Patent application number | Description | Published |
20120064141 | Drug-Coated Balloon With Location-Specific Plasma Treatment - Method of coating an expandable member, e.g. balloon, is provided, the method comprising providing an expandable member having an outer surface. The method includes a plasma treatment with a supply of gas performed on at least a portion of the outer surface of the expandable member. A therapeutic agent is applied on at least the plasma treated portion of the outer surface of the expandable member after the plasma treatment is performed. The plasma treatment can reduce the adhesion of therapeutic agent to the surface of the expandable member. A medical device made by the disclosed method is also provided. | 03-15-2012 |
20120064223 | Drug Coated Balloon Surface Relaxation Process To Minimize Drug Loss - Method of coating an expandable member is provided. The method comprises providing an expandable member having deflated and fully expanded configurations, and inflating the expandable member with a select amount of inflation medium, the select amount of inflation medium applied at a nominal pressure, disposing a therapeutic agent on at least a portion of the expandable member; and partially deflating the expandable member, wherein partially deflating includes releasing an initial amount of inflation medium from the expandable member such that the expandable member partially re-folds. The therapeutic agent can be dried on the expandable member, and a remaining amount of inflation medium can be withdrawn such that the expandable member resumes the completely folded configuration. | 03-15-2012 |
20120065583 | Process For Folding Of Drug Coated Balloon - Method of coating an expandable member is provided. The method comprises providing an expandable member with a plurality of folds defined therein, the expandable member having a folded configuration and a fully expanded configuration at a rated nominal pressure. The expandable member is inflated to an initial pressure of from 10% to about 300% of nominal pressure. A therapeutic agent is disposed on at least a portion of the expandable member. The expandable member is partially deflated to an intermediate pressure by withdrawing an amount of inflation medium from the expandable member, and by applying an external force to the expandable member. | 03-15-2012 |
20120165922 | METHOD OF MODIFYING A COATING ON A MEDICAL DEVICE - Method of modifying the coating of a surface of a medical device by applying a coating to the surface of the medical device, exposing the medical device to an environmental condition that alters the coating morphology, and drying the coating on the medical device. The disclosed subject matter also provides a coated medical device whose one or more surfaces have been modified by this method. | 06-28-2012 |
20120315376 | Method And System To Maintain A Fixed Distance During Coating Of A Medical Device - Method and system to coat an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A tracking mechanism maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the at least one outlet relative to the expandable member. | 12-13-2012 |
20130190725 | MEDICAL DEVICE HAVING TISSUE ENGAGING MEMBER AND METHOD FOR DELIVERY OF A THERAPEUTIC AGENT - Medical device includes a tubular member having a proximal end and distal end defining a longitudinal axis therebetween, an expandable member proximate the distal end of the tubular member having at least one axial fold in a deflated condition, a tissue engaging member comprising at least one straight wire extending along at least part of the longitudinal axis of the expandable member, and a therapeutic agent disposed on at least the expandable member or the tissue engaging member. The at least one straight wire of the tissue engaging member is located inside the at least one fold of the expanded member when in the deflated condition. The tissue engaging member is configured for deployment at a select location upon inflation of the expandable member. A method of delivering a therapeutic agent is also provided. | 07-25-2013 |
20140188045 | PROCESS FOR FOLDING DRUG COATED BALLOON - Device, system, method of coating an expandable member is provided. The method comprises providing an expandable member with a plurality of folds defined therein, the expandable member having a folded configuration and a fully expanded configuration at a rated nominal pressure. The expandable member is inflated to an initial pressure of from 10% to about 300% of nominal pressure. A therapeutic agent is disposed on at least a portion of the expandable member. The expandable member is partially deflated to an intermediate pressure by withdrawing an amount of inflation medium from the expandable member, and by applying an external force to the expandable member. | 07-03-2014 |
Patent application number | Description | Published |
20090157043 | LOW PROFILE AGENT DELIVERY PERFUSION CATHETER HAVING A FUNNEL SHAPED MEMBRANE - An agent delivery catheter and method configured to deliver an agent to an inner surface of a patient's body lumen wall by forming a funnel shaped agent containment chamber around at least one portion of the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure. | 06-18-2009 |
20090204068 | AGENT DELIVERY CATHETER HAVING AN INFLATION BRIDGE BETWEEN TWO AXIALLY SPACED BALLOONS - An agent delivery catheter having two or more axially spaced balloons and an inflation bridge providing fluid communication between the two balloons. The catheter generally has a proximal balloon, a distal balloon, and a tube defining an inflation bridge lumen which is located in part within the inflatable interiors of the balloons, and which extends therebetween, and which has a proximal port within the proximal balloon interior and a distal port within the distal balloon interior to thereby provide for inflation of the distal balloon by placing the distal balloon interior in fluid communication with the proximal balloon interior of the shaft. | 08-13-2009 |
20090270787 | SYSTEMS AND METHODS FOR CREATING ENLARGED MIGRATION CHANNELS FOR THERAPEUTIC AGENTS WITHIN THE ENDOTHELIUM - A system for enlarging endothelium migration channels at a treatment site in a coronary vessel wall, to enable enhanced delivery of a therapeutic agent thereto. The system includes an enlarging agent, for enlarging endothelium migration channels at a treatment site in a coronary vessel wall. It also includes a delivery system, for delivering the enlarging agent to the treatment site, so that the enlarging agent will be delivered thereby to enlarge the endothelium migration channels at the treatment site, and for delivering the therapeutic agent to the delivery site. The therapeutic agent will thereby be delivered into the enlarged migration channels at the treatment site, to treat the treatment site with the therapeutic agent. | 10-29-2009 |
20100145265 | AGENT DELIVERY CATHETER HAVING A RADIALLY EXPANDABLE CENTERING SUPPORT MEMBERS - A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member. | 06-10-2010 |
20100211009 | PERFUSION CATHETER HAVING ARRAY OF FUNNEL SHAPED MEMBRANES - An agent delivery catheter configured to deliver an agent to an inner surface of a patient's body lumen wall by forming an array of cells defining agent containment chambers at multiple locations along the catheter's shaft, while minimizing ischemic conditions during the procedure. | 08-19-2010 |
20110238039 | Method and Apparatus for Improving Delivery of an Agent to a Kidney - Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members. | 09-29-2011 |
20110245766 | Method and Apparatus for Improving Delivery of an Agent to a Kidney - Methods for more uniformly delivering drugs or other treatment agents locally to the vasculature of a mammal are disclosed. These methods use one or more strategies to facilitate rapid mixing with the blood flowing past a device or otherwise improve the uniformity of drug delivery. Some of these strategies employ medical devices with diffusion members. | 10-06-2011 |
20110281020 | Maintaining A Fixed Distance During Coating Of Drug Coated Balloon - A system and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and a dispenser positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A guide maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the expandable member relative to the at least one outlet. | 11-17-2011 |
20120128863 | TENSIONING PROCESS FOR COATING BALLOON - Method of coating an expandable member includes providing an expandable member having a proximal and a distal end with a guidewire lumen extending therebetween, the expandable member having a deflated and fully expanded configurations, and inflating the expandable member to an initial inflation pressure; positioning a mandrel within the guidewire lumen; tensioning the mandrel to straighten the guidewire lumen within the expandable member; and disposing a therapeutic agent on at least a portion of the expandable member. Method further includes partially deflating the expandable member to an intermediate pressure, and drying the therapeutic agent on the expandable member, and, if a folded expandable member is used, at least partially refolding the expandable member. | 05-24-2012 |
20120136367 | MULTI-SEGMENT PROTECTIVE SHEATH FOR EXPANDABLE MEDICAL DEVICES - A protective sheath for covering an elongated medical device includes two or more sheath segments. Each sheath segment has a lumen extending the length of the segment with an inner diameter sufficient to receive the elongated medical device within the lumen. Each sheath segment also has a first end and a second end, with the first end of each sheath segment being configured to engage the second end of an adjacent sheath segment in an interlocking engagement. The first end of each sheath segment has a first coupling portion and the second end of each sheath segment has a second coupling portion, which are complementary of one another and configured to couple adjacent sheath segments to one another when the first end of one sheath segment is engaged with the second end of an adjacent sheath segment. | 05-31-2012 |
20120143139 | AGENT DELIVERY CATHETER HAVING A RADIALLY EXPANDABLE CENTERING SUPPORT MEMBER - A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member. | 06-07-2012 |
20120315374 | Maintaining A Fixed Distance By Laser Or Sonar Assisted Positioning During Coating Of A Medical Device - System and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and an applicator positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A positioning device is provided to determine the distance to the surface of the expandable member at a corresponding location and relays the information to a controller or the like to maintain a substantially fixed distance between the outlet of the applicator and the surface of the expandable member when in alignment with the corresponding location. | 12-13-2012 |
20140046300 | LOW PROFILE AGENT DELIVERY PERFUSION CATHETER HAVING A FUNNEL-SHAPED MEMBRANE - An agent delivery catheter and method configured to deliver an agent to an inner surface of a patient's body lumen wall by forming a funnel shaped agent containment chamber around at least one portion of the inner surface of the body lumen wall, while minimizing ischemic conditions during the procedure. | 02-13-2014 |
20140121603 | AGENT DELIVERY CATHETER HAVING RADIALLY EXPANDABLE CENTERING SUPPORT MEMBER - A catheter for delivering an agent to an injection site in a wall of a patient's body lumen, with an elongated shaft having a needle-through lumen slidably containing a needle therein, and an expandable member on the distal shaft section which has a collapsed configuration and a radially expanded configuration. In the radially expanded configuration, the expandable member supports the shaft in a position spaced away from the body lumen wall, and the needle slidably exits the needle-through lumen in the extended configuration through the port spaced away from the body lumen wall as a portion of the expandable member maintains the position of the port section of the shaft in the body lumen. The expandable member typically has an open-walled, helical, or lobed configuration providing a perfusion path along the expandable member. | 05-01-2014 |
20150096491 | MAINTAINING A FIXED DISTANCE DURING COATING OF DRUG COATED BALLOON - A system and method for coating an expandable member of a medical device comprising a support structure to support the expandable member and a dispenser positioned with at least one outlet proximate a surface of an expandable member. A drive assembly establishes relative movement between the at least one outlet and the surface of the expandable member to apply fluid on the surface of the expandable member along a coating path. A guide maintains a substantially fixed distance between the at least one outlet and the surface of the expandable member during relative movement therebetween by displacing the expandable member relative to the at least one outlet. | 04-09-2015 |
Patent application number | Description | Published |
20160065597 | SYSTEM FOR DOMAIN REPUTATION SCORING - The disclosure is related to computer-implemented methods for domain name scoring. In one example, the method includes receiving a request to provide a reputation score of a domain name, receiving input data associated with the domain name, extracting a plurality of features from the input data and the domain name, generating a feature vector based on the plurality of features, and calculating the reputation score of the domain name by a machine-learning classifier based on a graph database, which includes feature vectors associated with at least a plurality of reference domain names, a plurality of servers, a plurality of domain name owners, and so forth. In another example, the method can calculate the reputation score by finding a similarity between the feature vector and one of domain name clusters in the graph database. The reputation score represents a probability that the domain name is associated with malicious activity. | 03-03-2016 |
20160065611 | ANALYZING DNS REQUESTS FOR ANOMALY DETECTION - A computer-implemented method for detecting anomalies in DNS requests comprises receiving a plurality of DNS requests generated within a predetermined period. The predetermined period includes a plurality of DNS data fragments. The method further includes receiving a first DNS request and selecting a plurality of second DNS requests from the plurality of DNS requests such that each of the second DNS requests is a subset of the first DNS request. The method also includes calculating a count value for each of the DNS data fragments, where each of the count values represents a number of instances the second DNS requests appear within one of the DNS data fragments. In some embodiments, the count values for each of the DNS data fragments can be normalized. The method further includes determining an anomaly trend, for example, based on determining that at least one of the count values exceeds a predetermined threshold value. | 03-03-2016 |
20160099961 | DISTINGUISHING HUMAN-DRIVEN DNS QUERIES FROM MACHINE-TO-MACHINE DNS QUERIES - The present disclosure is related to a computer-implemented method and system for distinguishing human-driven Domain Name System (DNS) queries from Machine-to-Machine (M2M) DNS queries. The method includes receiving a DNS query, which includes a domain name, generating a probability score for the domain name based on one or more predetermined rules, and categorizing the DNS query as a human-driven DNS query or a M2M DNS query based on the probability score. | 04-07-2016 |
Patent application number | Description | Published |
20090253832 | COLORANT COMPATIBLE HYDROPHOBICALLY MODIFIED POLYURETHANE THICKENER FOR PAINT - A synthetic polymer has a water-soluble or water-swellable polyurethane backbone and terminal groups and/or intermediate groups of blocks of hydrophobes of alkyl- or aryl compounds containing a polymerizable cyclic monomer or a polymerizable double bond (or alkene) group or derivatives thereof. The blocks of hydrophobes are composed of two or more units of the same or different hydrophobes. These synthetic polymers are used as rheology modifiers, especially in latex paints. | 10-08-2009 |
20100324177 | COLORANT COMPATIBLE HYDROPHOBICALLY MODIFIED POLYETHYLENEGLYCOL THICKENER FOR PAINT - A synthetic polymer has a water-soluble or water-swellable polyethyleneglycol backbone and terminal groups and/or intermediate groups of blocks of hydrophobes of alkyl- or aryl compounds containing a polymerizable cyclic monomer or a polymerizable double bond (or alkene) group or derivatives thereof. The blocks of hydrophobes are composed of two or more units of the same or different hydrophobes. These synthetic polymers are used as rheology modifiers, especially in latex paints. | 12-23-2010 |
20120247367 | WATER SOLUBLE POLYMER POWDER FORMULATION HAVING IMPROVED DISPERSING PROPERTIES - The present invention relates generally to water soluble polymer powder formulations, and more particularly, to a cellulose ether formulation which in powder form is suitable for direct addition to water-based systems to produce smooth, lump free solutions. The cellulose ethers are crosslinked with an aldehyde crosslinker and include a dry weak acid which slows hydrolysis of the hermiacetal linkage formed by the crosslinker. The selected acid does not adversely affect solubility stability. | 10-04-2012 |
20130030091 | READILY DISSOLVABLE SOLID NONIONIC SYNTHETIC ASSOCIATIVE THICKENERS - The presently disclosed and claimed inventive concept(s) relates to a particulate product. The particulate product comprises a nonionic synthetic associative thickener NSAT) rheology modifier and a dissolution promotion water soluble additive. The NSAT rheology modifier is selected from the group consisting of hydrophobically-modified ethoxylated urethane (HEUR), hydrophobically-modified polyethylene glycol and hydrophobically-modified polyacetal-polyether (HMPAPE). The particulate product is incorporated into a waterborne paint formula. | 01-31-2013 |
20130237651 | Viscosity Suppression of Associative Thickeners Using Organophosphates - The viscosity of solutions of nonionic synthetic associative thickeners is controlled by adding organophosphates to the solution of associative thickeners. The associative thickeners are hydrophobically modified polymers and the organophosphates include one or more hydrophobic groups. | 09-12-2013 |
20140249235 | Pharmaceutical Compositions With Enhanced Performance and Improved Processability - The presently disclosed and claimed inventive concept(s) relates to a polymer for enhancing drug performance and improving processability. Specifically, the polymer comprises hydroxypropyl methyl cellulose acetate succinate (HPMC-AS). On the HPMC-AS, the percentage of total succinoyl degree of substitution is less than 12% at C6-OH position and greater than 53% at C3-OH, and the percentage of total acetyl degree of substitution is greater than 32% at C6-OH position. | 09-04-2014 |
20150112000 | METHOD FOR MAKING A PARTICULATE PRODUCT CONTAINING NONIONIC SYNTHETIC ASSOCIATIVE THICKENER AND DISSOLUTION PROMOTION WATER SOLUBLE ADDITIVE - The presently disclosed and claimed inventive concept(s) relates to a method for making a particular product comprising a nonionic synthetic associative (NSAT) rheology modifier and a dissolution promotion water soluble additive. The method comprising the steps of: (a) obtaining the NSAT theology modifier and the dissolution promotion water soluble additive; (b) melting the NSAT theology modifier and the dissolution promotion water soluble additive; (c) mixing the molten NSAT theology modifier and the dissolution promotion water soluble additive; and (d) producing the particulate product from step (c). The NSAT rheology modifier is selected from the group consisting of hydrophobically-modified ethoxylated urethane (HEUR), hydrophobically-modified polyethylene glycol (HMPEG), and hydrophobically-modified polyacetal-polyether (HMPAPE). The particulate product prepared from the method is incorporated into a waterborne paint formula. | 04-23-2015 |
20150191642 | CEMENTING FLUID AND METHODS FOR PRODUCING THE SAME - The presently disclosed and/or claimed inventive concept(s) relates generally to a cementing fluid for use in high temperature wellbore application. More particularly, the presently disclosed and/or claimed inventive concept(s) relates to a cementing fluid comprising an aqueous fluid, a hydraulically-active cementitous material, and a suspending agent, wherein the suspending agent is a high molecular weight hydrophobic copolymer or a cross-linked hydrophobic copolymer particulate. Additionally, the presently disclosed and/or claimed inventive concept(s) relates generally to the methods of making the cementing fluid containing the suspending agent. | 07-09-2015 |
Patent application number | Description | Published |
20140075567 | Service Processor Configurations for Enhancing or Augmenting System Software of a Mobile Communications Device - A device comprising non-volatile memory capable of being partitioned into first and second partitions, the first partition for storing device system software, the second partition for storing a service processor and having one or more system execution properties for enhancing or augmenting the device system software, and comprising one or more processors for verifying integrity of the device system software using a first security element, verifying integrity of the service processor using a second security element, obtaining the service processor from the non-volatile memory, executing the obtained service processor, and updating, installing, removing, or modifying the service processor in the second partition of the non-volatile memory without affecting the device system software in the first partition. | 03-13-2014 |
20140098671 | Intermediate Networking Devices - A wireless communication device comprising: one or more network modems enabling the wireless communication device to communicate over a first wireless network; one or more network modems enabling the wireless communication device to communicate with two or more end-point devices over a second wireless network; one or more processors configured to execute one or more instructions; and memory coupled to the one or more processors and configured to provide the one or more processors with the one or more instructions. The one or more instructions, when executed by the processors, cause processors to: establish a first connection between the wireless communication device and a first end-point device; establish a second connection between the wireless communication device and a second end-point device; apply a first control to traffic transmitted by or to the first end-point device; and apply a second control to traffic transmitted by or to the second end-point device. | 04-10-2014 |
20140337519 | Techniques For Attribution Of Mobile Device Data Traffic To Initiating End-User Application - A method performed by a network system communicatively coupled to a device over a wireless access network, the method comprising transmitting a traffic flow to, or receiving the traffic flow from, a software application on the device, the traffic flow comprising one or more related data transfers over the wireless access network, the traffic flow being routed between the software application and the network system through an assisting element comprising a control application or a proxy agent on the device, wherein the traffic flow has a characteristic associating the traffic flow with the first software application, the characteristic preserving the association between the traffic flow and the software application when the traffic flow is routed by the one or more assisting elements; identifying the characteristic; and implementing at least a portion of a control, accounting, or notification service policy based on the identified characteristic. | 11-13-2014 |
20140337520 | Attribution Of Mobile Device Data Traffic To End-User Application Based On Socket Flows - A method performed by a network system communicatively coupled to a device over a wireless access network, the method comprising transmitting a traffic flow to, or receiving the traffic flow from, a software application on the device, the traffic flow comprising one or more related data transfers over the wireless access network, the traffic flow being routed between the software application and the network system through an assisting element comprising a control application or a proxy agent on the device, wherein the traffic flow has a characteristic associating the traffic flow with the first software application, the characteristic preserving the association between the traffic flow and the software application when the traffic flow is routed by the one or more assisting elements; identifying the characteristic; and implementing at least a portion of a control, accounting, or notification service policy based on the identified characteristic. | 11-13-2014 |
20150207708 | Data Usage Monitoring for Media Data Services used by Applications - A wireless end-user device contains a wireless modem, a network stack configurable to receive and transmit network data via the wireless modem, a media service manager, and a service classification agent. The media service manager manages network data transfers for media objects as requested by multiple applications. Even though the media service manager manages the network data transfers, the service classification agent provides a capability to associate network data usage for the network data transfers with the applications that requested the service from the media service manager. | 07-23-2015 |