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| 20110110290 | ROBUST COOPERATIVE RELAYING IN A WIRELESS LAN: CROSS-LAYER DESIGN - A distributed and opportunistic medium access control (MAC) layer protocol for randomized distributed space-time coding (R-DSTC), which may be deployed in an IEEE 802.11 wireless local area network (WLAN), is described. Unlike other cooperative MAC designs, there is no need to predetermine, before packet transmission, which stations will serve as relays. Instead, the MAC layer protocol opportunistically recruits relay stations on the fly. Network capacity and delay performance is much better than legacy IEEE 802.11g network, and even cooperative forwarding using one relay station. Avoiding the need to collect the station-to-station channel statistics considerably reduces overhead otherwise required for channel measurement and signaling. | 05-12-2011 |
| 20110216662 | COOPMAX: A COOPERATIVE MAC WITH RANDOMIZED DISTRIBUTED SPACE TIME CODING FOR AN IEEE 802.16 NETWORK - Cooperative communication is a technique that can be employed to meet the increased throughput needs of next generation WiMAX systems. In a cooperative scenario, multiple stations can jointly emulate the antenna elements of a multi-input multi-output system in a distributed fashion. A framework for a randomized distributed space-time coding (“R-DSTC”) technique in the emerging relay-assisted WiMAX network, and the development of a cooperative medium access control (“MAC”) layer protocol, called CoopMAX, for R-DSTC deployment in an IEEE 802.16 system, is described. The technique described couples the MAC layer with the physical (PHY) layer for performance optimization. The PHY layer yields significant diversity gain, while the MAC layer achieves a substantial end-to-end throughput gain. | 09-08-2011 |
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| 20090004118 | Multifunctional Nanoparticle Conjugates And Their Use - Disclosed herein are conjugates comprising a nanocarrier, a therapeutic agent or imaging agent and a targeting agent. Also disclosed herein are compositions comprising such conjugates and methods for using the conjugates to deliver therapeutic and/or imaging agents to cells. Also disclosed are methods for using the conjugates to treat particular disorders, such as proliferative disorders. | 01-01-2009 |
| 20090123365 | Multifunctional nanostructures, methods of synthesizing thereof, and methods of use thereof - A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a nanospecies, a hydrophobic protection structure including at least one compound selected from a capping ligand, an amphiphilic copolymer, and combinations thereof, wherein the hydrophobic protection structure encapsulates the nanospecies, and at least one histidine-tagged peptide or protein conjugated to the hydrophobic protection structure, wherein the at least one histidine-tagged peptide or protein has at least one binding site. | 05-14-2009 |
| 20090140206 | Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof - Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among others, includes a surface-enhanced Raman spectroscopic active composite nanostructure. The surface-enhanced Raman spectroscopic active composite nanostructure includes a core, at least one reporter molecule, and an encapsulating material. The reporter molecule is bonded to the core. The reporter molecule is selected from: an isothiocyanate dye, a multi-sulfur organic dye, a multi-heterosulfur organic dye, a benzotriazole dye, and combinations thereof The encapsulating material is disposed over the core and the reporter molecule. After encapsulation with the encapsulating material, the reporter molecule has a measurable surface-enhanced Raman spectroscopic signature. | 06-04-2009 |
| 20090169861 | POROUS MATERIALS EMBEDDED WITH NANOSPECIES, METHODS OF FABRICATION THEREOF, AND METHODS OF USE THEREOF - Briefly described, embodiments of this disclosure include structures, methods of forming the structures, and methods of using the structures. One exemplary structure, among others, includes a nanospecies and a porous material. The nanospecies has a first characteristic and a second detectable characteristic. In addition, a second detectable energy is produced corresponding to the second detectable characteristic upon exposure to a first energy. The porous material has the first characteristic and a plurality of pores. The first characteristic causes the nanospecies to interact with the porous material and become disposed in the pores of the porous material. | 07-02-2009 |
| 20090196831 | NANOSTRUCTURES, METHODS OF SYNTHESIZING THEREOF, AND METHODS OF USE THEREOF - A nanostructure and methods of synthesizing same. In one embodiment, the nanostructure includes a magnetic iron oxide nanoparticle, a hydrophobic protection structure including at least an amphiphilic copolymer, wherein the hydrophobic protection structure encapsulates the magnetic iron oxide nanoparticle, and at least one amino-terminal fragment (ATF) peptide or epidermal growth factor receptor (EGFR) antibody conjugated to the amphiphilic copolymer. | 08-06-2009 |
| 20100304358 | METHODS OF IDENTIFYING BIOLOGICAL TARGETS AND INSTRUMENTATION TO IDENTIFY BIOLOGICAL TARGETS - Methods of measuring and/or detecting biological targets, methods of distinguishing among the same type of biological target, single-molecule detection systems, fluorescent/biological target complexes, methods of using fluorescent/biological target complexes, and the like are disclosed. | 12-02-2010 |
| 20110060036 | Branched Multifunctional Nanoparticle Conjugates And Their Use - Disclosed herein are compounds and compositions including a polyglycerol nanocarrier, a therapeutic agent or imaging agent, and optionally a targeting agent. In certain aspects the disclosed compounds include biocompatible hyperbranched polymer nanocarriers. Such compounds and compositions are useful for the targeted delivery of antitumor agents and imaging agents to tumors in vivo. Methods are also disclosed for detecting and treating such tumors. | 03-10-2011 |
| 20110152692 | SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE - According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light source configured to emit a beam of visible light; second light source configured to emit a beam of near-infrared light; a handheld probe optically coupled to the second light source; a second imaging device configured to detect visible light; a third imaging device configured to detect near-infrared light having a first predetermined wavelength; a fourth imaging device configured to detect near-infrared light having a second predetermined wavelength; a display for displaying at least one visual representation of data; and, a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure. | 06-23-2011 |
| 20110165077 | IN VIVO TUMOR TARGETING AND SPECTROSCOPIC DETECTION WITH SURFACE ENHANCED RAMAN NANOPARTICLE TAGS - Nanostructures, methods of preparing nanostructures, methods of detecting targets in subjects, and methods of treating diseases in subjects, are disclosed. An embodiment, among others, of the nanostructure includes a metallic gold surface-enhanced Raman scattering nanoparticle, a Raman reporter and a protection structure. The protection structure may include a thiol-polyethylene glycol to which may be attached a target-specific probe. | 07-07-2011 |
| 20110189102 | COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF - The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific cellular binding and to maintain the small size of quantum dot probes. Embodiments of the coated quantum dots of the disclosure are just slightly larger than the diameter of uncoated quantum dots, and are bright with high quantum yields. They are also very stable under both basic and acidic conditions. Embodiments of the hydroxylated quantum dots result in significant reductions in non-specific binding relative to that of carboxylated dots, and to protein and PEG-coated dots. Embodiments of the disclosure are advantageous in a range of biological applications where non-specific binding is a major problem, such as in multiplexed biomarker staining in cells and tissues, detection of biomarkers in body fluid samples (blood, urine, etc.), as well as live cell imaging. | 08-04-2011 |
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| 20110122146 | SYSTEMS AND METHODS FOR MATCHING MEDICAL IMAGES - A system and method is provided for matching visual features in at least two related medical images. The differences in visual features between at least two related images are identified, such as separate mammography images of a left breast and a right breast of a patient. The visual features may include the image brightness, contrast, sharpness (or edge strength), alignment or dynamic range. The visual features of at least one of the images is then adjusted to match the visual features of the other image, or both images are adjusted to match a predefined value of visual features for a medical image. The adjusted images may then be displayed to a user, such as a radiologist or technician, who is able to more accurately identify physiological inconsistencies between the two images now that they have similar underlying visual features. | 05-26-2011 |
| 20110123074 | SYSTEMS AND METHODS FOR SUPPRESSING ARTIFICIAL OBJECTS IN MEDICAL IMAGES - A system and method are provided for altering the appearance of an artificial object in a medical image. An artificial object is first identified in the medical image, such as identifying a breast implant in a mammography image. The prominence of the artificial object is then reduced, for example by suppressing the brightness or masking the artificial object out altogether. The resulting medical image with the altered artificial object is then displayed to a user so that the medical image can be more accurately analyzed without requiring the user to adjust the image on his or her own. | 05-26-2011 |
| 20110123075 | SYSTEMS AND METHODS FOR MARKING A MEDICAL IMAGE WITH A DIGITAL INDICATOR - A system and method is provided for automatically detecting and marking a region of interest in a medical image. A region of interest is first identified in the medical image, such as a nipple of a breast region in a mammography image. The identified nipple is then marked with a digital indicator, such as a bright circle, so that a user viewing the image can easily identify the nipple. The digital indicator can be temporarily removed so that no portion of the region of interest is obscured by the digital indicator. A region of interest corresponding to another anatomical feature may also be marked, such as a pectoral muscle, which may be marked by placing a digital outline around the border of the pectoral muscle. A user viewing the medical image with the digital indicators can easily identify the marked regions of interest. | 05-26-2011 |
| 20110123086 | SYSTEMS AND METHODS FOR ENHANCING MEDICAL IMAGES - A system and method is provided for enhancing a region of interest in a medical image to improve its visibility. A region of interest is first identified in the medical image, such as identifying a breast region in a mammography image. The identified region of interest is then enhanced using an image processing technique, for example by adjusting the intensity or contrast, or by performing edge enhancement. Other regions of the medical image outside the region of interest remain unaltered, or may be diminished, such that the clarity of the region of interest is improved in comparison with the other regions of the medical image. A user viewing the enhanced image is less distracted by the non-enhanced regions and is not required to adjust the image on his or her own. The user can more quickly and effectively review the medical image to identify abnormalities and diagnose disease. | 05-26-2011 |
| 20110123087 | SYSTEMS AND METHODS FOR MEASUREMENT OF OBJECTS OF INTEREST IN MEDICAL IMAGES - A system and method are provided for the measurement and display of attributes of an object of interest in a medical image. An object of interest is identified, such as a lesion or cluster of lesions in a breast area on a mammography image. At least one attribute of the lesion is then automatically measured, such as the area of the lesion, the width and height of a cluster of lesions, the number of lesions in a cluster, or the distance from one or more lesions to an anatomical feature such as the nipple, skin line or chest wall. The measurements are then displayed to a user, for example by displaying the measurements on the mammography image. Additionally, anatomical zones, such as standard, quadrant and clock zones of the breast area may be determined and displayed on the mammography image or diagram to display the location of the lesion as it corresponds to the zones. | 05-26-2011 |
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| 20090247501 | PROTEIN KINASE INHIBITORS - Pyrimidine- and triazine-based chemical compounds that are useful, for example, as protein kinase inhibitors for treating cancer, neurological disorders, autoimmune disorders, and other diseases, and methods of using such compounds | 10-01-2009 |
| 20090281092 | POLO-LIKE KINASE INHIBITORS - Compounds of the following formula are provided for use with kinases: | 11-12-2009 |
| 20090291938 | POLO-LIKE KINASE INHIBITORS - Compounds of the following formula are provided for use with kinases: | 11-26-2009 |
| 20110082111 | POLO-LIKE KINASE INHIBITORS - Compounds of the following formula are provided for use with kinases: | 04-07-2011 |
| 20110152273 | FUSED HETEROAROMATIC PYRROLIDINONES - Disclosed are compounds of Formula 1, | 06-23-2011 |
| 20110201818 | POLO-LIKE KINASE INHIBITORS - Compounds of the following formula are provided for use with kinases: | 08-18-2011 |
