Patent application number | Description | Published |
20090204224 | Method And Apparatus For Wrist Arthroplasty - A wrist prosthesis system to replace at least a portion of a bone of a wrist of a patient. The system includes a carpal implant to replace at least a portion of a carpal bone of a carpal complex of the patient. The carpal implant includes a base and an augment that replaces at least a portion of the carpal bone. The augment is removably coupled to the base. | 08-13-2009 |
20090319050 | Method and Apparatus for Wrist Arthroplasty - A wrist prosthesis system to replace at least a portion of a bone of a wrist of a patient. The system includes a carpal implant to replace at least a portion of a carpal bone of a carpal complex of the patient. The carpal implant includes a base and an augment that replaces at least a portion of the carpal bone. The augment is removably coupled to the base. | 12-24-2009 |
20100010636 | Method and Apparatus for Wrist Arthroplasty - A prosthesis for placement relative to a carpal complex of a wrist can generally include a carpal implant having a body including an ulnar flange and a radial flange. The body can have a bone abutment surface and at least one flange extending from the bone abutment surface. The at least one flange can extend from the bone abutment surface a distance that spans at least one bone in an implanted position. The at least one flange can have a securing aperture that selectively receives a bone screw that advances into an identified bone of the carpal complex. A wrist bearing component can selectively mate with the carpal implant. | 01-14-2010 |
20100069936 | SURGICAL INSTRUMENT AND METHOD OF USE FOR RELEASING SOFT TISSUE - A surgical instrument for use in releasing soft tissue within the human body. The surgical instrument has a handle with proximal and distal ends with a tube connected to the distal end. The surgical instrument also includes a blade member that slidingly engages the tube moving along the length of the tube to cut soft tissue. Further included in the surgical instrument is a guard member that is attached to the blade member. The guard member has a hood portion and a capture portion. The hood portion is connected to the blade member with the distally positioned capture portion acting to displace surrounding tissue while capturing certain soft tissue structures resulting in the blade member being in operative position to cut and release the soft tissue. A surgical instrument kit including a plurality of modular surgical instruments and method for releasing soft tissue using the surgical instrument are also disclosed. | 03-18-2010 |
20120078376 | Method And Apparatus For Wrist Arthroplasty - A method of implanting a distal radial wrist implant relative to a host radius while salvaging at least portions of fractured radial bone can include, determining a size of a host radius. A distal radial component can be selected based on the determination. The distal radial component can have a body that includes a first connection portion. A stem portion can be selected based on the determination. The stem portion can have a second connection portion. Portions of the fractured radial bone can be located around the body. The portions of the fractured radial bone can be secured relative to the body. The first connection portion of the distal radial component can be coupled with the second connection portion of the stem portion. The distal radial implant can be implanted relative to the host radius. | 03-29-2012 |
Patent application number | Description | Published |
20100015129 | Methods of using F-spondin as a biomarker for cartilage degenerative conditions and bone diseases - Methods for identifying subjects having, or at risk for developing, osteoarthritis or other cartilage degenerative conditions by measuring levels of expression of F-spondin are provided. Assays, kits and methods for determining and assaying the presence of F-spondin in individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods are disclosed for identifying candidate compounds that modulate F-spondin levels of expression and/or function or for determining and evaluating an individual's response to drugs and therapeutic agents, are provided. The invention further relates to the modulation of F-spondin, particularly the inhibition of F-spondin, for increasing or stimulating bone formation and/or growth and mediating the alleviation of bone disease, disorders or conditions. The use of F-spondin, an active fragment thereof, or a modulator thereof for enhancing cartilage repair or preventing or treating cartilage degeneration, degenerative diseases or arthritic conditions is also provided. | 01-21-2010 |
20140274766 | METHODS OF USING F-SPONDIN AS A BIOMARKER FOR CARTILAGE DEGENERATIVE CONDITIONS AND BONE DISEASES - Methods for identifying subjects having, or at risk for developing, osteoarthritis or other cartilage degenerative conditions by measuring levels of expression of F-spondin are provided. Assays, kits and methods for determining and assaying the presence of F-spondin in individual patients are disclosed. Oligonucleotide probes and primers for use in the assays, kits and methods are described. Assays and methods are disclosed for identifying candidate compounds that modulate F-spondin levels of expression and/or function or for determining and evaluating an individual's response to drugs and therapeutic agents, are provided. The invention further relates to the modulation of F-spondin, particularly the inhibition of F-spondin, for increasing or stimulating bone formation and/or growth and mediating the alleviation of bone disease, disorders or conditions. The use of F-spondin, an active fragment thereof, or a modulator thereof for enhancing cartilage repair or preventing or treating cartilage degeneration, degenerative diseases or arthritic conditions is also provided. | 09-18-2014 |
Patent application number | Description | Published |
20090012059 | DIPEPTIDYL PEPTIDASE INHIBITORS - Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: | 01-08-2009 |
20090270442 | POLYMORPHS OF HYDROCHLORIDE SALT OF 5-(3-(ETHYLSULFONYL)PHENYL)-3,8-DIMETHYL-N-(1-METHYLPIPERIDIN-4-YL)-9H-PY- RIDO[2,3-B]INDOLE-7-CARBOXAMIDE AND METHODS OF USE THEREFOR - Polymorphic forms of the hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide (referred to herein as Compound 1) which has the formula: | 10-29-2009 |
20090275750 | DIPEPTIDYL PEPTIDASE INHIBITORS - Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase. | 11-05-2009 |
20090318450 | COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF - The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure. | 12-24-2009 |
Patent application number | Description | Published |
20130112520 | Bi-Directional Overrunning Clutch Having Split Roll Cage - A bi-directional overrunning clutch includes a housing and a pair of hubs substantially coaxially aligned within the housing. A pair of roll cages position a plurality of rollers between each hub and an inner cam surface of the housing. The rollers are positioned to wedge between the hub and the inner cam surface when one of the hub and the housing is rotated with respect to the other. End caps are attached to the housing adjacent to the hubs. A friction disk mechanism includes a friction plate rotating in combination with each the roll cage and a spring compressed between the end cap and the roll cage for biasing the friction member into frictional contact with the hub. An intermittent coupler is located between each roll cage and configured to engage the roll cages so as to permit indexing of one roll cage relative to the other. | 05-09-2013 |
20130134006 | Friction Disk Mechanism for Bi-Directional Overrunning Clutch - A bi-directional overrunning clutch includes a housing and first and second hubs substantially coaxially aligned within the housing. A roll cage positions a plurality of rollers in an annular space between each of the hubs and an inner cam surface of the housing. The rollers are adapted to wedgingly engage between the hub and the inner cam for transmitting torque therebetween. End caps are attached to the housing adjacent to the hubs. A friction disk mechanism located on each side of the roll cage includes a roll cage plate attached to the roll cage, an inner hub friction member attached to the hub, a slip disk, and a spring compressed between the slip disk and the inner hub friction member biasing the inner hub friction member into frictional contact with the roll cage plate. | 05-30-2013 |
20130199886 | BI-DIRECTIONAL OVERRUNNING CLUTCH HAVING SPLIT ROLL CAGE - A bi-directional overrunning clutch includes a housing and a pair of hubs substantially coaxially aligned within the housing. A pair of roll cages position a plurality of rollers between each hub and an inner cam surface of the housing. The rollers are positioned to wedge between the hub and the inner cam surface when one of the hub and the housing is rotated with respect to the other. End caps are attached to the housing adjacent to the hubs. A friction disk mechanism includes a friction plate rotating in combination with each the roll cage and a spring compressed between the end cap and the roll cage for biasing the friction member into frictional contact with the hub. An intermittent coupler is located between each roll cage and configured to engage the roll cages so as to permit indexing of one roll cage relative to the other. | 08-08-2013 |
20140038763 | True Four Wheel Drive System for Vehicle - A drive train for a four wheel drive vehicle including a front differential engaged with a front drive shaft and front axles through a front differential gear set. The front differential includes a front bi-directional overrunning clutch that controls transmission of torque transfer between the front drive shaft and the front axles. A rear differential is engaged with rear axles and the transmission through a rear differential gear set. The rear differential includes a rear bi-directional overrunning clutch that controls torque transfer between the transmission and the rear axles. The differentials are configured with a gear ratio that is within five percent of a 1:1 gear ratio. | 02-06-2014 |
20150159743 | TWIN RATIO DIFFERENTIAL WITH BI-DIRECTIONAL OVERRUNNING CLUTCH - A front differential for a four wheel drive vehicle including a pinion assembly with first and second pinions that are engaged with a ring gear assembly with first and second ring gears. The first pinion and first ring gear combination are rotatable independent from the second pinion and second ring gear combination, thus permitting one to rotate relative to the other. The first pinion and first ring gear combination are adapted to rotate one driven shaft, and the second pinion and second ring gear combination are adapted to rotate the other driven shaft. A bi-directional overrunning clutch assembly is engaged with an end of the drive shaft and includes one set of rolls located adjacent to the first pinion shaft, and another set of rolls located adjacent to the second pinion shaft. The clutch assembly control torque transmission between the pinion shafts and the drive shaft. | 06-11-2015 |
Patent application number | Description | Published |
20160084257 | AIR-MOVING ASSEMBLIES WITH FLYWHEELS - Apparatuses and methods are provided for facilitating air-cooling of, for instance, one or more electronics racks within a data center. The apparatus includes an air-moving assembly and one or more flywheels. The air-moving assembly includes a shaft, one or more mechanical fans coupled to the shaft to rotate, at least in part, with the shaft, and a motor coupled to the shaft to rotatably drive the shaft. The flywheel(s) is sized and coupled to the shaft of the air-moving assembly to store rotational energy, and to facilitate, for a specified period of time, continued rotation of the shaft during interruption in power to the motor. In one implementation, the flywheel(s) is sized and coupled to the shaft to facilitate, for the specified time period, continued rotation of the shaft at a specified percentage, or greater, rotational speed of the shaft compared with shaft speed when rotatably driven by the motor. | 03-24-2016 |
20160088764 | AIR-MOVING ASSEMBLIES WITH FLYWHEELS - Apparatuses and methods are provided for facilitating air-cooling of, for instance, one or more electronics racks within a data center. The apparatus includes an air-moving assembly and one or more flywheels. The air-moving assembly includes a shaft, one or more mechanical fans coupled to the shaft to rotate, at least in part, with the shaft, and a motor coupled to the shaft to rotatably drive the shaft. The flywheel(s) is sized and coupled to the shaft of the air-moving assembly to store rotational energy, and to facilitate, for a specified period of time, continued rotation of the shaft during interruption in power to the motor. In one implementation, the flywheel(s) is sized and coupled to the shaft to facilitate, for the specified time period, continued rotation of the shaft at a specified percentage, or greater, rotational speed of the shaft compared with shaft speed when rotatably driven by the motor. | 03-24-2016 |
Patent application number | Description | Published |
20100041766 | Medthods, Devices And Formulations For Targeted Endobronchial Therapy - The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 02-18-2010 |
20140014103 | Methods, Devices and Formulations for Targeted Endobronchial Therapy - The present invention provides a method and novel devices for treating tracheobronchitis and pneumonia in the intubated patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In a preferred embodiment, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The devices eliminate the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 01-16-2014 |
20140053830 | Methods, Devices And Formulations For Targeted Endobronchial Therapy - The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen. | 02-27-2014 |
Patent application number | Description | Published |
20110302375 | Multi-Part Aggregated Variable in Structured External Storage - A mechanism is provided for multi-part aggregated variables in structured external storage. The shared external storage provides a serialized, aggregated structure update capability. The shared external storage identifies each local value for which a group value is needed by name. Each time a member writes out its value, the member specifies the name of the object, the member's current value, and the type of aggregate function to apply (e.g., minimum, maximum, etc.). The structured external storage in one atomic operation updates the member's value, recalculates the aggregate of all of the individual values, and returns the aggregate to the member. The advantage of this approach is that it requires only one write operation to the structured external storage. The update operation does not require locking, because the operation is atomic. | 12-08-2011 |
20110302377 | Automatic Reallocation of Structured External Storage Structures - A mechanism for automatic reallocation of shared external storage structures is provided. The shared external storage divides the dynamically allocable storage into fixed sized blocks referred to as allocation units. To create an object of a specific type, the shared external storage uses some number of allocation units. If the object will fit in one allocation unit, then it is placed in one allocation unit. If the object is larger than one allocation unit, then the appropriate number of allocation units is obtained and chained together to contain all of the information of the required object. When an object so allocated is no longer needed, the shared external storage breaks the object down to a set of one or more fixed sized allocation units. The shared external storage then returns the allocation units to the pool of available objects. | 12-08-2011 |
20120089735 | Two-Level Management of Locks on Shared Resources - In a shared data system comprising one or more primary nodes and a plurality of secondary nodes, global lock manager on a primary node manages locks for shared resources by exchanging an abstract lock state with local lock managers on the secondary nodes. The abstract lock state includes a particular representation of all of the applications on the nodes that are requesting or are granted locks. The exchange of these particular lock states instead of individual requests improves performance by increasing concurrency and reducing off-machine communication. A global deadlock detector on a node detects and resolves global deadlocks, in conjunction with local deadlock detectors on the secondary nodes. | 04-12-2012 |
20140032765 | Two-Level Management of Locks on Shared Resources - In a shared data system comprising one or more primary nodes and a plurality of secondary nodes, global lock manager on a primary node manages locks for shared resources by exchanging an abstract lock state with local lock managers on the secondary nodes. The abstract lock state includes a particular representation of all of the applications on the nodes that are requesting or are granted locks. The exchange of these particular lock states instead of individual requests improves performance by increasing concurrency and reducing off-machine communication. A global deadlock detector on a node detects and resolves global deadlocks, in conjunction with local deadlock detectors on the secondary nodes. | 01-30-2014 |
20150019739 | TWO-LEVEL MANAGEMENT OF LOCKS ON SHARED RESOURCES - In a shared data system comprising one or more primary nodes and a plurality of secondary nodes, global lock manager on a primary node manages locks for shared resources by exchanging an abstract lock state with local lock managers on the secondary nodes. The abstract lock state includes a particular representation of all of the applications on the nodes that are requesting or are granted locks. The exchange of these particular lock states instead of individual requests improves performance by increasing concurrency and reducing off-machine communication. A global deadlock detector on a node detects and resolves global deadlocks, in conjunction with local deadlock detectors on the secondary nodes. | 01-15-2015 |
Patent application number | Description | Published |
20130056395 | Integrated Processes For Recovery of Hydrocarbon From Oil Sands - Processes are described for extracting hydrocarbon from a mineable deposit, such as bitumen from oil sands. The integration of solvent-based extraction processes with aqueous extraction processes is described. In one embodiment, water is removed from an aqueous bituminous feed that is then directed into a solvent-based extraction process. In another embodiment, a stream produced through solvent extraction is directed into a water-based extraction process. In the solvent-based extraction processes, agglomeration of fines may be employed to simplify subsequent solid-liquid separation. The process permits recovery of hydrocarbon that has conventionally may have been too difficult to recover from oil sands processing, and thus has previously been lost. Advantageously, a fungible product can be formed more efficiently according to certain integrated processes described herein. | 03-07-2013 |
20130319662 | Systems and Methods For Hydrotreating A Shale Oil Stream Using Hydrogen Gas That Is Concentrated From The Shale Oil Stream - Systems and methods for hydrotreating a liquid fraction of a shale oil stream using hydrogen gas that is concentrated from a gaseous fraction of the shale oil stream. The systems and methods include providing a portion of the gaseous fraction to a sorptive separation assembly and separating a concentrated hydrogen stream from the portion of the gaseous fraction within the sorptive separation assembly. The system and methods further include providing the concentrated hydrogen stream and the liquid fraction to a hydrotreater and reacting the concentrated hydrogen stream with the liquid fraction within the hydrotreater to produce the hydrotreated liquid stream. The systems and methods may include generating the shale oil stream within a subterranean formation using an in situ process, such as an in situ shale oil conversion process and/or providing a supplemental hydrogen stream to the hydrotreater. | 12-05-2013 |
20140034553 | Method of Processing a Bituminous Feed Using an Emulsion - The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with a bridging liquid-in-extraction liquor emulsion to form a slurry. Solids in the slurry are agglomerated, using agitation, to form an agglomerated slurry comprising agglomerated solids and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Emulsifying the bridging liquid prior to contacting it with the oil sands may reduce the amount of energy required for the agglomeration process. Other potential benefits may include the production of smaller and more uniform agglomerates. The former may lead to higher bitumen recoveries and the latter may improve the solid-liquid separation rate. | 02-06-2014 |
20140054201 | Method of Processing a Bituminous Feed Using Agglomeration in a Pipeline - The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. The slurry is then flowed through a pipeline. A bridging liquid is added to the slurry to assist agglomeration. Agitation is also used to assist agglomeration. The result is an agglomerated slurry comprising agglomerates and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Performing the agglomeration in a pipeline as opposed to in a conventional agitating vessel may provide certain advantages, such as improved sealing in order to contain the potentially flammable mixture of oil sands slurry from the atmosphere, production of smaller and more uniform agglomerates due to improved mixing of the bridging liquid into the oil sands slurry, and the flexibility to have a long residence time for the extraction and agglomeration processes. | 02-27-2014 |
20140076784 | METHOD OF PROCESSING A BITUMINOUS FEED WITH FEEDBACK CONTROL - Described herein is a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. A bridging liquid is added to the slurry, and, solids are agitated within the slurry to form an agglomerated slurry comprising agglomerates and a low solids bitumen extract. In order to control agglomeration, the slurry is analyzed and the processing method is adjusted accordingly. | 03-20-2014 |
20140209512 | Method of Processing Tailings from Solvent-Based Hydrocarbon Extraction - Described is a method of processing a bituminous feed. The bituminous feed is solvent extracted to form a bitumen-rich stream and a bitumen-lean stream. Solvent is recovered from the bitumen-rich stream to form a bitumen product. Solvent and water are recovered from the bitumen-lean stream to form dry tailings with a moisture content of less than 40 wt.%. The dry tailings are separated into at least two streams, each stream having a moisture content of less than 40 wt. %, based on at least one physical or chemical property. At least one of the at least two streams is then used at an oil sands mine site. In this way, the dry tailings may be used more effectively. | 07-31-2014 |
20140262964 | Method of Processing a Bituminous Feed By Staged Addition of a Bridging Liquid - The present disclosure relates to a method of processing a bituminous feed. The bituminous feed is contacted with an extraction liquor to form a slurry. A bridging liquid is added to the slurry in at least two stages and solids within the slurry are agitated to form an agglomerated slurry comprising agglomerated solids and a low solids bitumen extract. The agglomerates are then separated from the low solids bitumen extract. Potential benefits may include the production of smaller and more uniform agglomerates. The former may lead to higher bitumen recoveries and the latter may improve the solid-liquid separation rate. The bridging liquid may be added in an area of relatively high shear rates. Between stages of bridging liquid addition, agglomerates may be removed. | 09-18-2014 |
20140305000 | Systems and Methods For Dewatering Mine Tailings With Water-Absorbing Polymers - Systems and methods for dewatering mine tailings with water-absorbing polymers. The systems and methods may include combining a mine tailings slurry, which includes mine tailings and water, with a water-absorbing polymer. The water-absorbing polymer may absorb water from the mine tailings, thereby increasing a solids content of the mine tailings. The mine tailings may be combined with the water-absorbing polymer prior to, during, and/or subsequent to transfer of the mine tailings to a mine tailings dewatering and/or disposal site. In some embodiments, the water-absorbing polymer may be an encapsulated water-absorbing polymer. | 10-16-2014 |