Palladino, US
Alicia M. Palladino, Pittsburgh, PA US
Patent application number | Description | Published |
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20130274314 | MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF - Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped, non-polyadenylated, and actively directed to mitochondria. The disclosed vectors are capable of delivering either non-coding RNA molecules or RNA molecules encoding a protein of interest to the mitochondria. In particular, the disclosed vectors include (1) an RNAPIII initiation (promoter) sequence, (2) a non-coding leader sequence (NCL), (3) a mitochondrial translation initiation sequence and an ORF encoding a protein of interest, or a sequence encoding a non-coding RNA, and (4) an RNAPIII termination sequence. | 10-17-2013 |
20150038561 | MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF - Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped, non-polyadenylated, and actively directed to mitochondria. The disclosed vectors are capable of delivering either non-coding RNA molecules or RNA molecules encoding a protein of interest to the mitochondria. In particular, the disclosed vectors include (1) an RNAPIII initiation (promoter) sequence, (2) a non-coding leader sequence (NCL), (3) a mitochondrial translation initiation sequence and an ORF encoding a protein of interest, or a sequence encoding a non-coding RNA, and (4) an RNAPIII termination sequence. | 02-05-2015 |
Gary Palladino, Cambridge, MA US
Patent application number | Description | Published |
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20130117917 | Applicator for an Adhesive Lavatory Treatment Composition - Disclosed is an applicator for an adhesive lavatory treatment composition. The applicator comprises a quantity of an adhesive lavatory composition, a piston part moveably engageable with a base part, wherein the piston part includes a piston plate and a grip element, the base part includes an upper cavity, and a lower cavity, wherein the piston plate is fitted within the upper cavity of the base part and is moveable within the upper cavity of the base part. The applicator may be a single use applicator adapted to dispense only a single dose of an adhesive lavatory treatment composition, or may be a multi-use applicator which may be refilled and reused to deliver plural doses of an adhesive lavatory treatment composition. | 05-16-2013 |
Gary Vincent Palladino, Cambridge, MA US
Patent application number | Description | Published |
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20110130627 | Visualization Instrument - A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses. | 06-02-2011 |
20110130632 | Visualization Instrument - A visualization instrument comprising a display support component removably coupled to a component insertable into a target space. The insertable component includes a camera providing images of the target space. The images are presented in a display device supported by the display support component. The insertable component may be discarded after a permitted number of uses. | 06-02-2011 |
James Palladino, Winona Lake, IN US
Patent application number | Description | Published |
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20080254347 | VEHICLE BATTERY STATE OF CHARGE INDICATOR - A system for modeling a battery installed on a motor vehicle including a crank started engine, a voltage sensor connected to provide measurements of battery voltage and a temperature sensor providing temperature measurements provides for correcting capacity of the battery starting from the battery's rated capacity. A vehicle body computer implements the model through a stored program implementing an energy flow model of the target battery and stored data relating to model parameters including battery rated capacity and cranking current required for engine start over a temperature range. The stored program being responsive upon execution by the vehicle body computer for using the battery voltage measurements and temperature measurements during engine cranking to correct battery capacity. | 10-16-2008 |
20080269977 | AUTOMATED SYNCHRONIZED SERVICE INTERVALS FOR VEHICLES - User generated service rules operate upon selected vehicle operating variables, vehicle configurations and vehicle vocations to produce estimates of the service life of diverse, routine service items. Items with corresponding projected service lives are grouped for service to reduce overall service frequency. | 10-30-2008 |
James David Palladino, Liverpool, NY US
Patent application number | Description | Published |
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20150206098 | SYSTEM AND METHOD OF LOADING PLANT SPECIES FOR TRANSPORTATION - A computer system, computer program product and method of optimizing the positioning of objects for transportation that includes a processor obtaining information describing at least one rack, where the rack includes one or more shelves and determining load parameters related to the rack. The processor also obtains order information that includes data describing objects in an order, at least in part from a memory resource. Based on obtaining the order information, the processor creates one or more buffer elements. Each buffer element represents a quantity of objects of the plurality of objects that can fit on a given shelf. Based on the load parameters, the processor analyzes each shelf and assigns a shelf type variable to each shelf and the processor determines the amount of objects that can fit on the individual. Based on the shelf type variable, the processor assigns shelves to each buffer element. | 07-23-2015 |
Linda O. Palladino, Stormville, NY US
Patent application number | Description | Published |
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20090004161 | Methods for treating pustular conditions of the skin - The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination. | 01-01-2009 |
20090010899 | Methods related to surgery - The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination. | 01-08-2009 |
20090054339 | Novel cellular factor-containing solution compositions - The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof. | 02-26-2009 |
20090328240 | Genetically modified mice as predictors of immune response - The invention is directed to novel genetically modified organisms and uses thereof. In particular, the invention is directed to novel genetically modified mice and uses of such mice to assess the immunogenic potential of human therapeutic antigens and to predict immune responses. | 12-31-2009 |
20100075905 | Novel cellular factor-containing solution compositions - The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof. | 03-25-2010 |
20100144604 | Novel cellular factor-containing solution compositions - The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof. | 06-10-2010 |
20110311609 | Wound healing device - The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix. | 12-22-2011 |
20120121547 | Methods and compositions for treating chronic wounds - The invention is directed to novel methods for treating wounds, in particular, chronic wounds such as diabetic ulcers. Such methods utilize novel cell and cell-product compositions in combination with insulin. | 05-17-2012 |
20120164115 | Methods related to surgery - The invention is directed to methods related to surgery, for example gastrointestinal surgery. In particular, the invention is methods of treating fistulae, promoting accelerated healing of anastomoses and preventing failure of anastomoses. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination. | 06-28-2012 |
20120225048 | Novel Cellular Factor-Containing Solution Compositions - The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof. | 09-06-2012 |
20120237607 | Immortalized cell compositions and compositions derived therefrom - The invention is directed to immortalized cell compositions and compositions derived therefrom. The invention is further directed to methods of making and using such immortalized cell compositions and compositions derived therefrom. Such immortalized cell compositions include but are not limited to Immortalized Amnion-derived Multipotent Progenitor cells (herein referred to as I-AMP cells) and conditioned media derived therefrom (herein referred to as I-Amnion-derived Cellular Cytokine Solution or I-ACCS). | 09-20-2012 |
20120322731 | NOVEL CYTOKINE CONTAINING COMPOSITIONS - The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof. | 12-20-2012 |
20130040880 | Novel Cytokine Containing Compositions - The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof. | 02-14-2013 |
20130071457 | Wound Healing Device - The invention is directed to a wound healing device. Such wound healing device utilizes novel wound healing compositions embedded onto or into a natural plant-derived cloth-based matrix. | 03-21-2013 |
20130183387 | Methods for treating pustular conditions of the skin - The invention is directed to methods for treating pustular conditions of the skin, for example, acne. Such methods utilize novel compositions, including but not limited to extraembryonic cytokine secreting cells (herein referred to as ECS cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as AMP cells), conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or ACCS), cell lysates derived therefrom, and cell products derived therefrom, each alone or in combination. | 07-18-2013 |
20130302307 | Novel Cellular-Factor Containing Solution Compositions - The invention is directed to novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions), methods of making such novel compositions and uses thereof. | 11-14-2013 |
20140271910 | Methods for treating urushiol-induced contact dermatitis - The invention is directed to methods for treating urushiol-induced contact dermatitis. Specifically, the invention is directed to treating and reducing inflammation associated with poison ivy, poison sumac and poison oak by administering to a subject suffering from such conditions novel cellular factor-containing solution compositions (referred to herein as “CFS” compositions), including novel sustained-release cellular factor-containing solution compositions (referred to herein as “SR-CFS” compositions). | 09-18-2014 |
20150079190 | Immortalized cell compositions and compositions derived therefrom - The invention is directed to immortalized cell compositions and compositions derived therefrom. The invention is further directed to methods of making and using such immortalized cell compositions and compositions derived therefrom. Such immortalized cell compositions include but are not limited to Immortalized Amnion-derived Multipotent Progenitor cells (herein referred to as I-AMP cells) and conditioned media derived therefrom (herein referred to as I-Amnion-derived Cellular Cytokine Solution or I-ACCS). | 03-19-2015 |
Marco Palladino, San Francisco, CA US
Patent application number | Description | Published |
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20130132584 | CLOUD-BASED HUB FOR FACILITATING DISTRIBUTION AND CONSUMPTION OF APPLICATION PROGRAMMING INTERFACES - Systems and methods for facilitating distribution of application programming interfaces (APIs) in a social hub are described herein. The social API hub enables users (i.e., API consumers) to access (e.g., search, test, and/or otherwise utilize or consume) APIs that other users (i.e., API developers) submitted to the hub in a standardized manner. Additionally, users can wrap submitted APIs in a standard description format and add various add-ons on top of an existing API infrastructure in order to provide additional functionality. | 05-23-2013 |
Michael A. Palladino, Encinitas, CA US
Patent application number | Description | Published |
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20090148445 | METHODS OF SENSITIZING CANCER TO THERAPY-INDUCED CYTOTOXICITY - The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts as a therapeutic agent to kill or inhibit cancer cells after sensitization of the cells by an antibody or other chemosensitizing reagents. The cancer cells can be either therapy-sensitive or therapy resistant. The present application further demonstrates that Salinosporamide A induces the expression of Raf kinase inhibitor protein (RKIP) and PTEN, tumor suppressor proteins, and inhibits the expression of YY1, a transcriptional regulator protein overexpressed in cancer cells and also inhibits the growth factor pleiotrophin (PTN). | 06-11-2009 |
Michael A. Palladino, Olivenhain, CA US
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20080221122 | ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THEAPEUTIC USE - Compounds represented by the following structure (II) are disclosed: | 09-11-2008 |
20090156469 | METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF IN TREATING WALDENSTROM'S MACROGLOBULINEMIA - Disclosed are methods of treating Waldenstrom's Macroglobulinemia comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula I. | 06-18-2009 |
20110160309 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS - Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection. | 06-30-2011 |
20120238634 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS - Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection. | 09-20-2012 |
20140349965 | COMPOSITIONS AND METHODS FOR TREATING NEOPLASTIC DISEASES - Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma. | 11-27-2014 |
Michael J. Palladino, Pittsburgh, PA US
Patent application number | Description | Published |
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20130274314 | MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF - Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped, non-polyadenylated, and actively directed to mitochondria. The disclosed vectors are capable of delivering either non-coding RNA molecules or RNA molecules encoding a protein of interest to the mitochondria. In particular, the disclosed vectors include (1) an RNAPIII initiation (promoter) sequence, (2) a non-coding leader sequence (NCL), (3) a mitochondrial translation initiation sequence and an ORF encoding a protein of interest, or a sequence encoding a non-coding RNA, and (4) an RNAPIII termination sequence. | 10-17-2013 |
20150038561 | MITOCHONDRIAL TARGETED RNA EXPRESSION SYSTEM AND USE THEREOF - Described herein is a mitochondrial-targeted RNA expression system (mtTRES) for delivery of RNA molecules to mitochondria. mtTRES vectors generate RNAs in vivo that are un-capped, non-polyadenylated, and actively directed to mitochondria. The disclosed vectors are capable of delivering either non-coding RNA molecules or RNA molecules encoding a protein of interest to the mitochondria. In particular, the disclosed vectors include (1) an RNAPIII initiation (promoter) sequence, (2) a non-coding leader sequence (NCL), (3) a mitochondrial translation initiation sequence and an ORF encoding a protein of interest, or a sequence encoding a non-coding RNA, and (4) an RNAPIII termination sequence. | 02-05-2015 |
Michael William Palladino, Marietta, GA US
Patent application number | Description | Published |
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20150103662 | ROUTING SYSTEM FOR INTERNET TRAFFIC - A deterministic approach for route selection in the Internet and other multi-homed networks is presented that is based upon a mathematical model that takes into consideration performance and costs while satisfying commitment constraints. The approach is expressed with a linear programming formulation that can be solved with conventional linear programming solver software. Performance metrics can be defined and combined in order to achieve the best route selection depending on requirements. Some of the potential benefits of the approach include: a global optimal solution for routing traffic (using metrics such as performance, cost, and other constraints), a dynamic weight assignment for performance metrics, and a flexible problem definition to add routing rules (e.g. static and restricted routes) to the model. | 04-16-2015 |
Nicholas Palladino, Chicago, IL US
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20110286121 | Node, apparatus, system and method regarding a frame support for solar mirrors - A node for a solar frame including an elongate portion having a channel extending through it in which a structural element is disposed or a solid elongate portion on to which a structural element is disposed. The node comprises a fin extending radially outward from the elongate portion where at least 5% of the volume of the fin is replaced by at least a single void extending essentially in parallel with the channel or the extrusion direction of the solid elongate portion. An apparatus for transmitting torque in a solar frame having structural elements and a support. A system for solar mirrors. A node for a solar frame. A method for connecting a structural element with a strut having a strut end piece of a solar mirror support frame. A method for producing a node for solar minor frame. | 11-24-2011 |
20130027796 | Solar Mirror Array System, Methods and Apparatuses Thereto - An apparatus for transferring force to a frame of a solar mirror array. The frame has at least one structural element. The apparatus includes a torque plate. The apparatus includes at least one node attached to and in contact with the plate which connects with the structural clement. An apparatus for attaching a primary solar mirror frame array with a secondary mirror frame array. A solar trough frame for holding solar mirrors. | 01-31-2013 |
20140102993 | Node, Apparatus, System and Method Regarding a Frame Support for Solar Mirrors - A node for a solar frame including an elongate portion having a channel extending through it in which a structural element is disposed or a solid elongate portion on to which a structural element is disposed. The node comprises a fin extending radially outward from the elongate portion where at least 5% of the volume of the fin is replaced by at least a single void extending essentially in parallel with the channel or the extrusion direction of the solid elongate portion. An apparatus for transmitting torque in a solar frame having structural elements and a support. A system for solar mirrors. A node for a solar frame. A method for connecting a structural element with a strut having a strut end piece of a solar mirror support frame. A method for producing a node for solar mirror frame. | 04-17-2014 |
Richard Palladino, Evergreen, CO US
Patent application number | Description | Published |
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20090071376 | LIGHTWEIGHT DRAINABLE CELLULAR CONCRETE - A lightweight pervious cellular concrete is provided. The concrete has an internal structure comprising interconnected channels, resulting in a permeability K value of less than about 1×10 | 03-19-2009 |
20120207552 | SUBMERGED VOID FILLNG - Systems and methods for filling submerged voids with a foam-fluidized fill material in an efficient and economical manner are disclosed herein. The foam fluidized fill material is a granular solid material fluidized with a foam. The foam-fluidized fill material is pumped or gravity-fed through an insertion tube into the submerged void. The insertion tube terminates at a point lying below a surface of the liquid within the void. Since the foam-fluidized fill material is heavier than the liquid, the foam-fluidized fill material exiting the insertion tube sinks to the bottom of the void and expands laterally at the bottom of the void displacing the liquid. The liquid is forced upward and out of the void where it may be collected. Further, as the fill material fills the void, the foam dissipates and the fill material self compacts, making the filled void sufficiently load bearing. | 08-16-2012 |
20120211415 | LIGHTWEIGHT DRAINABLE CELLULAR CONCRETE - A lightweight previous cellular concrete is provided. The concrete has an internal structure comprising interconnected channels, resulting in a permeability K value of less than about 1×10 | 08-23-2012 |
Tyre Palladino, Avoca, NY US
Patent application number | Description | Published |
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20130340687 | UNITARY ANIMAL LEASH AND COLLAR - A unitary animal leash and collar comprising a strap having a grasping loop formed by affixing one end of the strap on a portion of the strap and strategically disposing hook and loop portions on the opposing surfaces of the strap where a collar can be sized and formed by mating a hook portion with a loop portion. A band keeper comprises two ends where one end is slidably secured to the strap and hook and loop portions disposed on opposing surfaces of the band keeper. Upon forming a collar around an animal's neck, the band keeper is positioned adjacent a portion of the strap where hook and loop portions of the strap have been mated and the band keeper is wrapped around the strap such that a hook portion of the band keeper is mated with a loop portion of the band keeper. | 12-26-2013 |
Vinent Palladino, Anaheim, CA US
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20110010868 | Trowel roofing knife - The present invention provides an improved roofing knife comprising an additional blade added to the end of the knife which renders the knife more useful as a tool, safer and increases the reach of the knife. The additional blade added to the end of the knife renders the task easier and more productive. The additional blade on the end allows removal of the excess tar without the need to locate and retrieve an additional tool. The Trowel Roofing Knife is able to complete jobs necessary for utility knives, while also providing an extendable blade that facilitates the spreading of material into hot asphalt while also allowing users to easily and safely remove impurities from hot tar., the Trowel Roofing Knife is a specially designed tool configured for use with roofing knives that turns the tool into a trowel and a spreader, combining several implements into one convenient unit. | 01-20-2011 |