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Nguyen, MA

Anh Nguyen, Woburn, MA US

Patent application numberDescriptionPublished
20090306476AUTOMATED CONTROL OF IRRIGATION AND ASPIRATION IN A SINGLE-USE ENDOSCOPE - The present invention is an integrated and automated irrigation and aspiration system for use in an endoscopic imaging system. The system provides for the automated cleaning of poorly prepared patients during a colonoscopy procedure as well as automated cleaning of an imaging system of an endoscope. The invention analyzes images obtained from an image sensor to detect the presence of an obstructed field of view, whereupon a wash routine is initiated to remove the obstruction. The wash routine may be adjusted in accordance with environmental conditions within the patient that are sensed by one or more sensors within the endoscope. In another embodiment, insufflation is automatically controlled to inflate a patient's colon as a function of one or more sensor readings obtained from one or more environmental sensor(s) on the endoscope.12-10-2009

Patent applications by Anh Nguyen, Woburn, MA US

Ha Nguyen, Quincy, MA US

Patent application numberDescriptionPublished
20110083974Method and apparatus for monitoring alteration of flow characteristics in a liquid sample - A device for measuring blood coagulation time is formed from a first substrate; a second substrate; a spacer layer disposed between the first and second substrates, said spacer layer having an opening formed therein defining a sample receiving chamber, a vented sink chamber, and an elongated reservoir forming a conduit for liquid movement between the sample receiving chamber and the sink chamber; a first electrode disposed on the first substrate, said first electrode being exposed in the reservoir portion through a first opening in the spacer layer; and a second electrode disposed on the second substrate, said second electrode being exposed in the reservoir portion through a second opening in the spacer layer. The device of the invention is used in combination with an apparatus that is connected to the first and second electrodes for measuring current flow between the first and second electrodes. Changes in observed current are indicative of flow through the device, and a cessation of flow indicates coagulation.04-14-2011

Hanh Nho Nguyen, Arlington, MA US

Patent application numberDescriptionPublished
20090069297Aurora kinase modulators and method of use - The present invention relates to chemical compounds having a general formula I03-12-2009
20100280008AURORA KINASE MODULATORS AND METHOD OF USE - The present invention relates to chemical compounds having a general formula I11-04-2010
20110201602PROTEIN KINASE MODULATORS AND METHOD OF USE - The present invention relates to chemical compounds having a general formula I08-18-2011
20110251190SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE - The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and other related conditions. In one embodiment, the compounds have a general Formula I10-13-2011
20110263530Aurora Kinase Modulators and Method of Use - The present invention relates to chemical compounds having a general formula I10-27-2011
20110294837Aurora Kinase Modulators and Methods of Use - The present invention relates to chemical compounds having a general formula I12-01-2011

Patent applications by Hanh Nho Nguyen, Arlington, MA US

Han Nho Nguyen, Arlington, MA US

Patent application numberDescriptionPublished
20090163501Aurora kinase modulators and method of use - The present invention relates to chemical compounds having a general formula I06-25-2009

Huy Q. Nguyen, Dorchester, MA US

Patent application numberDescriptionPublished
20110053336METHOD FOR SELECTIVE DEPOSITION OF DIELECTRIC LAYERS ON SEMICONDUCTOR STRUCTURES - A method for forming a capacitor and a transistor device on different surface portions of a semiconductor structure includes forming a passivation dielectric layer for the device; forming a bottom electrode for the capacitor; forming a removable layer extending over the bottom electrode and over the passivation dielectric layer with a window therein, such window exposing said bottom electrode; depositing a capacitor dielectric layer of the same or different material as the passivation dielectric layer over the removable layer with first portions passing through the window onto the exposed bottom electrode and second portions being over the removable layer, the thickness of the deposited layer being different from the thickness of the passivation layer; removing the removable layer with the second portions thereon while leaving said first portions on the bottom electrode; and forming a top electrode for the capacitor on the second portions remaining on the bottom electrode.03-03-2011

Jonathan K. Nguyen, Rockland, MA US

Patent application numberDescriptionPublished
20100061897Microencapsulation of amines - A system for microencapsulation of an amine in a polymer shell in an aqueous environment.03-11-2010

Jonathan Kim Nguyen, Lexington, MA US

Patent application numberDescriptionPublished
20110286080ELECTROPHORETIC MEDIA, AND MATERIALS FOR USE THEREIN - An electrophoretic medium comprises a continuous phase and a discontinuous phase. The discontinuous phase comprises a plurality of droplets, each of which comprises a fluid and at least one charged particle disposed within the fluid and capable of moving through the fluid upon application of an electric field to the electrophoretic medium. The continuous phase surrounds and encapsulates the discontinuous phase and comprising a polymeric binder and a salt, the salt having an anion containing at least one fluorine atom and having a water solubility of at least about 0.25 per cent by weight at 25° C.11-24-2011

Khiem Nguyen, Tewksbury, MA US

Patent application numberDescriptionPublished
20080303703Cross-Coupled Switched Capacitor Circuit with a Plurality of Branches - A cross-coupled switched capacitor circuit that has two branches. During a first phase for the first branch, an input voltage is provided that causes charge to move through a resistor and to be placed onto a plate of the capacitor within the branch. An equivalent amount of charge is transferred to an output node. The output node may be a summing node of a sigma-delta modulator. The summing node is one of the inputs to an operational amplifier that is part of the integrator of the sigma-delta modulator. The resistor and the capacitor in the first branch define an RC circuit and corresponding RC time constant. During the first phase, the capacitor does not reach a fully settled voltage for a desired resolution. During the second phase, the capacitor in the first branch of the circuit is set to a defined voltage. The defined voltage may be the settling voltage had the capacitor been allowed to settle during the first phase. The second branch of the switched capacitor feedback circuit operates similar to the first branch, but on opposite phases. By not requiring the voltage to settle during the first phase, power can be conserved, since the integrator of the sigma-delta modulator does not need to operate as fast with respect to movement of charge.12-11-2008
20090102551OPERATIONAL AMPLIFIER WITH IMPROVED CURRENT MONITORING AND SCALABLE OUTPUT - A low-power, low-voltage feedback class AB operational amplifier is disclosed. The minimum supply voltage is one gate-source voltage and two saturation voltages. Currents on the output p-type and n-type transistors are monitored as part of the feedback loop control. Accurate monitoring is achieved by connecting current monitors directly to the corresponding voltage rail. Additional output stages may be selectively connected to the primary output stage to dynamically adjust to changes source conditions. Thus by connecting the appropriate number and type of additional output stages, continuous time adaptive power supply compensation is achieved. Both single ended and differential topologies are described.04-23-2009

Patent applications by Khiem Nguyen, Tewksbury, MA US

Khiem Quang Nguyen, Tewksbury, MA US

Patent application numberDescriptionPublished
20100149012SYSTEM AND METHOD FOR AREA-EFFICIENT THREE-LEVEL DYNAMIC ELEMENT MATCHING - A system for converting digital signals into analog signals using sigma-delta modulation and includes a signed thermometer encoder for converting a plurality of signed binary data received at the encoder into a plurality of signed thermometer data and a rotational dynamic element matching (DEM) arrangement for receiving the plurality of signed binary data and the plurality of signed thermometer data. The rotational DEM arrangement further includes a first barrel shifter for receiving a positive thermometer data at a cycle, the first barrel shifter having a first pointer indicating a starting position of next positive thermometer data, and a second barrel shifter for receiving a negative thermometer data at a cycle, the second shifter having a second pointer indicating a starting position of next negative thermometer data, wherein the first pointer is circularly shifted as a function of positive binary data and the second pointer is circularly shifted as a function of negative binary data.06-17-2010

Linh Tuong Nguyen, Randolph, MA US

Patent application numberDescriptionPublished
20110112576Tissue Repair Devices - The present disclosure relates to an anchor assembly. The anchor assembly includes an anchor defining a cavity and an opening to the cavity; and a headless insertion member configured for arrangement within the anchor cavity, the insertion member including a body having a threaded proximal portion, a non-threaded distal portion, and a cannulation extending a partial length of the insertion member. Other anchor assemblies, anchors, and delivery devices are also disclosed.05-12-2011

Lonnissa Nguyen, Cambridge, MA US

Patent application numberDescriptionPublished
20110262493MULTI-LAYERED HYDROGEL CONSTRUCTS AND ASSOCIATED METHODS - Multi-layered hydrogel constructs comprising: a first layer comprising a first polymerizable material, hyaluronic acid and a plurality of cells; a second layer comprising a second polymerizable material, chondroitin sulfate and a plurality of cells; and a third layer comprising a third polymerizable material, chondroitin sulfate, a matrix metalloprotease sensitive peptide, and a plurality of cells are provided. Associated methods are also provided.10-27-2011

Nam Hoang Nguyen, Lowell, MA US

Patent application numberDescriptionPublished
20110213761SEARCHABLE WEB SITE DISCOVERY AND RECOMMENDATION - A searchable web site discovery and recommendation system and method for discovering and recommending searchable web sites to a user of a search engine. In general, given a search query by a user embodiments of the system and method discover and then recommend a list of searchable web sites. Embodiments of the system and method discover and recommend searchable web sites using client-side query behavior logs. A set of descriptive features is automatically extracted from the logs. In addition, embodiments of the system and method expand the initial search query by submitting the query to a general search engine and leveraging snippets from the search engine results. Embodiments of the system and method model a conditional probability of a searchable web site based on four components and the extracted descriptive features. A ranked list of recommended searchable web sites is obtained from the conditional probability and displayed to a user.09-01-2011

Nguyen D. Nguyen, Dorchester, MA US

Patent application numberDescriptionPublished
20090243912Automotive Radar Sensor Blockage Detection System and Related Techniques - A blockage detection system and method for use in a sensor such as a side object detection (SOD) sensor in an automotive radar system is described. The sensor emits signals and receives return signals (i.e. reflected signals) from a passing object. If the passing object is within a virtual detection zone, the sensor uses the information from the passing object to determine if a blockage condition exists in the sensor. The technique utilizes statistics related to the passing object to determine whether a blockage condition exists within the sensor. In one embodiment, a SOD sensor mounted in a first vehicle uses information from a second passing vehicle (e.g. radar return information) to determine whether a blockage condition exists within the SOD sensor itself.10-01-2009

Nhung Nguyen, Westford, MA US

Patent application numberDescriptionPublished
20110098267TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS - The invention relates to a topical composition and a method for treating psoriasis. The topical composition comprises one or more compound that inhibits the production of IL-12 and IL-23.04-28-2011

Peter Q. Nguyen, Boston, MA US

Patent application numberDescriptionPublished
20110287462PROTEIN FRAGMENT COMPLEMENTATION ASSAY FOR THERMOPHILES - A protein fragment complementation assay for thermophiles is provided wherein a thermophilic bacteria having a temperature-sensitive adenylate kinase is transformed with one or more vectors having sequences encoding a first test peptide operatively fused to a first portion of a thermostable adenylate and a second test peptide operatively fused to a second portion of the thermostable adenylate kinase. Association of the first and second test peptides allows association of the first and second portions of the thermostable adenylate kinase and growth of the thermophilic bacteria at a temperature greater than 70° C.11-24-2011

Phu C. Nguyen, Cambridge, MA US

Patent application numberDescriptionPublished
20110305909ARTICLES HAVING NON-FOULING SURFACES AND PROCESSES FOR PREPARING THE SAME WITHOUT ALTERING BULK PHYSICAL PROPERTIES - Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.12-15-2011

Phuong Nguyen, Cambridge, MA US

Patent application numberDescriptionPublished
20090325903BORONATE ESTER COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF - The present invention provides novel compounds useful as proteasome inhibitors. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.12-31-2009
20110130327Multi-Arm Amines and Uses Thereof - Multi-arm amine compounds and compositions for enhancing intracellular, in vitro, and in vivo delivery of drug, active, and therapeutic substances including ribonucleic acids. This disclosure provides novel compounds and compositions for making and using delivery materials and carriers which increase the efficiency of delivery of biologically active and pharmacologically active molecules. Embodiments of this disclosure may further provide delivery of various therapeutic agents including nucleic acid therapeutics such as regulatory RNA, interfering RNA, and agents for RNAi, as well as other protein and peptide therapeutics. In some aspects, this disclosure provides multi-arm amine compounds and compositions which can enhance permeation of a drug substance.06-02-2011

Thi T. Nguyen, Saugus, MA US

Patent application numberDescriptionPublished
20090192220TREATMENT FOR SOLID TUMORS - A method for treating a solid tumor in a subject comprises administering to the subject an ACAT inhibitory compound or a prodrug thereof, for example avasimibe, wherein (a) the solid tumor is at least about 2 mm in diameter and (b) the compound or prodrug thereof is administered in an amount that is therapeutically effective, but ineffective to cause unacceptable toxicity to normoxic tissues.07-30-2009

Toan B. Nguyen, Reading, MA US

Patent application numberDescriptionPublished
20100160314Small Molecule Inhibitors of Toll-Like Receptor 9 - Small molecule compounds and compositions containing said compounds useful for inhibiting signaling by certain Toll-like receptors (TLRs), particularly TLR9, are provided. The compounds and compositions can be used to inhibit immune responses, including unwanted immune responses in particular. Compounds, compositions, and methods are provided to treat a variety of conditions involving unwanted immune responses, including for example autoimmune disease, inflammation, transplant rejection, and sepsis.06-24-2010

Truong Q. Nguyen, Burlington, MA US

Patent application numberDescriptionPublished
20100166077APPARATUS AND METHOD FOR COMPRESSING VIDEO INFORMATION - A method and apparatus is disclosed for efficiently encoding data representing a video image, thereby reducing the amount of data that must be transferred to a decoder. The method includes transforming data sets utilizing a tensor product wavelet transform which is capable of transmitting remainders from one subband to another. Collections of subbands, in macro-block form, are weighted, detected, and ranked enabling prioritization of the transformed data. A motion compensation technique is performed on the subband data producing motion vectors and prediction errors which are positionally encoded into bit stream packets for transmittal to the decoder. Subband macro-blocks and subband blocks which are equal to zero are identified as such in the bit stream packets to further reduce the amount of data that must be transferred to the decoder.07-01-2010

Vinh Nguyen, Chelsea, MA US

Patent application numberDescriptionPublished
20100291060SUBCUTANEOUS ADMINISTRATION OF ALPHA-GALACTOSIDASE A - The invention relates, in part, to improved methods of administering α-galactosidase A for the treatment of α-galactosidase A deficiencies including Fabry disease.11-18-2010

Vinh T. Nguyen, Chelsea, MA US

Patent application numberDescriptionPublished
20110091414STABILIZED COMPOSITIONS OF PROTEINS HAVING A FREE THIOL MOIETY - Compositions of proteins having free thiols, and methods of making and using such compositions, are described.04-21-2011