Patent application number | Description | Published |
20110098328 | HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS - The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 04-28-2011 |
20110124869 | Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 05-26-2011 |
20110306607 | HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS - The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 12-15-2011 |
20120149742 | HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS - The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 06-14-2012 |
20120309758 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators. | 12-06-2012 |
20130072687 | Process for Preparing Modulators of Cystic Fibrosis Transmembrane Conductance Regulator - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 03-21-2013 |
20130131107 | PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions comprising a compound of Formulas I and II, optionally in combination with a Compound of Formula III and/or a Compound of Formula IV. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. | 05-23-2013 |
20130158071 | PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF - The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis. | 06-20-2013 |
20130338119 | Pyrrolidinone Benzenesulfonamide Derivatives as Modulators of Ion Channels - The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 12-19-2013 |
20140080826 | MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS - Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention. | 03-20-2014 |
20140171427 | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels - The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. | 06-19-2014 |
20140187787 | PROCESS FOR PREPARING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 07-03-2014 |
20140336393 | PROCESS FOR PREPARING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR - The present invention relates to processes for preparing solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide, including Compound 1 Form A, Compound 1 Form A-HCl, Compound 1 Form B, and Compound 1 Form B-HCl, any combination of these forms, pharmaceutical compositions thereof, and methods of treatment therewith. | 11-13-2014 |
Patent application number | Description | Published |
20140238767 | WHEEL LOADER - A wheel loader comprises an engine, an exhaust gas post-processing device, an engine room, a top plate, a cooling room, a partition wall, and a drainage mechanism. The exhaust gas post-processing device is disposed above the engine in the engine room and includes a diesel particulate filtering device and a selective catalyst reduction catalyst device. The top plate has a sloping part with a height that decreases toward the rear, and a first ventilation part that includes a plurality of through-holes formed in the sloping part. The top plate defines an upper plane of the engine room. The cooling room accommodates a cooling unit and is disposed to the rear of the engine room, separated by the partition wall. The drainage mechanism is disposed below the first ventilation part, and configured to drain water entering the engine room from the first ventilation part to the outside of the engine room. | 08-28-2014 |
20140291059 | WORK VEHICLE AND WHEEL LOADER - A work vehicle includes an engine, an exhaust gas post-processing device, an engine room and a partitioning member. The exhaust gas post-processing device includes a diesel particulate filtering device, a selective catalyst reduction device, a connecting pipe connecting the diesel particulate filtering and the selective catalyst reduction device, and an injection device configured to inject a reducing agent into the connecting pipe. The engine room accommodates the engine and the exhaust gas post-processing device. The partitioning member includes a first partition part disposed between the injection device and the diesel particulate filtering device, and a second partition part disposed between the injection device and the selective catalyst reduction device. | 10-02-2014 |
20150075892 | WORK VEHICLE AND WHEEL LOADER - A work vehicle includes an engine, an exhaust gas post-processing device, an engine room, a cooling fan, a cooling unit and a first exhaust pipe. The exhaust gas post-processing device includes a diesel particulate filtering device, a selective catalyst reduction device, a connecting pipe connecting the diesel particulate filtering device and the selective catalyst reduction device, and an injection device configured and arranged to inject a reducing agent into the connecting pipe. The engine room accommodates the engine and the exhaust gas post-processing device. The cooling fan is configured to suck in air from one side and to exhaust air from another side to produce an air flow. The cooling unit is disposed on the one side of the cooling fan. The first exhaust pipe has one end arranged to suck in air around the injection device and another end located between the cooling fan and the cooling unit. | 03-19-2015 |