Overkleeft
Herman Overkleeft, Leiden NL
Patent application number | Description | Published |
---|---|---|
20120214732 | Inhibitors of the Trypsin-Like Site of the Proteasome and Methods of Use Thereof - The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the β2/β2i site of a proteasome and treat a proteasome-mediated disease or condition are also described. | 08-23-2012 |
20130102527 | INHIBITORS OF THE TRYPSIN-LIKE SITE OF THE PROTEASOME AND METHODS OF USE THEREOF - The present invention is an inhibitor of the trypsin-like β2/β2i sites of the proteasome. The inhibitor is characterized as being a peptide-based epoxyketone or vinyl sulfone that contains an arginine or 4-aminomethylene-L-phenylalanine at the C-terminus (i.e., at the P1 position). Methods for using the inhibitor to inhibit the activity of the β2/β2i site of a proteasome and treat a proteasome-mediated disease or condition are also described. | 04-25-2013 |
Herman Stevem Overkleeft, Leiden NL
Patent application number | Description | Published |
---|---|---|
20100323976 | NOVEL ANTI-INFLAMMATORY PRO-DRUGS - The present invention relates to compounds according to formula (I): wherein R | 12-23-2010 |
Herman Steven Overkleeft, Leiden NL
Patent application number | Description | Published |
---|---|---|
20090312521 | Antibiotic drosocin derivatives - The invention concerns derivatives of drosocin which have an increased half-life in mammalian serum by substituting one or more of the amino acid residues of wild type drosocin with another amino acid or a peptidomimetic moiety capable of replacing said amino acid. These derivatives can be used for antibiotic therapy or in a bacteriocidal composition. | 12-17-2009 |
20130143228 | ACTIVITY BASED PROBES (ABPs) INTERACTING WITH GLYCOSIDASES - An activity based probe (ABP) comprising a glycosidase inhibitor, and a detection-group. The ABPs of the inventions are used for diagnosing storage disorder for screening of compounds suitable for preventing and/or treating a storage disorder, for monitoring of therapeutic enzymes for lysosomal storage disorders, and for ultra-sensitive visualization of glycosidase-fusion proteins in molecular imaging. | 06-06-2013 |