Pale
John A. Pale, Troy, MI US
Patent application number | Description | Published |
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20090241629 | METHOD OF PRODUCING A STEPPED SHAFT - A method for forming a stepped shaft includes: forming a billet of a predetermined mass; heating the billet; cross-wedge rolling the billet to form an intermediate workpiece having a first cylindrical portion and a second cylindrical portion that are axially spaced apart by a neck that is smaller in diameter than the first and second cylindrical portions; and performing at least one upset forging operation on the end of the intermediate workpiece to enlarge the first cylindrical portion such that in at least one location its diameter is larger than a diameter of any other portion of the stepped shaft and larger than a diameter of the billet. | 10-01-2009 |
Jonathan Pale, Warwick, RI US
Patent application number | Description | Published |
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20140273717 | THREE WAY MULTIDIRECTIONAL INTERACTIVE TOY - Systems and methods for interaction between a user and a plurality of toys is disclosed where an interactive physical toy character senses inputs from a player and from a virtual toy character in a virtual environment. The virtual toy character likewise senses inputs from a player and a physical toy character so that bidirectional, multi-way gameplay involving a player, a physical toy and a virtual toy in a virtual environment is achieved. | 09-18-2014 |
Patrick Pale, Strasbourg FR
Patent application number | Description | Published |
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20100069504 | AMINOBENZOCYCLOHEPTENE DERIVATIVES, METHODS FOR PREPARING THE SAME AND USES THEREOF IN THERAPY - A compound of the general formula (I) as an active principle for treating cancer, specifically tumors, in particular diseases involving inhibition of metalloproteases, such as Aminopeptidase-N. Pharmaceutical compositions comprising the compound of general formula (I). Methods of treatment using the compound of general formula (I). | 03-18-2010 |
20110118202 | Molecules which Bind to the Dimerization Initiation Site (DIS) of HIV RNA, Their Synthesis and Their Applications as Drugs - The dimerization of HIV RNA is a key step in the virus replication cycle. Based on RNA DIS crystal structures, a novel kind of compounds, dimeric or not, based on neamine was designed and synthesized. Biological studies showed that such compounds bind and interfere with the targeted RNA sequence, opening a new anti-HIV approach. The crystal structures and bio-chemical experiments showed that the DIS of HIV-1 genomic RNA is a target for new anti-HIV drugs and that those drugs could be derived from aminoglycosides. The results revealed that binding of aminoglycosides to the DIS is specific regarding both the aminoglycoside family and the RNA subtype. | 05-19-2011 |