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Obitsu
Hideshi Obitsu, Kanagawa JP
| Patent application number | Description | Published |
|---|---|---|
| 20100016875 | Intravascular foreign matter removing wire and medical implement - An intravascular foreign matter removing wire has a flexible long wire body, a first catching section located on the tip side of the wire body and operative to catch a foreign matter present inside a blood vessel, and a second catching section located in the vicinity of and on the base end side of the first catching section and operative to catch a foreign matter present inside a blood vessel. | 01-21-2010 |
Kazuyoshi Obitsu, Chuo-Ku JP
| Patent application number | Description | Published |
|---|---|---|
| 20100173946 | BENZIMIDAZOLYLIDENE PROPANE-1,3-DIONE DERIVATIVE OR SALT THEREOF - Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene or thiophene ring substituted with a group derived from 1-hydroxymethyl, shows excellent availability, in addition to its excellent GnRH receptor antagonism, thereby accomplishing the invention. Since the compound of the invention shows excellent availability, in addition to its strong GnRH receptor antagonism, it can be expected that it exerts superior drug effect in the living body, and it is useful for the treatment of sex hormone dependent diseases such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma, benign prostatic hypertrophy and the like. In addition, since the compound of the invention is excellent in metabolic stability in human and also is less in drug interaction, it has more desirable properties as a medicament to be used for the aforementioned diseases. | 07-08-2010 |
Kazuyoshi Obitsu, Tokyo JP
| Patent application number | Description | Published |
|---|---|---|
| 20090018177 | Propane-1,3-Dione Derivative or Salt Thereof - Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene or thiophene ring substituted with a group derived from 1-hydroxymethyl, shows excellent availability, in addition to its excellent GnRH receptor antagonism, thereby accomplishing the invention. Since the compound of the invention shows excellent availability, in addition to its strong GnRH receptor antagonism, it can be expected that it exerts superior drug effect in the living body, and it is useful for the treatment of sex hormone dependent diseases such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma, benign prostatic hypertrophy and the like. In addition, since the compound of the invention is excellent in metabolic stability in human and also is less in drug interaction, it has more desirable properties as a medicament to be used for the aforementioned diseases. | 01-15-2009 |
Tetsuo Obitsu, Osaka JP
| Patent application number | Description | Published |
|---|---|---|
| 20100137318 | BICYCLIC HETEROCYCLIC COMPOUND - A compound of a formula (I): | 06-03-2010 |