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Ni, CA

Bin Ni, Fremont, CA US

Patent application numberDescriptionPublished
20090030944CONTRACT-CENTRIC CONTENT SYSTEM - A method and system to manage content is provided to generate an abstraction layer between a user application and content, based on a formal definition of content (referred to as a content contract). An example content system comprises a content bundle module, a user application, and a content access interface module. The content bundle module may be configured to store content items. A content item may include text items and placeholders. The user application, which does not have to be coded with specific knowledge regarding the content bundle, may be configured to receive a request to provide to a to a client system a presentation package (e.g., a web page) that has the content item, and to obtain the content item and any associated metadata from the content access interface module. Content item metadata may include, for example, information regarding a value to populate a placeholder in the content item.01-29-2009
20090031287CONTAINER-LESS JSP TEMPLATE - A container-less JSP system is provided. An example container-less JSP system comprises a detector, a trigger module, and an invoker. The detector may be configured to detect a request initiated by a client application to invoke a JSP template. The request is a protocol-neutral Java™ interface. The trigger module may be configured to trigger the protocol-neutral Java™ interface to invoke the JSP template. The invoker may be configured to invoke the JSP template.01-29-2009
20100280915SYSTEMS AND METHODS FOR PROVIDING INFORMATION ON A MOBILE DEVICE - Example methods and systems described herein provide information on a mobile device. Some example embodiments may include receiving information that is current as of a specific period. The information may be subject to change with a progression of time. An example embodiment includes causing the received information to be output to a user interface of a mobile device at the same time that an element of a computing application is being output to the user interface. The element of the computing application may be associated with a computing application that is being executed by the mobile device.11-04-2010
20110197197WIDGET FRAMEWORK, REAL-TIME SERVICE ORCHESTRATION, AND REAL-TIME RESOURCE AGGREGATION - A method to optimize calls to a service by components of an application running on an application server is provided. The method includes receiving a first call and a second call, the first call made to a service by a first one of a plurality of components included in the application, and the second call made to the service by a second one of the plurality of components; selecting one of a plurality of optimizations, the plurality of optimizations including orchestrating the first call and the second call into a third call to the service; and, in response to the selecting of the orchestrating of the first call and the second call into the third call as the one of the plurality of optimizations, orchestrating the first call and the second call into the third call.08-11-2011

Patent applications by Bin Ni, Fremont, CA US

Bin Ni, Sunnyvale, CA US

Patent application numberDescriptionPublished
20110273974METHOD AND APPARATUS FOR OFFSET AND GAIN CORRECTION - Aspects of the disclosure provide a signal processing circuit that has fast response time to sudden profile changes in an electrical signal. The signal processing circuit includes a processing path configured to process an electrical signal that is generated in response to reading data on a storage medium, and a feed-forward correction module. The feed-forward correction module is configured to detect a profile variation based the electrical signal in a time window, and correct the electrical signal in the time window based on the detected profile variation.11-10-2011

Demai Ni, Davis, CA US

Patent application numberDescriptionPublished
20080215534COST-BASED SUBQUERY CORRELATION AND DECORRELATION - Techniques are provided that determine that a query includes at least one subquery that may be correlated or decorrelated. An internal representation of the query that represents the subquery in both correlated and decorrelated form is generated, wherein the internal representation includes at least one virtual table.09-04-2008

Hongjie Ni, Torrance, CA US

Patent application numberDescriptionPublished
20080198162A METHOD OF GENERATING CURVED BASELINE FOR MAP LABELING - Apparatus and methods of generating a curved baseline for a map labeling include receiving a polyline P={p08-21-2008

Jim Ni, San Jose, CA US

Patent application numberDescriptionPublished
20090086448SOLID STATE DRIVE WITH COVERLESS CASING - The present invention discloses a solid state drive with a coverless casing, which comprises: a printed circuit board assembly and a coverless casing. In the resent invention, the coverless casing is free of a top cover; thereby, air circulation can be enhanced to cool down the electronic components on a printed circuit board assembly more efficiently. Further, in the present invention, the coverless casing is designed to have the printed circuit board assembly electrically connected to the chassis ground of the host system via the coverless casings; thereby, unwanted electrostatic charges can be dissipated to the chassis ground of the host system before it can damage the electronic components on the printed circuit board assembly; thus, the ESD resistance thereof is promoted. Furthermore, the solid state drive with a coverless casing of the present invention is made of lightweight materials and easy to fabricate and simple to assemble; therefore, the present invention have the advantages of light weight and low cost.04-02-2009
20090097215UV-EPOXY AND ULTRASONIC CASE ASSEMBLY METHODS FOR USB FLASH DRIVE - The present invention discloses UV-epoxy and ultrasonic case assembly methods for a USB flash drive, wherein a transparent or translucent top cover is fastened to a bottom cover containing a printed circuit board assembly via an UV-cure epoxy glue or an ultrasonic weld method. As the top cover of the USB flash drive is transparent or translucent, the USB flash drive has a see-through property and presents an aesthetic taste, which can attract the attention of consumers. Further, the method of the present invention uses less case parts and fewer steps and thus can fabricate a USB flash drive having a lower cost and a better quality at a higher throughput. Furthermore, the USB flash drive fabricated according to the method of the present invention has a better moisture resistance and a better water resistance.04-16-2009
20100000655Memory Module Assembly Including Heat Sink Attached To Integrated Circuits By Adhesive And Clips - A memory module assembly includes two-plate heat sink attached to one or more of the integrated circuits (e.g., memory devices) of a memory module PCBA by adhesive. The adhesive is either heat-activated or heat-cured. The adhesive is applied to either the memory devices or the heat-sink plates, and then compressed between the heat-sink plates and memory module using a fixture. The fixture is then passed through an oven to activate/cure the adhesive. The two heat sink plates are then secured by a clip to form a rigid frame.01-07-2010

Patent applications by Jim Ni, San Jose, CA US

Jing Ni, Sunnyvale, CA US

Patent application numberDescriptionPublished
20110070661RAMAN-ACTIVE REAGENTS AND THE USE THEREOF - The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).03-24-2011
20110070662RAMAN-ACTIVE REAGENTS AND THE USE THEREOF - The present invention provides a new class of Raman-active reagents for use in biological and other applications, as well as methods and kits for their use and manufacture. Each reagent includes a Raman-active reporter molecule, a binding molecule, and a surface enhancing particle capable of causing surface enhanced Raman scattering (SERS). The Raman-active reporter molecule and the binding molecule are affixed to the particle to give both a strong SERS signal and to provide biological functionality, i.e. antigen or drug recognition. The Raman-active reagents can function as an alternative to fluorescence-labeled reagents, with advantages in detection including signal stability, sensitivity, and the ability to simultaneously detect several biological materials. The Raman-active reagents also have a wide range of applications, especially in clinical fields (e.g., immunoassays, imaging, and drug screening).03-24-2011

Patent applications by Jing Ni, Sunnyvale, CA US

John Ni, San Leandro, CA US

Patent application numberDescriptionPublished
20110084371MODULAR LOW STRESS PACKAGE TECHNOLOGY - A protective modular package cover has first and second fastening sections located at opposing first and second ends with one or more subassembly receiving sections disposed thereto and is configured to fasten the protective modular package cover to a core. Each fastening section has a foot surface located on a bottom surface of a fastening section and configured to make contact with the core, a mounting hole configured to receive a fastener, and a torque element. Each subassembly receiving section is configured to receive a subassembly and has a cross member formed along the underside of the protective modular package cover. Activation of the first torque element transfers a downward clamping force generated at the fastening element to a top surface of one or more subassemblies disposed in the one or more subassembly receiving sections via the cross member of each of the one or more subassembly receiving sections.04-14-2011
20110084376MODULAR LOW STRESS PACKAGE TECHNOLOGY - A protective modular package assembly with one or more subassemblies, each having a base element, a sidewall element coupled to the base element, and a semiconductor device disposed within and coupled to the sidewall element and the base element; a protective modular package cover having fastening sections located at opposing ends of the cover, torque elements disposed on the opposing ends and configured to fasten the cover to a core, and subassembly receiving sections disposed between the fastening sections with each subassembly receiving section operable to receive a subassembly and having a cross member along the underside of the cover; and an adhesive layer configured to affix subassemblies to respective subassembly receiving sections. The torque elements are configured to transfer a downward clamping force generated at the fastening elements to a top surface of the subassemblies via the cross member of each of the one or more subassembly receiving sections.04-14-2011
20110086469MODULAR LOW STRESS PACKAGE TECHNOLOGY - A method of manufacturing a protected package assembly: providing a protective modular package cover in accordance with a modular design; selectively applying an adhesive to the cross member of each subassembly receiving section of the protective modular package cover that will receive a subassembly to form an adhesive layer of the protective modular package cover; encapsulating the one or more subassemblies in the subassembly receiving sections on the selectively applied adhesive layer to generate a protected package assembly; and controlling application of a distributed downward clamping force applied to the top surfaces of the subassemblies received by the protective modular package cover and useful for mounting the protected package assembly to a core through activation of fastener elements and cross members of the subassembly receiving sections.04-14-2011
20110087353MODULAR LOW STRESS PACKAGE TECHNOLOGY - A method of designing a modular package: determining a package outline of a modular package assembly from package outline design data; determining seating plane and overall package length characteristics of the assembly from seating plane and package length design data; the design tool calculating minimum package height of the modular package assembly from the seating plane and package length design data; designing the dimensions and configuration of one or more subassemblies from subassembly design data; defining dimensions and configuration of a plurality of mechanical layers of a protective modular package cover given the defined package outline, the seating plane, overall package length, the minimum package height, and the subassemblies; defining an adhesive deposition strategy to join mechanical layers of the cover; designing the cover in accordance with the dimensions and configuration of the mechanical layers; and incorporating the assembly and the adhesive deposition strategy into a manufacturing assembly process.04-14-2011
20110087356MODULAR LOW STRESS PACKAGE TECHNOLOGY - A method of designing a desired modular package assembly: determining the configuration and dimensions of the assembly from received user input design data, the assembly having a protective modular package cover with first and second fastening sections, subassembly receiving sections disposed between the fastening sections and having a cross member formed along the underside of the protective modular package cover and configured to receive a subassembly, and one or more subassemblies to be received by the subassembly receiving sections; determining an adhesive deposition strategy for deposition of an adhesive layer to the cross members of the subassembly receiving sections sufficient to affix the top side of the subassemblies to the cross members on the underside of the subassembly receiving sections; and incorporating the configuration and dimensions of the modular package assembly and the adhesive deposition strategy into a manufacturing assembly process configured to manufacture the modular package assembly.04-14-2011

Karl Ni, San Diego, CA US

Patent application numberDescriptionPublished
20100118970TEMPORAL ERROR CONCEALMENT FOR VIDEO COMMUNICATIONS - Methods and systems for processing video data are described. A set of candidate motion vectors is selected from motion vectors associated with macroblocks in a first frame of video data and from motion vectors associated with macroblocks in a second frame of the video data. A statistical measure of the set is determined. The statistical measure defines a motion vector for a macroblock of interest in the second frame.05-13-2010

Ling Ni, Milpitas, CA US

Patent application numberDescriptionPublished
20110295836SYSTEMS AND METHODS FOR PROVIDING VALUE HIERARCHIES, RAGGED HIERARCHIES AND SKIP-LEVEL HIERARCHIES IN A BUSINESS INTELLIGENCE SERVER - A business intelligence (BI) server and repository are described which support a set of hierarchical relationships among the data. The BI server receives user input specifying a set of parent-child or other ancestral relationship among a set of data in a data source. The BI server generates a set of SQL queries and executes the queries to pre-populate a set of tables which specify the parent child relationships among the data in the data source. One such table is a parent-child relationship closure table that defines the inter-member relationships among the data members. Once the tables are populated, the BI server uses the closure tables to answer queries that require knowledge of the ancestral relationships among data.12-01-2011
20110295837SYSTEMS AND METHODS FOR PROVIDING MULTILINGUAL SUPPORT FOR DATA USED WITH A BUSINESS INTELLIGENCE SERVER - A business intelligence (BI) server is described that supports data and schemas stored in multiple languages. The BI server implements a lookup table and lookup function that allows users to work with queries in different languages. When the user logs in, a session object is created for the user, which maintains the state information. A session variable specifies the language currently being used by the user. The BI server can inspect this session variable to determine the language of the user and perform the lookup translations as necessary. For example, if the language used by the session is different from the language of the base table storing the necessary information, the BI server can perform a translation by invoking a lookup function. The execution of the lookup can include performing a join operation of the base table with the lookup table to yield a translated value requested by the query.12-01-2011
20110295870SYSTEMS AND METHODS FOR PROVIDING CUSTOM OR CALCULATED DATA MEMBERS IN QUERIES OF A BUSINESS INTELLIGENCE SERVER - A business intelligence (BI) server and repository are described which support a set of customized and/or calculated data members. In accordance with an embodiment, the BI server maintains a connection to a plurality of data sources which may store a set of dimension members. The data source can be relational, file storage based, multidimensional and other types. In accordance with an embodiment, the BI server can accept queries from the user that contain calculated members as a parameter. The calculated member is defined by an expression including multiple dimension members and one or more arithmetic operators. The BI server can parse and validate the query and rewrite the query for the data source. After the query is rewritten and optimized, it is executed against the data source and a set of results is received.12-01-2011

Michael Ni, Cupertino, CA US

Patent application numberDescriptionPublished
20100011166Data Cache Virtual Hint Way Prediction, and Applications Thereof - A virtual hint based data cache way prediction scheme, and applications thereof. In an embodiment, a processor retrieves data from a data cache based on a virtual hint value or an alias way prediction value and forwards the data to dependent instructions before a physical address for the data is available. After the physical address is available, the physical address is compared to a physical address tag value for the forwarded data to verify that the forwarded data is the correct data. If the forwarded data is the correct data, a hit signal is generated. If the forwarded data is not the correct data, a miss signal is generated. Any instructions that operate on incorrect data are invalidated and/or replayed.01-14-2010

Min Ni, Santa Clara, CA US

Patent application numberDescriptionPublished
20110095367ESD/ANTENNA DIODES FOR THROUGH-SILICON VIAS - Roughly described, an antenna diode is formed at least partially within the exclusion zone around a TSV, and is connected to the TSV by way of a metal 1 layer conductor at the same time that the TSV is connected to either the gate poly or a diffusion region of one or more transistors placed outside the exclusion zone.04-28-2011
20110138157CONVOLUTION COMPUTATION FOR MANY-CORE PROCESSOR ARCHITECTURES - A convolution of the kernel over a layout in a multi-core processor system includes identifying a sector, called a dynamic band, of the layout including a plurality of evaluation points. Layout data specifying the sector of the layout is loaded in shared memory, which is shared by a plurality of processor cores. A convolution operation of the kernel and the evaluation points in the sector is executed. The convolution operation includes iteratively loading parts of the basis data set, called a stride, into space available in shared memory given the size of the layout data specifying the sector. A plurality of threads is executed concurrently using the layout data for the sector and the currently loaded part of the basis data set. The iteration for the loading basis data set proceeds through the entire data set until the convolution operation is completed.06-09-2011

Ming Ni, Laguna Niguel, CA US

Patent application numberDescriptionPublished
20120077857INHIBITION OF INFLAMMATION BYSIMULTANEOUS BLOCKADE OF MULTIPLE PROSTANOID RECEPTORS - The present invention provides a method for treating inflammation in a patient in need thereof comprising administering to said patient an effective amount of a compound according to formula03-29-2012

Nan Ni, Goleta, CA US

Patent application numberDescriptionPublished
20090027292Ultra-Wideband Log-Periodic Dipole Array with Linear Phase Characteristics - A log-periodic dipole array system employs a structure for the transmitter and the receiver designed in a way such that they compensate for the non-linear characteristics of each other to realize linear phase characteristics as a pair. Radiation elements on the receiver are positioned with respect to its corresponding transmission line in an order opposite to the positioning of the radiation elements on the transmitter. Although neither the transmitter dipole array nor the receiver dipole array itself has linear phase characteristics, the overall dipole array antenna system can realize linear phase characteristic. The log-periodic dipole array system has the advantages that linear phase characteristics can be obtained without sacrificing high radiation efficiency and gain.01-29-2009
20090153431Continuously Tunable Impedance Matching Network Using BST Capacitor - An impedance matching circuit employs a variable capacitor, such as a BST capacitor. The bias voltage to the variable capacitor may be adjusted in order to match several different frequencies used with the antenna to the signal source.06-18-2009

Nan Ni, Santa Barbara, CA US

Patent application numberDescriptionPublished
20100053007TUNABLE DUAL-BAND ANTENNA USING LC RESONATOR - An Inverted-F antenna (IFA) includes a tunable parallel LC resonator physically inserted between two antenna bodies of the IFA structure. The LC resonator is comprised of a tunable capacitor C03-04-2010

Tuqiang Ni, Fremont, CA US

Patent application numberDescriptionPublished
20100327085Gas injection system for plasma processing - A plasma processing system for plasma processing of substrates such as semiconductor wafers. The system includes a plasma processing chamber, a substrate support for supporting a substrate within the processing chamber, a dielectric member having an interior surface facing the substrate support, the dielectric member forming a wall of the processing chamber, a gas injector fixed to, part of or removably mounted in an opening in the dielectric window, the gas injector including a plurality of gas outlets supplying process gas into the chamber, and an RF energy source such as a planar or non-planar spiral coil which inductively couples RF energy through the dielectric member and into the chamber to energize the process gas into a plasma state. The arrangement permits modification of gas delivery arrangements to meet the needs of a particular processing regime. In addition, compared to consumable showerhead arrangements, the use of a removably mounted gas injector can be replaced more easily and economically.12-30-2010

Patent applications by Tuqiang Ni, Fremont, CA US

Tuqiang Ni, Pleasanton, CA US

Patent application numberDescriptionPublished
20080202688Silicon Carbide Gas Distribution Plate and RF Electrode for Plasma Etch Chamber - A showerhead for use in a capacitively-coupled plasma chamber and made of low resistivity bulk layer coated with CVD SiC. The bulk low resitivity material may be, for example, graphite, Silicon Carbide (SiC), converted graphite, SiC+C, etc. Sintered SiC may be used as the bulk material coated with CVD SiC to provide a showerhead that is suitable for use in a capacitively-coupled plasma chamber.08-28-2008
20110253673PLASMA PROCESSING METHOD AND APPARATUS WITH CONTROL OF PLASMA EXCITATION POWER - The amount of RF power supplied to a plasma in a vacuum plasma processing chamber is gradually changed on a preprogrammed basis in response to signals stored in a computer memory. The computer memory stores signals so that other processing chamber parameters (pressure, gas species and gas flow rates) remain constant while the gradual change occurs. The stored signals enable rounded corners, instead of sharp edges, to be etched, e.g., at an intersection of a trench wall and base.10-20-2011

Patent applications by Tuqiang Ni, Pleasanton, CA US

Wan Ni, Carlsbad, CA US

Patent application numberDescriptionPublished
20100237472Chip Guard Ring Including a Through-Substrate Via - At least one through-substrate via is formed around the periphery of a semiconductor chip or a semiconductor chiplet included in a semiconductor chip. The at least one through-substrate via may be a single through-substrate via that laterally surrounds the semiconductor chip or the semiconductor chiplet, or may comprise a plurality of through-substrate vias that surrounds the periphery with at least one gap among the through-substrate vias. A stack of back-end-of-line (BEOL) metal structures that laterally surrounds the semiconductor chip or the semiconductor chiplet are formed directly on the substrate contact vias and electrically connected to the at least one through-substrate via. A metallic layer is formed on the backside of the semiconductor substrate including the at least one through-substrate via. The conductive structure including the metallic layer, the at least one through-substrate via, and the stack of the BEOL metal structures function as an electrical ground built into the semiconductor chip.09-23-2010

Yang Ni, Sunnyvale, CA US

Patent application numberDescriptionPublished
20100057740ACCELERATING A QUIESCENCE PROCESS OF TRANSACTIONAL MEMORY - A method to perform validation of a read set of a transaction is presented. In one embodiment, the method compares a read signature of a transaction to a plurality of write signatures associated with a plurality of transactions. The method determines based on the result of comparison, whether to update a local value of the transaction to a commit value of another transaction from the plurality of the transactions.03-04-2010
20100058344ACCELERATING A QUIESCENCE PROCESS OF TRANSACTIONAL MEMORY - A method to perform validation of a read set of a transaction is presented. In one embodiment, the method compares a read signature of a transaction to a plurality of write signatures associated with a plurality of transactions. The method determines based on the result of comparison, whether to update a local value of the transaction to a commit value of another transaction from the plurality of the transactions.03-04-2010
20100153953UNIFIED OPTIMISTIC AND PESSIMISTIC CONCURRENCY CONTROL FOR A SOFTWARE TRANSACTIONAL MEMORY (STM) SYSTEM - A method and apparatus for unified concurrency control in a Software Transactional Memory (STM) is herein described. A transaction record associated with a memory address referenced by a transactional memory access operation includes optimistic and pessimistic concurrency control fields. Access barriers and other transactional operations/functions are utilized to maintain both fields of the transaction record, appropriately. Consequently, concurrent execution of optimistic and pessimistic transactions is enabled.06-17-2010
20110145512Mechanisms To Accelerate Transactions Using Buffered Stores - In one embodiment, the present invention includes a method for executing a transactional memory (TM) transaction in a first thread, buffering a block of data in a first buffer of a cache memory of a processor, and acquiring a write monitor on the block to obtain ownership of the block at an encounter time in which data at a location of the block in the first buffer is updated. Other embodiments are described and claimed.06-16-2011

Yongshen Ni, Santa Cara, CA US

Patent application numberDescriptionPublished
20120044391Image Sensor Apparatus And Method For Line Buffer Efficient Lens Distortion Correction - An image sensor apparatus is disclosed. The image sensor apparatus includes an image sensor for generating image data corresponding to an optical image. The image sensor apparatus also includes a color filter customized for a lens distortion model. A processor processes the image data with a plurality of distortion correction routines to generate a digital image.02-23-2012

Yunjie Ni, Redwood City, CA US

Patent application numberDescriptionPublished
20090099939CONFIGURABLE INTELLIGENT COUNTDOWN CLOCK FOR ONLINE AUCTIONS - This disclosure describes, generally, methods and systems for dynamically counting down to an on-line auction end time. The method includes initiating a countdown clock with an end time that corresponds to the on-line auction end time, and accessing an auction server to obtain data used to refresh a current time of the countdown clock. The auction server is accessed at an incrementally faster refresh rate as the on-line auction end time is approached. The method further includes presenting, based on the refresh data obtained from accessing the auction server, an updated countdown clock.04-16-2009

Zefeng Ni, Santa Barbara, CA US

Patent application numberDescriptionPublished
20110148858VIEW SYNTHESIS WITH HEURISTIC VIEW MERGING - Several implementations relate to view synthesis with heuristic view merging for 3D Video (3DV) applications. According to one aspect, a first candidate pixel from a first warped reference view and a second candidate pixel from a second warped reference view are assessed based on at least one of a backward synthesis process to assess a quality of the first and second candidate pixels, a hole distribution around the first and second candidate pixels, or on an amount of energy around the first and second candidate pixels above a specified frequency. The assessing occurs as part of merging at least the first and second warped reference views into a signal synthesized view. Based on the assessing, a result is determined for a given target pixel in the single synthesized view. The result may be determining a value for the given target pixel, or marking the given target pixel as a hole.06-23-2011
20110157229VIEW SYNTHESIS WITH HEURISTIC VIEW BLENDING - Various implementations are described. Several implementations relate to view synthesis with heuristic view blending for 3D Video (3DV) applications. According to one aspect, at least one reference picture, or a portion thereof, is warped from at least one reference view location to a virtual view location to produce at least one warped reference. A first candidate pixel and a second candidate pixel are identified in the at least one warped reference. The first candidate pixel and the second candidate pixel are candidates for a target pixel location in a virtual picture from the virtual view location. A value for a pixel at the target pixel location is determined based on values of the first and second candidate pixels.06-30-2011

Zhi Jie Ni, Fremont, CA US

Patent application numberDescriptionPublished
20090131304Semi-Synthetic Desmethyl-Vancomycin-Based Glycopeptides With Antibiotic Activity - Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of the desmethyl-vancomycin scaffold, in particular, acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. In addition, compounds of the invention include desmethyl-vancomycin scaffolds on which the acid moiety on the macrocyclic ring is converted to certain substituted amides and the amino substituent on the amino-substituted sugar moiety is alkylated with certain alkyl groups. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.05-21-2009
20090281100Benzimidazole quinolinones and uses thereof - Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.11-12-2009
20090285849Thiosemicarbazones as anti-virals and immunopotentiators - Novel immune potentiators, novel vaccine adjuvants, novel compounds and pharmaceutical compositions, as well as novel methods for treating viral infections, including HCV, by administering the compounds and compositions, and novel methods for modulating the immune response by administering the compounds and/or compositions.11-19-2009

Patent applications by Zhi Jie Ni, Fremont, CA US

Zhi-Jie Ni, Emeryville, CA US

Patent application numberDescriptionPublished
20080214444SEMI-SYNTHETIC REARRANGED VANCOMYCIN/DESMETHYL-VANCOMYCIN-BASED GLYCOPEPTIDES WITH ANTIBIOTIC ACTIVITY - Semi-synthetic glycopeptides that have antibacterial activity are based on modifications of a rearranged vancomycin or desmethyl-vancomycin scaffold, in particular, alkylation or acylation of the amino substituent on the amino-substituted sugar moiety on this scaffold with certain acyl groups; and/or conversion of the acid moiety on the macrocyclic ring of this scaffolds to certain substituted amides. Also provided are methods for synthesis of the compounds, pharmaceutical compositions containing the compounds, and methods of use of the compounds for the treatment and/or prophylaxis of diseases, especially bacterial infections.09-04-2008
20090042858LACTAM CONTAINING HCV INHIBITORS - The present invention discloses novel methods and compositions for viral inhibition, particularly inhibition of HCV and SARS. The invention also provides compositions including novel oxoazepanylacetamide derivatives useful for viral inhibition.02-12-2009
20100048547PI 3-KINASE INHIBITORS AND METHODS OF THEIR USE - Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.02-25-2010
20100075965PI3 KINASE INHIBITORS AND METHODS OF THEIR USE - Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.03-25-2010
20100249126PYRIMIDINE DERIVATIVES USED AS PI-3-KINASE INHIBITORS - Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.09-30-2010

Patent applications by Zhi-Jie Ni, Emeryville, CA US