Oreffo

Richard Oreffo, Southampton GB

Patent application number	Description	Published
20110306134	RETENTION OF A STEM CELL PHENOTYPE - A method for promoting the retention of a stem cell phenotype in a population of stem cells. A biocompatible substrate is provided, e.g. in the form of cultureware. The substrate has an arrangement of topographical features arrayed in a pattern based on a notional symmetrical lattice in which the distance between nearest neighbour notional lattice points is between 10 nm and 10 μm, and wherein the topographical features are either located in register with the respective notional lattice points or are locally misordered such that the centre of each topographical feature is at most 10% of the distance between nearest neighbour notional lattice points from its respective notional lattice point. A population of stem cells is provided in contact with said arrangement of topographical features. Culturing the population of stem cells under conditions that allow the stem cells to proliferate allows the retention of the stem cell phenotype in the population of stem cells.	12-15-2011

Patent application number	Description	Published
20090171467	IMPLANTABLE CARTILAGINOUS TISSUE REPAIR DEVICE - A cartilaginous tissue repair device with a biocompatible, bioresorbable three-dimensional silk or other fibre lay and a biocompatible, bioresorbable substantially porous silk-based or other hydrogel partially or substantially filling the interstices of the fibre lay; with or without an integral means of firmly anchoring the device to a patient's bone.	07-02-2009

Patent application number	Description	Published
20120003271	POLYMER BLENDS - A biocompatible polymer mixture for use as a matrix for cellular attachment includes a mixture of at least two polymers selected from the group consisting of: chitosan (CS), polyethylenimine (PEI), poly(L-lactic acid) (PLLA), poly(D-lactic acid) (PDLA), poly(2-hydroxy ethyl methacrylate) (PHEMA), poly(ε-caprolactone) (PCL), poly(vinyl acetate) (PVAc), poly(ethylene oxide) (PEO), poly[(R)-3-hydroxybutyric acid)] (PHB), cellulose acetate (CA), poly(lactide-co-glycolide) (PLGA) and poly(N-isopropylacrylamide) (PNIPAM). Implants making use of the polymer mixtures can support cell attachment, growth and differentiation, and tissue regeneration in vivo.	01-05-2012