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Nielsen, Soborg
Allan Kent Nielsen, Soborg DK
| Patent application number | Description | Published |
|---|---|---|
| 20090136995 | Mutated Prokaryotic Cells with High Secretion-Levels - A mutated prokaryotic cell, which secretes higher amounts of at least one heterologous polypeptide of interest and which has a reduced expression-level of YusZ or YusX, or homologues thereof, when compared with an otherwise isogenic but non-mutated cell, and methods for constructing and using such a cell in the production of polypeptides. | 05-28-2009 |
| 20100173286 | Mutant Cells Suitable for Recombinant Polypeptide Production - A mutated bacterial cell producing at least one heterologous polypeptide of interest, wherein said cell has a reduced expression-level of YugJ (SEQ ID NO: 2) or a homologue thereof when compared with an otherwise isogenic but non-mutated cell; methods for producing said cell, and methods for producing a polypeptide of interest using said cell. | 07-08-2010 |
Carsten M. Nielsen, Soborg DK
| Patent application number | Description | Published |
|---|---|---|
| 20080317842 | Fast Wet-Massing Method for the Preparation of Calcium-Containing Compositions - The present invention relates to a novel process for the preparation of a granulate comprising a calcium-containing compound as an active substance. The method comprises a method for the preparation of a granulate comprising a calcium-containing compound as an active substance, the method comprising, i) feeding a granulation chamber with a composition comprising the calcium-containing compound, ii) wet-massing the composition with a granulation liquid optionally comprising a pharmaceutically acceptable binder for a time period of at the most 30 sec to obtain a wet granulate, iii) drying the thus obtained wet granulate. A granulate obtained by the present method is especially suitable in the preparation of solid dosage forms, in particular in the preparation of tablets. | 12-25-2008 |
| 20090068268 | MELT GRANULATION OF A COMPOSITION CONTAINING A CALCIUM-CONTAINING COMPOUND - A novel method for the preparation of a tablet comprising a calcium-containing compound, the method involves a melt granulation process by which a sugar alcohol is melted and embeds the calcium-containing compound so that a sufficient taste masking of the chalkiness is substantially achieved and an unpleasant mouth feel of the calcium-containing compound is substantially avoided, while at the same time obtaining a low tablet volume. The method of the invention is especially suitable for the manufacturing of tablets having a high load of a calcium-containing compound. | 03-12-2009 |
Jens Ulrik Nielsen, Soborg DK
| Patent application number | Description | Published |
|---|---|---|
| 20120009499 | COMPRESSION ARRANGEMENT FOR FUEL OR ELECTROLYSIS CELLS IN A FUEL CELL STACK OR AN ELECTROLYSIS CELL STACK - A fuel cell stack or an electrolysis cell stack comprises a plurality of cells, which need to be compressed to ensure and maintain internal contact. To achieve an evenly distributed compression force throughout the electrochemically active area a frame with a central aperture is positioned on top of the cell stack between a resilient plate and a top plate. The enclosed aperture forms a compression chamber which is provided with pressurised gas from the cathode inlet, whereby an evenly distributed force is applied to the electrochemically area of the cell stack by the resilient plate. | 01-12-2012 |
Klaus Gregorius Nielsen, Soborg DK
| Patent application number | Description | Published |
|---|---|---|
| 20090104277 | Preparation of Molecular Imprinted Polymers - One aspect is a method for improved preparation of molecular imprinted polymer (MIP) particles, where initial compositions comprising insoluble MIP particles are enriched for those MIP particles that bind a particular target molecule, thus excluding non-binding and weakly binding particles from the final composition. Enrichment is typically accomplished via use of chromatographic methods capable of separating particulate material or by means of agglutination. Another aspect is preparation of improved insoluble MIPs by use of extended micronization of raw MIP particles with a view to expose a large number of binding sites per mass unit of MIP particles. In preferred embodiments the two aspects are combined. The resulting improved MIPs may be used for diagnostic, analytical and therapeutic purposes, notably as orally administered drugs which can bind substances such as cholesterol and bile acids and bile acid salts in the gastrointestinal tract. | 04-23-2009 |
| 20100285071 | PURIFICATION OF HER-2 VARIANTS - The present invention provides for a novel method for purification of EGFR family proteins obtained from cultures of insect cells. The process comprises subsequent steps of a) diafiltration and exchange of culture medium with buffer, b) immobilized metal affinity chromatography (IMAC), C) size exclusion chromatography (SEC), and d) anion exchange chromatography (AIE). The method also provides for an immunogenic variant of HER-2 protein which for which the purification process has been especially adapted, as well as means for the preparation of the variant. | 11-11-2010 |
Peter Caroe Nielsen, Soborg DK
| Patent application number | Description | Published |
|---|---|---|
| 20100151146 | PREPARATION OF A POLYMER ARTICLE FOR SELECTIVE METALLIZATION - The present invention relates to the field of selective metallization, and in particular to preparing a polymer article for selective metallization by submerging the article in a first liquid, and while submerged irradiate the article by a laser beam the area of the article on which the metal is to be deposited. An activation step, prior to the selective metallization, comprises submerging the article in an activation liquid for depositing seed particles in the selected area. The irradiation of the selected area is proportionate so as to cause a temporary melting of the polymer in the surface of the selected area of the polymer article. The invention is advantageous in that the preparation may be performed with a relatively high scan rate across the polymer article, and in that a quite limited use of toxic chemicals. | 06-17-2010 |
Peter Schultz Nielsen, Soborg DK
| Patent application number | Description | Published |
|---|---|---|
| 20090091049 | AGGLOMERATION APPARATUS AND METHOD FOR PRODUCING AGGLOMERATED PARTICLES - The invention relates to an agglomeration apparatus comprising a fluid bed, a source of descending particles, one or more nozzles for atomizing an agglomeration fluid and an outlet for discharging the agglomerated particles. In the fluid bed, the particles are guided towards the outlet and pass an outer and an inner zone. The apparatus provides for the production of an improved agglomerated particulate product with a low content of fine particles. | 04-09-2009 |
| 20100005683 | METHOD OF CONTROLLING A SPRAY DRYER APPARATUS BY REGULATING AN INLET AIR FLOW RATE, AND A SPRAY DRYER APPARATUS - A method of controlling a spray dryer apparatus having a spray dryer chamber ( | 01-14-2010 |