Palena
Claudia Palena, Rockville, MD US
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20140004135 | YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS | 01-02-2014 |
Claudia Palena, Potomac, MD US
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20160106824 | YEAST-BRACHYURY IMMUNOTHERAPEUTIC COMPOSITIONS - Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury. | 04-21-2016 |
Claudia M. Palena, Rockville, MD US
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20120230948 | BRACHYURY POLYPEPTIDES AND METHODS FOR USE - It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed. | 09-13-2012 |
Claudia M. Palena, Potomac, MD US
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20140135488 | BRACHYURY POLYPEPTIDES AND METHODS FOR USE - It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include small lung, colon, intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed. | 05-15-2014 |
20150224181 | BRACHYURY PROTEIN, NON-POXVIRUS NON-YEAST VECTORS ENCODING BRACHYURY PROTEIN, AND THEIR USE - protein can be used to induce | 08-13-2015 |
Claudia N. Palena, Rockville, MD US
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20100055121 | BRACHYURY POLYPEPTIDES AND METHODS FOR USE - It is disclosed herein that Brachyury is expressed in human tumors, specifically in tumors of the small intestine, stomach, kidney, bladder, uterus, ovary, and testes, as well as in lung, colon and prostate carcinomas. Immunogenic Brachyury polypeptides are disclosed herein. These polypeptides can be used in diagnostic assays for Brachyury expression, as well as for inducing an immune response to Brachyury. Polynucleotides encoding the immunogenic Brachyury polypeptides, vectors including these polypeptides, host cells transformed with these vectors, and methods of using these polypeptides, polynucleotides, vectors, and host cells are provided. Methods of diagnosing a Brachyury-expressing cancer are also provided. Exemplary cancers include lung, colon, small intestine, stomach, kidney, bladder, uterus, ovary, and testes and prostate cancers. Methods of treating cancer are also disclosed. | 03-04-2010 |
Patricia D. Palena, Plainsboro, NJ US
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20090220382 | NANO-GETTER DEVICE - A nano-structured device for detecting biological analytes, chemical, analytes, cancer and other physiological conditions, includes a carrier substrate, a transducer film disposed over a surface of the carrier substrate, and a dendrimer structure tethered to the transducer film. The transducer film generates a first signal in response to a mechanical stress applied thereto. The first signal indicates the detection of the biological analyte, chemical analyte, cancer or other physiological condition. The dendrimer structure includes a plurality of receptors for binding the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological conditions to the dendrimer structure. The dendrimer structure applies the mechanical stress to the transducer film, which is proportional to the strain induced into the dendrimer by the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological condition binding to the receptors, the mechanical stress causing the transducer film to generate the first signal indicating the detection of the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological condition. | 09-03-2009 |
20130018243 | THREE DIMENSIONAL MICROFLUIDIC MULTIPLEXED DIAGNOSTIC SYSTEM - A biosensor includes a microfluidics layer, a transduction layer and a transceiver layer. The transduction layer further includes a functionalized layer that reacts with a biomarker, and a plurality of carbon nanotubes adjacent the functionalized layer. The conductivity of the carbon nanotubes changes in response to a biomarker reacting with at least a portion of the functionalized layer. The functionalized layer can include dendrimers, such as a tadpole dendrimer scaffolding that includes a plurality of sites for receiving receptors for biomarkers. | 01-17-2013 |
20130040405 | METHODS FOR SENSITIVE AND RAPID DETECTION OF MOLECULES - In some embodiments, the present invention provides methods of detecting a molecule in a sample, such as an explosive. In some embodiments, the method comprises: associating the sample with an antigen/binding agent complex; measuring a rate of displacement of the binding agent from the antigen by the molecule in the sample; and correlating the measured rate of displacement to the presence of the molecule in the sample. In some embodiments, the measuring step comprises a determination of a change in frequency of the sample and a change in energy dissipation of the sample over a time interval. In some embodiments, the correlating step comprises a calculation of a ratio of a change in energy dissipation of the sample over a change in frequency of the sample over the time interval. In some embodiments, the method is used to determine the molecule concentration in the sample. | 02-14-2013 |
Travis Palena, Vancouver, WA US
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20080251063 | Rechargeable self-heating food container - A rechargeable, self-heating food container includes an inner chamber with a supersaturated salt solution and trigger means for initiating crystallization of the supersaturated salt solution. A rechargeable element for heating food includes a cylinder containing a supersaturated salt solution sealingly insertable into a food container, with a trigger in fluid contact with the supersaturated salt solution. A method of heating a food container includes providing a food container with an internal chamber, a supersaturated salt solution contained in the internal chamber, and a trigger to initiate crystal nucleation within the supersaturated salt solution in an exothermic reaction; and recharging by heating the food container until the salt crystals melt, and cooling the salt solution to a supersaturated state. A portable recharger for a rechargeable heating element includes an insulated sleeve with electric resistive heating element pluggable into an automobile or conventional ac outlet. | 10-16-2008 |