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Pabo
Carl Pabo, Mill Valley, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20080233641 | Simultaneous modulation of multiple genes - Disclosed herein are compositions and methods that regulate expression of two or more endogenous genes. | 09-25-2008 |
Carl O. Pabo, Mill Valley, CA US
| Patent application number | Description | Published |
|---|---|---|
| 20110030076 | Methods and compositions for targeted cleavage and recombination - Disclosed herein are methods and compositions for targeted cleavage of a genomic sequence, targeted alteration of a genomic sequence, and targeted recombination between a genomic region and an exogenous polynucleotide homologous to the genomic region. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain and polynucleotides encoding same. Methods for targeted cleavage include introduction of such fusion proteins, or polynucleotides encoding same, into a cell. Methods for targeted recombination additionally include introduction of an exogenous polynucleotide homologous to a genomic region into cells comprising the disclosed fusion proteins. | 02-03-2011 |
Carl O. Pabo, Newton, MA US
| Patent application number | Description | Published |
|---|---|---|
| 20090100535 | CHIMERIC DNA-BINDING PROTEINS - Chimeric proteins containing composite DNA-binding regions are disclosed together with DNA constructs encoding them, compositions containing them and applications in which they are useful. | 04-16-2009 |
| 20110014675 | Poly zinc finger proteins with improved linkers - Polynucleotides encoding chimeric proteins, and methods for their production and use are disclosed. The chimeric proteins comprise a flexible linker between two zinc finger DNA-binding domains, wherein the linker contains eight or more amino acids between the second conserved histidine residue of the carboxy-terminal zinc finger of the first domain and the first conserved cysteine residue of the amino-terminal zinc finger of the second domain. | 01-20-2011 |