Patent application number | Description | Published |
20100036478 | Method Of Improving Fracture Toughness Of Implantable Medical Devices Through Annealing - Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing are disclosed herein. A polymeric construct is annealed with no or substantially no crystal growth to increase nucleation density. After the annealing, crystallites are grown around the formed nuclei. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the crystallite growth. | 02-11-2010 |
20100038822 | Fracture Toughness Of Medical Devices With A Stereocomplex Nucleating Agent - Methods of fabricating a polymeric implantable device from a PLLA/PDLA blend such as a stent with improved fracture toughness are disclosed. The blend is melt processed to allow formation of stereocomplex crystallites, which are nucleation sites for crystal growth. A polymer construct is formed from the melt processed blend and device is formed from the polymer construct. The stereocomplex crystallites result in an in increase in nucleation density and reduced crystal size, which increases fracture toughness of the formed device. | 02-18-2010 |
20100251838 | Fixture for Mechanical Analysis of a Hollow Tube - A test fixture for use with a Dynamic Mechanical Analyzer (DMA) restrains a hollow cylindrical tube for purposes of performing either a tensile or transverse/bending load test. The fixture includes a clamp that is configured to restrain the tube without imparting a preload or changing a mechanical property of the tube. | 10-07-2010 |
20110022155 | Biodegradable Stent With Adjustable Degradation Rate - A biodegradable polymeric stent made from poly(L-lactide) and a low concentration of L-lactide monomer is disclosed. The concentration of L-lactide is adjusted to provide a degradation behavior that is suitable for different treatment applications including coronary, peripheral, and nasal. | 01-27-2011 |
20110022163 | Implantable Medical Device Comprising Copolymer Of L-Lactide With Improved Fracture Toughness - The present invention relates to implantable medical devices comprising a L-lactide-constitutional unit-containing copolymer having a wt % percent crystallinity of 40% or less. | 01-27-2011 |
20110062638 | Controlling Crystalline Morphology Of A Bioabsorbable Stent - Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stent manufacture and fabrication of a stent therefrom are disclosed. | 03-17-2011 |
20110065825 | Method To Minimize Molecular Weight Drop Of Poly(L-Lactide) Stent During Processing - A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing. | 03-17-2011 |
20110260352 | Stabilizing Semi-Crystalline Polymers To Improve Storage Performance Of Medical Devices - Methods are disclosed for improving the storage performance of polymeric stents that reduce or eliminate the effects of long term aging on the properties of the stents. A polymeric stent or a polymeric tube from which a stent is made is heated to a temperature between ambient and the glass transition temperature of the polymer for a period of time. The heating causes densification or an increase in density of the polymer which stabilizes the properties of the polymer in later processing steps and storage. The stent can be made from a polymeric tube that is expanded at a temperature above the glass transition temperature and cooled to maintain an expanded diameter. | 10-27-2011 |
20120091633 | Method To Minimize Chain Scission And Monomer Generation In Processing of Poly(L-Lactide) Stent - Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD. | 04-19-2012 |
20120239135 | STENTS INCLUDING POLY(L-LACTIDE) FORMULATIONS THAT MINIMIZE MOLECULAR WEIGHT DROP DURING PROCESSING - A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing. | 09-20-2012 |
20120290071 | Bioabsorbable Scaffold With Particles Providing Delayed Acceleration of Degradation - Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. A bioabsorbable scaffold having a plurality of particles incorporated into the scaffolding that accelerate the absorption of the scaffolding after an induction time during degradation is disclosed. | 11-15-2012 |
20120299226 | Method and System for Manufacturing a Polymer Endoprosthesis by Injection Molding and Blow Molding - A polymer endoprosthesis is fabricated by a combination of injection molding and blow molding which form a tubular substrate of polymer material, followed by laser cutting, crimping and sterilization. After the injection and blow molding processes, a subtractive process is performed on the tubular substrate to transform it into a stent having a network of stent struts. The tubular substrate can be made in an injection mold and blow mold which are attached to each other. The transition from injection molding and blow molding can be performed while the injection molded substrate remains at a temperature at or above Tg of the polymer material. | 11-29-2012 |
20130187313 | Controlling Crystalline Morphology of a Bioabsorbable Stent - Methods to expand polymer tubing with desirable or optimum morphology and mechanical properties for stem manufacture and fabrication of a stent therefrom are disclosed. | 07-25-2013 |
20130207314 | METHOD OF IMPROVING FRACTURE TOUGHNESS OF IMPLANTABLE MEDICAL DEVICES THROUGH ANNEALING - Methods of fabricating a polymeric implantable device with improved fracture toughness through annealing are disclosed herein. A polymeric construct is annealed with no or substantially no crystal growth to increase nucleation density. After the annealing, crystallites are grown around the formed nuclei. An implantable medical device, such as a stent, can be fabricated from the polymer construct after the crystallite growth. | 08-15-2013 |
20130255853 | Uniform Crimping and Deployment Methods for Polymer Scaffold - A medical device-includes a scaffold crimped to a catheter having an expansion balloon. The scaffold is crimped to the balloon by a process that includes one or more balloon pressurization steps. The balloon pressurization steps are selected to enhance scaffold retention to the balloon and maintain a relatively uniform arrangement of balloon folds about the inner surface of the crimped scaffold so that the scaffold expands in a uniform manner when the balloon is inflated. | 10-03-2013 |
20130261729 | CONTROL OF BALLOON INFLATION RATE DURING DEPLOYMENT OF SCAFFOLD - An apparatus and method for controlling inflation pressure and pressurization rate of a balloon during deployment of a stent or scaffold is disclosed. | 10-03-2013 |
20130300034 | METHOD TO MINIMIZE CHAIN SCISSION AND MONOMER GENERATION IN PROCESSING OF POLY(L-LACTIDE) STENT - Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD. | 11-14-2013 |
20140012365 | STENTS INCLUDING POLY(L-LACTIDE) FORMULATIONS THAT MINIMIZE MOLECULAR WEIGHT DROP DURING PROCESSING - A stent scaffolding including a polymer formulation comprising PLLA and polymandelide is disclosed. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing. | 01-09-2014 |
20140107761 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 04-17-2014 |
20140107762 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 04-17-2014 |
20140114394 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 04-24-2014 |
20140128959 | Biodegradable stent with enhanced fracture toughness - Stents and methods of manufacturing a stents with enhanced fracture toughness are disclosed. | 05-08-2014 |
20140239558 | SYSTEM FOR MANUFACTURING A POLYMER ENDOPROSTHESIS BY INJECTION MOLDING AND BLOW MOLDING - A polymer endoprosthesis is fabricated by a combination of injection molding and blow molding which form a tubular substrate of polymer material, followed by laser cutting, crimping and sterilization. After the injection and blow molding processes, a subtractive process is performed on the tubular substrate to transform it into a stent having a network of stent struts. The tubular substrate can be made in an injection mold and blow mold which are attached to each other. The transition from injection molding and blow molding can be performed while the injection molded substrate remains at a temperature at or above Tg of the polymer material. | 08-28-2014 |
20140277398 | DRUG DELIVERY DEVICE FOR PERIPHERAL ARTERY DISEASE - A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces. | 09-18-2014 |
20140288628 | METHOD TO MINIMIZE CHAIN SCISSION AND MONOMER GENERATION IN PROCESSING OF POLY(L-LACTIDE) STENT - Methods of fabricating an implantable medical devices such as stents made from biodegradable polymers are disclosed that reduce or minimize chain scission and monomer generation during processing steps. The method includes processing a poly(L-lactide) resin having an number average molecular weight between 150 to 200 kD in an extruder in a molten state. A poly(L-lactide) tube is formed from the processed resin and a stent is fabricated from the tube. The number average molecular weight of the poly(L-lactide) of the stent after sterilization is 70 to 100 kD. | 09-25-2014 |
20140298675 | CONTROLLING MOISTURE IN AND PLASTICIZATION OF BIORESORBABLE POLYMER FOR MELT PROCESSING - Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon. | 10-09-2014 |
20140319724 | BIOABSORBABLE SCAFFOLD WITH PARTICLES PROVIDING DELAYED ACCELERATION OF DEGRADATION - Methods of controlling the degradation profile of a biodegradable stent scaffolding are disclosed. A bioabsorbable scaffold having a plurality of particles incorporated into the scaffolding that accelerate the absorption of the scaffolding after an induction time during degradation is disclosed. | 10-30-2014 |
20150054202 | METHOD TO MINIMIZE MOLECULAR WEIGHT DROP OF POLY(L-LACTIDE) STENT DURING PROCESSING - A method to reduce or minimize the reduction in molecular weight of a stent during processing is disclosed. The stent has a scaffolding including a polymer formulation comprising PLLA and polymandelide. The polymandelide reduces the molecular weight drop during processing, particularly during sterilization. The stent scaffolding can further include one or more additional stabilizing agents that additionally reduce the molecular weight drop during processing. | 02-26-2015 |
20150073536 | Assessment of a drug eluting bioresorbable vascular scafford - A method of treating vascular disease in a patient is disclosed that comprises deploying a bioabsorbable polymer scaffold composed of a plurality of struts at a stenotic segment of an artery of a patient, wherein after the scaffold supports the segment at an increased diameter for a period of time the polymer degrades and is progressively replaced by de novo formation of malleable provisional matrix comprising proteoglycan, wherein as the scaffold becomes more malleable and becomes disconnected as it degrades, wherein following coverage of the struts by a neointima layer and loss of mechanical support provided by the scaffold, the scaffold is pulled outward by positive remodeling of the vessel wall of the scaffolded segment. | 03-12-2015 |
20150305899 | BRANCHED POLYHYDROXYALKANOATE SYSTEMS FOR BIORESORBABLE VASCULAR SCAFFOLD APPLICATIONS - An implantable medical devices such as a stent that includes sparse comb polyhydroxyalkanoate (PHA) systems is disclosed. The stent includes a stent body, scaffold, or substrate made partially or completely of polymer material including PHA. | 10-29-2015 |
Patent application number | Description | Published |
20100025894 | TUBE EXPANSION PROCESS FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods of fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube along its entire length at the same time and fabricating a stent from the expanded tube are disclosed herein. | 02-04-2010 |
20100198330 | Bioabsorbable Stent And Treatment That Elicits Time-Varying Host-Material Response - Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation. Upon complete absorption of the stent, the section moves and functions in a manner that is the same, more similar to, or substantially as a normal blood vessel. In particular, the section can have an increased diameter allowing increased blood flow and vasomotion is partially or substantially completely restored in the section. | 08-05-2010 |
20100198331 | Bioabsorbable Stent That Modulates Plaque Geometric Morphology And Chemical Composition - Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters. | 08-05-2010 |
20110278771 | TUBE EXPANSION PROCESSES AND SYSTEMS FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods of and systems for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube along its entire length at the same time and fabricating a stent from the expanded tube are disclosed herein. | 11-17-2011 |
20130026681 | TUBE EXPANSION PROCESSES FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold. | 01-31-2013 |
20130041129 | Controlling Moisture In And Plasticization Of Bioresorbable Polymer For Melt Processing - Methods and systems for controlling the moisture content of biodegradable and bioresorbable polymer resin during extrusion above a lower limit that allows for plasticization of the polymer resin melt and below an upper limit to reduce or prevent molecular weight loss are disclosed. Methods are further disclosed involving plasticization of a polymer resin for feeding into an extruder with carbon dioxide and freon. | 02-14-2013 |
20140374963 | TUBE EXPANSION PROCESSES FOR SEMICRYSTALLINE POLYMERS TO MAXIMIZE FRACTURE TOUGHNESS - Methods for fabricating a polymeric stent with improved fracture toughness including radial expansion of a polymer tube and fabricating a stent from the expanded tube are disclosed. The polymer tube is disposed within a mold and may be heated with radiation. The heated tube radially expands within the mold. | 12-25-2014 |
20150313735 | Bioabsorbable Stent and Treatment That Elicits Time-Varying Host-Material Response - Methods of treating a diseased blood vessel exhibiting stenosis with a bioabsorbable stent are disclosed. The implanted stent supports the section of the vessel at an increased diameter for a period of time to allow the vessel to heal. The stent loses radial strength sufficient to support the section of the vessel in less than 6 months after implantation, loses mechanical integrity, and then erodes away from the section. The biodegradable stent results in changes in properties of plaque with time as the stent degrades. The time-dependent properties include the luminal area of the plaque and plaque geometric morphology parameters. | 11-05-2015 |
20150359648 | HIGH MOLECULAR WEIGHT POLYLACTIDE AND POLYCAPROLACTONE COPOLYMER AND BLENDS FOR BIORESORBABLE VASCULAR SCAFFOLDS - Bioresorbable polymer vascular scaffolds made of combinations of polylactide and polycaprolactone having a high molecular weight polymer, thin struts in a selected range and sufficient radial strength to support a vessel upon deployment. The scaffolds have degradation behavior of molecular weight, radial strength, and mass that are conducive to healing of a vessel including providing patency to a vessel, reduction of radial strength, breaking up, and resorbing to allow return of the vessel to a natural state. | 12-17-2015 |