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Notte

Gregory Notte, San Mateo, CA US

Patent application numberDescriptionPublished
20110009410APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS - The present invention relates to compounds of Formula (I):01-13-2011
20110021521FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS - The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:01-27-2011

John A. Notte, Gloucester, MA US

Patent application numberDescriptionPublished
20080217555SYSTEMS AND METHODS FOR A GAS FIELD IONIZATION SOURCE - In one aspect the invention provides a gas field ion source assembly that includes an ion source in connection with an optical column such that an ion beam generated at the ion source travels through the optical column. The ion source includes an emitter having a width that tapers to a tip comprising a few atoms. In other aspects, the methods provide for manufacturing, maintaining and enhancing the performance of a gas field ion source including sharpening the tip of the ion source in situ.09-11-2008

Patrick P.b. Notte, Wavre BE

Patent application numberDescriptionPublished
20080234519Process For the Manufacture of Aminopolyalkylenephosphonic Acid Compounds - A beneficial method for the manufacture of amino polyalkylene phosphonic acids, under substantial absence of hydrohalogenic acid, is disclosed. The method, in essence, is based on reacting narrowly defined ratios of phosphorous acid, an amino, a formaldehyde in presence of specific ranges of an acid catalyst having a pKa equal or inferior to 3.1. The inventive method is capable of yielding economically and quality operational/capacity advantages, in particular significantly reduced one-step cycle duration under exclusion, of corrosion disadvantages and also is environmentally friendly without requiring, in that respect, anything more than nominal capital expenditures.09-25-2008
20100063316REACTIVE PHOSPHONATES - Novel reactive phosphonate compounds are disclosed corresponding to the structural formula set forth. The reactive moiety is preferably selected from the group of Cl, I, Br, HSO03-11-2010
20100145066PHOSPHONATE COMPOUNDS - Novel phosphonate compounds are disclosed embodying an aminophosphonate moiety and a selected reaction partner. These compounds offer beneficial alternatives, and additional possibilities, to extant phosphonates and are capable of delivering desirable benefits from an application standpoint and from a compatibility standpoint broadly.06-10-2010
20100174110PROCESS FOR THE MANUFACTURE OF ALKYLAMINO ALKYLENE PHOSPHONIC ACIDS - A process for the manufacture of alkylamino alkylene phosphonic acids is disclosed. In detail, a specific phosphonate is reacted with an agent selected to yield an alkylamino moiety substituted by a radical selected from OH, OR′, NH2, NHR′, N(R′)07-08-2010
20110124533METHOD OF SCALE INHIBITION - A method is disclosed to inhibit scale formation in aqueous systems whereby a threshold amount of a scale inhibiting agent, represented by an aminoacid alkylphosphonic acid, is added to the aqueous system. The aminoacid moiety can be represented by α-species or by species having, at least, two or more carbon atoms between the carboxylic moiety and the amine group. These aminoacid based inhibitors exhibit unusually superior performance and system acceptability compared to leading state-of-the-art inhibitors.05-26-2011

Patent applications by Patrick P.b. Notte, Wavre BE

Patrick Pierre Notte, Wavre BE

Patent application numberDescriptionPublished
20090242829Heat transfer fluids for low temperature application comprising aromatic hydrocarbons - Heat transfer fluids which can be used over a broad range of temperatures such as from −125° C. to +175° C. are disclosed. These transfer fluids consist essentially of a mixture of two either narrowly defined structurally non-identical alkyl- or polyalkyl-benzene components or a mixture of a narrowly defined aromatic alkyl- or polyalkyl-benzene component and an aliphatic hydrocarbons component. The level of the various ingredients is such that the transfer fluids exhibit a cloud point below −100° C., a vapor pressure at +175° C. below 827 kPa and a viscosity, measured at the cloud point temperature +10° C., below 400 cP.10-01-2009