Ng, MA
Arthur Y. Ng, Waltham, MA US
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20140089980 | SYSTEM AND METHOD FOR MODIFYING ADVERTISEMENT RESPONSIVE TO EPG INFORMATION - A system and method for utilizing data stored in an EPG database for modifying advertisement information. In this way, a service provider and/or an advertiser can transmit a single advertisement to all the television stations regardless of their geographic location and other user specific information, and need not re-transmit the advertisement even if there is a change in the show's program description. When the advertisement is displayed, the correct updated information is retrieved from the EPG database and inserted into the advertisement. | 03-27-2014 |
20140208362 | SYSTEM AND METHOD FOR MODIFYING ADVERTISEMENT RESPONSIVE TO EPG INFORMATION - A system and method for utilizing data stored in an EPG database for modifying advertisement information. In this way, a service provider and/or an advertiser can transmit a single advertisement to all the television stations regardless of their geographic location and other user specific information, and need not re-transmit the advertisement even if there is a change in the show's program description. When the advertisement is displayed, the correct updated information is retrieved from the EPG database and inserted into the advertisement. | 07-24-2014 |
Billy Ng, Wakefield, MA US
Patent application number | Description | Published |
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20090086622 | Method and Apparatus for Performing a Graceful Restart in a NSF-Capable Router Without Enhancing Link State Routing Protocols - A graceful restart is provided in a NSF capable router. When a switchover to a standby controller is required, the standby controller receives replicated link state message headers from an active controller. The standby controller generates a link state request (LSR) message from the link state message headers and transmits the LSRs to neighboring routers. The standby controller receives a link state update that includes the link state messages. By using the LSRs, the standby controller can be quickly synchronized with its neighbors well within the grace period, thereby maintaining adjacency. | 04-02-2009 |
Chee-Keng Ng, Arlington, MA US
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20090017460 | DIFFERENTIAL EXPRESSION PROFILING ANALYSIS OF CELL CULTURE PHENOTYPES AND USES THEREOF - The present invention provides, among other things, systems and methods for identifying genes and proteins that regulate and/or are indicative of cell phenotypes based on expression profiling analysis. The present invention further provides methods of manipulating identified genes and proteins to engineer improved cell lines. | 01-15-2009 |
Chee-Kiong Ng, Acton, MA US
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20130009578 | ELECTRONIC CIRCUIT AND METHOD GENERATING ELECTRIC MOTOR DRIVE SIGNALS HAVING PHASE ADVANCES IN ACCORDANCE WITH A USER SELECTED RELATIONSHIP BETWEEN ROTATIONAL SPEED OF AN ELECTRIC MOTOR AND THE PHASE ADVANCES - An electronic circuit and an associated method used to drive an electric motor provide a user selectable relationship between rotational speed of the electric motor and phase advances of signals used to drive the electric motor. By selecting the relationship, efficiency of the electric motor drive can be improved. | 01-10-2013 |
20130099704 | Motor Control Circuit And Method That Reduce Speed Jitter Of An Electric Motor - Motor control circuits and associated methods to control an electric motor provide a plurality of drive signal channels at the same phase, resulting in reduced jitter in the rotational speed of the electric motor. | 04-25-2013 |
20130099706 | Motor Control Circuit And Method That Synchronize A Speed Of An Electric Motor To An External Clock Signal - Motor control circuits and associated methods to control an electric motor provide an ability to synchronize a rotational speed of the electric motor with an external clock signal, resulting in reduced jitter in the rotational speed of the electric motor. | 04-25-2013 |
20140055064 | Systems and Methods for Controlling Motor Speeds - Electronic circuits for controlling the speed of a motor include a receiving node coupled to receive a speed command signal representative of a desired final speed of the motor. A speed control circuit applies a selected amount of power to a motor to allow a speed of the motor to approach a predetermined final speed, where the selected amount of power provided is based on the desired final speed of the motor. A signal represents the speed of the motor and a feedback circuit uses the signal to regulate the speed of the motor by phase-locking the speed of the motor to the speed command signal once the speed of the motor falls within a predetermined threshold of the final speed. Methods for controlling the speed of a motor are also disclosed. | 02-27-2014 |
20140167666 | Systems and Methods for Reduction of Motor Jitter While Driving an Electric Motor - An apparatus for driving a motor comprises a drive signal generation circuit configured to produce pulses on a pulse-width modulated drive signal in response to a control signal. A detection circuit is coupled to receive a commutation signal from the motor to monitor the speed of the motor. A control signal generation circuit is configured to dynamically generate the control signal so that a frequency of pulse-width modulated drive signal corresponds with the duration of the phase of the motor, so as to reduce the occurrence of an incomplete pulse on the drive signal. Methods for driving a motor are also disclosed. | 06-19-2014 |
20140292247 | System and Method for Serial Communication by an Electronic Circuit - A motor driver includes at least two terminals suitable for being coupled to a motor controller and to receive a motor command signal and transmit a motor status signal when the motor driver is controlling a motor. A serial data communication circuit may be configured to send and receive serial data over the at least two terminals when the at least two terminals are idle. | 10-02-2014 |
Dennis Ng, Northboro, MA US
Patent application number | Description | Published |
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20100202362 | Network-Initiated Session Recovery - Techniques for network-initiated session recovery are described. A relationship is maintained between two identifiers both associated with a session between a first device and an access terminal in a wireless network. The first identifier is associated with the first device, and the second identifier is associated with a second device in communication with the first device. After a breach of the session, communications associated with the session are preserved based on the relationship between the first and second identifiers. | 08-12-2010 |
Howard Ng, Belmont, MA US
Patent application number | Description | Published |
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20090018147 | Compounds for modulating TRPV3 function - The present application relates to compounds and methods for treating pain and other conditions related to TRPV3. | 01-15-2009 |
20090143377 | METHODS AND COMPOSITIONS FOR TREATING DISORDERS - Compounds and compositions for treating disorders related to TRPA1 are described herein. | 06-04-2009 |
20110151559 | Compounds for Modulating TRPV3 Function - The present application relates to compounds and methods for treating pain and other conditions related to TRPV3. | 06-23-2011 |
Howard P. Ng, Belmont, MA US
Patent application number | Description | Published |
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20100173413 | PYRIDINE COMPOUNDS - This invention features compounds of formula (I): | 07-08-2010 |
20110009397 | TRIAZONE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 01-13-2011 |
20110105749 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 05-05-2011 |
20110294798 | IL-12 MODULATORY COMPOUNDS - The invention relates to cyclic hydrazone compounds, compositions including the cyclic hydrazone compounds and methods of using and methods of making thereof. The compounds (and compositions) are useful, inter alia, in modulating IL-12 production and processes mediated by IL-12. | 12-01-2011 |
20110319447 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 12-29-2011 |
20120122869 | TRIZAOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 05-17-2012 |
20120330009 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY - The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of Hsp90 in a subject in need thereof and methods for preventing or treating hyperproliferative disorders, such as cancer, in a subject in need thereof comprising administering to the subject a substituted triazole compound of the invention, or a composition comprising such a compound. | 12-27-2012 |
Kenney Ng, Littleton, MA US
Patent application number | Description | Published |
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20110153635 | Interactive Visualization of Sender and Recipient Information In Electronic Communications - An approach is provided that visually distinguishes between entity types in a communication system. A Data store with entities is queried, with entities connected to one another as senders and receivers, resulting in a query result. A node data structure corresponding to each of the entities is created and an edge data structure corresponding to each of the connections between the entities is also created. Nodes corresponding to the node data structures are displayed, along with edges (e.g., connection lines) corresponding to the edge data structures. A user selects one of the nodes that is displayed, and the selected node is visually highlighted. Different types of non-selected nodes are identified based on the selected node. Types of nodes may include sender type nodes, receiver type nodes, and sender/receiver type nodes. The types of identified nodes are highlighted in a manner that visually distinguishes each type from the other types. | 06-23-2011 |
20130226951 | Interactive Visualization Of Sender and Recipient Information In Electronic Communications - An approach is provided that visually distinguishes between entity types in a communication system. A Data store with entities is queried, with entities connected to one another as senders and receivers, resulting in a query result. A node data structure corresponding to each of the entities is created and an edge data structure corresponding to each of the connections between the entities is also created. Nodes corresponding to the node data structures are displayed, along with edges (e.g., connection lines) corresponding to the edge data structures. A user selects one of the nodes that is displayed, and the selected node is visually highlighted. Different types of non-selected nodes are identified based on the selected node. Types of nodes may include sender type nodes, receiver type nodes, and sender/receiver type nodes. The types of identified nodes are highlighted in a manner that visually distinguishes each type from the other types. | 08-29-2013 |
Kenney Ng, Arlington, MA US
Patent application number | Description | Published |
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20110029491 | DYNAMICALLY DETECTING NEAR-DUPLICATE DOCUMENTS - Techniques for detecting one or more documents that are duplicate or near-duplicate of a first document are provided. The techniques include obtaining a first document, obtaining one or more additional documents, retrieving a set of one or more document signatures for each document, and detecting one or more documents that are duplicate or near-duplicate of the first document by detecting each of the one or more additional documents that have at least a minimum number of signatures in common with the first document, wherein detecting each of the one or more additional documents that have at least a minimum number of signatures in common with the first document comprises dynamically using at least one of a user-configurable similarity definition and a user-configurable similarity threshold value. | 02-03-2011 |
20120066209 | ELECTRONIC MAIL DUPLICATE DETECTION - Embodiments of the invention are related to a method and system for identifying linked electronic mails by receiving a query from a user, wherein the query comprises at least a segment of an electronic mail; and based on the segment received, rendering to the user at least one of related subsets or a related supersets of electronic mails related to the received segment, wherein the related subsets and related supersets are threads of the segment received and arranged in a hierarchical manner. | 03-15-2012 |
20120066227 | E-MAIL THREAD HIERARCHY DETECTION - A plurality of segments in an e-mail collection by parsing content of e-mails is generated. Corresponding segment signature for each segment is created and a signature index is populated using the generated segment signatures. After receiving a query e-mail, a plurality of query segments in the query e-mail is generated using content of the query e-mail and corresponding query segment signature for each query segment is generated. A query root segment is identified and corresponding query root segment signature is generated. A set of root segment signatures of the signature index is identified and the query root segment signature is compared with each root segment signature from the signature index. A subset of the signature index is identified, using a match between the root segment signature and the query root segment signature. An e-mail thread hierarchy is built using the identified subset of the signature index. | 03-15-2012 |
20120150867 | CLUSTERING A COLLECTION USING AN INVERTED INDEX OF FEATURES - Provided are techniques for creating an inverted index for features of a set of data elements, wherein each of the data elements is represented by a vector of features, wherein the inverted index, when queried with a feature, outputs one or more data elements containing the feature. The features of the set of data elements are ranked. For each feature in the ranked list, the inverted index is queried for data elements having the feature and not having any previously selected feature and a cluster of the data elements is created based on results returned in response to the query. | 06-14-2012 |
Kok-Hwee Ng, Stow, MA US
Patent application number | Description | Published |
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20090192566 | Device for and Method of Generating a Baroreflex Response - This patent relates to a device for and method of stimulating the carotid sinus baroreceptors to achieve a restoration or resetting of baroreflex response and natural blood pressure modulation. The stimulation may consist of low amplitude, wide bandwidth signals that produce a stochastic resonance effect. The ultimate affect is blood pressure modulation within a reduced range including establishment of thresholds at which baroreceptors trigger normal central nervous system functions. | 07-30-2009 |
Man Cheuk Ng, Cambridge, MA US
Patent application number | Description | Published |
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20080282032 | ADAPTIVE MECHANISMS AND METHODS FOR SUPPLYING VOLATILE DATA COPIES IN MULTIPROCESSOR SYSTEMS - In a computer system with a memory hierarchy, when a high-level cache supplies a data copy to a low-level cache, the shared copy can be either volatile or non-volatile. When the data copy is later replaced from the low-level cache, if the data copy is non-volatile, it needs to be written back to the high-level cache; otherwise it can be simply flushed from the low-level cache. The high-level cache can employ a volatile-prediction mechanism that adaptively determines whether a volatile copy or a non-volatile copy should be supplied when the high-level cache needs to send data to the low-level cache. An exemplary volatile-prediction mechanism suggests use of a non-volatile copy if the cache line has been accessed consecutively by the low-level cache. Further, the low-level cache can employ a volatile-promotion mechanism that adaptively changes a data copy from volatile to non-volatile according to some promotion policy, or changes a data copy from non-volatile to volatile according to some demotion policy. | 11-13-2008 |
20090043966 | Adaptive Mechanisms and Methods for Supplying Volatile Data Copies in Multiprocessor Systems - In a computer system with a memory hierarchy, when a high-level cache supplies a data copy to a low-level cache, the shared copy can be either volatile or non-volatile. When the data copy is later replaced from the low-level cache, if the data copy is non-volatile, it needs to be written back to the high-level cache; otherwise it can be simply flushed from the low-level cache. The high-level cache can employ a volatile-prediction mechanism that adaptively determines whether a volatile copy or a non-volatile copy should be supplied when the high-level cache needs to send data to the low-level cache. An exemplary volatile-prediction mechanism suggests use of a non-volatile copy if the cache line has been accessed consecutively by the low-level cache. Further, the low-level cache can employ a volatile-promotion mechanism that adaptively changes a data copy from volatile to non-volatile according to some promotion policy, or changes a data copy from non-volatile to volatile according to some demotion policy. | 02-12-2009 |
Nicholas Ng, San Diego, MA US
Patent application number | Description | Published |
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20150125857 | CANCER PATIENT SELECTION FOR ADMINISTRATION OF Wnt SIGNALING INHIBITORS USING RNF43 MUTATION STATUS - Disclosed are biomarkers, methods and assay for the identification of cancer patients who are predicted to benefit from the therapeutic administration of Wnt antagonist. The biomarkers include detection of RNF43 and ZNRF3 gene deletion, reduced RNF43 and ZNRF3 mRNA expression, reduced RNF43 and ZNRF3 protein expression, RNF43 and ZNRF3 inactivation mutation, phosphorylated LRP6, phophorylated Dishevelleds, and the expression of Frizzleds. These biomarkers can be associated with the better outcome for cancer patients treated with Wnt pathway inhibitors. | 05-07-2015 |
Pei-Sze Ng, Cambrige, MA US
Patent application number | Description | Published |
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20130011445 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 01-10-2013 |
Pei-Sze Ng, Cambridge, MA US
Patent application number | Description | Published |
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20100247668 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 09-30-2010 |
20100247669 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 09-30-2010 |
20100285144 | POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer or neurological deficits. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 11-11-2010 |
20110189092 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 08-04-2011 |
20110237686 | FORMULATIONS AND METHODS OF USE - The invention relates to the liquid and lyophilized formulations of small particulates, liposomes, and micelles, and methods for making and using the formulations. In particular, at least in some embodiments, the present invention relates to the production and lyophilization of PEGylated nanoparticles, microparticles, micelles, and liposomes for use and administration in to a subject. | 09-29-2011 |
20110262490 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 10-27-2011 |
20110268658 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 11-03-2011 |
20120225129 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS - Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions. | 09-06-2012 |
20120282306 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 11-08-2012 |
20120302505 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY - Described herein are CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. Also disclosed are methods of using (e.g., to treat a disorder) the CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. | 11-29-2012 |
20120302622 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS - Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions. | 11-29-2012 |
20130202659 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 08-08-2013 |
20130210724 | Cyclodextrin-Based Polymers for Therapeutic Delivery - Described herein are CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. Also disclosed are methods of using (e.g., to treat a disorder) the CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. | 08-15-2013 |
20140037573 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS - Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions. | 02-06-2014 |
20140072633 | POLYMER-EPOTHILONE CONJUGATES, PARTICLES, COMPOSITIONS AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer or neurological deficits. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 03-13-2014 |
20140099263 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 04-10-2014 |
20140135254 | THERAPEUTIC PEPTIDE-POLYMER CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS - Described herein are conjugates (e.g., therapeutic peptide-polymer conjugates and protein-polymer conjugates) and particles, which can be used, for example, in the treatment of a disorder such as cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the conjugates (e.g., therapeutic peptide-polymer conjugates and protein-polymer conjugates) and particles, methods of making the conjugates (e.g., therapeutic peptide-polymer conjugates and protein-polymer conjugates) and particles, methods of storing the particles and methods of analyzing the particles. | 05-15-2014 |
20140193510 | Polymer-Agent Conjugates, Particles, Compositions, and Related Methods of Use - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 07-10-2014 |
20140213504 | Cyclodextrin-Based Polymers for Therapeutic Delivery - Described herein are CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. Also disclosed are methods of using (e.g., to treat a disorder) the CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates, dosage forms comprising CDP-therapeutic peptide conjugates, and kits comprising CDP-therapeutic peptide conjugates. | 07-31-2014 |
20140286873 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 09-25-2014 |
20140296322 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Particles and conjugates for delivering nucleic acid agents. Compositions containing the particles, the conjugates, or both. Methods of using the particles, the conjugates, and the compositions. | 10-02-2014 |
20140328919 | POLYMER-AGENT CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE - Described herein are polymer-agent conjugates and particles, which can be used, for example, in the treatment of cancer. Also described herein are mixtures, compositions and dosage forms containing the particles, methods of using the particles (e.g., to treat a disorder), kits including the polymer-agent conjugates and particles, methods of making the polymer-agent conjugates and particles, methods of storing the particles and methods of analyzing the particles. | 11-06-2014 |
Pui Yee Ng, Boston, MA US
Patent application number | Description | Published |
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20090012080 | Sirtuin modulating compounds - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 01-08-2009 |
20090099170 | Sirtuin modulating compounds - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 04-16-2009 |
20090105246 | Sirtuin modulating compounds - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 04-23-2009 |
20110015192 | SIRTUIN MODULATING COMPOUNDS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benfit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 01-20-2011 |
20110130387 | SIRTUIN MODULATING COMPOUNDS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 06-02-2011 |
20110152254 | SIRTUIN MODULATING COMPOUNDS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 06-23-2011 |
20120022254 | SIRTUIN MODULATING COMPOUNDS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 01-26-2012 |
20120197013 | SIRTUIN MODULATING COMPOUNDS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 08-02-2012 |
20120252780 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 10-04-2012 |
Pui Yee Ng, Cambridge, MA US
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20110077248 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 03-31-2011 |
20110124637 | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS - Provided herein are sirtuin-modulating compounds of formula (II). The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders relating to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 05-26-2011 |
20110306609 | THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS - Provided herein are novel sirtuin-modulating compounds of Structural Formula (Ia) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 12-15-2011 |
20110319411 | ISOINDOLINONE AND RELATED ANALOGS AS SIRTUIN MODULATORS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 12-29-2011 |
20130085155 | THIAZOLOPYRIDINE SIRTUIN MODULATING COMPOUNDS - Provided herein are novel sirtuin-modulating compounds of Structural Formula (Ia) and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 04-04-2013 |
Pui Yee Ng, Waltham, MA US
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20150057272 | BENZIMIDAZOLES AND RELATED ANALOGS AS SIRTUIN MODULATORS - Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent. | 02-26-2015 |
Richard M. Ng, Needham, MA US
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20090006985 | USING INTERACTIVE SCRIPTS TO FACILITATE WEB-BASED AGGREGATION - Some embodiments of the present invention provide a system that facilitates interactivity during automated web-site accesses. During operation, the system executes a script which automatically accesses one or more websites. While executing the script, the system retrieves user-specific data associated with a user. The system then uses the user-specific data to access a target website. While accessing the target website, the system receives an interactivity request which the system presents to the user. The system then receives a response to the interactivity request from the user, and forwards the response to the website. | 01-01-2009 |
Sheau Ng, Wayland, MA US
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20100034522 | System and Method for Providing Digital Content - A method and device for receiving, storing, and viewing digital content, the method and device configured to receive and store a first content and a second content, associate the second content with the first content, and play the first content and the second content. | 02-11-2010 |
20110145849 | VIEWER-PERSONALIZED BROADCAST AND DATA CHANNEL CONTENT DELIVERY SYSTEM AND METHOD - Data is transmitted by or collected from individual receivers of broadcast content on a particularized basis. The broadcast content is transmitted without regard to selection of a particular content stream by any one or more receivers. The receiver data is analyzed, and may be analyzed in conjunction with other information such as details on broadcast content streams made during certain times, and selections of broadcast streams by particular receivers. System configuration changes and targeted content may then be transmitted by a bidirectional data exchange medium to the individualized receivers based upon the analysis. | 06-16-2011 |
20110145850 | DUAL CHANNEL AUDIENCE CUSTOMIZED BROADCAST DELIVERY SYSTEM AND METHOD - The broadcast of content over a unidirectional broadcast channel is adjusted by analysis of data received from receivers of the content via a bidirectional data exchange channel. The broadcast may be altered in signal, signal strength, signal direction, encoding, and so forth. The receivers may communicate the data over any suitable network, such as the Internet. The data may include past, current and planned selections of content, as well as geographic and demographic information, when available. | 06-16-2011 |
20120254404 | MULTI-TIERED AUTOMATIC CONTENT RECOGNITION AND PROCESSING - A multi-tiered approach to identifying digital content and acting upon the identification includes transmitting data from a device on which the content is stored or played to a first tier entity where the content and the device are identified. The first tier entity may use any one of many techniques for identifying the data and device. Once the identification data is determined, the information is transmitted to any one of multiple second tier entities that work in cooperation with the first tier entity. The second tier entities may then perform any desired functions based on the identification, such as providing offers, content, products and/or services to the device, or to other devices associated with the device or the device user. Other tiers may be employed for carrying out particular functions or activities, such as under the direction of the second tier entities. | 10-04-2012 |
20120300971 | MULTI-CHANNEL DIGITAL CONTENT WATERMARK SYSTEM AND METHOD - A multi-channel embedded data technique allows for embedding data, such as watermarks into multiple channels of audio, video, multi-media, and other digitized content streams. Two or more of the channels may be utilized. The embedded data may be segmented within each channel, and these segments may start and stop at identical times, or may be staggered or offset from one another. The available payload may be used for different data, or redundant data, providing enhanced reliability. Staggering allows for more rapid availability of at least some of the embedded data segments. References may be used between channels and between data streams to provide for highly complex configurations of encoding and decoding of the embedded data. | 11-29-2012 |
20140122512 | METHOD AND SYSTEM FOR MATCHING OBJECTS HAVING SYMMETRICAL OBJECT PROFILING - A system is described that implements symmetrical object profiles across one or more objects, wherein an object profile is influenced by other object profiles with which it interacts. In particular, the system includes a configuration for a first object profile that is associated with a first object, wherein the first object profile comprises a set of attributes having a first set of valuations. The system includes a configuration for a second object profile that is associated with a second object, wherein the second object profile comprises said set of attributes having a second set of valuations. The system includes a profile updater for managing the first object profile and the second object profile, wherein in a transaction involving the first and second objects, corresponding object profiles are updated based on valuations in the first and second set of valuations. | 05-01-2014 |
20140157347 | FLEXIBLE BROADCAST SYSTEM AND METHOD - Broadcasts over designated bands of the radiofrequency spectrum allow for flexible use of the spectrum as well as for the receipt of return signals from receivers. To obtain return signals, information indicating one or more return channels and/or one or more return time windows may be sent with the broadcast transmission. The broadcast transmission may be made over UHF bands, with the return signals being made over VHF bands. Spectrum may be utilized more efficiently by transmitting one or more beacon signals that define parameters for the broadcast transmission. Receivers may be adapted to decode the data of the beacon signals and rapidly tune to the broadcast transmission. | 06-05-2014 |
20140337091 | METHOD AND SYSTEM FOR CONTEXTUAL PROFILING FOR OBJECT INTERACTIONS AND ITS APPLICATION TO MATCHING SYMMETRICAL OBJECTS - A method for constructing a context profile within a system implementing symmetrical object profiles. The method includes establishing one or more contextual boundary parameters defining a context within which transactions occur. A plurality of transactions associated with the context is filtered using the contextual boundary parameters to obtain a pool of filtered transactions. Each of the transactions is conducted between at least two objects in the system including a plurality of objects associated with the symmetrical object profiles. An array of filtered objects including objects involved in at least one filtered transaction is established. Each filtered object is defined by a current version of a corresponding object profile and is associated with a corresponding transaction. The method includes generating a context object profile associated with the context that is based on attribute values of filtered object profiles associated with the array of filtered objects. | 11-13-2014 |
Sheau-Bao Ng, Wayland, MA US
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20090248747 | REMOVABLE MEMORY INFORMATION MANAGEMENT - A method and structure manage a database. A first device that includes data is coupled to a second device that includes metadata relating to the data. The second device is removed from the first device and the metadata is modified. The second device is again coupled to the first device and the modified metadata on the second device modifies the data on the first device. | 10-01-2009 |
20120030209 | METADATA/CONTENT RE-ASSOCIATION SYSTEM AND METHOD - Digital content, such as video, audio, multimedia, and similar files may be associated with metadata that is in some manner descriptive of the content by means of a unique identifier generated based on the content or a portion of the content. The two may be packaged in a wrapper. If the content is separated from the metadata, such as by circulation in a non-compliant environment, the content may be recognized by a regeneration of the identifier. Based upon the re-created identifier, the metadata may be re-associated with the content. Other scenarios may include generation of compilations for files that are not included in a wrapper with content and metadata, content that becomes dissociated with metadata by transcoding, and so forth. | 02-02-2012 |
20120042349 | BROADCAST/DIGITAL NETWORK SWITCHOVER SYSTEM AND METHOD - A technique is provided for the parallel communication of digital content via broadcast channels and two-way data communications channels. Mobile devices may receive the digital content by the broadcast channels, and depending upon user preferences, signal quality, signal strength and other factors, coordinated switchover may be made from reception and playback of the content from a broadcast channel to reception and content from a two-way data communications channel. | 02-16-2012 |
20120110608 | DIGITAL CONTENT AND RESPONSE PROCESSING SYSTEM AND METHOD - Systems and methods are provided for allowing responses to offers displayed with digital content. The responses may be provided on a receiver system via a conventional feedback through the same distribution channel through which the content and offer were provided, or through an alternative channel, with data being transmitted from an alternative channel device to a transacting entity. For time-shifted playback, content is identified and time-adapted offers may be provided, taking into account factors such as the content, the time of play back, the date of play back, and so forth. The alternate response channel may be more suitable for time-adapted offer responses then for contemporaneously transmitted offers. | 05-03-2012 |
20120110627 | TIME-ADAPTED CONTENT DELIVERY SYSTEM AND METHOD - A system for coordinated playback of time-shifted content with time-adapted complimentary content is provided. The time-shifted content may be played back from storage media, both local and remote. Time-shifting may occur by independent playback such as from optical discs and other memory devices, as well as from user manipulation of features in a playback system based upon real-time or near real-time content distribution. The content is identified, along with timing information identifying where in the content the playback is occurring. Time-adapted complimentary content may then be selected and transmitted to the playback system. Such time-adapted content may include advertisement, product and service offerings, complimentary information, audio and/or video content, and so forth. | 05-03-2012 |
Shengyong Ng, Cambridge, MA US
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20120216304 | HUMANIZED ANIMALS VIA TISSUE ENGINEERING AND USES THEREOF - Engineered human tissue constructs are provided that are suitable for use in making humanized animals for use in pharmaceutical development. Humanized animals having the constructs implanted in vivo are provided. Methods of making and using the tissue-engineered constructs and humanized animals are also provided. | 08-23-2012 |
Siu Lung Ng, Stoneham, MA US
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20130093031 | SYSTEMS AND METHODS FOR AIR-RELEASE IN CAVITY PACKAGES - A housing for integrated devices that includes an air-release mechanism is disclosed. This is achieved, in various embodiments, by forming a vent hole in a package substrate, and arranging a package lid over the package substrate. The vent hole allows air to be released from within the cavity package, thereby ensuring that the package lid remains stably affixed to the package substrate despite increased temperatures during processing. The vent hole may be sealed upon mounting the package onto a mounting substrate. | 04-18-2013 |
Sze-Ling Ng, Somerville, MA US
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20150079052 | Methods for amelioration of autoimmune disease using stem cells transduced with T cell receptors from IL-10 secreting T cells - Methods, cells and vectors are provided for treating a subject for an autoimmune disease using stem cells transduced with genes encoding T cell receptors from IL-10 secreting regulatory T cells. The IL-10 secreting regulatory T cells are obtained from a donor of stem cells, the donor having been immunized with peptidic compositions used in the treatment of the autoimmune disease. | 03-19-2015 |
Tat Fong Ng, Somerville, MA US
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20090238800 | ISOLATION AND THERAPEUTIC APPLICATION OF ADULT RETINAL STEM CELLS COLLECTED FROM EXTRA-RETINAL TISSUES - The present invention is directed to an adult retinal cell line isolated from extra-retinal ocular tissue, and methods of isolating adult retinal cells from extra-retinal ocular tissue. The present invention is further directed to adult retinal stem cells isolated from vestigial tissue dissected from the eye of a donor mammal suffering from persistent fetal vasculature. The present invention is further directed to a culture medium for growing or maintaining retinal stem cells, and methods of maintaining adult retinal cells in culture. The present invention is further directed to methods of treating a treating an eye with retinal dystrophy using retinal stem cells, and an eye with glaucomatous injury with retinal stem cells. The present invention is further directed to kits for harvesting extra-retinal ocular tissue comprising a sterile container and a harvesting solution, wherein the kit allows the survival of the tissue until later dissociation of cells from the tissue. | 09-24-2009 |
Tung Ng, Andover, MA US
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20120005366 | METHOD AND APPARATUS FOR RETRIEVING AND RENDERING LIVE STREAMING DATA - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. A file format compatible with legacy HTTP infrastructure is used to deliver media over a persistent connection. Legacy client media players can dynamically change the encoded rate of the media delivered over a persistent connection. Standard HTTP servers may be used without modification, leveraging standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. | 01-05-2012 |
Tung Ng, North Andover, MA US
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20120004960 | METHOD AND SYSTEM FOR EFFICIENT STREAMING VIDEO DYNAMIC RATE ADAPTATION - A streaming media system employs dynamic rate adaptation. The method includes a file format compatible with legacy HTTP infrastructure to deliver media over a persistent connection. The method further includes the ability for legacy client media players to dynamically change the encoded delivery rate of the media over a persistent connection. The method provided works transparently with standard HTTP servers, requiring no modification and leverages standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. A system is also specified for implementing a client and server in accordance with the method. | 01-05-2012 |
20120005365 | METHOD AND SYSTEM FOR EFFICIENT STREAMING VIDEO DYNAMIC RATE ADAPTATION - A streaming media system employs dynamic rate adaptation. The method includes a file format compatible with legacy HTTP infrastructure to deliver media over a persistent connection. The method further includes the ability for legacy client media players to dynamically change the encoded delivery rate of the media over a persistent connection. The method provided works transparently with standard HTTP servers, requiring no modification and leverages standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. A system is also specified for implementing a client and server in accordance with the method. | 01-05-2012 |
20120011267 | LIVE STREAMING MEDIA DELIVERY FOR MOBILE AUDIENCES - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. The live streaming system includes a live streaming recorder operative to (1) capture a live media stream generated by a live media source and save the captured live media stream as a recorded stream in a recorded media file, and (2) transcode the recorded stream into a plurality of transcoded media files of respective different media encoding formats. The system further includes a stream distribution subsystem operative to generate a plurality of distributed media streams each generated from one or more of the transcoded media files, each distributed media stream being delivered to a corresponding set of the mobile endpoint devices. | 01-12-2012 |
20150113100 | SOFTWARE-DEFINED MEDIA PLATFORM - A software-defined media platform having one or more media processing units that may be dynamically instantiated, interconnected and configured according to changes in demand, resource availability, and other parameters affecting system performance relative to demand. In one example media processing method, a source media stream may be received via multicast or unicast. The source media stream may be processed into one or more levels of work product segments having different media characteristics by a plurality of transcoding processing units, as needed. One or more levels of work product segments, or the source media stream, may be packaged (e.g., including resegmenting) into final work product segments having select media characteristics, which may be uploaded to a cloud storage unit for delivery to end users. | 04-23-2015 |
Tung Ng, N. Andover, MA US
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20120002717 | METHOD AND SYSTEM FOR LIVE STREAMING VIDEO WITH DYNAMIC RATE ADAPTATION - A live streaming system/method provides cross platform live streaming capabilities to mobile devices. A file format compatible with legacy HTTP infrastructure is used to deliver media over a persistent connection. Legacy client media players can dynamically change the encoded rate of the media delivered over a persistent connection. Standard HTTP servers may be used without modification, leveraging standard media players embedded in mobile devices for seamless media delivery over wireless networks with high bandwidth fluctuations. | 01-05-2012 |
20120005364 | SYSTEM AND METHOD FOR NETWORK AWARE ADAPTIVE STREAMING FOR NOMADIC ENDPOINTS - In a system for streaming data over a network, the type and rate of streaming are automatically varied based on available network bandwidth. Video media is transcoded into different bit rate encodings that are divided into segment files. Segments are sent from a network-aware adaptive streaming (NAAS) server and reassembled and presented to a media player at a client device. The system may download additional segment files ahead of time from multiple NAAS servers to increase throughput. A playback status (“bookmark”) may be maintained to keep track of what the user has viewed and to allow the user to continue playing from where the user left off. The user may continue watching from the bookmark point on the same device or on a different device. | 01-05-2012 |
Yin Shan Ng, North Billerica, MA US
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20100092532 | Materials and Methods for Treating and Managing Angiogenesis-Mediated Diseases - Disclosed herein are materials and methods suitable for treating sites of pathological angiogenesis and abnormal neovascularization. Sites of pathological angiogenesis or abnormal neovascularization can be treated by contacting a surface at or adjacent or in the vicinity of an area of pathological angiogenesis or abnormal neovascularization with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected site. The composition can be a flexible planar material or a flowable composition. Diseases susceptible to treatment with the present invention include, for example, macular degeneration, rheumatoid arthritis, psoriasis, psoriatic arthritis, systemic inflammatory diseases, and treatment of tumors by surgical resection, radiation therapy or chemotherapy. | 04-15-2010 |
20100185156 | Methods and Devices for Minimally-Invasive Delivery of Cell-Containing Flowable Compositions - The present invention relates to a device for delivering a flowable composition comprising cells, wherein the flowable composition is in an amount effective to treat an injured or diseased site. The device comprises a delivery device adapted for minimally-invasive delivery of the flowable composition through which the flowable composition can be passed while maintaining the effectiveness and viability of the cells of the flowable composition. The present invention further relates to a method for delivering the flowable composition comprising cells. The method comprises the steps of percutaneously inserting a delivery device adapted for minimally-invasive delivery of the flowable composition through which the flowable composition can be passed while maintaining the effectiveness and viability of the cells of the flowable composition and administering the flowable composition at, adjacent to or in the vicinity of the injured or diseased site. | 07-22-2010 |
20110070282 | Materials and Methods for Treating Skeletal System Damage and Promoting Skeletal System Repair and Regeneration - Disclosed herein are materials and methods suitable for treating injured, damaged or diseased mineralized and non-mineralized skeletal tissues, including bones, joints, tendons, ligaments, cartilage and/or other non-mineralized skeletal tissues. The affected structure can be treated by contacting a surface of the skeletal element at or adjacent to or in the vicinity of an area of injury, damage or disease with an implantable material. The implantable material comprises a biocompatible matrix and cells and is in an amount effective to treat the affected structure. A composition comprising a biocompatible matrix and cells engrafted therein or thereon can be used to treat the affected structure. The composition can be a flexible planar material or a flowable composition. | 03-24-2011 |