| Patent application number | Description | Published |
|---|
| 20100261226 | UNIVERSAL BIOREACTORS AND METHODS OF USE - Bioreactors suitable for housing a predetermined volume of culture medium comprising a plurality of containers of approximately equal internal volume in which the culture medium resides, wherein the predetermined volume of culture medium is retained in approximately equal amounts within each of the plurality of containers during operation of the bioreactor, and wherein the internal volume of each container is selected so that the amount of culture medium in each container exceeds 50 vol. % of the container internal volume during operation of the bioreactor, and related methods of use. | 10-14-2010 |
| 20110117538 | BIOREACTORS FOR FERMENTATION AND RELATED METHODS - Bioreactors suitable for housing a predetermined volume of liquid comprising nutrient medium and biological culture comprising: (a) a container having at least one interior wall; (b) at least one nutrient medium inlet; (c) at least one liquid outlet; (d) at least one gas inlet; (e) at least one gas outlet; and (f) at least one cylindrical sparging filter attached to the at least one gas inlet, wherein the sparging filter comprises a plurality of pores along its axis which permit gas to be emitted radially from the sparging filter into the liquid, wherein the diameter of the plurality of pores does not exceed about 50 μm, and wherein the orientation of the at least one sparging filter within the container provides for immersion of the plurality of pores within the liquid and substantially uniform distribution of emitted gas throughout the liquid, and related methods of using said bioreactors to prepare various biological products. | 05-19-2011 |
| 20110198286 | Separative Bioreactor - A bioreactor that combines the steps of recombinant expression and separation of a biological product by binding the secreted biological product with a resin, discarding the nutrient medium and eluting the biological product as a concentrated solution, eliminating the steps of sterile filtration and volume reduction. The method also allows loading of resin for column-purification, eliminating all steps of perfusion process and maintaining a sink condition of a toxic product in nutrient medium to optimize productivity of host cells. The instant invention also allows harvesting of solubilized inclusion bodies after the cells have been lysed and refolding of proteins inside the bioreactor. | 08-18-2011 |
| 20110201050 | Gas Scrubbed Perfusion Filter - Fine gas bubbles traveling at fast speed are employed to scrub a hard-surface filter for harvesting liquids from suspensions including those consisting of nutrient media and cell culture, on a continuous basis without clogging the filters. | 08-18-2011 |
| 20110207170 | Bioreactor Exhaust - An exhaust system suitable for high volume exhaust from flexible disposable bags is described that prevents nutrient media volume loss and prevents cross-contamination without using any filters. The invention described here allows the use of disposable two-dimensional bioreactors for the cultivation of bacterial and other organisms and cells require high aeration. | 08-25-2011 |
| 20110217690 | Interconnected Bioreactors - A method of combining the content of bioreactors allowing homogeneous mixing in accordance with CFR21 is described that allows processing of variable size batches using a single validated bioreactor is described. | 09-08-2011 |
| 20110217767 | Single-use Stationary Bioreactors and Mixing Vessels - Stationary bioreactors and mixing vessels fitted with single-use flexible bags utilizing wave hydrodynamic principle are described for use in every type of biological process and products. | 09-08-2011 |
| 20110287404 | Stationary Bubble Reactors - Reactors that allow mixing and gasification by converting the entire floor of the reactor vessel to a sparge filter is described. | 11-24-2011 |
| 20110290745 | Concentrator Filter - A method and an apparatus for separating suspended matter from liquid includes a concentrator filter that draws the liquid out of the suspension while the filter kept unblocked by a sparging filter that allows scrubbing of the concentrator filter by gas bubbles. This invention can be used to replace cross-flow filtration and centrifugation in the bioprocess industry and to reduce the volume of suspensions to concentrate the yield of the end product in the chemical industry. | 12-01-2011 |
| 20120006526 | Single-container manufacturing of biological products - A single-pass HVAC systems to isolate zones and to maintain a required clean air quality standard is provided that operates by producing a positive pressure in all zones, while exhausting on a minimal quantity of air required by law. The zones are kept clean by a recirculating fan filter in each zone. The exhaust air is used to exchange heat with incoming air to conserve energy further. | 01-12-2012 |
| 20120016113 | BUOYANT PROTEIN HARVESTING DEVICE - A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification. | 01-19-2012 |
| 20120018380 | PREPARATIVE CHROMATOGRAPHY COLUMN AND METHODS - A chromatography column that captures components in a process liquid in a free flow state and allows elution in steps is described. | 01-26-2012 |
| 20120040331 | Noninvasive Bioreactor Monitoring - A pair or receptacles capable of housing an emitter probe and a detector probe are installed inside a bioreactor to monitor the properties of the nutrient media without contacting the nutrient media. | 02-16-2012 |
| Patent application number | Description | Published |
|---|
| 20090132653 | FRAMEWORK AND METHOD FOR REAL-TIME EMBEDDED COLLABORATION USING BUSINESS PROCESS AND TRANSACTION CONTEXT - Embodiments of the present invention provide techniques for facilitating collaboration between participants of a process supported by a software application (e.g., a business process supported by a business application). According to one set of embodiments, a request to initiate a collaboration session for a transaction of the process is submitted through a user interface of the process itself within the software application. The collaboration session is then initiated using process and transaction context information retrieved from the software application. In some embodiments, portions of the process and transaction context information are made available to participants in the collaboration session. In further embodiments, the transaction and process context information is used to automatically match the initiator of the collaboration session with one or more appropriate collaboration participants. In this manner, the operational inefficiencies and delays associated with prior collaboration methods may be minimized or avoided. | 05-21-2009 |
| 20110153477 | PREDICTIVE TIME ENTRY FOR WORKFORCE MANAGEMENT SYSTEMS - This disclosure describes, generally, methods and systems for predictive approaches used to auto-populate timecards for an employee/contractor. A system/framework is proposed that can auto-populate timecards for employees using predictive approaches. The predictive approaches may look at the patterns of time entry for the individual who is performing entry of the time. The system can also look at patterns of time entry for other team members within an organization or group whose time entry patterns may be similar or identical to other individuals. | 06-23-2011 |
| 20110154372 | AGILE HELP, DEFECT TRACKING, AND SUPPORT FRAMEWORK FOR COMPOSITE APPLICATIONS - This disclosure describes, generally, methods and systems for implementing agile and dynamic help, defect tracking, and support frameworks for composite applications. The method includes implementing, on a computer system including a storage database, a composite application including a plurality of application components and establishing, in the computer system's storage database, a storage container for each of the plurality of application components. The storage containers are configured to store support information for each of the component applications. The method further includes storing, in the storage database, support data for each of the plurality of component applications, removing at least one of the plurality of component applications from the composite application, and maintaining, in the storage database, the support data for the remaining component applications of the composite application. | 06-23-2011 |
