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| 20100203044 | DR6 ANTAGONISTS AND USES THEREOF IN TREATING NEUROLOGICAL DISORDERS - Methods and compositions comprising DR6 antagonists for use in treating neurological disorders, including Alzheimer's disease, are provided. The DR6 antagonists include anti-APP antibodies, anti-DR6 antibodies, DR6 immunoadhesins and DR6 variants (and fusion proteins thereof) which enhance growth, regeneration or survival of mammalian neuronal cells or tissue. | 08-12-2010 |
| 20110110942 | METHOD OF PROMOTING DENDRITIC SPINE DENSITY - The invention relates to methods of increasing density of dendritic spines as a means to retain or improve cognition and to treat disorders associated with decreased dendritic spine morphology and a psychiatric disorder such as addiction and schizophrenia or a disorder associated with impaired cognition such as autism, Lett Syndrome, Tourette Syndrome, and Fragile-X Syndrome. | 05-12-2011 |
| 20110223630 | METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION - Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue. | 09-15-2011 |
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| 20080251715 | INTRODUCTION OF IONS INTO A MAGNETIC FIELD - In a mass spectrometer that uses a space-restricted magnetic field, such as an ion cyclotron resonance mass spectrometer, ions with a wide mass range generated in an ion supply located outside the magnetic field are transported in the direction of the magnetic field lines to an ion storage device located inside the magnetic field without losing ions by guiding the ions through the region in which the magnetic field strength increases with a special ion guide. This ion guide consists of an arrangement of coaxial ring diaphragms which are alternately supplied with the phases of an RF voltage. In an alternative embodiment, the ion guide uses two wires wound in a double helix where each wire is supplied with one phase of a two-phase RF voltage. | 10-16-2008 |
| 20100193679 | GUIDING CHARGED DROPLETS AND IONS IN AN ELECTROSPRAY ION SOURCE - Charged spray droplets are guided in a pseudopotential distribution generated by audio frequency voltages at electrodes of a guiding device, focusing the spray droplets toward the axis. An axial electric field profile and an axial flow profile of a drying gas in the guiding device allow the drift of different-sized droplets to be controlled in the longitudinal direction of the guiding device, so that the droplets are roughly equal in size when they leave the guiding device and finally dry up shortly after leaving. As a result, the ions are formed in a relatively small spatial region. Electrostatic potentials guide the analyte ions from this small spatial region to the entrance aperture of the inlet capillary; during this process, very light ions, especially protons and water-proton complexes, can be filtered out by a mobility filter. | 08-05-2010 |
| 20110186728 | ION MANIPULATION CELL WITH TAILORED POTENTIAL PROFILES - An ion cell having an axis includes a sheath of individual electrodes that extends along the axis and defines an internal volume. Adjacent individual electrodes are electrically insulated from each other. The individual electrodes each receive a DC potential and RF voltage. At least some of the individual electrodes have a width that varies in the axial direction such that an electrical effect on an axis potential varies along the axis of the ion cell. | 08-04-2011 |
| 20120043461 | KINGDON MASS SPECTROMETER WITH CYLINDRICAL ELECTRODES - The invention relates to measuring devices of an electrostatic Fourier transform mass spectrometer and measurement methods for the acquisition of mass spectra with high mass resolution. The measuring device includes electrostatic measuring cells according to the Kingdon principle, in which ions can, when appropriate voltages are applied, orbit on circular trajectories around the cylinder axis between two concentric cylindrical surfaces, which are composed of specially shaped sheath electrodes, insulated from each other by parabolic gaps, and can harmonically oscillate in the axial direction, independently of their orbiting motion. In the longitudinal direction, the two cylindrical surfaces of the measuring cell are divided by the parabolic separating gaps into different types of double-angled and tetragonal sheath electrode segments. Appropriate voltages at the sheath electrode segments generate a potential distribution between the two concentric cylindrical surfaces which forms a parabolic potential well in the axial direction for orbiting ions. The ion clouds oscillating harmonically in the axial direction in this potential well induce image currents in suitable electrodes, from which the oscillation frequencies can be determined by Fourier analyses. | 02-23-2012 |
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| 20110014681 | GLUCOAMYLASE VARIANTS - The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants having altered properties (e.g., improved thermostability and/or increased specific activity) as compared to a corresponding parent glucoamylase. The present invention also provides enzyme compositions comprising the variant glucoamylases; DNA constructs comprising polynucleotides encoding the variants; and methods of producing the glucoamylase variants in host cells. | 01-20-2011 |
| 20110020899 | GLUCOAMYLASE VARIANTS WITH ALTERED PROPERTIES - The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent glucoamylase. The present invention also relates to enzyme compositions comprising a variant glucoamylase (e.g., starch hydrolyzing compositions); DNA constructs comprising polynucleotides encoding the variants and methods of producing the variant glucoamylases in host cells | 01-27-2011 |
| 20110236935 | OXIDATION PROCESS - A method of oxidising a saccharide, by contacting the saccharide with an alcohol dehydrogenase (ADH) enzyme selected from a quinone redox cofactor-dependent ADH, a nicotinamide adenine dinucleotide (NAD | 09-29-2011 |
| 20110256571 | PROTEINS - An amino acid sequence is described. The amino acid may comprise a signal sequence that is SEQ ID NO. 1a (or a variant or homologue or derivative or fragment thereof) that is expressed as a fusion protein that comprises a protein of interest. The signal sequence directs secretion of the protein of interest. The protein of interest may be a heterologous protein. Secretion of the fusion protein aids purification. | 10-20-2011 |
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| 20090185315 | MAGNETIC SENSOR INCLUDING A FREE LAYER HAVING PERPENDICULAR TO THE PLANE ANISOTROPY - A magnetic sensor includes a reference layer having a first magnetization direction and a free layer assembly having an effective magnetization direction substantially perpendicular to the first magnetization direction and substantially perpendicular to a plane of each layer of the free layer assembly. A spacer layer is between the reference layer and the free layer, and a signal enhancement layer is exchange coupled to the free layer assembly on a side opposite the spacer layer. | 07-23-2009 |
| 20100323100 | CONTROLLING THICKNESS UNIFORMITY AND INTERFACES IN STACKS - A method of creating a stack having multiple layers of deposited film onto a substrate is discussed. The method includes depositing a first layer of a first material onto the substrate and depositing a second layer onto the first layer. Depositing the second layer includes depositing a first amount of the second material onto the first layer at a first deposition temperature selected to set the normalized diffusion activation energy of the second material. | 12-23-2010 |
| 20110006033 | Magnetic Device Definition with Uniform Biasing Control - A method of fabricating a magnetic device is described. A mask removing layer is formed on a layered sensing stack and a hard mask layer is formed on the mask removing layer. A first reactive ion etch is performed with a non-oxygen-based chemistry to define the hard mask layer using an imaged layer formed on the hard mask layer as a mask. A second reactive ion etch is performed with an oxygen-based chemistry to define the mask removing stop layer using the defined hard mask layer as a mask. A third reactive ion etch is performed to define the layered sensing stack using the hard mask layer as a mask. The third reactive ion etch includes an etching chemistry that performs at a lower etching rate on the hard mask layer than on the layered sensing stack. | 01-13-2011 |
| 20110006384 | MAGNETIC TUNNEL JUNCTION HAVING COHERENT TUNNELING STRUCTURE - A magnetic tunnel junction includes an amorphous ferromagnetic reference layer having a first reference layer side and an opposing second reference layer side. The first reference layer side has a greater concentration of boron than the second reference layer side. A magnesium oxide tunnel barrier layer is disposed on the second side of the amorphous ferromagnetic reference layer. The magnesium oxide tunnel barrier layer has a crystal structure. An amorphous ferromagnetic free layer is disposed on the magnesium oxide tunnel barrier layer. | 01-13-2011 |
| 20110164335 | MAGNETIC SENSOR INCLUDING A FREE LAYER HAVING PERPENDICULAR TO THE PLANE ANISOTROPY - A magnetic sensor includes a reference layer having a first magnetization direction and a free layer assembly having an effective magnetization direction substantially perpendicular to the first magnetization direction and substantially perpendicular to a plane of each layer of the free layer assembly. A spacer layer is between the reference layer and the free layer, and a signal enhancement layer is exchange coupled to the free layer assembly on a side opposite the spacer layer. | 07-07-2011 |
| 20110200845 | CURRENT PERPENDICULAR TO THE PLANE READER WITH IMPROVED GIANT MAGNETO-RESISTANCE - In some embodiments, a current perpendicular to the plane giant magneto-resistance (CPP GMR) read sensor may include a reference layer and/or a free layer that includes a plurality of sub-layers. For example, at least one of the reference layer or free layer may include a first ferromagnetic sub-layer, a second ferromagnetic sub-layer, and a Heusler alloy layer located between the first ferromagnetic sub-layer and the second ferromagnetic sub-layer. In some embodiments, a CPP GMR read sensor may include a current closed path (CCP) spacer layer between the reference layer and the free layer. The CCP spacer layer may include Ag and Al | 08-18-2011 |
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| 20090217385 | Cryptographic control for mobile storage means - A system and method that regulates the various operations between computing stations and storage devices. Storage devices are the storage means that are contained upon devices that are able to have data stored upon them. Any operation that involves or may lead to the exchange or accessing of content (data) between a storage device and computing station may be regulated by means of a policy which comprise a set of rules. Rules may be defined according to specific criteria, including the type of storage device, the type of content, the attributes of the content, and other attributes associated with the storage device and/or the content. The policy will be dynamically installed upon a computing station for specific user(s) and will regulate the data operations that may take place between the computing stations and storage devices based on evaluation of the policy. Based on the evaluation of the policy, the requested operation is permitted, restricted in some areas, or denied. | 08-27-2009 |
| 20100058072 | CONTENT CRYPTOGRAPHIC FIREWALL SYSTEM - A system and method that regulates the various operations between computing stations and storage or content. Any operation that involves or may lead to the exchange or accessing of content (data) between storage or hosting content container and computing station may be regulated by means of a policy which comprise a set of rules. Rules may be defined according to specific criteria, including the type of storage, the type of content, the attributes of the content, and other attributes associated with the storage device and/or the content. The policy will be dynamically installed/updated upon a computing station for specific User(s) and will regulate the data operations that may take place between the computing stations and storage or content based on evaluation of the policy. Based on the evaluation of the policy, the requested operation is permitted, restricted in some areas, or denied. | 03-04-2010 |
