| Patent application number | Description | Published |
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| 20090151012 | Animal Model Having a Chimeric Human Liver and Susceptible to Human Hepatitis C Virus Infection - The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids. | 06-11-2009 |
| 20100104555 | HCV neutralizing epitopes - The invention relates to modified hepatitis C virus E2 polypeptides that are effective in eliciting the production of cross-neutralizing antibodies against hepatitis C virus. The invention provides modified hepatitis C virus E2 polypeptides, preparations and pharmaceutical compositions containing them, as well as methods for using these modified E2 polypeptides. | 04-29-2010 |
| 20110167507 | Animal Model Having a Chimeric Human Liver and Suceptible to Human Hepatitis C Virus Infection - The present invention features a non-human animal model that is susceptible to infection by human hepatotrophic pathogens, particularly human hepatitis C virus (HCV). The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having antiviral activity against HCV infection. The animals of the invention are also useful in assessing toxicity of various agents, as well as the activity of agents in decreasing blood lipids. | 07-07-2011 |
| Patent application number | Description | Published |
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| 20090084604 | COMPRESSIBLE OBJECTS HAVING PARTIAL FOAM INTERIORS COMBINED WITH A DRILLING FLUID TO FORM A VARIABLE DENSITY DRILLING MUD - A compressible object is described that may be utilized in drilling mud and with a drilling system to manage the density of the drilling mud. The compressible object includes a shell that encloses an interior region. The interior region of the shell is at least partially filled with a foam. The internal pressure of the compressible object may be greater than about 200 psi (pounds per square inch) at atmospheric pressure, greater than 500 psi at atmospheric pressure, greater than 1500 psi at atmospheric pressure or more preferably greater than 2000 psi at atmospheric pressure. | 04-02-2009 |
| 20090090558 | Compressible Objects Having A Predetermined Internal Pressure Combined With A Drilling Fluid To Form A Variable Density Drilling Mud - A compressible object is described that may be utilized in drilling mud and with a drilling system to manage the density of the drilling mud. The compressible object includes a shell that encloses an interior region. Also, the compressible object has an internal pressure (i) greater than about 200 pounds per square inch at atmospheric pressure and (ii) selected for a predetermined external pressure, wherein external pressures that exceed the internal pressure reduce the volume of the compressible object and wherein the shell being designed to reduce localized strains of the compressible object during expansion and compression of the compressible object. | 04-09-2009 |
| 20090090559 | COMPRESSIBLE OBJECTS COMBINED WITH A DRILLING FLUID TO FORM A VARIABLE DENSITY DRILLING MUD - A compressible object is described that may be utilized in drilling mud and with a drilling system to manage the density of the drilling mud. The compressible object includes a shell that encloses an interior region. The shell experiences less strain when the external pressure is about equal to the internal pressure than when the external pressure is above or below a predetermined compression interval of the compressible object includes a shell that encloses an interior region. | 04-09-2009 |
| 20090091053 | METHOD FOR FABRICATING COMPRESSIBLE OBJECTS FOR A VARIABLE DENSITY DRILLING MUD - Methods for fabricating compressible object are described. These compressible objects may be utilized in drilling mud and with a drilling system to manage the density of the drilling mud. The method includes selecting an architecture for a compressible object; selecting a wall material for the compressible object; and fabricating the compressible object, wherein the compressible object has a shell that encloses an interior region, and has an internal pressure (i) greater than about 200 pounds per square inch at atmospheric pressure and (ii) selected for a predetermined external pressure, wherein external pressures that exceed the internal pressure reduce the volume of the compressible object. | 04-09-2009 |
