Patent application number | Description | Published |
20080269235 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS - New pyridazin-3(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of phosphodiesterase 4. | 10-30-2008 |
20090029996 | Pyridazin-3(2H)-One Derivatives And Their Use As Pde4 Inhibitors - The invention relates to new therapeutically useful pyridazin-3(2H)-one derivatives, to processes for their preparation and to pharmaceutical compositions containing them. These compounds are potent and selective inhibitors of phosphodiesterase 4 (PDE4) and are thus useful in the treatment, prevention and suppression of related pathological conditions, diseases and disorders, in particular asthma, chronic obstructive pulmonary disease, rheumatoid arthritis, topic dermatitis, psoriasis or irritable bowel disease. | 01-29-2009 |
20090111819 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES - Pyridazin-3(2H)-one derivatives of formula (I) are found to inhibit PDE-4: | 04-30-2009 |
20100204241 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES - Pyridazin-3(2H)-one derivatives of formula (I) are found to inhibit PDE-4: | 08-12-2010 |
20110053936 | SUBSTITUTED SPIRO[CYCLOALKYL-1,3'-INDOL]-2'(1'H)-ONE DERIVATIVES AND THEIR USE AS P38 MITOGEN-ACTIVATED KINASE INHIBITORS - The present disclosure is directed to new inhibitors of the p38 mitogen-activated protein kinase having the general formula (I), processes for preparation thereof, pharmaceutical compositions thereof, and methods of use thereof. | 03-03-2011 |
20110200557 | NEW 2-AMIDOTHIADIAZOLE DERIVATIVES - The present disclosure relates to 2-amidothiadiazole derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the S1P1 receptors. | 08-18-2011 |
20110274657 | OXADIAZOLE DERIVATIVES AS S1P1 RECEPTOR ANTAGONISTS - The present disclosure relates to oxadiazole derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the S1P1 receptor. | 11-10-2011 |
20110311485 | 1,2,4-OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE - The present disclosure relates to 1, 2, 4 oxadiazole derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the S1P1 receptors. | 12-22-2011 |