Nichols, CO
Anthony Lynn Nichols, Erie, CO US
Patent application number | Description | Published |
---|---|---|
20090094698 | METHOD AND SYSTEM FOR EFFICIENTLY SCANNING A COMPUTER STORAGE DEVICE FOR PESTWARE - A method and system for efficiently scanning a computer storage volume for pestware is described. One embodiment determines whether a file on the storage device has been modified since it was last scanned for pestware; includes the file in a set of files to be scanned for pestware when it is determined that the file has been modified since it was last scanned for pestware; omits the file from the set of files to be scanned for pestware when it is determined that the file has not been modified since it was last scanned for pestware; scans the files in the set of files for pestware; and reports results of the pestware scan to a user. | 04-09-2009 |
Anthony Lynn Nichols, Eric, CO US
Patent application number | Description | Published |
---|---|---|
20090063570 | METHOD AND SYSTEM FOR COUNTING FILES AND DIRECTORIES IN A NEW-TECHNOLOGY-FILE-SYSTEM (NTFS) VOLUME THAT ARE RELEVANT TO A COMPUTERIZED PROCESS - A method and system for counting files and directories in a New-Technology-File-System (NTFS) volume that are relevant to a computerized process is described. One illustrative embodiment counts bits corresponding to used MFT entries in a Master File Table (MFT) bitmap associated with the NTFS volume to obtain a first count; counts one or more files or directories in the NTFS volume that are not relevant to the computerized process to obtain a second count; subtracts the second count from the first count to obtain a count of files and directories in the NTFS volume that are relevant to the computerized process; and displays a progress indicator that indicates, with the passage of time, what proportion of the files and directories included in the count of files and directories in the NTFS volume that are relevant to the computerized process has been processed by the computerized process. | 03-05-2009 |
Kimberly Nichols, Louisville, CO US
Patent application number | Description | Published |
---|---|---|
20100197023 | MODIFIED POLYNUCLEOTIDES FOR USE IN RNA INTERFERENCE - Methods and compositions for performing RNA interference comprising a wide variety of stabilized siRNAs suitable for use in serum-containing media and for in vivo applications, such as therapeutic applications, are provided. These siRNAs permit effective and efficient applications of RNA interference to applications such as diagnostics and therapeutics through the use of one or more modifications including orthoesters, terminal conjugates, modified linkages and 2′ modified nucleotides. Uniquely modified siRNAs have been developed that reduces off-target effects incurred in gene-silencing. The modifications include phosphorylation of the first 5′ terminal antisense nucleotide; 2′ carbon modifications of the first and second or first, second, and third 5′ terminal antisense nucleotides; and optionally 2′ carbon modifications of the first and second or first, second, and third 5′ terminal sense nucleotide. Control and exaequo molecules are also provided. siRNA molecules and related control, trackability and exaequo agents with specific stability modifications were developed. | 08-05-2010 |
Paul Nichols, Firestone, CO US
Patent application number | Description | Published |
---|---|---|
20090148407 | Novel Macrocyclic Inhibitors of Hepatitis C Virus Replication - The embodiments provide compounds of the general Formulae (I) through general Formula (VIII), as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 06-11-2009 |
20090169510 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 07-02-2009 |
20120208995 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION - The embodiments provide compounds of the general Formulae I through general Formula VIII, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. | 08-16-2012 |
Paul Nichols, Boulder, CO US
Patent application number | Description | Published |
---|---|---|
20140128442 | PREPARATION OF AND FORMULATION COMPRISING A MEK INHIBITOR - The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound. | 05-08-2014 |
Paul J. Nichols, Boulder, CO US
Patent application number | Description | Published |
---|---|---|
20100130748 | SNAR PROCESS FOR PREPARING BENZIMIDAZOLE COMPOUNDS - Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ia-2 and their synthetic intermediates: wherein X | 05-27-2010 |
Pete Nichols, Boulder, CO US
Patent application number | Description | Published |
---|---|---|
20110311798 | Method of Forming a Reconstituted Wood Block - A method of forming a reconstituted wood block can include providing a recovered wood having a high aspect ratio along wood grains of the recovered wood. The recovered wood can be radially crushed or obtained as strips of recovered veneer. The recovered wood can be pretreated to increase resin absorption to form a degreased wood. The degreased wood can then be dried sufficient to reduce a moisture content to produce a dried wood. The dried wood can be soaked in a resin solution to form a resin impregnated wood. The resin impregnated wood can be dried to reduce the moisture content without substantially curing the resin to form a dried resin impregnated wood. The dried resin impregnated wood can then be molded having wood fibers oriented in a non-random predetermined pattern substantially common direction and compacted to form an uncured molded wood. The pattern can be oriented along a substantially common direction or portions may be oriented transverse to others to obtain a knotted appearance. The uncured molded wood can then be cured to form the reconstituted wood block. | 12-22-2011 |
Rebecca L. Nichols, Broomfield, CO US
Patent application number | Description | Published |
---|---|---|
20080199548 | Efficient method for producing compositions enriched in total phenols - A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 μg/mL. | 08-21-2008 |
20080207770 | COMPOSITIONS ENRICHED IN PHENOLIC COMPOUNDS AND METHODS FOR PRODUCING THE SAME - Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens. | 08-28-2008 |