Patent application number | Description | Published |
20080269342 | Pleuromutilin Derivatives and Its Use - The invention is directed to the L-tartrate salt of trans-3-aminocyclobutyl (1S,2R,3S,4S,6R,7R,8,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxotricyclo[5.4.3.01,8]tetradec-6-yl imidodicarbonate (Compound IA.) Compound IA is useful for the treatment of a variety of diseases and conditions, such as respiratory tract and skin and skin structure infections. Accordingly, the invention is further directed to pharmaceutical compositions comprising Compound IA. The invention is still further directed to methods of treating respiratory tract and skin and skin structure infections using Compound IA or a pharmaceutical composition comprising Compound IA. | 10-30-2008 |
20100286041 | (5Z)-5-(6-QUINOXALINYLMETHYLIDENE)-2-[(2,6-DICHLOROPHENYL)AMINO]-1,3-THIAZ- OL-4(5H)-ONE - Invented is the compound (5Z)-5-(6-quinoxalinylmethylidene)-2-[(2,6-dichlorophenyl)amino]-1,3-thiazol-4(5H)-one, and/or pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are pharmaceutical compositions containing this compound, methods of preparing this compound and pharmaceutically acceptable salts, hydrates, solvates and pro-drugs thereof. Also invented are methods of using this compound as an inhibitor of hYAK3 proteins. | 11-11-2010 |
Patent application number | Description | Published |
20110152237 | Chemical Compounds - Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts. | 06-23-2011 |
20110251218 | NOVEL COMPOUNDS - The present invention relates to a tris salt of 8-chloro-3-pentyl-3,7-dihydro-1H-purine-2,6-dione of Formula (A) or a pharmaceutically acceptable salt thereof: | 10-13-2011 |
20130072690 | Chemical Compounds - Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts. | 03-21-2013 |
20130274304 | Chemical Compounds - Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts. | 10-17-2013 |
20140371455 | Chemical compounds - Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts. | 12-18-2014 |
20150374668 | CHEMICAL COMPOUNDS - Disclosed are compounds of Formula III. Also disclosed are salts of the compounds, pharmaceutical composition comprising the compounds or salts, and methods for treating HCV infection by administration of the compounds or salts. | 12-31-2015 |
Patent application number | Description | Published |
20090322041 | Rotating Coupling for Robotic Tool Changer with Actuation Mechanism - In a robotic tool coupler, a rotating cam surface ring having a plurality of surfaces formed therein urges a plurality of ball members in one tool coupling unit radially to contact a coupling surface in the other tool coupling unit. Mechanical energy captured and stored upon decoupling the units is used by an actuation mechanism, upon manual initiation, to at least partially automatically couple the two units by partially rotating the rotating cam surface ring. Further manual rotation of the cam member exerts a radial force through the ball members onto the coupling surface. A component of that force is directed by the coupling surface toward the opposite tool coupling unit, locking the two units together. | 12-31-2009 |
20100009825 | Compliant Service Transfer Module for Robotic Tool Changer - A compliant service transfer module, which transfers services such as electricity, data, pneumatic fluid, etc., between a robotic arm and an attached tool, aligns service transfer points as the two units of the module mate, when the units are misaligned. A floating structure disposed in the first unit is operative to move laterally within a chamber in the housing of the first unit, to align service transfer points with the corresponding service transfer points of a second unit, when the two units are mated together but are not fully aligned. The floating structure protrudes from the first housing, and in the case of misalignment, contacts an angled inner wall of a chamber in the housing of the second unit, which moves the floating structure laterally to align the service transfer points. The floating structure returns to a default, centered position when the two units are not mated together. | 01-14-2010 |
20100059943 | Manual Robotic Tool Changer with Rolling Members - A manually actuated robotic tool changer comprises master and tool units, each adapted to be connected to a different one of a robotic arm and a robotic tool. The tool changer includes a plurality of rolling members retained in one of the units and a piston mounted in one of the units and moveable in an axial direction. The piston includes a multi-faceted cam surface including an initial contact surface, a locking surface, and a failsafe surface interposed between the initial contact surface and the locking surface. When the piston is in a locked position in the tool changer, the cam surface is operative to contact the rolling members in one of the units and to urge each rolling member against a surface of the other unit to couple the master and tool units together. | 03-11-2010 |
20100062919 | Manual Robotic Tool Changer with Rotating Piston - A manually actuated robotic tool changer includes a first housing having a generally cylindrical piston with a central axis partially extending from the first housing, the piston rotatable about the axis. A plurality of tabs are disposed about the circumference of a portion of the piston extending from the first housing. A second housing has a bore to receive a portion of the piston. A plurality of locking lugs are disposed about the bore. The tool changer is manually actuated from an unlocked position wherein the piston assumes a position with respect to the first housing such that the extending portion of the piston may be moved within the bore with the tabs moving between the locking lugs, to a locked position wherein the piston is rotated with respect to the first housing such that the tabs move beneath the locking lugs to lock the first and second housings together. | 03-11-2010 |
20100113236 | Manual Robotic Tool Changer Having Rapid Coupling Mechanism - A manually actuated robotic tool changer includes a rapid coupling mechanism. The tool changer includes a master unit having a piston moveable along its axis between an unlocked position and a fully locked position, and a tool unit that is coupled to the master unit when the units are adjacent and the piston is moved to the fully locked position. A piston movement control mechanism selectively allows free axial motion of the piston between the unlocked position and a nearly locked position, when the control mechanism is actuated. The piston may be biased toward the locked position, allowing the master and tool units to be rapidly coupled by positioning the units adjacently, actuating the control mechanism to allow the piston to rapidly advance to a nearly locked position, releasing the control mechanism to restrict free axial motion of the piston, and manually advancing the piston to a fully locked position. | 05-06-2010 |
20120252646 | Rotating Coupling for Robotic Tool Changer with One-Way Clutch and Dual-Button Handle Mechanism - A manual robotic tool changer provides a compact, lightweight means to manually selectively couple a robotic tool, such as a surgical tool, to a robot arm. The tool changer includes numerous safety features to prevent inadvertent decoupling of the robotic tool. These include a dual-button handle locking mechanism operative to lock the tool changer closed in the fully coupled position, and requiring simultaneous actuation of both of two latch buttons to unlock; a one-way clutch mechanism that prevents rotation of the coupling mechanism towards the decoupled position, unless the handle is actuated to unlock the tool changer; and a spring biasing the tool changer to an at least partially coupled state when no force is applied to the handle, thus requiring a positive force against the spring, moving the handle to a fully open position, to insert or remove a robotic tool. | 10-04-2012 |
20140041187 | Utility Coupler with Failsafe Features - A utility coupler comprises a coupling unit that is coupled to a tool unit via the reciprocal linear actuation of a hooking cam member in the coupling unit engaging a latching pin in the tool unit. The hooking cam member includes a composite cam surface operative to couple and hold the two units together as the latching pin engages different surfaces of the composite cam surface. Failsafe features prevent the inadvertent decoupling of the units. | 02-13-2014 |
20140270926 | Ball Lock Compensator for Use with a Robotic Device - A compensation device configured to be positioned between a robotic arm and a robotic tool. The device may be configured to directly attach to the tool, or may be configured to be positioned away from the tool. The device generally includes a first section that connects to the robotic arm and a second section that connects to the tool. The second section is movable relative to the first section to provide for the tool to be positioned at various orientations. The second section may comply rotationally about a first axis. The second section may be movable in a second plane. In one embodiment, the second plane is perpendicular to the first axis. | 09-18-2014 |
20160059424 | SAFE ROBOTIC TOOL CHANGER - In an inherently safe robotic tool changer, a master unit couples to a tool unit via a first power source, and decouples from the tool unit using a separate, second power source. The second power source is only available when an attached tool is safely disposed in a tool stand. In embodiments where the first power source is not selectively applied, such as the constant bias provided by a spring, a detent mechanism maintains the master unit in a decoupled state when the master unit is removed from the tool unit. The detent mechanism allows the master unit to couple to a different tool unit upon physically abutting the new tool unit. | 03-03-2016 |
Patent application number | Description | Published |
20100060893 | ASSAY PARTICLE CONCENTRATION AND IMAGING APPARATUS AND METHOD - An assay apparatus having a sample vessel within which an assay may be performed. The apparatus further includes a holder having a receptacle, socket or other device configured to operatively receive the sample vessel in a precise and easily repeated location with respect to the holder. A magnet may be operatively associated with the holder such that a magnetic field generated by the magnet intersects a portion of the sample vessel defining a magnetic concentration region within the sample vessel. A separate or integrated detection or interrogation instrument, typically a spectrometer, may be provided. | 03-11-2010 |
20130169971 | OCT IMAGING SYSTEM FOR CURVED SAMPLES - This patent specification describes an OCT imaging system that implements at least one of the following: (1) adjusting the path length of a reference arm during an OCT scan of a curved sample or between OCT scans; (2) adjusting the focus of a scanning beam as the scanning beam moves across the curved sample during the OCT scan or between OCT scans; (3) adjusting polarization control during the OCT scan or between OCT scans; and/or (4) changing dispersion compensation across the OCT scan or between OCT scans. | 07-04-2013 |
20140340634 | OPTICAL COHERENCE TOMOGRAPHY SYSTEMS AND METHODS - An optical coherence tomography system may have a reflector system that reflects light from a light source to provide a plurality of light rays that fall within different wavelength ranges, optical componentry that directs a subset of a first beam of light including the plurality of light rays to an object to be imaged, a detector that detects the subset after reflection from the object, and signal processing componentry that processes signals from the detector to provide an optical coherence tomography image of the object. The reflector system may be configured such that the optical pathways followed by the light rays change in length at an even increment, so that the first beam of light will project wavelength groups at relatively even time increments. The optical pathways may be collinear or offset from each other. An interleaver may be used to enable detection of the first beam by multiple detectors. | 11-20-2014 |
Patent application number | Description | Published |
20100261263 | UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES - A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ | 10-14-2010 |
20110021970 | NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS FOR IN-SITU PHOTOBIOMODULATION - Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy to a subject thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ | 01-27-2011 |
20130171060 | UP AND DOWN CONVERSION SYSTEMS FOR PRODUCTION OF EMITTED LIGHT FROM VARIOUS ENERGY SOURCES - A system for energy upconversion and/or down conversion and a system for producing a photostimulated reaction in a medium. These systems include 1) a nanoparticle configured, upon exposure to a first wavelength λ | 07-04-2013 |
20140243934 | NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS - Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ | 08-28-2014 |
20150251016 | NON-INVASIVE ENERGY UPCONVERSION METHODS AND SYSTEMS - Products, compositions, systems, and methods for modifying a target structure. The methods may be performed in a non-invasive manner by placing a nanoparticle having a metallic shell on at least a fraction of a surface in a vicinity of a target structure in a subject and applying an initiation energy thus producing an effect on or change to the target structure directly or via a modulation agent. The nanoparticle is configured, upon exposure to a first wavelength λ | 09-10-2015 |