Ohta, US
Aaron Ohta, Honolulu, HI US
Patent application number | Description | Published |
---|---|---|
20100101960 | SINGLE-SIDED LATERAL-FIELD AND PHOTOTRANSISTOR-BASED OPTOELECTRONIC TWEEZERS - Described herein are single-sided lateral-field optoelectronic tweezers (LOET) devices which use photosensitive electrode arrays to create optically-induced dielectrophoretic forces in an electric field that is parallel to the plane of the device. In addition, phototransistor-based optoelectronic tweezers (PhOET) devices are described that allow for optoelectronic tweezers (OET) operation in high-conductivity physiological buffer and cell culture media. | 04-29-2010 |
20110223314 | EFFICIENT MICROENCAPSULATION - A device and method for generating microcapsules employs an inertial-focusing channel for introducing particles dispersed in a prepolymer suspension fluid, a droplet-generating junction for introducing oil evenly onto the flow of particles to create separated droplets of prepolymer suspension fluid encapsulating respective particles in a streamline flow, and a polymerization section for exposing the droplets to UV light or heat to cause polymerization of a polymer coating on separate microcapsules each containing a respective particle. Preferred suspension fluids may be aqueous solution of poly(ethylene-glycol)-diacrylate (PEGDA), or poly(N-isopropyl-acryalmide) (PNIPAAM). The preferred device may employ a curved or linear inertial-focusing microchannel. Functional tags and/or handles may be added to the microcapsules allowing easy detection, measurement and handling of the microcapsules. | 09-15-2011 |
20120118740 | METHODS AND DEVICES FOR SORTING CELLS AND OTHER BIOLOGICAL PARTICULATES - An optical pattern-driven light induced dielectrophoresis (DEP) apparatus and separation methods are described which provide for the manipulation of particles or cells and selection based on traits correlated with the DEP response. Embodiments of the apparatus use DEP electric field patterns in combination with microfluidic laminar flows to measure response, separate, segregate and extract particles from heterogeneous mixtures according to the relative response of the particles to one or more DEP fields without damaging living cells. The methods are particularly suited for selecting and extracting the best sperm and embryo candidates based on fitness for use with existing artificial reproduction procedures and excluding defective or non-viable gametes. | 05-17-2012 |
Aaron T. Ohta, Berkeley, CA US
Patent application number | Description | Published |
---|---|---|
20090170186 | OPTOELECTRONIC TWEEZERS FOR MICROPARTICLE AND CELL MANIPULATION - An optical image-driven light induced dielectrophoresis (DEP) apparatus and method are described which provide for the manipulation of particles or cells with a diameter on the order of 100 μm or less. The apparatus is referred to as optoelectric tweezers (OET) and provides a number of advantages over conventional optical tweezers, in particular the ability to perform operations in parallel and over a large area without damage to living cells. The OET device generally comprises a planar liquid-filled structure having one or more portions which are photoconductive to convert incoming light to a change in the electric field pattern. The light patterns are dynamically generated to provide a number of manipulation structures that can manipulate single particles and cells or groups of particles/cells. The OET preferably includes a microscopic imaging means to provide feedback for the optical manipulation, such as detecting position and characteristics wherein the light patterns are modulated accordingly. | 07-02-2009 |
Akiko Ohta, Newton, MA US
Patent application number | Description | Published |
---|---|---|
20140377240 | METHODS AND COMPOSITIONS FOR EXPANDING IMMUNOSUPPRESSIVE T REGULATORY CELLS IN VITRO AND USES THEREOF - Disclosed herein are methods and compositions for expanding T-regulatory cells (“Treg” cells), resulting in “conditioned Treg cells.” Also disclosed herein are methods and compositions useful for modulating an autoimmune reaction and for treating or ameliorating immune-related diseases, disorders and conditions using the conditioned Treg cells. | 12-25-2014 |
Akio Ohta, Newton, MA US
Patent application number | Description | Published |
---|---|---|
20100178299 | METHODS AND COMPOSITIONS FOR IMPROVING IMMUNE RESPONSES - The present invention relates to compositions and methods for enhancing an immune response, for example to a vaccine, by combining the administration of oxygen (O | 07-15-2010 |
20110300183 | METHOD OF PREPARING ADENOSINE-RESISTANT ANTI-TUMOR T LYMPHOCYTES FOR ADOPTIVE IMMUNOTHERAPY - In the past, adoptive immunotherapy often failed because the transferred immune cells were inactive in vivo. This disclosure provides a method of producing immune cells that are highly active in vivo. The immune cells may be expanded in vitro in the presence of an adenosine receptor agonist or an antisense nucleic acid that downregulates expression of an adenosine receptor, for example. The immune cells may be tumor-infiltrating lymphocytes (TIL), cytotoxic T lymphocytes (CTL), natural killer (NK) cells, or lymphokine-activated killer (LAK) cells, for example. The methods described herein may be used to treat a number of diseases including cancer, infectious diseases, and immunodeficiencies. | 12-08-2011 |
20130324461 | METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING OBESITY - The invention includes methods of treating, preventing, or limiting obesity or weight gain, or reducing or suppressing appetite, by the administration of A2A adenosine receptor pathway agonists. The A2AR pathway agonists may be administered in conjunction with a therapeutic agent having a side effect of weight gain, in order to prevent or limit that weight gain. In some instances, the A2AR pathway agonist is administered as a sleeping pill, and in other instances the A2AR pathway agonist is administered in a non-drowsy formulation. | 12-05-2013 |
20140056922 | METHODS FOR USING EXTRACELLULAR ADENOSINE INHIBITORS AND ADENOSINE RECEPTOR INHIBITORS TO ENHANCE IMMUNE RESPONSE AND INFLAMMATION - A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction. | 02-27-2014 |
20140377240 | METHODS AND COMPOSITIONS FOR EXPANDING IMMUNOSUPPRESSIVE T REGULATORY CELLS IN VITRO AND USES THEREOF - Disclosed herein are methods and compositions for expanding T-regulatory cells (“Treg” cells), resulting in “conditioned Treg cells.” Also disclosed herein are methods and compositions useful for modulating an autoimmune reaction and for treating or ameliorating immune-related diseases, disorders and conditions using the conditioned Treg cells. | 12-25-2014 |
Akio Ohta, Rockville, MD US
Patent application number | Description | Published |
---|---|---|
20120093856 | METHODS FOR USING EXTRACELLULAR ADENOSINE INHIBITORS AND ADENOSINE RECEPTOR INHIBITORS TO ENHANCE IMMUNE RESPONSE AND INFLAMMATION - A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction. | 04-19-2012 |
Hiroaki Ohta, Goleta, CA US
Patent application number | Description | Published |
---|---|---|
20110007766 | STRUCTURE FOR IMPROVING THE MIRROR FACET CLEAVING YIELD OF (Ga,Al,In,B)N LASER DIODES GROWN ON NONPOLAR OR SEMIPOLAR (Ga,Al,In,B)N SUBSTRATES - A structure for improving the mirror facet cleaving yield of (Ga,Al,In,B)N laser diodes grown on nonpolar or semipolar (Ga,Al,In,B)N substrates. The structure comprises a nonpolar or semipolar (Ga,Al,In,B)N laser diode including a waveguide core that provides sufficient optical confinement for the device's operation in the absence of p-type doped aluminum-containing waveguide cladding layers, and one of more n-type doped aluminum-containing layers that can be used to assist with facet cleaving along a particular crystallographic plane. | 01-13-2011 |
20110062415 | ANISOTROPIC STRAIN CONTROL IN SEMIPOLAR NITRIDE QUANTUM WELLS BY PARTIALLY OR FULLY RELAXED ALUMINUM INDIUM GALLIUM NITRIDE LAYERS WITH MISFIT DISLOCATIONS - An epitaxial structure for a III-Nitride based optical device, comprising an active layer with anisotropic strain on an underlying layer, where a lattice constant and strain in the underlying layer are partially or fully relaxed in at least one direction due to a presence of misfit dislocations, so that the anisotropic strain in the active layer is modulated by the underlying layer. | 03-17-2011 |
20110064103 | SEMIPOLAR NITRIDE-BASED DEVICES ON PARTIALLY OR FULLY RELAXED ALLOYS WITH MISFIT DISLOCATIONS AT THE HETEROINTERFACE - A dislocation-free high quality template with relaxed lattice constant, fabricated by spatially restricting misfit dislocation(s) around heterointerfaces. This can be used as a template layer for high In composition devices. Specifically, the present invention prepares high quality InGaN templates (In composition is around 5-10%), and can grow much higher In-composition InGaN quantum wells (QWs) (or multi quantum wells (MQWs)) on these templates than would otherwise be possible. | 03-17-2011 |
20110103418 | SUPERLUMINESCENT DIODES BY CRYSTALLOGRAPHIC ETCHING - An optoelectronic device, comprising an active region and a waveguide structure to provide optical confinement of light emitted from the active region; a pair of facets on opposite ends of the device, having opposite surface polarity; and one of the facets which has been roughened by a crystallographic chemical etching process, wherein the device is a nonpolar or semipolar (Ga,In,Al,B)N based device. | 05-05-2011 |
20110170569 | SEMIPOLAR III-NITRIDE LASER DIODES WITH ETCHED MIRRORS - A semipolar {20-21} III-nitride based laser diode employing a cavity with one or more etched facet mirrors. The etched facet mirrors provide an ability to arbitrarily control the orientation and dimensions of the cavity or stripe of the laser diode, thereby enabling control of electrical and optical properties of the laser diode. | 07-14-2011 |
Kazuhisa Ohta, Sunnyvale, CA US
Patent application number | Description | Published |
---|---|---|
20120179700 | SYSTEM AND METHOD FOR EFFICIENTLY TRANSLATING MEDIA FILES BETWEEN FORMATS USING A UNIVERSAL REPRESENTATION - An apparatus and method are described for reading a file into a universal representation and translating from that universal representation into various file formats. For example, a method according to one embodiment comprises: reading compressed audio data from a first audio file, the first audio file comprising audio data compressed using a first compression algorithm and bookkeeping data having a first format, the bookkeeping data specifying a location of the compressed audio data within the first audio file; and generating a universal representation of the first audio file without decompressing and recompressing the audio data, the universal representation having bookkeeping data of a second format specifying the location of compressed audio data within the universal representation. | 07-12-2012 |
20130339034 | SYSTEM AND METHOD FOR EFFICIENTLY TRANSLATING MEDIA FILES BETWEEN FORMATS USING A UNIVERSAL REPRESENTATION - An apparatus and method are described for reading a file into a universal representation and translating from that universal representation into various file formats. For example, a method according to one embodiment comprises: reading compressed audio data from a first audio file, the first audio file comprising audio data compressed using a first compression algorithm and bookkeeping data having a first format, the bookkeeping data specifying a location of the compressed audio data within the first audio file; and generating a universal representation of the first audio file without decompressing and recompressing the audio data, the universal representation having bookkeeping data of a second format specifying the location of compressed audio data within the universal representation. | 12-19-2013 |
Kazuomi Ohta US
Patent application number | Description | Published |
---|---|---|
20150330807 | POOR VISIBILITY ESTIMATION SYSTEM AND POOR VISIBILITY ESTIMATION METHOD - Provided are a poor visibility estimation system and a poor visibility estimation method that can estimate poor visibility using a simpler configuration. A center has a change amount calculation unit for calculating the change amounts of operation elements of vehicles. A visibility estimation unit estimates poor visibility on the basis of the change amounts calculated by the change amount calculation unit. The center also has a distribution unit for distributing the estimation results of the visibility estimation unit. | 11-19-2015 |
Seiya Ohta, Seattle, WA US
Patent application number | Description | Published |
---|---|---|
20090054939 | Automated External Defibrillator (AED) With Context-Sensitive Help - A defibrillator system is disclosed including an operational state input, a user-operated information request input, and a user guidance output. The defibrillator system can be implemented as an AED, a manual defibrillator, or as a defibrillator trainer. The defibrillator system further utilizes the state and request inputs to determine a context-sensitive rescue information which is provided to the output. | 02-26-2009 |
Seiya Ohta, Ithaca, NY US
Patent application number | Description | Published |
---|---|---|
20150252934 | ADJUSTABLE FRAME ASSEMBLIES, METHODS FOR ASSEMBLING A FILTER APPARATUS, AND FILTER APPARATUSES - An adjustable frame assembly for filter modules includes a lower base arrangement, an upper base arrangement, and an adjustable frame structure connected between the lower and upper base arrangements. Both the lower and upper base arrangements include mounts for positioning and supporting the filter modules. At least one of the base arrangements includes a piping system for supplying fluid to and/or receiving fluid from the filter modules. The adjustable frame structure is moveable between a first position, in which the lower and upper base arrangements are spaced a smaller first distance apart, and a second position, in which the lower and upper base arrangements are spaced a larger second distance apart. Filter modules may be mounted to the adjustable frame assembly when the adjustable frame structure is in the second position to form a filter apparatus. | 09-10-2015 |
20150252935 | MODULAR FILTRATION FRAME ASSEMBLY - A modular filtration frame assembly is provided for holding components of a pipe system and filtration system. The modular frame assembly comprises a skid formed by a base and a central spine. The base has at least two legs and at least one lateral support disposed between the two legs, and the central spine has two uprights and at least one cross bar disposed between the two uprights. A component support member is attached to the central spine for supporting components of the pipe system. In the modular frame assembly, the base, central spine and component supports can be formed by selecting from predetermined and presized components in response to the design and size of the pipe system and filtration system. The component support member holds predetermined components of the pipe and filtration system having a predetermined centerline at the same vertical distance from the cross bar, thereby maintaining the same centerline for all pipe system components supported by the skid regardless of component diameter. | 09-10-2015 |
Seiya Ohta, Issaquah, WA US
Patent application number | Description | Published |
---|---|---|
20100153857 | SHARED SPACE FOR COMMUNICATING INFORMATION - Embodiments provide a shared space for communicating information. In an embodiment a number of users associated with a computing environment can use a shared space to communicate information with one another. Each computing device of the computing environment can include a shared space application. The shared space application includes a number of interactive tools that can be used to persist various communications between associated computing devices of a computing environment. | 06-17-2010 |
20150256574 | SHARED SPACE FOR COMMUNICATING INFORMATION - Embodiments provide a shared space for communicating information. In an embodiment a number of users associated with a computing environment can use a shared space to communicate information with one another. Each computing device of the computing environment can include a shared space application. The shared space application includes a number of interactive tools that can be used to persist various communications between associated computing devices of a computing environment. | 09-10-2015 |