBIN (HbA1C) VALUE FROM STRUCTURED SPOT MEASUREMENTS OF BLOOD GLUCOSE - A method and system for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements are disclosed. The bG measurements and associated context of the bG measurement are collected at daily times specified by a structured sampling schema, and the collected bG measurements are weighted based on the associated context. The estimated true mean bG value and the estimate HbA1C value are then determined from the weighted measurements of the collected bG measurements. A computer program for implementing the method for providing both an estimated true mean blood glucose value and estimated glycated hemoglobin (HbA1C) value from spot blood glucose (bG) measurements is also disclosed. | 12-30-2010 |
Zhiguo Pan, Cary, NC US
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20140062221 | System For Distributing Electric Power To An Electrical Grid - A system for distributing electric power to an electrical grid. The system includes a DC/AC inverter arranged to convert a DC voltage output from an electric power generator to an AC voltage, a transformer arranged to receive the AC voltage, transform the AC voltage and deliver the transformed AC voltage to the grid, and a connector arranged to selectively connect and disconnect the transformer from the grid. The DC/AC inverter is arranged to control primary winding magnetizing current delivered to the transformer. Further, the connector is arranged to selectively connect and disconnect the grid to and from the transformer on the basis of the controlled magnetizing current. | 03-06-2014 |
20150061606 | METHODS AND SYSTEMS FOR ELECTRICAL DC GENERATION - An electrical DC generation system is disclosed. According to one aspect, a system for electrical DC generation system includes an electrical machine, having a positive output terminal and a negative output terminal, a plurality of stator windings, a plurality of passive rectifiers connected to the plurality of stator windings, the plurality of passive rectifiers being connected in series to form an intermediate bus having a positive terminal and a negative terminal. The system also includes a DC-DC converter circuit having input terminals connected to the positive and negative terminals of the intermediate bus and having output terminals electrically isolated from the input terminals and connected in series with the intermediate bus. The DC-DC converter output voltage is adjusted to regulate torque of the electrical machine by adjusting stator current of the electrical machine. | 03-05-2015 |
20150061607 | METHODS AND SYSTEMS FOR AN INTEGRATED ELECTRICAL GENERATOR WITH HYBRID RECTIFIER - An electrical DC generation system is disclosed. According to one aspect, a system for electrical DC generation includes an electrical machine having multiple stator windings and multiple rectifiers for connection to portions of the stator windings. At least one active rectifier and at least one passive rectifier are connected in series to form a DC bus having a positive terminal and a negative terminal, where the positive terminal of the DC bus is connected to a positive output terminal of the electrical machine and where the negative terminal of the DC bus is connected to a negative output terminal of the electrical machine. The at least one active rectifier is used to control a current flowing through the DC bus and/or an output voltage of the electrical machine. | 03-05-2015 |
Zhihong Pan, Morrisville, NC US
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20130137961 | Systems and Methods for Hyperspectral Medical Imaging - Under one aspect, an apparatus for analyzing the skin of a subject includes a hyperspectral sensor for obtaining a hyperspectral image of the subject. The apparatus further includes a control computer that is in electronic communication with the hyperspectral sensor and which controls at least one operating parameter of the hyperspectral sensor. The control computer includes a processor unit and a computer readable memory. The memory includes executable instructions for controlling the at least one operating parameter of the hyperspectral sensor. The memory includes executable instructions for applying a wavelength dependent spectral calibration standard constructed for the hyperspectral sensor to a hyperspectral image collected by the hyperspectral sensor. The apparatus further includes a light source that illuminates the skin of the subject for the hyperspectral sensor. | 05-30-2013 |
Zhiqiang Pan, Oxford, MS US
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20110225676 | Two Novel Alkylresorcinol Synthase Genes from Sorghum; Cloning, Expression, Transformation and Characterization - Sorghum is considered to be an allelopathic crop species, producing phytotoxins such as the lipid benzoquinone sorgoleone (2-hydroxy-5-methoxy-3-[(Z,Z)-8′,11′,14′-pentadecatriene]-p-benzoquinone) which likely accounts for much of its allelopathic properties. Prior investigations into the biosynthesis of sorgoleone have suggested the participation of one or more alkylresorcinol synthases (ARS), which are type III polyketide synthases (PKS) that produce 5-alkylresorcinols using medium to long-chain fatty acyl-CoA starter units via iterative condensations with malonyl-CoA. Current evidence suggests that sorgoleone biosynthesis occurs exclusively in root hair cells, involving the synthesis of a 5-pentadecatrienyl resorcinol intermediate derived from an unusual 16:3 fatty acyl-CoA starter unit. To characterize the enzymes responsible for the biosynthesis of this alkylresorcinol intermediate, a previously-described expressed sequence tag (EST) database prepared from isolated root hairs was first mined for all PKS-like sequences. Quantitative real-time RT-PCR analyses revealed that two of these sequences were preferentially expressed in root hairs, and recombinant enzyme studies demonstrated that both sequences (designated ARS1 and ARS2) encode ARS enzymes capable of accepting a variety of fatty acyl-CoA starter units. Furthermore, RNA interference (RNAi) experiments directed against ARS1 and ARS2 resulted in the generation of multiple independent transformant events exhibiting dramatically reduced sorgoleone levels. Thus, both ARS1 and ARS2 are likely to participate in the biosynthesis of sorgoleone in planta. The sequences of ARS1 and ARS2 were also used to identify several rice genes encoding ARSs, which are likely involved in the production of defense-related alkylresorcinols. | 09-15-2011 |
20140308731 | Novel Cytochrome P450 Enzymes From Sorghum Bicolor - Two novel cytochrome P450 genes are isolated from sorghum, each gene encoding a protein having pentadecatrienyl resorcinol hydroxylase activity. Expression vectors containing these sequences are made and used to elevate levels of pentadecatrienyl resorcinol hydroxylase in transgenic cells and organisms. | 10-16-2014 |
Zhuo-Hua Pan, Troy, MI US
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20100015095 | RESTORATION OF VISUAL RESPONSES BY IN VIVO DELIVERY OF RHODOPSIN NUCLEIC ACIDS - Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in photoreceptor-degenerated retina in an animal model. Such treatment restored visual perception and various aspects of vision. A method of restoring light sensitivity to a retina of a subject suffering from vision loss due to photoreceptor degeneration, as in retinitis pigmentosa or macular degeneration, is provided. The method comprises delivering to the subject by intravitreal or subretinal injection, the above nucleic acid vector which comprises an open reading frame encoding a rhodopsin, to which is operatively linked a promoter and transcriptional regulatory sequences, so that the nucleic acid is expressed in inner retinal neurons. These cells, normally light-insensitive, are converted to a light-sensitive state and transmit visual information to the brain, compensating for the loss, and leading to restoration of various visual capabilities. | 01-21-2010 |
20130259833 | AAV-Mediated Subcellular Targeting of Heterologous Rhodopsins in Retinal Ganglion Cells - Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are expressed in retinal ganglion cells upon transduction using recombinant AAV vectors. Selective targeting of these transgenes for expression in discrete subcellular regions or sites is achieved by including a sorting motif in the vector that can target either the central area or surround (off-center) area of these cells. Nucleic acid molecules comprising nucleotide sequences encoding such rhodopsins and sorting motifs and their use in methods of differential expression of the transgene are disclosed. These compositions and methods provide significant improvements for restoring visual perception and various aspects of vision, particular in patients with retinal disease. | 10-03-2013 |
20140121265 | Restoration of Visual Responses by In Vivo Delivery of Rhodopsin Nucleic Acids - Nucleic acid vectors encoding light-gated cation-selective membrane channels, in particular channelrhodopsin-2 (Chop2), converted inner retinal neurons to photosensitive cells in photoreceptor-degenerated retina in an animal model. Such treatment restored visual perception and various aspects of vision. A method of restoring light sensitivity to a retina of a subject suffering from vision loss due to photoreceptor degeneration, as in retinitis pigmentosa or macular degeneration, is provided. The method comprises delivering to the subject by intravitreal or subretinal injection, the above nucleic acid vector which comprises an open reading frame encoding a rhodopsin, to which is operatively linked a promoter and transcriptional regulatory sequences, so that the nucleic acid is expressed in inner retinal neurons. These cells, normally light-insensitive, are converted to a light-sensitive state and transmit visual information to the brain, compensating for the loss, and leading to restoration of various visual capabilities. | 05-01-2014 |
20150044181 | IDENTIFICATION OF CHANNELRHODOPSIN-2 (CHR2) MUTATIONS AND METHODS OF USE - The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant ChR2 protein. Methods of the invention include administering a composition comprising a mutant ChR2 to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels. | 02-12-2015 |